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Vaccines and Infectious Diseases in the Ageing PopuLation

Descrizione del progetto

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Efficacia della vaccinazione negli anziani

La vaccinazione è una delle strategie chiave per proteggere gli individui dalle malattie infettive. Tuttavia, il naturale invecchiamento è associato al deterioramento del sistema immunitario, inibendo l’efficacia dei vaccini. Il progetto VITAL, finanziato dall’UE, studierà i fattori responsabili della mancata risposta immunologica ed elaborerà strategie innovative per affrontare il problema. Usando un approccio multidisciplinare, i ricercatori assoceranno i profili immunitari di persone anziane con le risposte ai vaccini, offrendo conoscenze empiriche senza precedenti sull’efficacia dei vaccini esistenti. È importante osservare che il progetto fornirà un quadro concepito appositamente per l’immunizzazione degli anziani con l’obiettivo di promuovere un invecchiamento sano.

Obiettivo

Today’s major challenge is to improve efficacy of vaccines to protect the growing ageing population against infectious diseases (ID). The VITAL project aims to address this challenge by assessing the ID burden and mechanisms of immunosenescence to provide evidence-based knowledge on vaccination strategies to establish healthy ageing. Links with existing projects containing data sources combined with novel data acquired through our extensive network
of data registries across Europe will result in a database of epidemiology, risk factors and burden of disease of both vaccine-preventable (VP) and potential vaccine-preventable ID. Crucial knowledge on factors that hamper immune responsiveness and in-depth analyses of immune compartments involved in inducing effective immune responses to different vaccines in the ageing host will be gathered. We will identify novel predictive, potentially universal immune profiles of vaccine responses using novel technologies, unique experimental models and (infection) cohorts of elderly subjects in which (bio)markers of frailty have already been identified. Novel strategies to address the problem of immunosenescence will be tested, in particular whether vaccination of middle-aged individuals can maintain proper memory immune responses in the elderly, to improve memory immunity before reaching old age. Using data on epidemiology of VPID and immune responsiveness, novel agent-based models will be developed to build a user- friendly tool to be used by health care professionals for optimal implementation of vaccination strategies for older people and to develop dissemination protocols for the obtained knowledge for the healthcare field. Finally, we will deliver a framework that forms the basis for designing, implementing and regularly updating vaccination schemes for the ageing population. Thereby, VITAL will initiate an important impetus to a more targeted immunization program for the elderly in Europe that will enhance healthy aging.

Campo scientifico

Parole chiave

Programma(i)

Argomento(i)

Invito a presentare proposte

H2020-JTI-IMI2-2017-12-two-stage

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Meccanismo di finanziamento

RIA - Research and Innovation action

Coordinatore

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Contribution nette de l'UE
€ 603 686,00
Indirizzo
HEIDELBERGLAAN 100
3584 CX Utrecht
Paesi Bassi

Mostra sulla mappa
Regione
West-Nederland Utrecht Utrecht
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
€ 681 186,00

Partecipanti (24)

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Ultimo aggiornamento: 21 Maggio 2024

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Permalink: https://cordis.europa.eu/project/id/806776/it

European Union, 2024