Advancing osteoporosis medicine by observing bone microstructure and remodelling using a four-dimensional nanoscope

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Publications

Neutrophil Extracellular Traps Promote the Development and Growth of Human Salivary Stones.

Auteurs: Schapher M, Koch M, Weidner D, Scholz M, Wirtz S, Mahajan A, Herrmann I, Singh J, Knopf J, Leppkes M, Schauer C, Grüneboom A, Alexiou C, Schett G, Iro H, Muñoz LE, Herrmann M.
Publié dans: Cells, Numéro 9(9), 2020, Page(s) 2139, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells9092139

Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells

Auteurs: Bergmann C, Müller F, Distler JHW, Györfi AH, Völkl S, Aigner M, Kretschmann S, Reimann H, Harrer T, Bayerl N, Boeltz S, Wirsching A, Taubmann J, Rösler W, Spriewald B, Wacker J, Atzinger A, Uder M, Kuwert T, Mackensen A, Schett G.
Publié dans: Annals of Rheumatic Disease, 2023, ISSN 0003-4967
Éditeur: BMJ Publishing Group
DOI: 10.1136/ard-2023-223952

Secukinumab leads to shifts from stage-based towards response-based disease clusters—comparative data from very early and established psoriatic arthritis

Auteurs: Eleni Kampylafka, Koray Tascilar, Veronika Lerchen, Christina Linz, Maria Sokolova, Ana Zekovic, Arnd Kleyer, David Simon, Jürgen Rech, Michael Sticherling, Georg Schett, Axel J. Hueber
Publié dans: Arthritis Research & Therapy, Numéro 22/1, 2020, ISSN 1478-6362
Éditeur: BMC part of Springer Nature SharedIt
DOI: 10.1186/s13075-020-02268-y

Neutrophil Heterogeneity Identifies an Association of LAMP1 With Proliferative Lupus Nephritis

Auteurs: Lennard Ostendorf, Panagiotis Garantziotis, Frank Y. Huang, Georg Schett, null null, James A. Lederer, Andrea Fava, Deepak A. Rao, Ricardo Grieshaber‐Bouyer
Publié dans: European Journal of Immunology, Numéro 55, 2025, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/eji.70022

Auteurs: Anna‐Maria Liphardt, Eva Manger, Sonja Liehr, Lisa Bieniek, Arnd Kleyer, David Simon, Koray Tascilar, Michael Sticherling, Jürgen Rech, Georg Schett, Axel J. Hueber
Publié dans: ACR Open Rheumatology, Numéro 2/12, 2020, Page(s) 734-740, ISSN 2578-5745
Éditeur: Wiley Online Libary
DOI: 10.1002/acr2.11196

Additional file 5 of A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Auteurs: Sokolova, Maria; Simon, David; Nas, Kemal; Zaiss, Mario; Yubin Luo; Zhao, Yi; JÃ¼rgen Rech; Schett, Georg
Publié dans: Arthritis Research & Therapy, Numéro 2, 2020, Page(s) 26, ISSN 1478-6354
Éditeur: BioMed Central
DOI: 10.6084/m9.figshare.11846322.v1

Patients with COVID-19: in the dark-NETs of neutrophils.

Auteurs: Ackermann M, Anders HJ, Bilyy R, Bowlin GL, Daniel C, De Lorenzo R, Egeblad M, Henneck T, Hidalgo A, Hoffmann M, Hohberger B, Kanthi Y, Kaplan MJ, Knight JS, Knopf J, Kolaczkowska E, Kubes P, Leppkes M, Mahajan A, Manfredi AA, Maueröder C, Maugeri N, Mitroulis I, Muñoz LE, Narasaraju T, Naschberger E, Neeli I, Ng LG, Radic MZ, Ritis K, Rovere-Querini P, Schapher M, Schauer C, Simon HU, Singh J,
Publié dans: Cell Death Differ, Numéro 28(11), 2021, Page(s) 3125-3139, ISSN 1350-9047
Éditeur: Nature Publishing Group
DOI: 10.1038/s41418-021-00805-z

Loss of myeloperoxidase aggravates skin and joint inflammation in the mannan-induced psoriatic arthritis mouse model

Auteurs: Mark Ringer, Antonio Maccataio, Rico Zapf, Anastasia Gaculenko, Susanne Adam, Oliver Aust, Sandra Loskarn, Julia Luther, Burak Aksoy, Vanessa Popp, Daniela Weidner, Madelaine Eck, Luis Munoz, Aline Bo
Publié dans: Journal of Leukocyte Biology, 2025, ISSN 1938-3673
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/jleuko/qiaf110

Chronic Systemic Infection of Mice with Leishmania infantum Leads to Increased Bone Mass.

Auteurs: Lai C, Heinemann J, Schleicher U, Schett G, Bogdan C, Bozec A, Soulat D.
Publié dans: Journal of Bone Mineral Research, 2023, ISSN 0884-0431
Éditeur: American Society for Bone and Mineral Research
DOI: 10.1002/jbmr.4733

Epithelial HIF2α expression induces intestinal barrier dysfunction and exacerbation of arthritis.

Auteurs: Wen J, Lyu P, Stolzer I, Xu J, Gießl A, Lin Z, Andreev D, Kachler K, Song R, Meng X, Cao S, Guggino G, Ciccia F, Günther C, Schett G, Bozec A.
Publié dans: Annals of Rheumatic Disease, 2022, ISSN 0003-4967
Éditeur: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-222035

A network of trans-cortical capillaries as mainstay for blood circulation in long bones

Auteurs: Anika Grüneboom, Ibrahim Hawwari, Daniela Weidner, Stephan Culemann, Sylvia Müller, Sophie Henneberg, Alexandra Brenzel, Simon Merz, Lea Bornemann, Kristina Zec, Manuela Wuelling, Lasse Kling, Mike Hasenberg, Sylvia Voortmann, Stefanie Lang, Wolfgang Baum, Alexandra Ohs, Oliver Kraff, Harald H. Quick, Marcus Jäger, Stefan Landgraeber, Marcel Dudda, Renzo Danuser, Jens V. Stein, Manfred Rohde, K
Publié dans: Nature Metabolism, Numéro 1/2, 2019, Page(s) 236-250, ISSN 2522-5812
Éditeur: Nature Research
DOI: 10.1038/s42255-018-0016-5

Osteocytes support bone metastasis of melanoma cells by CXCL5

Auteurs: Yewei Jia, Fulin Zhang, Xianyi Meng, Darja Andreev, Pang Lyu, Wenshuo Zhang, Chaobo Lai, Georg Schett, Aline Bozec
Publié dans: Cancer Letters, Numéro 590, 2024, Page(s) 216866, ISSN 0304-3835
Éditeur: Elsevier BV
DOI: 10.1016/j.canlet.2024.216866

CD19 Chimeric Antigen Receptor T Cell Treatment: Unraveling the Role of B Cells in Systemic Lupus Erythematosus

Auteurs: Jule Taubmann, Fabian Müller, Melek Yalcin Mutlu, Simon Völkl, Michael Aigner, Aline Bozec, Andreas Mackensen, Ricardo Grieshaber-Bouyer, Georg Schett
Publié dans: Arthritis & Rheumatology, 2025, ISSN 2326-5191
Éditeur: Wiley
DOI: 10.1002/art.42784

Synovial fibroblast activation occurs before the onset of rheumatoid arthritis and influences the risk of developing disease

Auteurs: Armin Atzinger, Koray Tascilar, Arnd Kleyer, Axel J Hueber, Christian Schmidkonz, Torsten Kuwert, Michael Beck, Filippo Fagni, Giulia Corte, Andreas Ramming, Georg Schett, Sara Bayat
Publié dans: RMD Open, Numéro 11, 2026, Page(s) e005775, ISSN 2056-5933
Éditeur: BMJ
DOI: 10.1136/rmdopen-2025-005775

Increased Type H Blood Vessels Precedes Pathological Osteogenesis And Inflammation In Experimental Spondyloarthritis.

