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European Health Data and Evidence Network

Leistungen

Second Report on the implementation of the analytical pipeline for personalized medicine

This deliverable will provide an update on the analytical pipeline for patient-level prediction and risk effect estimation. Moreover, it will contain results of proof-of-concept studies in these domains.

Report on educational and training material for the developed analytical tools (1)

Report on the training materials that have been developed and a status on the delivery to the different target audiences (SME's, researchers, hospitals and GPs, registries and biobanks etc.).

Yearly Progress report on technical framework (2)

A description of the progress on the technical platform and outlook for the following 12 months.

Selected priority therapeutic areas

A short report on the completion of task 2.1

Final version of the Framework for quality benchmarking

This deliverable will offer the comprehensive framework.

Yearly Progress report on technical framework (1)

A description of the progress on the technical platform and outlook for the following 12 months.

Report on key data source/s of interest for WP1 Use Cases

This report will provide the rationale for mapping different types of data as relevant for the proposed use cases.

First Report on educational and training material for the developed analytical tools

This deliverable will provide an update on the creation of educational and training material for the analytical tools developed in this work package.

"Results of ""validation"" Use Case 1 study"

A validation study replicating analyses on RMM Effectiveness Use Case 1 using unmapped as well as OMOPmapped data will be conducted A report with its results will be delivered by the end of Month 37

Report on Federated Network Studies (1)

These deliverables will update on the deployment of the study execution pipeline in the context of the Use Case in WP13 and possibly for other stakeholders later in the project

Ethics Advisory Board nomination

Nomination of the Ethics Advisory Board pursuant to the Ethics Review

Report on liaison with other BD4BO projects

This deliverable will report on the relationship and collaborations established with other BD4BO projects with an evaluation of results obtained and impact

Selection of use cases for personalized medicine

We will perform a survey including all the stakeholders to develop a list to use cases for the personalized medicine pipeline. This will include prediction and risk effect estimation use cases.

Third Report on the implementation of the analytical pipeline for personalized medicine

This deliverable will provide an update on the analytical pipeline including the disease trajectory pipeline

First Report on the implementation of selected use cases in the data network

This report describes the progress made on testing the analytical pipelines in the data network

First report on community building

This deliverable will report the results of deployment of outreach activities in terms of stakeholders both institutions and professionals successfully involved in EHDEN and established working dynamics describing gaps and areas that should be reinforced according to the evolution of the field

ICHOM standards defined using OMOP terminology

This deliverable provides insight on how the prioritized ICHOM standard sets as defined in D2.1 can be implemented using the OMOP-CDM.

Analysis of potential Public-Private Partnership exploitation models

This deliverable will analyse both successful and unsuccessful exploitation models used by initiatives similar to EHDEN studying their application domain and their potential to serve as blueprint for EHDEN sustainability

Roadmap for interoperability solutions

Description of the process for and technology applied for interoperability with other 'standard' platforms.

Report on SME Certification Procedure and Data Source Grant Awarding Procedure developed and implemented

Report on SME Certification Procedure and Data Source Grant Awarding Procedure developed and implemented. This will include the Open Call announcement text and instructions for applicants, definition of selection and evaluation committees and description of eligibility criteria.

Stakeholder mapping

This deliverable will report on the different stakeholder types that will need a value proposition for successful outreach, including if necessary sub-categories.

First Report on the implementation of the analytical pipeline for personalized medicine

This deliverable will provide an update on the analytical pipeline for patient-level prediction and risk effect estimation

First version of the Framework for quality benchmarking

This deliverable will contain the description of the quality management and control framework with a primary focus on the mapping process, also incorporating stakeholder consultations.

Report on Quality Assurance and Control Procedures

This report discusses the implementation of the quality assurance and control procedures for the full eco-system.

Yearly Progress report on technical framework (3)

A description of the progress on the technical platform and outlook for the following 12 months

Technical framework design and architecture

The identification of the individual components, the functional and technical integration of these components in the EHDEN platform are the subject of this first deliverable.

Assessment of regulatory requirements for patient-level decision making

Report on the mapping of regulatory requirements across Europe for risk prediction models.

Implementation of RMM Effectiveness testing methods

Tools for interrupted time series analyses will be integrated and fully accessible as part of the EHDEN toolkit.

OMOP-CDM enhancements for Outcome Driven Healthcare

This deliverable describes the changes needed in the OMOP-CDM to capture the information for the ICHOM standard sets and Patient Reported Outcomes in general. This includes structural changes as well as changes to the Standardized Vocabularies.

