Advancing osteoporosis medicine by observing bone microstructure and remodelling using a four-dimensional nanoscope

Publications

Neutrophil Extracellular Traps Promote the Development and Growth of Human Salivary Stones.

Author(s): Schapher M, Koch M, Weidner D, Scholz M, Wirtz S, Mahajan A, Herrmann I, Singh J, Knopf J, Leppkes M, Schauer C, Grüneboom A, Alexiou C, Schett G, Iro H, Muñoz LE, Herrmann M.
Published in: Cells, 9(9), 2020, Page(s) 2139, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9092139

Secukinumab leads to shifts from stage-based towards response-based disease clusters—comparative data from very early and established psoriatic arthritis

Author(s): Eleni Kampylafka, Koray Tascilar, Veronika Lerchen, Christina Linz, Maria Sokolova, Ana Zekovic, Arnd Kleyer, David Simon, Jürgen Rech, Michael Sticherling, Georg Schett, Axel J. Hueber
Published in: Arthritis Research & Therapy, 22/1, 2020, ISSN 1478-6362
Publisher: BMC part of Springer Nature SharedIt
DOI: 10.1186/s13075-020-02268-y

Author(s): Anna‐Maria Liphardt, Eva Manger, Sonja Liehr, Lisa Bieniek, Arnd Kleyer, David Simon, Koray Tascilar, Michael Sticherling, Jürgen Rech, Georg Schett, Axel J. Hueber
Published in: ACR Open Rheumatology, 2/12, 2020, Page(s) 734-740, ISSN 2578-5745
Publisher: Wiley Online Libary
DOI: 10.1002/acr2.11196

Additional file 5 of A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Author(s): Sokolova, Maria; Simon, David; Nas, Kemal; Zaiss, Mario; Yubin Luo; Zhao, Yi; JÃ¼rgen Rech; Schett, Georg
Published in: Arthritis Research & Therapy, 2, 2020, Page(s) 26, ISSN 1478-6354
Publisher: BioMed Central
DOI: 10.6084/m9.figshare.11846322.v1

Patients with COVID-19: in the dark-NETs of neutrophils.

Author(s): Ackermann M, Anders HJ, Bilyy R, Bowlin GL, Daniel C, De Lorenzo R, Egeblad M, Henneck T, Hidalgo A, Hoffmann M, Hohberger B, Kanthi Y, Kaplan MJ, Knight JS, Knopf J, Kolaczkowska E, Kubes P, Leppkes M, Mahajan A, Manfredi AA, Maueröder C, Maugeri N, Mitroulis I, Muñoz LE, Narasaraju T, Naschberger E, Neeli I, Ng LG, Radic MZ, Ritis K, Rovere-Querini P, Schapher M, Schauer C, Simon HU, Singh J,
Published in: Cell Death Differ, 28(11), 2021, Page(s) 3125-3139, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-021-00805-z

A network of trans-cortical capillaries as mainstay for blood circulation in long bones

Author(s): Anika Grüneboom, Ibrahim Hawwari, Daniela Weidner, Stephan Culemann, Sylvia Müller, Sophie Henneberg, Alexandra Brenzel, Simon Merz, Lea Bornemann, Kristina Zec, Manuela Wuelling, Lasse Kling, Mike Hasenberg, Sylvia Voortmann, Stefanie Lang, Wolfgang Baum, Alexandra Ohs, Oliver Kraff, Harald H. Quick, Marcus Jäger, Stefan Landgraeber, Marcel Dudda, Renzo Danuser, Jens V. Stein, Manfred Rohde, K
Published in: Nature Metabolism, 1/2, 2019, Page(s) 236-250, ISSN 2522-5812
Publisher: Nature Research
DOI: 10.1038/s42255-018-0016-5

AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9

Author(s): Silvia Vergarajauregui, Robert Becker, Ulrike Steffen, Maria Sharkova, Tilman Esser, Jana Petzold, Florian Billing, Michael S Kapiloff, George Schett, Ingo Thievessen, Felix B Engel
Published in: eLife, 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.61669

Performance of a Handheld Ultrasound Device to Assess Articular and Periarticular Pathologies in Patients with Inflammatory Arthritis.