Auteurs: Kaaij MH, van Hamburg JP, van Rooijen CCN, Grüneboom A, Kan YY, Pots D, Schett G, van Ruijven LJ, van Duivenvoorde LM, Huitema LFA, Baeten DLP, Tas SW.
Publié dans: Arthritis Rheumatology, 2023, ISSN 2326-5205
Éditeur: Wiley-Blackwell
DOI: 10.1002/art.42449

Suppression of neutrophils by sodium exacerbates oxidative stress and arthritis

Auteurs: Leticija Zlatar, Aparna Mahajan, Marco Muñoz-Becerra, Daniela Weidner, Galyna Bila, Rostyslav Bilyy, Jens Titze, Markus H. Hoffmann, Georg Schett, Martin Herrmann, Ulrike Steffen, Luis E. Muñoz, Jas
Publié dans: Frontiers in Immunology, Numéro 14, 2023, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2023.1174537

Performance of a Handheld Ultrasound Device to Assess Articular and Periarticular Pathologies in Patients with Inflammatory Arthritis.

Auteurs: Corte G, Bayat S, Tascilar K, Valor-Mendez L, Schuster L, Knitza J, Fagni F, Schett G, Kleyer A, Simon D.
Publié dans: Diagnostics, Numéro 11(7), 2021, Page(s) 1139, ISSN 2075-4418
Éditeur: MDPI AG, 2011
DOI: 10.3390/diagnostics11071139

Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis

Auteurs: Jule Taubmann, Brenda Krishnacoumar, Christina Böhm, Maria Faas, Dorothea I. H. Müller, Susanne Adam, Cornelia Stoll, Martin Böttcher, Dimitrios Mougiakakos, Uwe Sonnewald, Jörg Hofmann, Georg Schett, Gerhard Krönke, Carina Scholtysek
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-77892-4

Neutrophils seeking new neighbors: radiotherapy affects the cellular framework and the spatial organization in a murine breast cancer model

Auteurs: C. M. Reichardt, M. Muñoz-Becerra, A. Rius Rigau, M. Rückert, R. Fietkau, G. Schett, U. S. Gaipl, B. Frey, L. E. Muñoz
Publié dans: Cancer Immunology, Immunotherapy, Numéro 73, 2024, ISSN 1432-0851
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s00262-024-03653-1

Technical Note: PYRO‐NN: Python reconstruction operators in neural networks

Auteurs: Christopher Syben, Markus Michen, Bernhard Stimpel, Stephan Seitz, Stefan Ploner, Andreas K. Maier
Publié dans: Medical Physics, Numéro 46/11, 2019, Page(s) 5110-5115, ISSN 0094-2405
Éditeur: American Association of Physicists in Medicine
DOI: 10.1002/mp.13753

Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis

Auteurs: Darja Andreev, Mengdan Liu, Katerina Kachler, Mireia Llerins Perez, Philipp Kirchner, Julia Kölle, Andreas Gießl, Simon Rauber, Rui Song, Oliver Aust, Anika Grüneboom, Arnd Kleyer, Juan D Cañete, Arif Ekici, Andreas Ramming, Susetta Finotto, Georg Schett, Aline Bozec
Publié dans: Annals of the Rheumatic Diseases, Numéro 80/4, 2021, Page(s) 451-468, ISSN 0003-4967
Éditeur: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-218902

Butyrophilin 2a2 (Btn2a2) expression on thymic epithelial cells promotes central T cell tolerance and prevents autoimmune disease.

Auteurs: Frech M, Danzer H, Uchil P, Azizov V, Schmid E, Schälter F, Dürholz K, Mauro D, Rauber S, Muñoz L, Taher L, Ciccia F, Schober K, Irla M, Sarter K, Schett G, Zaiss MM.
Publié dans: Journal of Autoimmunity, 2021, ISSN 0896-8411
Éditeur: Academic Press
DOI: 10.1016/j.jaut.2023.103071

The Transcription Factor FRA-1/AP-1 Controls Lipocalin-2 Expression and Inflammation in Sepsis Model.

Auteurs: Cao S, Schnelzer A, Hannemann N, Schett G, Soulat D, Bozec A.
Publié dans: Frontiers of Immunology, Numéro 12, 2021, Page(s) 701675, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.701675

Why remission is not enough: underlying disease mechanisms in RA that prevent cure

Auteurs: Georg Schett, Yoshiya Tanaka, John D. Isaacs
Publié dans: Nature Reviews Rheumatology, Numéro 17/3, 2021, Page(s) 135-144, ISSN 1759-4790
Éditeur: Nature Publishing Group
DOI: 10.1038/s41584-020-00543-5

Non-invasive metabolic profiling of inflammation in joints and entheses by multispectral optoacoustic tomography.

Auteurs: Tascilar K, Fagni F, Kleyer A, Bayat S, Heidemann R, Steiger F, Krönke G, Bohr D, Ramming A, Hartmann F, Klett D, Federle A, Regensburger AP, Wagner AL, Knieling F, Neurath MF, Schett G, Waldner M, Simon D.
Publié dans: Rheumatology, 2023, ISSN 1462-0324
Éditeur: Oxford University Press
DOI: 10.1093/rheumatology/keac346

CAR T-cell therapy in autoimmune diseases

Auteurs: Georg Schett, Andreas Mackensen, Dimitrios Mougiakakos
Publié dans: The Lancet, Numéro 402, 2025, Page(s) 2034-2044, ISSN 0140-6736
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(23)01126-1

DL-based inpainting for metal artifact reduction for cone beam CT using metal path length information

Auteurs: Tristan M. Gottschalk, Andreas Maier, Florian Kordon, Björn W. Kreher
Publié dans: Medical Physics, 2022, ISSN 2473-4209
Éditeur: Wiley
DOI: 10.1002/mp.15909

Comment on: Rescue therapy of anti-synthetase syndrome with CD19-targeted CART cells after failure of several B cell–depleting antibodies: reply

Auteurs: Jule Taubmann, Johannes Knitza, Fabian Müller, Simon Völkl, Michael Aigner, Sascha Kretschmann, Armin Atzinger, Torsten Kuwert, Andreas Mackensen, Georg Schett
Publié dans: Rheumatology, Numéro 63, 2024, Page(s) e312-e314, ISSN 1462-0324
Éditeur: Oxford University Press
DOI: 10.1093/rheumatology/kead669

Humoral and Cellular Immune Responses to SARS-CoV-2 Infection and Vaccination in Autoimmune Disease Patients With B Cell Depletion.

Auteurs: Simon D, Tascilar K, Schmidt K, Manger B, Weckwerth L, Sokolova M, Bucci L, Fagni F, Manger K, Schuch F, Ronneberger M, Hueber A, Steffen U, Mielenz D, Herrmann M, Harrer T, Kleyer A, Krönke G, Schett G.
Publié dans: Arthritis & Rheumatology, Numéro 74(1), 2022, Page(s) 33-37, ISSN 2326-5191
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/art.41914

Aggregated neutrophil extracellular traps occlude Meibomian glands during ocular surface inflammation

Auteurs: Aparna Mahajan; Lenka Hasíková; Ulrike Hampel; Anika Grüneboom; Xiaomei Shan; Irmgard Herrmann; Fabian Garreis; Felix Bock; Jasmin Knopf; Jeeshan Singh; Christine Schauer; Siddharth Mahajan; Moritz Leppkes; Friedrich Paulsen; Ursula Schlötzer-Schrehardt; Veit Krenn; Anselm Jünemann; Bettina Hohberger; Georg Schett; Martin Herrmann; Luis E. Muñoz
Publié dans: Ocular Surface, Numéro 2, 2020, Page(s) 1-12, ISSN 1542-0124
Éditeur: Ethis Communications
DOI: 10.1016/j.jtos.2020.12.005

Rescue therapy of antisynthetase syndrome with CD19-targeted CAR-T cells after failure of several B-cell depleting antibodies

Auteurs: Jule Taubmann, Johannes Knitza, Fabian Müller, Simon Völkl, Michael Aigner, Arnd Kleyer, Regina Gary, Sascha Kretschmann, Sebastian Boeltz, Armin Atzinger, Torsten Kuwert, Frank Roemer, Michael Uder
Publié dans: Rheumatology, Numéro 63, 2024, Page(s) e12-e14, ISSN 1462-0324
Éditeur: Oxford University Press
DOI: 10.1093/rheumatology/kead330

Antibodies against citrullinated proteins of IgA isotype are associated with progression to rheumatoid arthritis in individuals at-risk.