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Veröffentlichungen

A standardized framework for risk-based assessment of treatment effect heterogeneity in observational healthcare databases

Autoren: Rekkas, Alexandros; van Klaveren, David; Ryan, Patrick B.; Steyerberg, Ewout W.; Kent, David M.; Rijnbeek, Peter R.
Veröffentlicht in: arXiv, 2, 2020, ISSN 2331-8422
Herausgeber: arXiv
DOI: 10.5281/zenodo.4087988

Development and validation of patient-level prediction models for symptoms, hospitalization and treatment initiation amongst prostate cancer patients on watchful waiting

Autoren: Sebastiaan Remmers, Lana Lai Yin Hui, Carolin Schimmelpfennig, Peter-Paul Willemsen, Markus Kreuz, Philip Cornford, Nicolas Mottet, Nazanin Zounemat-Kermani
Veröffentlicht in: Protocol Exhange, 2021, ISSN 2043-0116
Herausgeber: Nature Publisher
DOI: 10.21203/rs.3.pex-1525/v1

A standardized analytics pipeline for reliable and rapid development and validation of prediction models using observational health data

Autoren: Sara Khalid, Cynthia Yang, Clair Blacketer,  View ORCID ProfileTalita Duarte-Salles, Sergio Fernández-Bertolín, Chungsoo Kim, Rae Woong Park, Jimyung Park, Martijn Schuemie,  View ORCID ProfileAnthony Sena,  View ORCID ProfileMarc A. Suchard, Seng Chan You, Peter Rijnbeek, Jenna Reps
Veröffentlicht in: Computer Methods and Programs in Biomedicine, 2021, ISSN 0169-2607
Herausgeber: Elsevier BV
DOI: 10.1016/j.cmpb.2021.106394

Smoking and COVID-19 Infection and Related Mortality: A Prospective Cohort Analysis of UK Biobank Data.

Autoren: Prats-Uribe A, Xie J, Prieto-Alhambra D, Petersen I.
Veröffentlicht in: Clin Epidemiol, 2021, ISSN 1179-1349
Herausgeber: Dove Medical Press Ltd
DOI: 10.2147/clep.s300597

Body Mass Index and Risk of COVID-19 Diagnosis, Hospitalization, and Death: A Cohort Study of 2 524 926 Catalans

Autoren: Recalde M, Pistillo A, Fernandez-Bertolin S, Roel E, Aragon M, Freisling H, Prieto-Alhambra D, Burn E, Duarte-Salles T.
Veröffentlicht in: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Herausgeber: The Endocrine Society
DOI: 10.1210/clinem/dgab546

The natural history of symptomatic COVID-19 during the first wave in Catalonia.

Autoren: Burn E, Tebé C, Fernandez-Bertolin S, Aragon M, Recalde M, Roel E, Prats-Uribe A, Prieto-Alhambra D, Duarte-Salles T.
Veröffentlicht in: Nature Communications, 2021, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-021-21100-y

COVID-19 in patients with autoimmune diseases: characteristics and outcomes in a multinational network of cohorts across three countries.

Autoren: Tan EH, Sena AG, Prats-Uribe A, You SC, Ahmed WU, Kostka K, Reich C, Duvall SL, Lynch KE, Matheny ME, Duarte-Salles T, Bertolin SF, Hripcsak G, Natarajan K, Falconer T, Spotnitz M, Ostropolets A, Blacketer C, Alshammari TM, Alghoul H, Alser O, Lane JCE, Dawoud DM, Shah K, Yang Y, Zhang L, Areia C, Golozar A, Recalde M, Casajust P, Jonnagaddala J, Subbian V, Vizcaya D, Lai LYH, Nyberg F, Morales DR
Veröffentlicht in: Rheumatology, 2021, ISSN 1462-0324
Herausgeber: Oxford University Press
DOI: 10.1093/rheumatology/keab250

Characteristics and Outcomes of Over 300,000 Patients with COVID-19 and History of Cancer in the United States and Spain.

Autoren: Roel E, Pistillo A, Recalde M, Sena AG, Fernández-Bertolín S, Aragón M, Puente D, Ahmed WU, Alghoul H, Alser O, Alshammari TM, Areia C, Blacketer C, Carter W, Casajust P, Culhane AC, Dawoud D, DeFalco F, DuVall SL, Falconer T, Golozar A, Gong M, Hester L, Hripcsak G, Tan EH, Jeon H, Jonnagaddala J, Lai LYH, Lynch KE, Matheny ME, Morales DR, Natarajan K, Nyberg F, Ostropolets A, Posada JD, Prats
Veröffentlicht in: Cancer Epidemiol Biomarkers Prev., 2021, ISSN 1055-9965
Herausgeber: American Association for Cancer Research
DOI: 10.1158/1055-9965.epi-21-0266

Characterizing the incidence of adverse events of special interest for COVID-19 vaccines across eight countries: a multinational network cohort study

Autoren: Xintong Li;  Anna Ostropolets; Rupa Makadia; Azza Shaoibi; Gowtham Rao;  Anthony G. Sena; Eugenia Martinez-Hernandez; Antonella Delmestri; Katia Verhamme;  Peter R Rijnbeek;  Talita Duarte-Salles;  Marc Suchard; Patrick Ryan; George Hripcsak;  Daniel Prieto-Alhambra
Veröffentlicht in: BMJ, 2021, ISSN 2044-6055
Herausgeber: BMJ Publishing Group
DOI: 10.1136/bmj.n1435

Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study

Autoren: Edward Burn, Seng Chan You, Anthony G. Sena, Kristin Kostka, Hamed Abedtash, Maria Tereza F. Abrahão, Amanda Alberga, Heba Alghoul, Osaid Alser, Thamir M. Alshammari, Maria Aragon, Carlos Areia, Juan M. Banda, Jaehyeong Cho, Aedin C. Culhane, Alexander Davydov, Frank J. DeFalco, Talita Duarte-Salles, Scott DuVall, Thomas Falconer, Sergio Fernandez-Bertolin, Weihua Gao, Asieh Golozar, Jill Hardin,
Veröffentlicht in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-020-18849-z

"Research Protocol for an Observational Health Data Analysis to Assess the Long-term Outcomes of Prostate Cancer Patients Undergoing non-interventional Management (i.e. Watchful Waiting) and the Impact of Comorbidities and Life Expectancy - PIONEER IMI's ""Big Data for Better Outcomes"" program"

Autoren: Giorgio Gandaglia, Kees van Bochove, Anders Bjartell, Alberto Briganti, Phil Conford, Susan Evans Axelsson, Asieh Golozar, Mieke Van Hemelrijck, Katharina Beyer, Peter-Paul Willemse, Muhammad Imran Omar, James N’Dow, Alex Asiimwe, Monique Roobol, Robert Snijder, Carl Steinbeisser, Roderick Van Den Bergh, Samuel Fatoba, Ariel Achtman, Thamir M Alshammari, Nicolas Thurin, Adam Kinnaird, Sebastian
Veröffentlicht in: Protocol Exchange, 2021, ISSN 2043-0116
Herausgeber: Nature Publication
DOI: 10.21203/rs.3.pex-1468/v1

Associations of BNT162b2 vaccination with SARS-CoV-2 infection and hospital admission and death with covid-19 in nursing homes and healthcare workers in Catalonia: prospective cohort study.

Autoren: Cabezas C, Coma E, Mora-Fernandez N, Li X, Martinez-Marcos M, Fina F, Fabregas M, Hermosilla E, Jover A, Contel JC, Lejardi Y, Enfedaque B, Argimon JM, Medina-Peralta M, Prieto-Alhambra D.
Veröffentlicht in: BMJ, 2021, ISSN 2044-6055
Herausgeber: BMJ Publishing Group
DOI: 10.1136/bmj.n1868

Implementation of the COVID-19 Vulnerability Index Across an International Network of Health Care Data Sets: Collaborative External Validation Study.

Autoren: Reps JM, Kim C, Williams RD, Markus AF, Yang C, Duarte-Salles T, Falconer T, Jonnagaddala J, Williams A, Fernández-Bertolín S, DuVall SL, Kostka K, Rao G, Shoaibi A, Ostropolets A, Spotnitz ME, Zhang L, Casajust P, Steyerberg EW, Nyberg F, Kaas-Hansen BS, Choi YH, Morales D, Liaw ST, Abrahão MTF, Areia C, Matheny ME, Lynch KE, Aragón M, Park RW, Hripcsak G, Reich CG, Suchard MA, You SC, Ryan P
Veröffentlicht in: JMIR Med Inform, 2021, ISSN 2291-9694
Herausgeber: JMIR Publications
DOI: 10.2196/21547

Growing backlog of planned surgery due to covid-19

Autoren: Carr A, Smith JA, Camaradou J, Prieto-Alhambra D.
Veröffentlicht in: BMJ, 2021, ISSN 2044-6055
Herausgeber: BMJ Publishing Group
DOI: 10.1136/bmj.n339

Mortality, falls and fracture risk are positively associated with frailty: a SIDIAP cohort study of 890,000 patients

Autoren: Middleton R, Poveda JL, Orfila Pernas F, Martinez Laguna D, Diez Perez A, Nogués X, Carbonell Abella C, Reyes C, Prieto-Alhambra D.
Veröffentlicht in: J Gerontol A Biol Sci Med Sci, 2021, ISSN 1079-5006
Herausgeber: Gerontological Society of America
DOI: 10.1093/gerona/glab102

Using the Data Quality Dashboard to Improve the EHDEN Network

Autoren: Clair Blacketer, Erica A Voss, Frank DeFalco, Nigel Hughes, Martijn J Schuemie, Maxim Moinat, Peter R Rijnbeek
Veröffentlicht in: Journal of Applied Sciences, 2021, ISSN 2076-3417
Herausgeber: MDPI
DOI: 10.3390/app112411920

Common Problems, Common Data Model Solutions: Evidence Generation for Health Technology Assessment

Autoren: Seamus Kent, Edward Burn, Dalia Dawoud, Pall Jonsson, Jens Torup Østby, Nigel Hughes, Peter Rijnbeek, Jacoline C. Bouvy
Veröffentlicht in: PharmacoEconomics, 2020, ISSN 1170-7690
Herausgeber: Adis International Ltd.
DOI: 10.1007/s40273-020-00981-9

Standardizing registry data to the OMOP Common Data Model: experience from three pulmonary hypertension databases

Autoren: Patricia Biedermann, Rose Ong, Alexander Davydov, Alexandra Orlova, Philip Solovyev, Hong Sun, Graham Wetherill, Monika Brand, Eva-Maria Didden
Veröffentlicht in: BMC Medical Research Methodology, 2021, ISSN 1471-2288
Herausgeber: BioMed Central
DOI: 10.1186/s12874-021-01434-3

Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience.