Author(s): Corte G, Bayat S, Tascilar K, Valor-Mendez L, Schuster L, Knitza J, Fagni F, Schett G, Kleyer A, Simon D.
Published in: Diagnostics, 11(7), 2021, Page(s) 1139, ISSN 2075-4418
Publisher: MDPI AG, 2011
DOI: 10.3390/diagnostics11071139

Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis

Author(s): Jule Taubmann, Brenda Krishnacoumar, Christina Böhm, Maria Faas, Dorothea I. H. Müller, Susanne Adam, Cornelia Stoll, Martin Böttcher, Dimitrios Mougiakakos, Uwe Sonnewald, Jörg Hofmann, Georg Schett, Gerhard Krönke, Carina Scholtysek
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-77892-4

Technical Note: PYRO‐NN: Python reconstruction operators in neural networks

Author(s): Christopher Syben, Markus Michen, Bernhard Stimpel, Stephan Seitz, Stefan Ploner, Andreas K. Maier
Published in: Medical Physics, 46/11, 2019, Page(s) 5110-5115, ISSN 0094-2405
Publisher: American Association of Physicists in Medicine
DOI: 10.1002/mp.13753

Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis

Author(s): Darja Andreev, Mengdan Liu, Katerina Kachler, Mireia Llerins Perez, Philipp Kirchner, Julia Kölle, Andreas Gießl, Simon Rauber, Rui Song, Oliver Aust, Anika Grüneboom, Arnd Kleyer, Juan D Cañete, Arif Ekici, Andreas Ramming, Susetta Finotto, Georg Schett, Aline Bozec
Published in: Annals of the Rheumatic Diseases, 80/4, 2021, Page(s) 451-468, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-218902

The Transcription Factor FRA-1/AP-1 Controls Lipocalin-2 Expression and Inflammation in Sepsis Model.

Author(s): Cao S, Schnelzer A, Hannemann N, Schett G, Soulat D, Bozec A.
Published in: Frontiers of Immunology, 12, 2021, Page(s) 701675, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.701675

Why remission is not enough: underlying disease mechanisms in RA that prevent cure

Author(s): Georg Schett, Yoshiya Tanaka, John D. Isaacs
Published in: Nature Reviews Rheumatology, 17/3, 2021, Page(s) 135-144, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/s41584-020-00543-5

Humoral and Cellular Immune Responses to SARS-CoV-2 Infection and Vaccination in Autoimmune Disease Patients With B Cell Depletion.

Author(s): Simon D, Tascilar K, Schmidt K, Manger B, Weckwerth L, Sokolova M, Bucci L, Fagni F, Manger K, Schuch F, Ronneberger M, Hueber A, Steffen U, Mielenz D, Herrmann M, Harrer T, Kleyer A, Krönke G, Schett G.
Published in: Arthritis & Rheumatology, 74(1), 2022, Page(s) 33-37, ISSN 2326-5191
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/art.41914

Aggregated neutrophil extracellular traps occlude Meibomian glands during ocular surface inflammation

Author(s): Aparna Mahajan; Lenka Hasíková; Ulrike Hampel; Anika Grüneboom; Xiaomei Shan; Irmgard Herrmann; Fabian Garreis; Felix Bock; Jasmin Knopf; Jeeshan Singh; Christine Schauer; Siddharth Mahajan; Moritz Leppkes; Friedrich Paulsen; Ursula Schlötzer-Schrehardt; Veit Krenn; Anselm Jünemann; Bettina Hohberger; Georg Schett; Martin Herrmann; Luis E. Muñoz
Published in: Ocular Surface, 2, 2020, Page(s) 1-12, ISSN 1542-0124
Publisher: Ethis Communications
DOI: 10.1016/j.jtos.2020.12.005

Impact of cytokine inhibitor therapy on the prevalence, seroconversion rate and longevity of the humoral immune response against SARS-CoV-2 in an unvaccinated cohort.