Auteurs: Sokolova MV, Hartmann F, Sieghart D, Bang H, Steiner G, Kleyer A, Schett G, Steffen U
Publié dans: Rheumatic & Musculoskeletal Disease Open, 2023, ISSN 2056-5933
Éditeur: BMJ Publishing Group Ltd
DOI: 10.1136/rmdopen-2022-002705

DeepNAPSI multi-reader nail psoriasis prediction using deep learning.

Auteurs: Folle L, Fenzl P, Fagni F, Thies M, Christlein V, Meder C, Simon D, Minnopoulou I, Sticherling M, Schett G, Maier A, Kleyer A.
Publié dans: Science Report, 2023, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-32440-8

Neutrophil Extracellular Traps Initiate Gallstone Formation

Auteurs: Luis E. Muñoz, Sebastian Boeltz, Rostyslav Bilyy, Christine Schauer, Aparna Mahajan, Navena Widulin, Anika Grüneboom, Irmgard Herrmann, Edgyda Boada, Manfred Rauh, Veit Krenn, Mona H.C. Biermann, Ma
Publié dans: Immunity, Numéro 51, 2025, Page(s) 443-450.e4, ISSN 1074-7613
Éditeur: Cell Press
DOI: 10.1016/j.immuni.2019.07.002

Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase

Auteurs: Darja Andreev, Katerina Kachler, Mengdan Liu, Zhu Chen, Brenda Krishnacoumar, Mark Ringer, Silke Frey, Gerhard Krönke, David Voehringer, Georg Schett, Aline Bozec
Publié dans: Nature Communications, Numéro 15, 2024, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-45261-8

Impact of cytokine inhibitor therapy on the prevalence, seroconversion rate and longevity of the humoral immune response against SARS-CoV-2 in an unvaccinated cohort.

Auteurs: Simon D, Tascilar K, Kleyer A, Fagni F, Krönke G, Meder C, Dietrich P, Orlemann T, Kliem T, Mößner J, Liphardt AM, Schönau V, Bohr D, Schuster L, Hartmann F, Leppkes M, Ramming A, Pachowsky M, Schuch F, Ronneberger M, Kleinert S, Hueber AJ, Manger K, Manger B, Atreya R, Berking C, Sticherling M, Neurath MF, Schett G.
Publié dans: Athritis & Rheumatology, Numéro 74(5), 2022, Page(s) 783-790, ISSN 2326-5205
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/art.42035

Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis

Auteurs: Katerina Kachler, Darja Andreev, Shreeya Thapa, Dmytro Royzman, Andreas Gießl, Shobika Karuppusamy, Mireia Llerins Perez, Mengdan Liu, Jörg Hofmann, Arne Gessner, Xianyi Meng, Simon Rauber, Alexande
Publié dans: Annals of the Rheumatic Diseases, Numéro 83, 2025, Page(s) 1691-1706, ISSN 0003-4967
Éditeur: BMJ Publishing Group
DOI: 10.1136/ard-2023-224774

Is Medical Chest X-ray Data Anonymous?

Auteurs: Packhäuser, Kai; Gündel, Sebastian; Münster, Nicolas; Syben, Christopher; Christlein, Vincent; Maier, Andreas
Publié dans: arxiv.org, Numéro 1, 2021, ISSN 2331-8422
Éditeur: Cornell University

RETRO study group. Advanced machine learning for predicting individual risk of flares in rheumatoid arthritis patients tapering biologic drugs.

Auteurs: Vodencarevic A, Tascilar K, Hartmann F, Reiser M, Hueber AJ, Haschka J, Bayat S, Meinderink T, Knitza J, Mendez L, Hagen M, Krönke G, Rech J, Manger B, Kleyer A, Zimmermann-Rittereiser M, Schett G, Simon D.
Publié dans: Arthritis Research & Therapy, Numéro 23(1), 2021, Page(s) 67, ISSN 1478-6362
Éditeur: BioMed Central
DOI: 10.1186/s13075-021-02439-5

Synthetic Image Rendering Solves Annotation Problem in Deep Learning Nanoparticle Segmentation

Auteurs: Leonid Mill, David Wolff, Nele Gerrits, Patrick Philipp, Lasse Kling, Florian Vollnhals, Andrew Ignatenko, Christian Jaremenko, Yixing Huang, Olivier De Castro, Jean‐Nicolas Audinot, Inge Nelissen, Tom Wirtz, Andreas Maier, Silke Christiansen
Publié dans: Small Methods, 2021, Page(s) 2100223, ISSN 2366-9608
Éditeur: Wiley
DOI: 10.1002/smtd.202100223

A multidimensional analysis of temporomandibular joint and ankle joint erosion in inflammatory arthritis

Auteurs: Darja Andreev, Pauline Porschitz, Daniela Weidner, Rui Song, Matthias Weider, Georg Schett, Lina Gölz, Aline Bozec
Publié dans: Frontiers in Immunology, Numéro 16, 2025, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1560723

Precision of handheld multispectral optoacoustic tomography for muscle imaging

Auteurs: Alexandra L. Wagner, Vera Danko, Anna Federle, Daniel Klett, David Simon, Rafael Heiss, Jörg Jüngert, Michael Uder, Georg Schett, Markus F. Neurath, Joachim Woelfle, Maximilian J. Waldner, Regina Trollmann, Adrian P. Regensburger, Ferdinand Knieling
Publié dans: Photoacoustics, Numéro In Press, Journal Pre-proof, 2020, Page(s) 100220, ISSN 2213-5979
Éditeur: Elsevier GmbH
DOI: 10.1016/j.pacs.2020.100220

Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis

Auteurs: Andreev D, Liu M, Kachler K, Llerins Perez M, Kirchner P, Kölle J, Gießl A, Rauber S, Song R, Aust O, Grüneboom A, Kleyer A, Cañete JD, Ekici A, Ramming A, Finotto S, Schett G, Bozec A.
Publié dans: Annals of Rheumatic Diseases, Numéro 80, 2021, Page(s) 451-468, ISSN 1468-2060
Éditeur: BMJ
DOI: 10.1136/annrheumdis-2020-218902

COVID-19: risk for cytokine targeting in chronic inflammatory diseases?

Auteurs: Georg Schett, Michael Sticherling, Markus F. Neurath
Publié dans: Nature Reviews Immunology, Numéro 20, 2023, Page(s) 271-272, ISSN 1474-1733
Éditeur: Nature Publishing Group
DOI: 10.1038/s41577-020-0312-7

Baricitinib Improves Bone Properties and Biomechanics in Patients With Rheumatoid Arthritis: Results of the Prospective Interventional <scp>BARE BONE</scp> Trial

Auteurs: David Simon, Ioanna Minopoulou, Stephan Kemenes, Sara Bayat, Koray Tascilar, Melek Yalcin Mutlu, Larissa Valor‐Méndez, Gerhard Krönke, Axel J. Hueber, Georg Schett, Arnd Kleyer
Publié dans: Arthritis & Rheumatology, Numéro 75, 2025, Page(s) 1923-1934, ISSN 2326-5191
Éditeur: Wiley
DOI: 10.1002/art.42617

Effects of CD19 CAR T Cell Therapy on Quality of Life and Direct Healthcare Costs in Systemic Lupus Erythematosus: A Preliminary Analysis

Auteurs: Jule Taubmann, Melanie Hagen, Fabian Müller, Andreas Wirsching, Alp Temiz, Simon Völkl, Michael Aigner, Ricardo Grieshaber-Bouyer, Andreas Mackensen, Georg Schett
Publié dans: The Journal of Rheumatology, Numéro 53, 2026, Page(s) 33-37, ISSN 0315-162X
Éditeur: Journal of Rheumatology Publishing Co., Ltd.
DOI: 10.3899/jrheum.2024-1301

Microbiota and metabolites in rheumatic diseases.