Autoren: Duarte-Salles T, Vizcaya D, Pistillo A, Casajust P, Sena AG, Lai LYH, Prats-Uribe A, Ahmed WU, Alshammari TM, Alghoul H, Alser O, Burn E, You SC, Areia C, Blacketer C, DuVall S, Falconer T, Fernandez-Bertolin S, Fortin S, Golozar A, Gong M, Tan EH, Huser V, Iveli P, Morales DR, Nyberg F, Posada JD, Recalde M, Roel E, Schilling LM, Shah NH, Shah K, Suchard MA, Zhang L, Zhang Y, Williams AE, Reich C
Veröffentlicht in: Pedatrics, 2021, ISSN 0031-4005
Herausgeber: American Academy of Pediatrics
DOI: 10.1542/peds.2020-042929

Opioid use, postoperative complications, and implant survival after unicompartmental versus total knee replacement: a population-based network study

Autoren: Edward Burn, James Weaver, Daniel Morales, Albert Prats-Uribe, Antonella Delmestri, Victoria Y Strauss, Ying He, Danielle E Robinson, Rafael Pinedo-Villanueva, Spyros Kolovos, Talita Duarte-Salles, William Sproviero, Dahai Yu, Michel Van Speybroeck, Ross Williams, Luis H John, Nigel Hughes, Anthony G Sena, Ruth Costello, Belay Birlie, David Culliford, Caroline O'Leary, Henry Morgan, Theresa Burkar
Veröffentlicht in: The Lancet Rheumatology, 1/4, 2019, Page(s) e229-e236, ISSN 2665-9913
Herausgeber: Elsevier
DOI: 10.1016/s2665-9913(19)30075-x

Patient data discovery platforms as enablers of biomedical and translational research: A systematic review

Autoren: Alina Trifan, José Luís Oliveira
Veröffentlicht in: Journal of Biomedical Informatics, 93, 2019, Page(s) 103154, ISSN 1532-0464
Herausgeber: Academic Press
DOI: 10.1016/j.jbi.2019.103154

Cancer and the risk of coronavirus disease 2019 diagnosis, hospitalisation and death: A population-based multistate cohort study including 4 618 377 adults in Catalonia, Spain

Autoren: Roel E, Pistillo A, Recalde M, Fernández-Bertolín S, Aragón M, Soerjomataram I, Jenab M, Puente D, Prieto-Alhambra D, Burn E, Duarte-Salles T.
Veröffentlicht in: Cancer Epidemiology, 2021, ISSN 1877-7821
Herausgeber: Elsevier BV
DOI: 10.1002/ijc.33846

Feasibility and evaluation of a large-scale external validation approach for patient-level prediction in an international data network: validation of models predicting stroke in female patients newly diagnosed with atrial fibrillation

Autoren: Jenna M. Reps, Ross D. Williams, Seng Chan You, Thomas Falconer, Evan Minty, Alison Callahan, Patrick B. Ryan, Rae Woong Park, Hong-Seok Lim, Peter Rijnbeek
Veröffentlicht in: BMC Medical Research Methodology, 20/1, 2020, ISSN 1471-2288
Herausgeber: BioMed Central
DOI: 10.1186/s12874-020-00991-3

The role of explainability in creating trustworthy artificial intelligence for health care: A comprehensive survey of the terminology, design choices, and evaluation strategies

Autoren: Aniek F. Markus, Jan A. Kors, Peter R. Rijnbeek
Veröffentlicht in: Journal of Biomedical Informatics, 113, 2021, Page(s) 103655, ISSN 1532-0464
Herausgeber: Academic Press
DOI: 10.1016/j.jbi.2020.103655

Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study

Autoren: Jennifer C E Lane, James Weaver, Kristin Kostka, Talita Duarte-Salles, Maria Tereza F Abrahao, Heba Alghoul, Osaid Alser, Thamir M Alshammari, Patricia Biedermann, Juan M Banda, Edward Burn, Paula Casajust, Mitchell M Conover, Aedin C Culhane, Alexander Davydov, Scott L DuVall, Dmitry Dymshyts, Sergio Fernandez-Bertolin, Kristina Fišter, Jill Hardin, Laura Hester, George Hripcsak, Benjamin Skov K
Veröffentlicht in: The Lancet Rheumatology, 2/11, 2020, Page(s) e698-e711, ISSN 2665-9913
Herausgeber: The Lancet Rheumatology
DOI: 10.1016/S2665-9913(20)30276-9

Use of repurposed and adjuvant drugs in hospital patients with covid-19: multinational network cohort study

Autoren: Albert Prats-Uribe, Anthony G Sena, Lana Yin Hui Lai, Waheed-Ul-Rahman Ahmed, Heba Alghoul, Osaid Alser, Thamir M Alshammari, Carlos Areia, William Carter, Paula Casajust, Dalia Dawoud, Asieh Golozar, Jitendra Jonnagaddala, Paras P Mehta, Mengchun Gong, Daniel R Morales, Fredrik Nyberg, Jose D Posada, Martina Recalde, Elena Roel, Karishma Shah, Nigam H Shah, Lisa M Schilling, Vignesh Subbian, Davi
Veröffentlicht in: BMJ, 2021, ISSN 2044-6055
Herausgeber: BMJ Publishing Group
DOI: 10.1136/bmj.n1038

Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multinational network cohort study

Autoren: Jennifer C E Lane, James Weaver, Kristin Kostka, Talita Duarte-Salles, Maria Tereza F Abrahao, Heba Alghoul, Osaid Alser, Thamir M Alshammari, Carlos Areia, Patricia Biedermann, Juan M Banda, Edward Burn, Paula Casajust, Kristina Fister, Jill Hardin, Laura Hester, George Hripcsak, Benjamin Skov Kaas-Hansen, Sajan Khosla, Spyros Kolovos, Kristine E Lynch, Rupa Makadia, Paras P Mehta, Daniel R Moral
Veröffentlicht in: Rheumatology, 2020, ISSN 1462-0324
Herausgeber: Oxford University Press
DOI: 10.1093/rheumatology/keaa771

Heterologous vaccine regimens against COVID-19.

Autoren: Duarte-Salles T, Prieto-Alhambra D.
Veröffentlicht in: The Lancet, 2021, ISSN 0140-6736
Herausgeber: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(21)01442-2

Increasing trust in real-world evidence through evaluation of observational data quality

Autoren: Clair Blacketer, Patrick Ryan, Frank DeFalco, Peter Rijnbeek
Veröffentlicht in: JAMIA, 2021, ISSN 1067-5027
Herausgeber: Hanley and Belfus, Inc.
DOI: 10.1093/jamia/ocab132

Renin–angiotensin system blockers and susceptibility to COVID-19: an international, open science, cohort analysis

Autoren: Daniel R Morales, Mitchell M Conover, Seng Chan You, Nicole Pratt, Kristin Kostka, Talita Duarte-Salles, Sergio Fernández-Bertolín, Maria Aragón, Scott L DuVall, Kristine Lynch, Thomas Falconer, Kees van Bochove, Cynthia Sung, Michael E Matheny, Christophe G Lambert, Fredrik Nyberg, Thamir M Alshammari, Andrew E Williams, Rae Woong Park, James Weaver, Anthony G Sena, Martijn J Schuemie, Peter R
Veröffentlicht in: The Lancet Digital Health, 2020, ISSN 2589-7500
Herausgeber: The Lancet
DOI: 10.1016/S2589-7500(20)30289-2

Clinical concept normalization on medical records using word embeddings and heuristics

Autoren: Silva, João Figueira; Antunes, Rui; Almeida, João Rafael; Matos, Sérgio
Veröffentlicht in: 15, 2020
Herausgeber: IOS Press
DOI: 10.3233/shti200129

Baseline phenotype and 30-day outcomes of people tested for COVID-19: an international network cohort including >3.32 million people tested with real-time PCR and >219,000 tested positive for SARS-CoV-2 in South Korea, Spain and the United States

Autoren: Asieh Golozar; Lana YH Lai; Anthony G. Sena; David Vizcaya; Lisa M. Schilling; Vojtech Huser; Fredrik Nyberg; Scott L. Duvall; Daniel R. Morales; Thamir M Alshammari; Hamed Abedtash; Waheed-Ul-Rahman Ahmed; Osaid Alser; Heba Alghoul; Ying Zhang; Mengchun Gong; Yin Guan; Carlos Areia; Jitendra Jonnagaddala; Karishma Shah; Jennifer C.E. Lane; Albert Prats-Uribe; Jose D. Posada; Nigam H. Shah; Vignes
Veröffentlicht in: medRxiv, 2020
Herausgeber: medRxiv
DOI: 10.1101/2020.10.25.20218875

How little data do we need for patient-level prediction?

Autoren: John, Luis H.; Kors, Jan A.; Reps, Jenna M.; Ryan, Patrick B.; Rijnbeek, Peter R.
Veröffentlicht in: arXiv, 10, 2020
Herausgeber: arXiv
DOI: 10.5281/zenodo.3988940

Body mass index and risk of COVID-19 diagnosis, hospitalisation, and death: a population-based multi-state cohort analysis including 2,524,926 people in Catalonia, Spain

Autoren: Martina Recalde; Andrea Pistillo; Sergio Fernandez-Bertolin; Elena Roel; Maria Aragon; Heinz Freisling; Daniel Prieto-Alhambra; Edward Burn; Talita Duarte-Salles
Veröffentlicht in: medRxiv, 2020
Herausgeber: medRxiv
DOI: 10.1101/2020.11.25.20237776

Safety of hydroxychloroquine, alone and in combination with azithromycin, in light of rapid widespread use for COVID-19: a multinational, network cohort and self-controlled case series study

