3DProSeed: the first ready-to-use, pre-assembled, hydrogel microtiter plate for 3D cell culturess

Informations projet

3DProSeed

N° de convention de subvention: 807327

DOI

10.3030/807327

Projet clôturé

Date de signature de la CE 8 Février 2018

Date de début 1 Janvier 2018

Date de fin 30 Avril 2018

Financé au titre de

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Coût total

€ 71 429,00

Contribution de l’UE

€ 50 000,00

Coordonné par

ECTICA TECHNOLOGIES AG
Switzerland

Periodic Reporting for period 1 - 3DProSeed (3DProSeed: the first ready-to-use, pre-assembled, hydrogel microtiter plate for 3D cell culturess)

Période du rapport: 2018-01-01 au 2018-04-30

Résumé du contexte et des objectifs généraux du projet

Ectica Technologies develops innovative manufacturing processes for hydrogel materials and hydrogel-based products for bioresearch and drug discovery. Hydrogels are the first-choice class of materials to recreate in vitro the three-dimensional (3D) matrix of which human tissues are constituted and in which the human cells are organized.
The company developed its first product, the 3DProSeedTM hydrogel well-plate. The objective of this study was to assess the technical and financial feasibility of the realization of an upgraded and fully automated manufacturing line for 3DProSeed.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

We designed the process and engineered an upgraded manufacturing line for 3DProSeed yielding at least 100 plates/day with a discard ratio of less than 1%. The line is features a high level of automation and online quality control systems. We defined the actions to reduce current COGS making this product fit for commercialization. Also, based on the feedback of the current beta-users we developed a portfolio featuring more than ten products, varying in terms of product format and composition. Last, we developed a financial plan for the commercialization of 3DProSeed following implementation of the new line.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

The 3DProSeed technology will drastically accelerate the adoption of hydrogel-based cell culture platforms in bio-research and drug discovery because the users can now benefit from the advantages of a hydrogel-based 3D cell culture system while maintaining the highest level of integration in standard workflows previously used for 2D cultures. In particular, users are freed from time-consuming hydrogel assembly steps. The adoption of more physiologically-relevant in vitro systems in early drug discovery will contribute in making the drug development more efficient and in decreasing the cost linked to late failures.

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