Auteurs: Tong Y, Marion T, Schett G, Luo Y, Liu Y.
Publié dans: Autoimmunity Reviews, Numéro Volume 19, Numéro 8, 2020, Page(s) 102530, ISSN 1568-9972
Éditeur: Elsevier BV
DOI: 10.1016/j.autrev.2020.102530

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

Auteurs: Jasna Friščić, Martin Böttcher, Christiane Reinwald, Heiko Bruns, Benjamin Wirth, Samantha-Josefine Popp, Kellie Irene Walker, Jochen A. Ackermann, Xi Chen, Jason Turner, Honglin Zhu, Lisa Seyler, Maximilien Euler, Philipp Kirchner, René Krüger, Arif B. Ekici, Triin Major, Oliver Aust, Daniela Weidner, Anita Fischer, Fabian T. Andes, Zeljka Stanojevic, Vladimir Trajkovic, Martin Herrmann, Ad
Publié dans: Immunity, Numéro 54/5, 2021, Page(s) 1002-1021.e10, ISSN 1074-7613
Éditeur: Cell Press
DOI: 10.1016/j.immuni.2021.03.003

Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease: a prospective cohort study.

Auteurs: Simon D, Tascilar K, Fagni F, Kleyer A, Krönke G, Meder C, Dietrich P, Orlemann T, Mößner J, Taubmann J, Mutlu MY, Knitza J, Kemenes S, Liphardt AM, Schönau V, Bohr D, Schuster L, Hartmann F, Minopoulou I, Leppkes M, Ramming A, Pachowsky M, Schuch F, Ronneberger M, Kleinert S, Hueber AJ, Manger K, Manger B, Atreya R, Berking C, Sticherling M, Neurath MF, Schett G.
Publié dans: The Lancet Rheumatology, 2022, ISSN 2665-9913
Éditeur: Elsevier
DOI: 10.1016/s2665-9913(22)00191-6

Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin

Auteurs: Darja Andreev, Mengdan Liu, Daniela Weidner, Katerina Kachler, Maria Faas, Anika Grüneboom, Ursula Schlötzer-Schrehardt, Luis E. Muñoz, Ulrike Steffen, Bettina Grötsch, Barbara Killy, Gerhard Krönke, Andreas M. Luebke, Andreas Niemeier, Falk Wehrhan, Roland Lang, Georg Schett, Aline Bozec
Publié dans: Journal of Clinical Investigation, Numéro 130/9, 2020, Page(s) 4811-4830, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci134214

Assessment of myocardial fibrosis in patients with systemic sclerosis using [68Ga]Ga‑FAPI‑04‑PET‑CT

Auteurs: Treutlein C, Distler JHW, Tascilar K, Fakhouri SC, Györfi AH, Atzinger A, Matei AE, Dees C, Büttner-Herold M, Kuwert T, Prante O, Bäuerle T, Uder M, Schett G, Schmidkonz C, Bergmann C.
Publié dans: European Journal of Nuclear Medicine and Molecular Imaging, 2022, ISSN 1619-7070
Éditeur: Springer Verlag
DOI: 10.1007/s00259-022-06081-4

IgA displays site- and subclass-specific glycoform differences despite equal glycoenzyme expression

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Auteurs: Ioanna Minopoulou, Koray Tascilar, Giulia Corte, Melek Yalcin Mutlu, Katja Schmidt, Daniela Bohr, Fabian Hartmann, Karin Manger, Bernhard Manger, Klaus Korn, Arnd Kleyer, David Simon, Thomas Harrer, G
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JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function

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Known operator learning and hybrid machine learning in medical imaging—a review of the past, the present, and the future

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Double-Sided Graphene-Enhanced Raman Scattering and Fluorescence Quenching in Hybrid Biological Structures

Auteurs: George Sarau; George Sarau; Christoph Daniel; Martin Heilmann; Gerd Leuchs; Kerstin Amann; Silke Christiansen
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Anatomical pattern of entheseal and synovial fibroblast activation in patients with psoriasis and its risk of developing psoriatic arthritis

Auteurs: Giulia Corte, Armin Atzinger, Selahattin Alp Temiz, Rita Noversa de Sousa, Melek Yalcin Mutlu, Verena Schoenau, Maria Gabriella Raimondo, Arnd Kleyer, Torsten Kuwert, Andreas Ramming, David Simon, Mic
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Efficacy and safety of SARS-CoV-2 revaccination in non-responders with immune-mediated inflammatory disease.

Auteurs: Simon D, Tascilar K, Fagni F, Schmidt K, Krönke G, Kleyer A, Ramming A, Schoenau V, Bohr D, Knitza J, Harrer T, Manger K, Manger B, Schett G.
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CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-up

Auteurs: Fabian Müller, Jule Taubmann, Laura Bucci, Artur Wilhelm, Christina Bergmann, Simon Völkl, Michael Aigner, Tobias Rothe, Ioanna Minopoulou, Carlo Tur, Johannes Knitza, Soraya Kharboutli, Sascha Kret
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Rheumatic?-A Digital Diagnostic Decision Support Tool for Individuals Suspecting Rheumatic Diseases: A Multicenter Pilot Validation Study.

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Methotrexate hampers immunogenicity to BNT162b2 mRNA COVID-19 vaccine in immune-mediated inflammatory disease.

Auteurs: Haberman RH, Herati R, Simon D, Samanovic M, Blank RB, Tuen M, Koralov SB, Atreya R, Tascilar K, Allen JR, Castillo R, Cornelius AR, Rackoff P, Solomon G, Adhikari S, Azar N, Rosenthal P, Izmirly P, Samuels J, Golden B, Reddy SM, Neurath MF, Abramson SB, Schett G, Mulligan MJ, Scher JU.
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CD19-targeting CAR T-cell therapy in patients with diffuse systemic sclerosis: a case series

Auteurs: Janina Auth, Fabian Müller, Simon Völkl, Nadine Bayerl, Jörg H W Distler, Carlo Tur, Maria G Raimondo, Sara Chenguiti Fakhouri, Armin Atzinger, Birte Coppers, Markus Eckstein, Anna-Maria Liphardt,
Publié dans: The Lancet Rheumatology, Numéro 7, 2025, Page(s) e83-e93, ISSN 2665-9913
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Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids

Auteurs: Jean-Philippe Auger, Max Zimmermann, Maria Faas, Ulrich Stifel, David Chambers, Brenda Krishnacoumar, R. Verena Taudte, Charlotte Grund, Gitta Erdmann, Carina Scholtysek, Stefan Uderhardt, Oumaima Ben
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Will We Ever Have Conscious Machines?

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Efficacy and drug persistence of baricitinib monotherapy is similar to combination therapy in patients with active RA: a prospective observational study.

Auteurs: Bayat S, Tascilar K, Bohr D, Krönke G, Simon D, Knitza J, Hartmann F, Schett G, Kleyer A.
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Clinical efficacy and autoantibody seroconversion with CD19-CAR T cell therapy in a patient with rheumatoid arthritis and coexisting myasthenia gravis

Auteurs: Aiden Haghikia, Tobias Hegelmaier, Denise Wolleschak, Martin Böttcher, Vaia Pappa, Jeremias Motte, Dominic Borie, Ralf Gold, Eugen Feist, Georg Schett, Dimitrios Mougiakakos
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Mobile Health Usage, Preferences, Barriers, and eHealth Literacy in Rheumatology: Patient Survey Study

Auteurs: Johannes Knitza, David Simon, Antonia Lambrecht, Christina Raab, Koray Tascilar, Melanie Hagen, Arnd Kleyer, Sara Bayat, Adrian Derungs, Oliver Amft, Georg Schett, Axel J Hueber
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BCMA-Targeted T-Cell–Engager Therapy for Autoimmune Disease

Auteurs: Melanie Hagen, Laura Bucci, Sebastian Böltz, Danae-Mona Nöthling, Tobias Rothe, Kirill Anoshkin, Maria G. Raimondo, Carlo Tur, Andreas Wirsching, Jochen Wacker, Christina Düsing, Jörg H.W. Distler
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BCMA T-Cell Engager Therapy in Patients with Refractory Autoimmune Disease

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Ultralow-parameter denoising: Trainable bilateral filter layers in computed tomography.

Auteurs: Fabian Wagner; Mareike Thies; Mingxuan Gu; Yixing Huang; Sabrina Pechmann; Mayank Patwari; Stefan Ploner; Oliver Aust; Stefan Uderhardt; Georg Schett; Silke Christiansen; Andreas Maier
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Analysis of Hand Joint Space Morphology in Women and Men with Hereditary Hemochromatosis.