Autoren: Jennifer C.E.Lane; James Weaver; Kristin Kostka; Talita Duarte-Salles; Maria Tereza F. Abrahao; Heba Alghoul; Osaid Alser; Thamir M Alshammari; Patricia Biedermann; Edward Burn; Paula Casajust; Mitch Conover; Aedin C. Culhane; Alexander Davydov; Scott L. DuVall; Dmitry Dymshyts; Sergio Fernandez-Bertolin; Kristina Fišter; Jill Hardin; Laura Hester; George Hripcsak; Seamus Kent; Sajan Khosla; Spyr
Veröffentlicht in: medRxiv, 2020
Herausgeber: medRxiv
DOI: 10.1101/2020.04.08.20054551

Heterogeneity and temporal variation in the management of COVID-19: a multinational drug utilization study including 71,921 hospitalized patients from China, South Korea, Spain, and the United States of America

Autoren: Albert Prats-Uribe; Anthony G. Sena; Lana Yin Hui Lai; Waheed-Ul-Rahman Ahmed; Heba Alghoul; Osaid Alser; Thamir M Alshammari; Carlos Areia; William Carter; Paula Casajust; Dalia Dawoud; Asieh Golozar; Jitendra Jonnagaddala; Paras Mehta; Gong Menchung; Daniel R Morales; Fredrik Nyberg; Jose D Posada; Martina Recalde; Elena Roel; Karishma Shah; Nigam Shah; Lisa M Schilling; Vignesh Subbian; David V
Veröffentlicht in: medRxiv, 2020
Herausgeber: medRxiv
DOI: 10.1101/2020.09.15.20195545

Trajectories: a framework for detecting temporal clinical event sequences from health data standardized to the OMOP Common Data Model

Autoren: Kadri Künnapuu, Solomon Ioannou, Kadri Ligi, Raivo Kolde, Sven Laur, Jaak Vilo, Peter R. Rijnbeek, Sulev Reisberg
Veröffentlicht in: medRxiv, 2021
Herausgeber: medRxiv
DOI: 10.1101/2021.11.18.21266518

Using the OHDSI network to develop and externally validate a patient-level prediction model for Heart Failure in Type II Diabetes Mellitus

Autoren: Ross D. Williams; Jenna M. Reps; Jan A Kors; Patrick B Ryan; Ewout Steyerberg; Katia M. Verhamme; Peter R. Rijnbeek
Veröffentlicht in: medRxiv, 2021
Herausgeber: medRxiv
DOI: 10.1101/2021.04.06.21254966

Alpha-1 blockers and susceptibility to COVID-19 in benign prostate hyperplasia patients : an international cohort study

Autoren: Akihiko Nishimura; Junqing Xie; Kristin Kostka; Talita Duarte-Salles; Sergio Fernández Bertolín; María Aragón; Clair Blacketer; Azza Shoaibi; Scott L DuVall; Kristine Lynch; Michael E Matheny; Thomas Falconer; Daniel R Morales; Mitchell M Conover; Seng Chan You; Nicole Pratt; James Weaver; Anthony G Sena; Martijn J Schuemie; Jenna Reps; Christian Reich; Peter R Rijnbeek; 
Veröffentlicht in: medRxiv, 2021
Herausgeber: medRxiv
DOI: 10.1101/2021.03.18.21253778

The natural history of symptomatic COVID-19 in Catalonia, Spain: a multi-state model including 109,367 outpatient diagnoses, 18,019 hospitalisations, and 5,585 COVID-19 deaths among 5,627,520 people

Autoren: Edward Burn, Cristian Tebe, Sergio Fernandez-Bertolin, Maria Aragon, Martina Recalde, Elena Roel, Albert Prats-Uribe, Daniel Prieto-Alhambra, Talita Duarte-Salles
Veröffentlicht in: medRxiv, 2020
Herausgeber: medRxiv
DOI: 10.1101/2020.07.13.20152454

Baseline characteristics, management, and outcomes of 55,270 children and adolescents diagnosed with COVID-19 and 1,952,693 with influenza in France, Germany, Spain, South Korea and the United States: an international network cohort study

Autoren: Talita Duarte-Salles, David Vizcaya, Andrea Pistillo, Paula Casajust, Anthony G. Sena, Lana Yin Hui Lai, Albert Prats-Uribe, Waheed-Ul-Rahman Ahmed, Thamir M Alshammari, Heba Alghoul, Osaid Alser, Edward Burn, Seng Chan You, Carlos Areia, Clair Blacketer, Scott DuVall, Thomas Falconer, Sergio Fernandez-Bertolin, Stephen Fortin, Asieh Golozar, Mengchun Gong, Eng Hooi Tan, Vojtech Huser, Pablo Iveli
Veröffentlicht in: medRxiv, 2020
Herausgeber: medRxiv
DOI: 10.1101/2020.10.29.20222083

Using Real World Data to Understand HIV and COVID-19 in the U.S.A. and Spain: Characterizing Co-Infected Patients Across the Care Cascade

Autoren: Julianna Kohler; Kristin Kostka; Rupa Makadia; Roger Paredes; Talita Duarte-Salles; Scott Duvall; Alison Cheng; Asieh Golozar; Jennifer C. E. Lane; Anthony G. Sena; Peter R. Rijnbeek; Daniel R. Morales; Patrick B. Ryan; Christian Reich; Michael E. Matheny; Kristine E. Lynch; George K. Siberry; Daniel Prieto-Alhambra
Veröffentlicht in: medRxiv, 2020
Herausgeber: medRxiv
DOI: 10.1101/2020.11.10.20229401

