3DProSeed: the first ready-to-use, pre-assembled, hydrogel microtiter plate for 3D cell culturess

Projektinformationen

3DProSeed

ID Finanzhilfevereinbarung: 807327

DOI

10.3030/807327

Projekt abgeschlossen

EK-Unterschriftsdatum 8 Februar 2018

Startdatum 1 Januar 2018

Enddatum 30 April 2018

Finanziert unter

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Gesamtkosten

€ 71 429,00

EU-Beitrag

€ 50 000,00

Koordiniert durch

ECTICA TECHNOLOGIES AG
Switzerland

Periodic Reporting for period 1 - 3DProSeed (3DProSeed: the first ready-to-use, pre-assembled, hydrogel microtiter plate for 3D cell culturess)

Berichtszeitraum: 2018-01-01 bis 2018-04-30

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Ectica Technologies develops innovative manufacturing processes for hydrogel materials and hydrogel-based products for bioresearch and drug discovery. Hydrogels are the first-choice class of materials to recreate in vitro the three-dimensional (3D) matrix of which human tissues are constituted and in which the human cells are organized.
The company developed its first product, the 3DProSeedTM hydrogel well-plate. The objective of this study was to assess the technical and financial feasibility of the realization of an upgraded and fully automated manufacturing line for 3DProSeed.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

We designed the process and engineered an upgraded manufacturing line for 3DProSeed yielding at least 100 plates/day with a discard ratio of less than 1%. The line is features a high level of automation and online quality control systems. We defined the actions to reduce current COGS making this product fit for commercialization. Also, based on the feedback of the current beta-users we developed a portfolio featuring more than ten products, varying in terms of product format and composition. Last, we developed a financial plan for the commercialization of 3DProSeed following implementation of the new line.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

The 3DProSeed technology will drastically accelerate the adoption of hydrogel-based cell culture platforms in bio-research and drug discovery because the users can now benefit from the advantages of a hydrogel-based 3D cell culture system while maintaining the highest level of integration in standard workflows previously used for 2D cultures. In particular, users are freed from time-consuming hydrogel assembly steps. The adoption of more physiologically-relevant in vitro systems in early drug discovery will contribute in making the drug development more efficient and in decreasing the cost linked to late failures.

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