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Neutralizing monoclonal antibodies against SARS-CoV-2 for COVID-19 pneumonia in a rituximab treated patient with systemic sclerosis-A case report and literature review.

Auteurs: Yalcin Mutlu M, Taubmann J, Wacker J, Tascilar K, Fagni F, Gerner M, Klett D, Schett G, Manger B, Simon D.
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Advanced neural networks for classification of MRI in psoriatic arthritis, seronegative, and seropositive rheumatoid arthritis

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The Potential of OMICs Technologies for the Treatment of Immune-Mediated Inflammatory Diseases

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Aggregated neutrophil extracellular traps occlude Meibomian glands during ocular surface inflammation

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CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus.

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Bone Mass, Bone Microstructure and Biomechanics in Patients with Hand Osteoarthritis

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Bone microstructure and volumetric bone mineral density in patients with hyperuricemia with and without psoriasis

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Local immune effector cell-associated toxicity syndrome in CAR T-cell treated patients with autoimmune disease: an observational study

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Micro-structural bone changes are associated with broad-spectrum autoimmunity and predict the onset of rheumatoid arthritis.

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What Do We Really Need? Degenerating U-Net on Retinal Vessel Segmentation

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Hand Function Impairments Are More Pronounced in Female RA and PsA Patients and also Found in Patients without Concurrent Hand Inflammation

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Concise report: a minimal-invasive method to retrieve and identify entheseal tissue from psoriatic arthritis patients.

Auteurs: Pachowsky ML, Raimondo MG, Xu C, Rauber S, Tascilar K, Labinsky H, Vogg M, Aziz Saad MS, Simon D, Rech J, Soare A, Braeuer L, Kleyer A, Schett G, Ramming A.
Publié dans: Annals of Rheumatic Disease, 2022, ISSN 0003-4967
Éditeur: BMJ Publishing Group
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Gradient-based geometry learning for fan-beam CT reconstruction

Auteurs: Mareike Thies, Fabian Wagner, Noah Maul, Lukas Folle, Manuela Meier, Maximilian Rohleder, Linda-Sophie Schneider, Laura Pfaff, Mingxuan Gu, Jonas Utz, Felix Denzinger, Michael Manhart, Andreas Maier
Publié dans: Physics in Medicine and Biology, 2023, ISSN 0031-9155
Éditeur: Institute of Physics Publishing
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Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery

Auteurs: Pang Lyu, Jinming Wen, Wenshuo Zhang, Ning Liu, Iris Stolzer, Andreas Gießl, Yewei Jia, Daniele Mauro, Fulin Zhang, Francesco Ciccia, Didier Soulat, Claudia Günther, Georg Schett, Aline Bozec
Publié dans: Annals of the Rheumatic Diseases, Numéro 83, 2025, Page(s) 984-997, ISSN 0003-4967
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Differential molecular signatures in response to CD19-CAR T cell therapy compared with conventional pharmacotherapy in systemic lupus erythematosus

Auteurs: Panagiotis Garantziotis, Lorenzo Beretta, Julius Lindblom, Georgia-Savina Moysidou, Dionysis Nikolopoulos, Ricardo Grieshaber-Bouyer, Melanie Hagen, Christina Bergmann, Andreas Wirsching, Aline Bozec,
Publié dans: Annals of the Rheumatic Diseases, 2025, ISSN 0003-4967
Éditeur: BMJ Publishing Group
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Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion

Auteurs: David Simon, Koray Tascilar, Gerhard Krönke, Arnd Kleyer, Mario M. Zaiss, Franz Heppt, Christine Meder, Raja Atreya, Entcho Klenske, Peter Dietrich, Abdullah Abdullah, Thorsten Kliem, Giulia Corte, Harriet Morf, Moritz Leppkes, Andreas E. Kremer, Andreas Ramming, Milena Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Clara Maier, Axel J. Hueber, Karin Manger, Bernhard Manger, Caro
Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
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Effects of casirivimab/imdevimab on systemic and mucosal immunity against SARS-CoV-2 in B-cell depleted patients with autoimmune rheumatic diseases refractory to vaccination.

Auteurs: Fagni F, Schmidt K, Bohr D, Valor-Méndez L, Hartmann F, Tascilar K, Manger K, Manger B, Kleyer A, Simon D, Schett G, Harrer T.
Publié dans: Rheumatic & Musuloskeletal Disease Open, 2022, ISSN 2056-5933
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68Ga-FAPI-04 PET-CT for molecular assessment of fibroblast activation and risk evaluation in systemic sclerosis-associated interstitial lung disease: a single-centre, pilot study

Auteurs: Christina Bergmann, Jörg H W Distler, Christoph Treutlein, Koray Tascilar, Anna-Theresa Müller, Armin Atzinger, Alexandru-Emil Matei, Johannes Knitza, Andrea-Hermina Györfi, Anja Lück, Clara Dees,
Publié dans: The Lancet Rheumatology, Numéro 3, 2025, Page(s) e185-e194, ISSN 2665-9913
Éditeur: Elsevier BV
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Learning with Known Operators reduces Maximum Training Error Bounds

Auteurs: Maier, Andreas K.; Syben, Christopher; Stimpel, Bernhard; Würfl, Tobias; Hoffmann, Mathis; Schebesch, Frank; Fu, Weilin; Mill, Leonid; Kling, Lasse; Christiansen, Silke
Publié dans: Nature machine intelligence, Numéro 1, 2020, Page(s) 373–380, ISSN 2522-5839
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IgA2 Antibodies against SARS-CoV-2 Correlate with NET Formation and Fatal Outcome in Severely Diseased COVID-19 Patients

Auteurs: Léonie A. N. Staats, Hella Pfeiffer, Jasmin Knopf, Aylin Lindemann, Julia Fürst, Andreas E. Kremer, Holger Hackstein, Markus F. Neurath, Luis E. Muñoz, Susanne Achenbach, Moritz Leppkes, Martin Herrmann, Georg Schett, Ulrike Steffen
Publié dans: Cells, Numéro 9/12, 2020, Page(s) 2676, ISSN 2073-4409
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Why remission is not enough: underlying disease mechanisms in RA that prevent cure.

Auteurs: Georg Schett; Yoshiya Tanaka; John D. Isaacs; John D. Isaacs
Publié dans: Nature Reviews Rheumatology, Numéro 23, 2021, Page(s) 135–144, ISSN 1759-4790
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Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging

Auteurs: Christian Schmidkonz, Simon Rauber, Armin Atzinger, Rahul Agarwal, Theresa Ida Götz, Alina Soare, Michael Cordes, Olaf Prante, Christina Bergmann, Arnd Kleyer, Philipp Ritt, Simone Maschauer, Peter Hennig, Johannes Toms, Markus Köhner, Bernhard Manger, John H Stone, Uwe Haberkorn, Tobias Baeuerle, Jörg H W Distler, Abbas Agaimy, Torsten Kuwert, Georg Schett, Andreas Ramming
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Deep learning-based patient re-identification is able to exploit the biometric nature of medical chest X-ray data

Auteurs: Kai Packhäuser, Sebastian Gündel, Nicolas Münster, Christopher Syben, Vincent Christlein, Andreas Maier
Publié dans: Scientific Reports, 2022, ISSN 2045-2322
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Paucity of viral infection symptoms in patients with immune-mediated inflammatory diseases

Auteurs: Melek Yalcin Mutlu, Arnd Kleyer, Gerhard Kroenke, Filippo Fagni, Selahattin Alp Temiz, Christine Meder, Peter Dietrich, Till Orlemann, Johanna Mößner, Verena Schoenau, Daniela Bohr, Louis Schuster,
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AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9.