Author(s): Simon D, Tascilar K, Kleyer A, Fagni F, Krönke G, Meder C, Dietrich P, Orlemann T, Kliem T, Mößner J, Liphardt AM, Schönau V, Bohr D, Schuster L, Hartmann F, Leppkes M, Ramming A, Pachowsky M, Schuch F, Ronneberger M, Kleinert S, Hueber AJ, Manger K, Manger B, Atreya R, Berking C, Sticherling M, Neurath MF, Schett G.
Published in: Athritis & Rheumatology, 74(5), 2022, Page(s) 783-790, ISSN 2326-5205
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/art.42035

The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption

Author(s): F.T. Andes, S. Adam, M. Hahn, O. Aust, S. Frey, A. Grueneboom, L. Nitschke, G. Schett, U. Steffen
Published in: Bone, 143, 2021, Page(s) 115665, ISSN 8756-3282
Publisher: Elsevier BV
DOI: 10.1016/j.bone.2020.115665

RETRO study group. Advanced machine learning for predicting individual risk of flares in rheumatoid arthritis patients tapering biologic drugs.

Author(s): Vodencarevic A, Tascilar K, Hartmann F, Reiser M, Hueber AJ, Haschka J, Bayat S, Meinderink T, Knitza J, Mendez L, Hagen M, Krönke G, Rech J, Manger B, Kleyer A, Zimmermann-Rittereiser M, Schett G, Simon D.
Published in: Arthritis Research & Therapy, 23(1), 2021, Page(s) 67, ISSN 1478-6362
Publisher: BioMed Central
DOI: 10.1186/s13075-021-02439-5

Synthetic Image Rendering Solves Annotation Problem in Deep Learning Nanoparticle Segmentation

Author(s): Leonid Mill, David Wolff, Nele Gerrits, Patrick Philipp, Lasse Kling, Florian Vollnhals, Andrew Ignatenko, Christian Jaremenko, Yixing Huang, Olivier De Castro, Jean‐Nicolas Audinot, Inge Nelissen, Tom Wirtz, Andreas Maier, Silke Christiansen
Published in: Small Methods, 2021, Page(s) 2100223, ISSN 2366-9608
Publisher: Wiley
DOI: 10.1002/smtd.202100223

Precision of handheld multispectral optoacoustic tomography for muscle imaging

Author(s): Alexandra L. Wagner, Vera Danko, Anna Federle, Daniel Klett, David Simon, Rafael Heiss, Jörg Jüngert, Michael Uder, Georg Schett, Markus F. Neurath, Joachim Woelfle, Maximilian J. Waldner, Regina Trollmann, Adrian P. Regensburger, Ferdinand Knieling
Published in: Photoacoustics, In Press, Journal Pre-proof, 2020, Page(s) 100220, ISSN 2213-5979
Publisher: Elsevier GmbH
DOI: 10.1016/j.pacs.2020.100220

Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis

Author(s): Andreev D, Liu M, Kachler K, Llerins Perez M, Kirchner P, Kölle J, Gießl A, Rauber S, Song R, Aust O, Grüneboom A, Kleyer A, Cañete JD, Ekici A, Ramming A, Finotto S, Schett G, Bozec A.
Published in: Annals of Rheumatic Diseases, 80, 2021, Page(s) 451-468, ISSN 1468-2060
Publisher: BMJ
DOI: 10.1136/annrheumdis-2020-218902

Microbiota and metabolites in rheumatic diseases.

Author(s): Tong Y, Marion T, Schett G, Luo Y, Liu Y.
Published in: Autoimmunity Reviews, Volume 19, Issue 8, 2020, Page(s) 102530, ISSN 1568-9972
Publisher: Elsevier BV
DOI: 10.1016/j.autrev.2020.102530

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

Author(s): Jasna Friščić, Martin Böttcher, Christiane Reinwald, Heiko Bruns, Benjamin Wirth, Samantha-Josefine Popp, Kellie Irene Walker, Jochen A. Ackermann, Xi Chen, Jason Turner, Honglin Zhu, Lisa Seyler, Maximilien Euler, Philipp Kirchner, René Krüger, Arif B. Ekici, Triin Major, Oliver Aust, Daniela Weidner, Anita Fischer, Fabian T. Andes, Zeljka Stanojevic, Vladimir Trajkovic, Martin Herrmann, Ad
Published in: Immunity, 54/5, 2021, Page(s) 1002-1021.e10, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2021.03.003

Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin

Author(s): Darja Andreev, Mengdan Liu, Daniela Weidner, Katerina Kachler, Maria Faas, Anika Grüneboom, Ursula Schlötzer-Schrehardt, Luis E. Muñoz, Ulrike Steffen, Bettina Grötsch, Barbara Killy, Gerhard Krönke, Andreas M. Luebke, Andreas Niemeier, Falk Wehrhan, Roland Lang, Georg Schett, Aline Bozec
Published in: Journal of Clinical Investigation, 130/9, 2020, Page(s) 4811-4830, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci134214

Advanced machine learning for predicting individual risk of flares in rheumatoid arthritis patients tapering biologic drugs

Author(s): Asmir Vodencarevic, Koray Tascilar, Fabian Hartmann, Michaela Reiser, Axel J. Hueber, Judith Haschka, Sara Bayat, Timo Meinderink, Johannes Knitza, Larissa Mendez, Melanie Hagen, Gerhard Krönke, Jürgen Rech, Bernhard Manger, Arnd Kleyer, Marcus Zimmermann-Rittereiser, Georg Schett, David Simon
Published in: Arthritis Research & Therapy, 23/1, 2021, ISSN 1478-6362
Publisher: BMC Part of Springer nature
DOI: 10.1186/s13075-021-02439-5

Additional file 4 of A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Author(s): Sokolova, Maria; Simon, David; Nas, Kemal; Zaiss, Mario; Yubin Luo; Zhao, Yi; JÃ¼rgen Rech; Schett, Georg
Published in: Arthritis Research & Therapy, 22, 2020, Page(s) 26, ISSN 1478-6354
Publisher: BioMed Central
DOI: 10.6084/m9.figshare.11846319

The gut-bone axis: how bacterial metabolites bridge the distance

Author(s): Mario M. Zaiss, Rheinallt M. Jones, Georg Schett, Roberto Pacifici
Published in: Journal of Clinical Investigation, 129/8, 2019, Page(s) 3018-3028, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci128521

The ageing joint-standard age- and sex-related values of bone erosions and osteophytes in the hand joints of healthy individuals

Author(s): A. Berlin, D. Simon, K. Tascilar, C. Figueiredo, S. Bayat, S. Finzel, E. Klaus, J. Rech, A.J. Hueber, A. Kleyer, G. Schett
Published in: Osteoarthritis and Cartilage, 27/7, 2019, Page(s) 1043-1047, ISSN 1063-4584
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2019.01.019

JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function

Author(s): Susanne Adam, Nils Simon, Ulrike Steffen, Fabian T. Andes, Carina Scholtysek, Dorothea I. H. Müller, Daniela Weidner, Darja Andreev, Arnd Kleyer, Stephan Culemann, Madelaine Hahn, Georg Schett, Gerhard Krönke, Silke Frey, Axel J. Hueber
Published in: Science Translational Medicine, 12/530, 2020, Page(s) eaay4447, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aay4447

Limited angle tomography for transmission X-ray microscopy using deep learning.

Author(s): Yixing Huang; Shengxiang Wang; Yong Guan; Andreas Maier
Published in: Journal of Synchrotron Radiation, 2, 2020, Page(s) 477-485, ISSN 1600-5775
Publisher: Wiley
DOI: 10.1107/S160057752000017X

Systemic PPARγ Antagonism Reduces Metastatic Tumor Progression in Adipocyte-Rich Bone in Excess Weight Male Rodents.

