Skip to main content

Vaccines and Infectious Diseases in the Ageing PopuLation

Objective

Today’s major challenge is to improve efficacy of vaccines to protect the growing ageing population against infectious diseases (ID). The VITAL project aims to address this challenge by assessing the ID burden and mechanisms of immunosenescence to provide evidence-based knowledge on vaccination strategies to establish healthy ageing. Links with existing projects containing data sources combined with novel data acquired through our extensive network of dataregistries across Europe will result in a database of epidemiology, risk factors and burden of disease of both vaccine-preventable (VP) and potential vaccine-preventable ID. Crucial knowledge on factors that hamper immune responsiveness and in-depth analyses of immune compartments involved in inducing effective immune responses to different vaccines in the ageing host will be gathered. We will identify novel predictive, potentially universal immune profiles of vaccine responses using novel technologies, unique experimental models and (infection) cohorts of elderly subjects in which (bio)markers of frailty have already been identified. Novel strategies to address the problem of immunosenescence will be tested, in particular whether vaccination of middle-aged individuals can maintain proper memory immune responses in the elderly, to improve memory immunity before reaching old age. Using data on epidemiology of VPID and immune responsiveness, novel agent-based models will be developed to build a user-friendly tool to be used by health care professionals for optimal implementation of vaccination strategies for older people and to develop dissemination protocols for the obtained knowledge for the health care field. Finally, we will deliver a framework that forms the basis for designing, implementing and regularly updating vaccination schemes for the ageing population. Thereby, VITAL will initiate an important impetus to a more targeted immunization program for the elderly in Europe that will enhance healthy aging.

Field of science

  • /medical and health sciences/health sciences/infectious disease
  • /medical and health sciences/health sciences/epidemiology
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines

Call for proposal

H2020-JTI-IMI2-2017-12-two-stage
See other projects for this call

Funding Scheme

IMI2-RIA - Research and Innovation action

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Address
Heidelberglaan 100
3584 CX Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 781 750

Participants (23)

RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Netherlands
EU contribution
€ 1 977 721,25
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Activity type
Research Organisations
P95 CVBA
Belgium
EU contribution
€ 186 375
Address
Koning Leopold Iii - Laan 1
3001 Leuven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 363 750
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
FOLKEHELSEINSTITUTTET
Norway
EU contribution
€ 348 472,50
Address
Lovisenberggata 8
0456 Oslo
Activity type
Research Organisations
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 230 000
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
STATENS SERUM INSTITUT
Denmark
EU contribution
€ 206 936
Address
Artillerivej 5
2300 Kobenhavn S
Activity type
Research Organisations
UNIVERSITAET INNSBRUCK
Austria
EU contribution
€ 263 750
Address
Innrain 52
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 12 500
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 12 500
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 12 500
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 90 602,50
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
FUNDACION PARA EL FOMENTO DE LA INVESTIGACION SANITARIA Y BIOMEDICA DE LA COMUNITAT VALENCIANA
Spain
EU contribution
€ 291 423,75
Address
Calle Micer Masco 31
46010 Valencia
Activity type
Research Organisations
SYREON KUTATO INTEZET KORLATOLT FELELOSSEGU TARSASAG
Hungary
EU contribution
€ 230 976,25
Address
Mexikoi Ut 65/A
1142 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITA DEGLI STUDI DI FERRARA
Italy
EU contribution
€ 230 625
Address
Via Ariosto 35
44121 Ferrara
Activity type
Higher or Secondary Education Establishments
UNIVERSITE JEAN MONNET SAINT-ETIENNE
France
EU contribution
€ 200 000
Address
Rue Trefilerie 10
42023 Saint Etienne
Activity type
Higher or Secondary Education Establishments
MIHAJLOVIC JOVAN
Serbia
EU contribution
€ 60 000
Address
Omladinskih Radnih Akcija 54
21000 Novi Sad
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GLAXOSMITHKLINE BIOLOGICALS SA
Belgium
EU contribution
€ 0
Address
Rue De L Institut 89
1330 Rixensart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PFIZER LIMITED
United Kingdom
EU contribution
€ 0
Address
Ramsgate Road
CT13 9NJ Sandwich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SANOFI PASTEUR SA
France
EU contribution
€ 0
Address
Avenue Pont Pasteur, 2
69007 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MERCK SHARP & DOHME CORP
United States
EU contribution
€ 0
Address
One Merck Drive
08889 Whitehouse Station Nj
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
JANSSEN VACCINES & PREVENTION BV
Netherlands
EU contribution
€ 0
Address
Archimedesweg 4
2333 CN Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOMERIEUX SA
France
EU contribution
€ 0
Address
Chemin De L'orme
69280 Marcy L'etoile
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FEDERATION EUROPEENNE D'ASSOCIATIONS ET D'INDUSTRIES PHARMACEUTIQUES
Belgium
EU contribution
€ 0
Address
Rue Du Trone 108/1
1050 Bruxelles
Activity type
Other