Auteurs: Vergarajauregui S, Becker R, Steffen U, Sharkova M, Esser T, Petzold J, Billing F, Kapiloff MS, Schett G, Thievessen I, Engel FB.
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SARS-CoV-2 vaccination responses in untreated, conventionally treated and anticytokine-treated patients with immune-mediated inflammatory diseases

Auteurs: David Simon, Koray Tascilar, Filippo Fagni, Gerhard Krönke, Arnd Kleyer, Christine Meder, Raja Atreya, Moritz Leppkes, Andreas E Kremer, Andreas Ramming, Milena L Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Axel J Hueber, Karin Manger, Bernhard Manger, Carola Berking, Michael Sticherling, Markus F Neurath, Georg Schett
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Disease interception with interleukin-17 inhibition in high-risk psoriasis patients with subclinical joint inflammation—data from the prospective IVEPSA study

Auteurs: Eleni Kampylafka, David Simon, Isabelle d’Oliveira, Christina Linz, Veronika Lerchen, Matthias Englbrecht, Juergen Rech, Arnd Kleyer, Michael Sticherling, Georg Schett, Axel J. Hueber
Publié dans: Arthritis Research & Therapy, Numéro 21, 2020, ISSN 1478-6362
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Abatacept inhibits inflammation and onset of rheumatoid arthritis in individuals at high risk (ARIAA): a randomised, international, multicentre, double-blind, placebo-controlled trial

Auteurs: Juergen Rech, Koray Tascilar, Melanie Hagen, Arnd Kleyer, Bernhard Manger, Verena Schoenau, Axel J Hueber, Stefan Kleinert, Xenofon Baraliakos, Jürgen Braun, Uta Kiltz, Martin Fleck, Andrea Rubbert-R
Publié dans: The Lancet, Numéro 403, 2025, Page(s) 850-859, ISSN 0140-6736
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CD19-CAR T-cell therapy induces deep tissue depletion of B cells

Auteurs: Carlo Tur, Markus Eckstein, Joachim Velden, Simon Rauber, Christina Bergmann, Janina Auth, Laura Bucci, Giulia Corte, Melanie Hagen, Andreas Wirsching, Ricardo Grieshaber-Bouyer, Petra Reis, Nicolai K
Publié dans: Annals of the Rheumatic Diseases, Numéro 84, 2025, Page(s) 106-114, ISSN 0003-4967
Éditeur: BMJ Publishing Group
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Structural entheseal lesions in patients with psoriasis are associated with an increased risk of progression to psoriatic arthritis

Auteurs: David Simon, Koray Tascilar, Arnd Kleyer, Sara Bayat, Eleni Kampylafka, Maria Sokolova, Ana Zekovic, Axel J Hueber, Jürgen Rech, Louis Schuster, Klaus Engel, Michael Sticherling, Georg Schett
Publié dans: Arthritis & Rheumatology, 2020, ISSN 2326-5191
Éditeur: Wiley
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Selective CAR T cell–mediated B cell depletion suppresses IFN signature in SLE

Auteurs: Artur Wilhelm, David Chambers, Fabian Müller, Aline Bozec, Ricardo Grieshaber-Bouyer, Thomas Winkler, Dimitrios Mougiakakos, Andreas Mackensen, Georg Schett, Gerhard Krönke
Publié dans: JCI Insight, Numéro 9, 2024, ISSN 2379-3708
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A Detailed Analysis of the Association between Urate Deposition and Erosions and Osteophytes in Gout

Auteurs: Caroline Pecherstorfer, David Simon, Sara Unbehend, Hanna Ellmann, Matthias Englbrecht, Fabian Hartmann, Camille Figueiredo, Axel Hueber, Judith Haschka, Roland Kocijan, Arnd Kleyer, Georg Schett, Jürgen Rech, Sara Bayat
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Vascular occlusion by neutrophil extracellular traps in COVID-19

Auteurs: Moritz Leppkes, Jasmin Knopf, Elisabeth Naschberger, Aylin Lindemann, Jeeshan Singh, Irmgard Herrmann, Michael Stürzl, Léonie Staats, Aparna Mahajan, Christine Schauer, Anita N. Kremer, Simon Völkl, Kerstin Amann, Katja Evert, Christina Falkeis, Andreas Wehrfritz, Ralf J. Rieker, Arndt Hartmann, Andreas E. Kremer, Markus F. Neurath, Luis E. Muñoz, Georg Schett, Martin Herrmann
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Effect of disease-modifying anti-rheumatic drugs on bone structure and strength in psoriatic arthritis patients

Auteurs: David Simon, Arnd Kleyer, Sara Bayat, Koray Tascilar, Eleni Kampylafka, Timo Meinderink, Louis Schuster, Ramona Petrov, Anna-Maria Liphardt, Juergen Rech, Georg Schett, Axel J. Hueber
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Additional file 1 of Advanced machine learning for predicting individual risk of flares in rheumatoid arthritis patients tapering biologic drugs

Auteurs: Vodencarevic, Asmir; Tascilar, Koray; Hartmann, Fabian; Reiser, Michaela; Hueber, Axel J.; Haschka, Judith; Bayat, Sara; Meinderink, Timo; Knitza, Johannes; Mendez, Larissa; Hagen, Melanie; Krönke, Gerhard; Rech, Jürgen; Manger, Bernhard; Kleyer, Arnd; Zimmermann-Rittereiser, Marcus; Schett, Georg; Simon, David
Publié dans: Arthritis Research & Therapy, Numéro 23(1), 2021, Page(s) 67, ISSN 1478-6354
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IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation.

Auteurs: Faas M, Ipseiz N, Ackermann J, Culemann S, Grüneboom A, Schröder F, Rothe T, Scholtysek C, Eberhardt M, Böttcher M, Kirchner P, Stoll C, Ekici A, Fuchs M, Kunz M, Weigmann B, Wirtz S, Lang R, Hofmann J, Vera J, Voehringer D, Michelucci A, Mougiakakos D, Uderhardt S, Schett G, Krönke G.
Publié dans: Immunity, Numéro 54(11), 2021, Page(s) 2531-2546, ISSN 1074-7613
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Sensor-assessed grasping time as a biomarker of functional impairment in rheumatoid arthritis

Auteurs: Birte Coppers, Simon Heinrich, Koray Tascilar, Uday Phutane, Arnd Kleyer, David Simon, Johanna Bräunig, Johann Penner, Martin Vossiek, Verena Schönau, Sara Bayat, Georg Schett, Sigrid Leyendecker, A
Publié dans: Scientific Reports, Numéro 15, 2025, ISSN 2045-2322
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Murine Metatarsus Bone and Joint Collagen-I Fiber Morphologies and Networks Studied With SHG Multiphoton Imaging.

Auteurs: Vielreicher M, Bozec A, Schett G, Friedrich O.
Publié dans: Frontier Bioengeeniering Biotechnology, Numéro 9, 2021, Page(s) 608383, ISSN 2296-4185
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Biomechanical stress in the context of competitive sports training triggers enthesitis.

Auteurs: Simon D, Kleyer A, Bayat S, Knitza J, Valor-Mendez L, Schweiger M, Schett G, Tascilar K, Hueber AJ.
Publié dans: Arthritis Research & Therapy, Numéro 23(1), 2021, Page(s) 172, ISSN 1478-6362
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Deep learning-based classification of erosion, synovitis and osteitis in hand MRI of patients with inflammatory arthritis

Auteurs: Maja Schlereth, Melek Yalcin Mutlu, Jonas Utz, Sara Bayat, Tobias Heimann, Jingna Qiu, Chris Ehring, Chang Liu, Michael Uder, Arnd Kleyer, David Simon, Frank Roemer, Georg Schett, Katharina Breininger
Publié dans: RMD Open, Numéro 10, 2025, Page(s) e004273, ISSN 2056-5933
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Effects of different B-cell-depleting strategies on the lymphatic tissue

Auteurs: Carlo Tur, Markus Eckstein, Laura Bucci, Janina Auth, Christina Bergmann, Simon Rauber, Melanie Hagen, Danae-Mona Nöthling, Sebastian Böltz, Andreas Wirsching, Koray Tascilar, Filippo Fagni, Giulia
Publié dans: Annals of the Rheumatic Diseases, Numéro 84, 2025, Page(s) 2065-2074, ISSN 0003-4967
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Metabolic and molecular imaging in inflammatory arthritis

Auteurs: Rita Noversa de Sousa, Koray Tascilar, Giulia Corte, Armin Atzinger, Ioanna Minopoulou, Sarah Ohrndorf, Maximilian Waldner, Christian Schmidkonz, Torsten Kuwert, Ferdinand Knieling, Arnd Kleyer, Andre
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Successful Generation of CD19 Chimeric Antigen Receptor T Cells from Patients with Advanced Systemic Lupus Erythematosus.