Characteristics, outcomes, and mortality amongst 133,589 patients with prevalent autoimmune diseases diagnosed with, and 48,418 hospitalised for COVID-19: a multinational distributed network cohort analysis

Autoren: Eng Hooi Tan; Anthony G. Sena; Albert Prats-Uribe; Seng Chan You; Waheed-Ul-Rahman Ahmed; Kristin Kostka; Christian Reich; Scott L. Duvall; Kristine E. Lynch; Michael E. Matheny; Talita Duarte-Salles; Sergio Fernandez Bertolin; George Hripcsak; Karthik Natarajan; Thomas Falconer; Matthew Spotnitz; Anna Ostropolets; Clair Blacketer; Thamir M Alshammari; Heba Alghoul; Osaid Alser; Jennifer C.E. Lane
Veröffentlicht in: medRxiv, 2020
Herausgeber: medRxiv
DOI: 10.1101/2020.11.24.20236802

Risk of depression, suicidal ideation, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multi-national network cohort study

Autoren: Jennifer C.E Lane, James Weaver, Kristin Kostka, Talita Duarte-Salles, Maria Tereza F Abrahao, Heba Alghoul, Osaid Alser, Thamir M Alshammari, Carlos Areia, Juan M. Banda, Patricia Biedermann, Edward Burn, Paula Casajust, Kristina Fišter, Jill Hardin, Laura Hester, George Hripcsak, Benjamin Skov Kaas-Hansen, Sajan Khosla, Spyros Kolovos, Kristine E. Lynch, Rupa Makadia, Paras P. Mehta, Daniel R M
Veröffentlicht in: medRxiv, 2020
Herausgeber: medRxiv
DOI: 10.1101/2020.07.17.20156059

Deep phenotyping of 34,128 patients hospitalised with COVID-19 and a comparison with 81,596 influenza patients in America, Europe and Asia: an international network study

Autoren: Edward Burn; Seng Chan You; Anthony Sena; Kristin Kostka; Hamed Abedtash; Maria Tereza F. Abrahao; Amanda Alberga; Heba Alghoul; Osaid Alser; Thamir M Alshammari; Maria Aragon; Carlos Areia; Juan M Banda; Jaehyeong Cho; Aedin C Culhane; Alexander Davydov; Frank J DeFalco; Talita Duarte-Salles; Scott L DuVall; Thomas Falconer; Sergio Fernandez-Bertolin; Weihua Gao; Asieh Golozar; Jill Hardin; Georg
Veröffentlicht in: medRxiv, 2020
Herausgeber: medRxiv
DOI: 10.1101/2020.04.22.20074336

Development and validation of patient-level prediction models for adverse outcomes following total knee arthroplasty

Autoren: Ross D. Williams; Jenna M. Reps; Anthony G. Sena; Edward Burn; Ying He; Daniel R. Morales; David Culliford; Dahai Yu; Victoria Y. Strauss; Talita Duarte-Salles; Albert Prats-Uribe; Antonella Delmestri; James Weaver; William Sproviero; Danielle Robinson; Henry Morgan Stewart; Belay Birlie; Rafael Pinedo-Villanueva; Spyros Kolovos; Luis H. John; Ruth E. Costello; Michel van Speybroeck; Caroline O'Le
Veröffentlicht in: medRxiv, 2020
Herausgeber: medRxiv
DOI: 10.1101/2020.12.14.20240994

Characteristics and outcomes of 627 044 COVID-19 patients with and without obesity in the United States, Spain, and the United Kingdom

Autoren: Martina Recalde, Elena Roel, Andrea Pistillo, Anthony G Sena, Albert Prats-Uribe, Waheed Ul-Rahman Ahmed, Heba Alghoul, Thamir M Alshammari, Osaid Alser, Carlos Areia, Edward Burn, Paula Casajust, Dalia Dawoud, Scott L DuVall, Thomas Falconer, Sergio Fernandez-Bertolin, Asieh Golozar, Mengchun Gong, Lana Yin Hui Lai, Jennifer C.E Lane, Kristine E Lynch, Michael E Matheny, Paras P Mehta, Daniel R M
Veröffentlicht in: medRxiv, 2020
Herausgeber: medRxiv
DOI: 10.1101/2020.09.02.20185173

Characteristics and outcomes of 118,155 COVID-19 individuals with a history of cancer in the United States and Spain

Autoren: Elena Roel; Andrea Pistillo;  Martina Recalde;  Anthony G. Sena; Sergio Fernández-Bertolín; María Aragón; Diana Puente;  Waheed-Ul-Rahman Ahmed;  Heba Alghoul;  Osaid Alser;  Thamir M. Alshammari;  Carlos Areia;  Clair Blacketer; William Carter;  Paula Casajust; Aedin C. Culhane;  Dalia Dawoud;  Frank DeFalco;  Scott L. Duvall;  Thomas Falconer; Asieh Golozar;
Veröffentlicht in: medRxiv, 2021
Herausgeber: medRxiv
DOI: 10.1101/2021.01.12.21249672

