Nanoscale dynamics in the extracellular space of the brain in vivo

Project description

Insight into waste clearance mechanisms in the brain

Protein aggregation is the hallmark of neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. A large fraction of these protein aggregates accumulates in the extracellular space of the brain, but the mechanisms underlying the clearance of such toxic products is not fully understood. The EU-funded BrainNanoFlow project has developed nanotechnology-based tools and probes to study the fate of protein aggregates at the single-molecule level using high-resolution microscopy. Researchers will investigate the glymphatic system, a glial-dependent pathway in the brain responsible for waste clearance. Results will help unveil key physiological and pathological processes in the brain and pave the way towards fighting dementia.

Fields of science

Keywords

Host institution

THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS

Net EU contribution

€ 1 552 948,00

Address

North Street 66 College Gate
KY16 9AJ St Andrews
United Kingdom

Region

Eastern Scotland Clackmannanshire and Fife

Activity type

Higher or Secondary Education Establishments

Links

Contact the organisation Website

Participation in EU R&I programmes

HORIZON collaboration network

Other funding

€ 0,00

Beneficiaries (1)