Auteurs: Kretschmann S, Völkl S, Reimann H, Krönke G, Schett G, Achenbach S, Lutzny-Geier G, Müller F, Mougiakakos D, Dingfelder J, Flamann C, Hanssens L, Gary R, Mackensen A, Aigner M.
Publié dans: Transplantation and Cellular Therapy, 2023, ISSN 2666-6375
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“Keep it simple, scholar”: an experimental analysis of few-parameter segmentation networks for retinal vessels in fundus imaging

Auteurs: Weilin Fu, Katharina Breininger, Roman Schaffert, Zhaoya Pan, Andreas Maier
Publié dans: International Journal of Computer Assisted Radiology and Surgery, Numéro 16/6, 2021, Page(s) 967-978, ISSN 1861-6410
Éditeur: Springer Verlag
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Immobilization by 21 days of bed rest results in type II collagen degradation in healthy individuals

Auteurs: Anna-Maria Liphardt, Elie-Tino Godonou, Maren Dreiner, Annegret Mündermann, Koray Tascilar, Nadja Djalal, Martina Heer, Georg Schett, Frank Zaucke, Anja Niehoff
Publié dans: Osteoarthritis and Cartilage, Numéro 32, 2025, Page(s) 177-186, ISSN 1063-4584
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Inflammatory activation of the FcγR and IFNγR pathways co-influences the differentiation and activity of osteoclasts.

Auteurs: Groetsch B, Schachtschabel E, Tripal P, Schmid B, Smith AS, Schett G, Bozec A.
Publié dans: Frontier Immunology, 2022, ISSN 1664-3224
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Complexes Induce Neutrophil Extracellular Trap Formation More Potently Than IgG Complexes.

Auteurs: Gimpel AK, Maccataio A, Unterweger H, Sokolova MV, Schett G, Steffen U.
Publié dans: Frontier Immunology, Numéro 12, 2022, Page(s) 761816, ISSN 1664-3224
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B cell-targeting chimeric antigen receptor T cells as an emerging therapy in neuroimmunological diseases

Auteurs: Aiden Haghikia, Georg Schett, Dimitrios Mougiakakos
Publié dans: The Lancet Neurology, Numéro 23, 2024, Page(s) 615-624, ISSN 1474-4422
Éditeur: The Lancet Publishing Group
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A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19

Auteurs: Singh J, Herrmann I, Mahajan A, Schauer C, Shan X, Hartmann A, Rieker RJ, Evert K, Falkeis C, Naschberger E, von Stillfried S, Boor P, Muñoz LE, Schett G, Herrmann M, Knopf J.
Publié dans: International Journal of Molecular Science, 2022, ISSN 1422-0067
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Deep Learning-Based Classification of Inflammatory Arthritis by Identification of Joint Shape Patterns—How Neural Networks Can Tell Us Where to “Deep Dive” Clinically

Auteurs: Lukas Folle, David Simon, Koray Tascilar, Gerhard Krönke, Anna-Maria Liphardt, Andreas Maier, Georg Schett, Arnd Kleyer
Publié dans: Frontiers in Medicine, 2022, ISSN 2296-858X
Éditeur: Frontiers Media
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Immobilization by 21-days of bed rest causes changes in biomarkers of cartilage homeostasis in healthy individuals

Auteurs: Maren Dreiner, Elie-Tino Godonou, Annegret Mündermann, Koray Tascilar, Georg Schett, Frank Zaucke, Anna-Maria Liphardt, Anja Niehoff
Publié dans: Osteoarthritis and Cartilage Open, Numéro 7, 2025, Page(s) 100597, ISSN 2665-9131
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Additional file 3 of A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Auteurs: Sokolova, Maria; Simon, David; Nas, Kemal; Zaiss, Mario; Yubin Luo; Zhao, Yi; JÃ¼rgen Rech; Schett, Georg
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Next-generation imaging of the skeletal system and its blood supply

Auteurs: Anika Grüneboom, Lasse Kling, Silke Christiansen, Leonid Mill, Andreas Maier, Klaus Engelke, Harald H. Quick, Georg Schett, Matthias Gunzer
Publié dans: Nature Reviews Rheumatology, Numéro 15/9, 2019, Page(s) 533-549, ISSN 1759-4790
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Advancement and independent validation of a deep learning-based tool for automated scoring of nail psoriasis severity using the modified nail psoriasis severity index

Auteurs: Stephan Kemenes, Liu Chang, Maja Schlereth, Rita Noversa de Sousa, Ioanna Minopoulou, Pauline Fenzl, Giulia Corte, Melek Yalcin Mutlu, Michael Wolfgang Höner, Ioannis Sagonas, Birte Coppers, Anna-Mar
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PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass

Auteurs: Dorothea I. H. Müller, Cornelia Stoll, Katrin Palumbo-Zerr, Christina Böhm, Brenda Krishnacoumar, Natacha Ipseiz, Jule Taubmann, Max Zimmermann, Martin Böttcher, Dimitrios Mougiakakos, Jan Tuckermann, Farida Djouad, Georg Schett, Carina Scholtysek, Gerhard Krönke
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BigReg: an efficient registration pipeline for high-resolution X-ray and light-sheet fluorescence microscopy

Auteurs: Siyuan Mei, Fuxin Fan, Mareike Thies, Mingxuan Gu, Fabian Wagner, Oliver Aust, Ina Erceg, Zeynab Mirzaei, Georgiana Neag, Yipeng Sun, Yixing Huang, Andreas Maier
Publié dans: Journal of Medical Imaging, Numéro 12, 2025, ISSN 2329-4302
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Deep learning for terahertz image denoising in nondestructive historical document analysis

Auteurs: Balaka Dutta, Konstantin Root, Ingrid Ullmann, Fabian Wagner, Martin Mayr, Mathias Seuret, Mareike Thies, Daniel Stromer, Vincent Christlein, Jan Schür, Andreas Maier, Yixing Huang
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COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses.

Auteurs: Fagni F, Simon D, Tascilar K, Schoenau V, Sticherling M, Neurath MF, Schett G.
Publié dans: Lancet Rheumatology, Numéro 3(10), 2021, Page(s) e724-e736, ISSN 2665-9913
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Does methotrexate influence COVID-19 infection? Case series and mechanistic data.

Auteurs: Schälter F, Dürholz K, Bucci L, Burmester G, Caporali R, Figuereido C, Cobra JF, Manger B, Zaiss MM, Schett G.
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CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis

Auteurs: Simon Rauber, Hashem Mohammadian, Christian Schmidkonz, Armin Atzinger, Alina Soare, Christoph Treutlein, Samuel Kemble, Christopher B. Mahony, Manuel Geisthoff, Mario R. Angeli, Maria G. Raimondo, Co
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A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Auteurs: Maria V. Sokolova, David Simon, Kemal Nas, Mario M. Zaiss, Yubin Luo, Yi Zhao, Jürgen Rech, Georg Schett
Publié dans: Arthritis Research & Therapy, Numéro 22/1, 2020, ISSN 1478-6362
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Microbiota-Derived Propionate Modulates Megakaryopoiesis and Platelet Function.

Auteurs: Dürholz K, Schmid E, Frech M, Azizov V, Otterbein N, Lucas S, Rauh M, Schett G, Bruns H, Zaiss MM.
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The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption.

