Project description DEENESFRITPL New platform for early diagnosis of Alzheimer’s disease The estimation of functional decline in early Alzheimer’s disease (AD) is crucial for the treatment of patients. The EU-funded RADAR-AD project will develop a digital platform to discover minuscule functional deficits in early AD patients. The platform will integrate a combination of smartphone, wearable and home sensor-based parameters adequate for longitudinal studies and tests, identify the most relevant functional domains and the most encouraging remote measurement tools (RMTs). It will test the platform and selected RMTs in a real-world environment consisting of 240 participants, and perform statistical modelling to assess longitudinal predictions. RADAR-AD will discuss the results with regulatory agencies, patients and carer groups to acquire knowledge and guidance for future treatments. Show the project objective Hide the project objective Objective There is an urgent need for novel approaches assessing functional decline in early AD. The main goal of the RADAR-AD project is to develop a digital platform to detect subtle functional deficits in early Alzheimer’s disease (AD) individuals by integrating a meaningful combination of smartphone, wearable and/or home sensor based parameters. The system developed will be suitable for future longitudinal studies, including trials. The objectives are to 1) Identify the most relevant functional domains and the most promising remote measurement tools (RMTs) for these domains based on reviewing the literature and piloting of RMTs in small studies; 2) Optimise the RADAR-CNS platform for use in AD studies; 3) Test the platform and selected RMTs in a real world environment clinical study with 240 participants across the AD spectrum ranging from the preclinical AD to the dementia stage; 4) Perform statistical modelling to estimate longitudinal predictions; 5) Discuss results with regulatory agencies in order to obtain guidance about how to develop a path for formal qualification as outcome measurements in future therapeutic interventions. Considering the limited budget and project duration, we will rely upon already available technology platforms and on available longitudinal datasets where possible. The consortium includes experts in clinical dementia studies, computer science, bioinformatics, regulatory policies, ethics, and patient and public involvement (PPI). Additional strengths of the consortium are the deep and broad interface with RADAR-CNS and related IMI projects, and the access to large amount of patient-level data from key European cohort studies for modelling purposes. Fields of science medical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencescomputer and information sciencesengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsengineering and technologyelectrical engineering, electronic engineering, information engineeringinformation engineeringtelecommunicationsmobile phones Keywords functional impairment patient and public involvement (PPI) digital platform Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.7. - Innovative Medicines Initiative 2 (IMI2) Topic(s) IMI2-2017-12-01 - Development and validation of technology enabled, quantitative and sensitive measures of functional decline in people with early stage Alzheimer’s Disease (RADAR-AD) Call for proposal H2020-JTI-IMI2-2017-12-two-stage See other projects for this call Funding Scheme RIA - Research and Innovation action Coordinator KING'S COLLEGE LONDON Net EU contribution € 882 041,25 Address Strand WC2R 2LS London United Kingdom See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 218 296,28 Participants (16) Sort alphabetically Sort by Net EU contribution Expand all Collapse all STICHTING LYGATURE Netherlands Net EU contribution € 688 920,00 Address Jaarbeursplein 6 3521 AL Utrecht See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region West-Nederland Utrecht Utrecht Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 15 000,00 STICHTING VUMC Netherlands Net EU contribution € 1 273 127,00 Address De boelelaan 1117 1081 HV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 81 662,75 THE HYVE BV Netherlands Net EU contribution € 467 202,50 Address Arthur van schendelstraat 650 3511 MJ Utrecht See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region West-Nederland Utrecht Utrecht Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom Net EU contribution € 717 243,12 Address Wellington square university offices OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 106 738,97 KAROLINSKA INSTITUTET Sweden Net EU contribution € 124 096,25 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 AGENTSCHAP COLLEGE TER BEOORDELING VAN GENEESMIDDELEN Netherlands Net EU contribution € 50 000,00 Address Graadt van roggenweg 500 3531AH Utrecht See on map Region West-Nederland Utrecht Utrecht Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Germany Net EU contribution € 247 250,00 Address Hansastrasse 27c 80686 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ALZHEIMER EUROPE Luxembourg Net EU contribution € 200 500,00 Address Rue dicks 14 1417 Luxembourg See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Luxembourg Luxembourg Luxembourg Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 JANSSEN PHARMACEUTICA NV Belgium Net EU contribution € 0,00 Address Turnhoutseweg 30 2340 Beerse See on map Region Vlaams Gewest Prov. Antwerpen Arr. Turnhout Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 625 401,00 TAKEDA DEVELOPMENT CENTRE EUROPE LTD Participation ended United Kingdom Net EU contribution € 0,00 Address Aldwych 61 WC2B 4AE London See on map Region London Inner London — West Westminster Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 345 250,00 NOVARTIS PHARMA AG Switzerland Net EU contribution € 0,00 Address Lichtstrasse 35 4056 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 310 000,00 ELI LILLY AND COMPANY LTD United Kingdom Net EU contribution € 0,00 Address Lilly house basingview RG21 4FA Basingstoke See on map Region South East (England) Hampshire and Isle of Wight North Hampshire Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 301 579,00 SOFTWARE AG Germany Net EU contribution € 0,00 Address Uhlandstrasse 12 64297 Darmstadt See on map Region Hessen Darmstadt Darmstadt, Kreisfreie Stadt Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 223 132,00 ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS Greece Net EU contribution € 349 376,88 Address Charilaou thermi road 6 km 57001 Thermi thessaloniki See on map Region Βόρεια Ελλάδα Κεντρική Μακεδονία Θεσσαλονίκη Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ALTOIDA AG Switzerland Net EU contribution € 0,00 Address Hirschengraben 31 6003 Luzern See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Schweiz/Suisse/Svizzera Zentralschweiz Luzern Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 104 580,00 TAKEDA PHARMACEUTICALS INTERNATIONAL AG Switzerland Net EU contribution € 0,00 Address Thurgauerstrasse 130 8152 Glattpark See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 327 723,00