Clinical characteristics, symptoms, management and health outcomes in 8,598 pregnant women diagnosed with COVID-19 compared to 27,510 with seasonal influenza in France, Spain and the US: a network cohort analysis

Autoren: Lana Yin Hui Lai, Asieh Golozar, Anthony Sena, Andrea V. Margulis, Nuria Haro, Paula Casajust, Neus Valveny, Albert Prats-Uribe, Evan P. Minty, Waheed-Ul-Rahman Ahmed, Thamir M Alshammari, Daniel R. Morales, Heba Alghoul, Osaid Alser, Dalia Dawoud, Lin Zhang, Jose D. Posada, Nigam H. Shah, Clair Blacketer, Carlos Areia, Vignesh Subbian, Fredrik Nyberg, Jennifer C E Lane, Marc A Suchard, Mengchun G
Veröffentlicht in: medRxiv, 2020
Herausgeber: medRxiv
DOI: 10.1101/2020.10.13.20211821

Report on the EHDEN achievements during its foundational year (Nov 2018 - Oct 2019)

Autoren: The EHDEN consortium
Veröffentlicht in: 2020
Herausgeber: Self-published

Seek COVER: Development and validation of a personalized risk calculator for COVID-19 outcomes in an international network

Autoren: Ross D. Williams; Aniek Markus; Cynthia Yang; Talita Duarte Salles; Scott L. DuVall; Thomas Falconer; Jitendra Jonnagaddala; Chungsoo Kim; Yeunsook Rho; Andrew Williams; Amanda Alberga; Min Ho An; María Aragón; Carlos Areia; Edward Burn; Young Hwa Choi; Iannis Drakos; Maria Tereza Fernandes Abrahão; Sergio Fernández-Bertolín; George Hripcsak; Benjamin Skov Kaas-Hansen; Prasanna L Kandukuri; J
Veröffentlicht in: medRxiv, 16, 2020
Herausgeber: medRxiv
DOI: 10.1101/2020.05.26.20112649

Can we trust the prediction model? Demonstrating the importance of external validation by investigating the COVID-19 Vulnerability (C-19) Index across an international network of observational healthcare datasets

Autoren: Jenna M. Reps, Chungsoo Kim, Ross D. Williams, Aniek F. Markus, Cynthia Yang, Talita Duarte Salles, Thomas Falconer, Jitendra Jonnagaddala, Andrew Williams, Sergio Fernández-Bertolín, Scott L. DuVall, Kristin Kostka, Gowtham Rao, Azza Shoaibi, Anna Ostropolets, Matthew E Spotnitz, Lin Zhang, Paula Casajust, Ewout W. Steyerberg, Fredrik Nyberg, Benjamin Skov Kaas-Hansen, Young Hwa Choi, Daniel Mo
Veröffentlicht in: medRxiv, 2020
Herausgeber: medRxiv
DOI: 10.1101/2020.06.15.20130328

Renin-angiotensin system blockers and susceptibility to COVID-19: a multinational open science cohort study

Autoren: Daniel R. Morales, Mitchell M. Conover, Seng Chan You, Nicole Pratt, Kristin Kostka, Talita Duarte-Salles, Sergio Fernández-Bertolín, Maria Aragón, Scott L. DuVall, Kristine Lynch, Thomas Falconer, Kees van Bochove, Cynthia Sung, Michael E. Matheny, Christophe G. Lambert, Fredrik Nyberg, Thamir M. Alshammari, Andrew E. Williams, Rae Woong Park, James Weaver, Anthony G. Sena, Martijn J. Schuemie
Veröffentlicht in: medRxiv, 2020
Herausgeber: medRxiv
DOI: 10.1101/2020.06.11.20125849

EHDEN - Annual report year 2

Autoren: The EHDEN Consortium
Veröffentlicht in: 2021
Herausgeber: Self published
DOI: 10.5281/zenodo.4610138

Use of dialysis, tracheostomy, and extracorporeal membrane oxygenation among 240,392 patients hospitalized with COVID-19 in the United States

Autoren: Edward Burn; Anthony G. Sena; Albert Prats-Uribe; Matthew Spotnitz; Scott DuVall; Kristine E. Lynch; Michael E. Matheny; Fredrik Nyberg; Waheed-Ul-Rahman Ahmed; Osaid Alser; Heba Alghoul; Thamir Alshammari; Lin Zhang; Paula Casajust; Carlos Areia; Karishma Shah; Christian Reich; Clair Blacketer; Alan Andryc; Stephen Fortin; Karthik Natarajan; Mengchun Gong; Asieh Golozar; Daniel Morales; Peter Rij
Veröffentlicht in: medRxiv, 2020
Herausgeber: medRxiv
DOI: 10.1101/2020.11.25.20229088

The Book of OHDSI

Autoren: The OHDSI Community
Veröffentlicht in: 2019, Page(s) 1-470, ISBN 978-1088-855195
Herausgeber: Self published

Developing Computational Solutions for Personalized Medicine.

Autoren: Reisberg Sulev
Veröffentlicht in: 27/06/2019, 2019
Herausgeber: University of Tartu Press