Auteurs: Andes FT, Adam S, Hahn M, Aust O, Frey S, Grueneboom A, Nitschke L, Schett G, Steffen U.
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Learned cone-beam CT reconstruction using neural ordinary differential equations

Auteurs: Mareike Thies, Fabian Wagner, Mingxuan Gu, Lukas Folle, Lina Felsner, Andreas Maier
Publié dans: Proceedings 7th International Conference on Image Formation in X-Ray Computed Tomography, Numéro Volume 12304, 2022
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DOI: 10.1117/12.2646442

On the Benefit of Dual-Domain Denoising in a Self-Supervised Low-Dose CT Setting

Auteurs: Fabian Wagner; Mareike Thies; Laura Pfaff; Oliver Aust; Sabrina Pechmann; Daniela Weidner; Noah Maul; Maximilian Rohleder; Mingxuan Gu; Jonas Utz; Felix Denzinger; Andreas Maier
Publié dans: 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI), 2023
Éditeur: IEEE
DOI: 10.1109/isbi53787.2023.10230511

Cavity Segmentation in X-ray Microscopy Scans of Mouse Tibiae

Auteurs: Mingxuan Gu, Mareike Thies, Fabian Wagner, Sabrina Pechmann, Oliver Aust, Daniela Weidner, Georgiana Neag, Zhaoya Pan, Jonas Utz, Georg Schett, Silke Christiansen, Stefan Uderhardt, Andreas Maier
Publié dans: Bildverarbeitung für die Medizin 2023, 2023
Éditeur: Springer
DOI: 10.1007/978-3-658-41657-7_56

Noise2Contrast: Multi-contrast Fusion Enables Self-supervised Tomographic Image Denoising

Auteurs: Fabian Wagner, Mareike Thies, Laura Pfaff, Noah Maul, Sabrina Pechmann, Mingxuan Gu, Jonas Utz, Oliver Aust, Daniela Weidner, Georgiana Neag, Stefan Uderhardt, Jang-Hwan Choi, Andreas Maier
Publié dans: Information Processing in Medical Imaging 2023, 2023
Éditeur: Springer
DOI: 10.1007/978-3-031-34048-2_59

Robust Multi-Contrast Mri Denoising Using Trainable Bilateral Filters Without Noise-Free Targets

Auteurs: Laura Pfaff; Fabian Wagner; Julian Hossbach; Elisabeth Preuhs; Noah Maul; Mareike Thies; Felix Denzinger; Dominik Nickel; Tobias Wuerfl; Andreas Maier
Publié dans: 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI), 2023
Éditeur: IEEE
DOI: 10.1109/isbi53787.2023.10230627

Deep Learning-Based Anonymization of Chest Radiographs: A Utility-Preserving Measure for Patient Privacy

Auteurs: Kai Packhäuser, Sebastian Gündel, Florian Thamm, Felix Denzinger, Andreas Maier
Publié dans: Medical Image Computing and Computer Assisted Intervention – MICCAI 2023, 2023
Éditeur: Springer
DOI: 10.1007/978-3-031-43898-1_26

Geometric Constraints Enable Self-Supervised Sinogram Inpainting in Sparse-View Tomography

Auteurs: Fabian Wagner, Mareike Thies, Noah Maul, Laura Pfaff, Oliver Aust, Sabrina Pechmann, Christopher Syben, Andreas Maier
Publié dans: 17th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine (Fully3D), 2023
Éditeur: Fully3d

Focus on Content not Noise: Improving Image Generation for Nuclei Segmentation by Suppressing Steganography in CycleGAN

Auteurs: Jonas Utz, Tobias Weise, Maja Schlereth, Fabian Wagner, Mareike Thies, Mingxuan Gu, Stefan Uderhardt, Katharina Breininger
Publié dans: Proceedings of the IEEE/CVF International Conference on Computer Vision (ICCV) Workshops, 2023
Éditeur: CVF

Generation of Anonymous Chest Radiographs Using Latent Diffusion Models for Training Thoracic Abnormality Classification Systems

Auteurs: Kai Packhäuser; Lukas Folle; Florian Thamm; Andreas Maier
Publié dans: 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI), 2023
Éditeur: IEEE
DOI: 10.1109/isbi53787.2023.10230346

Optimizing CT Scan Geometries With and Without Gradients

Auteurs: Mareike Thies, Fabian Wagner, Noah Maul, Laura Pfaff, Linda-Sophie Schneider, Christopher Syben, Andreas Maier
Publié dans: 17th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine (Fully3D), 2023
Éditeur: Fully3d

Lesson Learnt: Modularization of Deep Networks Allow Cross-Modality Reuse

Auteurs: Fu, Weilin; Husvogt, Lennart; Maier, Stefan Ploner James G. Fujimoto Andreas
Publié dans: Bildverarbeitung für die Medizin 2020. Informatik aktuell., Numéro 2, 2020, Page(s) 274-279
Éditeur: Springer Vieweg
DOI: 10.1007/978-3-658-29267-6

Bildverarbeitung für die Medizin 2021 - Proceedings, German Workshop on Medical Image Computing, Regensburg, March 7-9, 2021

Auteurs: Yixing Huang, Leonid Mill, Robert Stoll, Lasse Kling, Oliver Aust, Fabian Wagner, Anika Gruneboom, Georg Schett, Silke Christiansen, Andreas Maier
Publié dans: Semi-permeable Filters for Interior Region of InterestDose Reduction in X-ray Microscopy, 2021, Page(s) 61-66, ISBN 978-3-658-33198-6
Éditeur: Springer Fachmedien Wiesbaden GmbH
DOI: 10.1007/978-3-658-33198-6

Monte Carlo Dose Simulation for In-Vivo X-Ray Nanoscopy

Auteurs: Fabian Wagner, Mareike Thies, Marek Karolczak, Sabrina Pechmann, Yixing Huang, Mingxuan Gu, Lasse Kling, Daniela Weidner, Oliver Aust, Georg Schett, Silke Christiansen, Andreas Maier
Publié dans: Bildverarbeitung für die Medizin, 2022
Éditeur: Springer
DOI: 10.1007/978-3-658-36932-3_22

Towards In-Vivo X-Ray Nanoscopy - Acquisition Parameters vs. Image Quality

Auteurs: Leonid Mill, Lasse Kling, Anika Grüneboom, Georg Schett, Silke Christiansen, Andreas Maier
Publié dans: Bildverarbeitung für die Medizin 2019 - Algorithmen – Systeme – Anwendungen. Proceedings des Workshops vom 17. bis 19. März 2019 in Lübeck, 2019, Page(s) 251-256, ISBN 978-3-658-25325-7
Éditeur: Springer Fachmedien Wiesbaden
DOI: 10.1007/978-3-658-25326-4_56

Towards In-Vivo X-Ray Nanoscopy - The Effect of Motion on Image Quality

Auteurs: Leonid Mill, Bastian Bier, Christopher Syben, Lasse Kling, Anika Klingberg, Silke Christiansen, Georg Schett, Andreas Maier
Publié dans: Bildverarbeitung für die Medizin 2018 - Algorithmen - Systeme - Anwendungen. Proceedings des Workshops vom 11. bis 13. März 2018 in Erlangen, 2018, Page(s) 115-120, ISBN 978-3-662-56536-0
Éditeur: Springer Berlin Heidelberg
DOI: 10.1007/978-3-662-56537-7_40

Degenerating U-Net on Retinal Vessel Segmentation - What Do We Really Need?

Auteurs: Weilin Fu, Katharina Breininger, Zhaoya Pan, Andreas Maier
Publié dans: Bildverarbeitung für die Medizin 2020 - Algorithmen – Systeme – Anwendungen. Proceedings des Workshops vom 15. bis 17. März 2020 in Berlin, 2020, Page(s) 33-38, ISBN 978-3-658-29266-9
Éditeur: Springer Fachmedien Wiesbaden
DOI: 10.1007/978-3-658-29267-6_7

Few-shot Unsupervised Domain Adaptation for Multi-modal Cardiac Image Segmentation

Auteurs: Mingxuan Gu, Sulaiman Vesal, Ronak Kosti, Andreas Maier
Publié dans: Bildverarbeitung für die Medizin, 2022
Éditeur: Springer
DOI: 10.1007/978-3-658-36932-3_5

Towards Mouse Bone X-ray Microscopy Scan Simulation

Auteurs: Weilin Fu, Leonid Mill, Stephan Seitz, Tobias Geimer, Lasse Kling, Dennis Possart, Silke Christiansen, Andreas Maier
Publié dans: Bildverarbeitung für die Medizin 2021 - Proceedings, German Workshop on Medical Image Computing, Regensburg, March 7-9, 2021, 2021, Page(s) 128-133, ISBN 978-3-658-33197-9
Éditeur: Springer Fachmedien Wiesbaden
DOI: 10.1007/978-3-658-33198-6_32

Degenerating U-Net on Retinal Vessel Segmentation

Auteurs: Fu, Weilin; Breininger, Katharina; Pan, Zhaoya; Maier, Andreas
Publié dans: Informatik aktuell, Numéro 1, 2020, Page(s) 33-38, ISBN 978-3-658-29266-6
Éditeur: Springer Vieweg
DOI: 10.1007/978-3-658-29266-6

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