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Remote Assessment of Disease and Relapse – Alzheimer’s Disease

Objective

There is an urgent need for novel approaches assessing functional decline in early AD. The main goal of the RADAR-AD project is to develop a digital platform to detect subtle functional deficits in early Alzheimer’s disease (AD) individuals by integrating a meaningful combination of smartphone, wearable and/or home sensor based parameters. The system developed will be suitable for future longitudinal studies, including trials. The objectives are to 1) Identify the most relevant functional domains and the most promising remote measurement tools (RMTs) for these domains based on reviewing the literature and piloting of RMTs in small studies; 2) Optimise the RADAR-CNS platform for use in AD studies; 3) Test the platform and selected RMTs in a real world environment clinical study with 240 participants across the AD spectrum ranging from the preclinical AD to the dementia stage; 4) Perform statistical modelling to estimate longitudinal predictions; 5) Discuss results with regulatory agencies in order to obtain guidance about how to develop a path for formal qualification as outcome measurements in future therapeutic interventions. Considering the limited budget and project duration, we will rely upon already available technology platforms and on available longitudinal datasets where possible. The consortium includes experts in clinical dementia studies, computer science, bioinformatics, regulatory policies, ethics, and patient and public involvement (PPI). Additional strengths of the consortium are the deep and broad interface with RADAR-CNS and related IMI projects, and the access to large amount of patient-level data from key European cohort studies for modelling purposes.

Field of science

  • /humanities/languages and literature/literature - general
  • /humanities/philosophy, ethics and religion/ethics
  • /engineering and technology/electrical engineering, electronic engineering, information engineering/information engineering/telecommunications/mobile phone
  • /medical and health sciences/basic medicine/neurology/alzheimer

Call for proposal

H2020-JTI-IMI2-2017-12-two-stage
See other projects for this call

Funding Scheme

IMI2-RIA - Research and Innovation action

Coordinator

KING'S COLLEGE LONDON
Address
Strand
WC2R 2LS London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 885 655

Participants (15)

STICHTING LYGATURE
Netherlands
EU contribution
€ 551 306,25
Address
Jaarbeursplein 6
3521 AL Utrecht
Activity type
Other
STICHTING VUMC
Netherlands
EU contribution
€ 1 335 127
Address
De Boelelaan 1117
1081 HV Amsterdam
Activity type
Research Organisations
THE HYVE BV
Netherlands
EU contribution
€ 352 352,50
Address
Arthur Van Schendelstraat 650
3511 MJ Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 997 145
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 100 171,25
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
AGENTSCHAP COLLEGE TER BEOORDELING VAN GENEESMIDDELEN
Netherlands
EU contribution
€ 50 000
Address
Graadt Van Roggenweg 500
3531AH Utrecht
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 231 250
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
ALZHEIMER EUROPE
Luxembourg
EU contribution
€ 230 500
Address
Rue Dicks 14
1417 Luxembourg
Activity type
Other
JANSSEN PHARMACEUTICA NV
Belgium
EU contribution
€ 0
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TAKEDA DEVELOPMENT CENTRE EUROPE LTD
United Kingdom
EU contribution
€ 0
Address
Aldwych 61
WC2B 4AE London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NOVARTIS PHARMA AG
Switzerland
EU contribution
€ 0
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Eli Lilly and Company Limited
United Kingdom
EU contribution
€ 0
Address
Lilly House, Priestley Road
RG24 9NL Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SOFTWARE AG
Germany
EU contribution
€ 0
Address
Uhlandstrasse 12
64297 Darmstadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS
Greece
EU contribution
€ 266 250
Address
Charilaou Thermi Road 6 Km
57001 Thermi Thessaloniki
Activity type
Research Organisations
ALTOIDA AG
Switzerland
EU contribution
€ 0
Address
Hirschengraben 31
6003 Luzern
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)