Author(s): Gaculenko A, Gregoric G, Popp V, Seyler L, Ringer M, Kachler K, Wu Z, Kisel W, Hofbauer C, Hofbauer LC, Uder M, Schett G, Bäuerle T, Bozec A.
Published in: Journal of Bone and Mineral Research, 36(12), 2021, Page(s) 2440-2452, ISSN 0884-0431
Publisher: American Society for Bone and Mineral Research
DOI: 10.1002/jbmr.4422

Known operator learning and hybrid machine learning in medical imaging—a review of the past, the present, and the future

Author(s): Andreas Maier, Harald Köstler, Marco Heisig, Patrick Krauss, Seung Hee Yang
Published in: Progress in Biomedical Engineering, 4/2, 2022, ISSN 2516-1091
Publisher: IOP Publishing
DOI: 10.1088/2516-1091/ac5b13

Double-Sided Graphene-Enhanced Raman Scattering and Fluorescence Quenching in Hybrid Biological Structures

Author(s): George Sarau; George Sarau; Christoph Daniel; Martin Heilmann; Gerd Leuchs; Kerstin Amann; Silke Christiansen
Published in: Advanced Materials Technologies, 6(9), 2021, Page(s) pp, ISSN 2365-709X
Publisher: Wiley-Blackwell
DOI: 10.1002/admt.202100385

Efficacy and safety of SARS-CoV-2 revaccination in non-responders with immune-mediated inflammatory disease.

Author(s): Simon D, Tascilar K, Fagni F, Schmidt K, Krönke G, Kleyer A, Ramming A, Schoenau V, Bohr D, Knitza J, Harrer T, Manger K, Manger B, Schett G.
Published in: Annal of the Rheumatic Diseases, 36(12), 2021, Page(s) 2440-2452, ISSN 1468-2060
Publisher: J Bone Miner Res.
DOI: 10.1136/annrheumdis-2021-221554

Methotrexate hampers immunogenicity to BNT162b2 mRNA COVID-19 vaccine in immune-mediated inflammatory disease.

Author(s): Haberman RH, Herati R, Simon D, Samanovic M, Blank RB, Tuen M, Koralov SB, Atreya R, Tascilar K, Allen JR, Castillo R, Cornelius AR, Rackoff P, Solomon G, Adhikari S, Azar N, Rosenthal P, Izmirly P, Samuels J, Golden B, Reddy SM, Neurath MF, Abramson SB, Schett G, Mulligan MJ, Scher JU.
Published in: Annal of the Rheumatic Diseases, 80(10), 2021, Page(s) 1339-1344, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220597

Will We Ever Have Conscious Machines?

Author(s): Patrick Krauss, Andreas Maier
Published in: Frontiers in Computational Neuroscience, 14, 2020, ISSN 1662-5188
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncom.2020.556544

Mobile Health Usage, Preferences, Barriers, and eHealth Literacy in Rheumatology: Patient Survey Study

Author(s): Johannes Knitza, David Simon, Antonia Lambrecht, Christina Raab, Koray Tascilar, Melanie Hagen, Arnd Kleyer, Sara Bayat, Adrian Derungs, Oliver Amft, Georg Schett, Axel J Hueber
Published in: JMIR mHealth and uHealth, 8/8, 2020, Page(s) e19661, ISSN 2291-5222
Publisher: Europe PMC
DOI: 10.2196/19661

Glaucoma classification in 3 x 3 mm en face macular scans using deep learning in a different plexus

Author(s): Julia Schottenhamml; Tobias Würfl; Sophia Mardin; Stefan B. Ploner; Lennart Husvogt; Bettina Hohberger; Robert Lämmer; Christian Y. Mardin; Andreas Maier
Published in: Biomed Opt Express, 2, 2021, Page(s) 7434-7444, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.439991

Advanced neural networks for classification of MRI in psoriatic arthritis, seronegative, and seropositive rheumatoid arthritis

Author(s): Lukas Folle, Sara Bayat, Arnd Kleyer, Filippo Fagni, Lorenz A Kapsner, Maja Schlereth, Timo Meinderink, Katharina Breininger, Koray Tascilar, Gerhard Krönke, Michael Uder, Michael Sticherling, Sebastian Bickelhaupt, Georg Schett, Andreas Maier, Frank Roemer, David Simon
Published in: Rheumatology, 2022, ISSN 1462-0332
Publisher: Oxford Academic
DOI: 10.1093/rheumatology/keac197

Hypoxia Promotes Neutrophil Survival After Acute Myocardial Infarction.

Author(s): Dölling M, Eckstein M, Singh J, Schauer C, Schoen J, Shan X, Bozec A, Knopf J, Schett G, Muñoz LE, Herrmann M.
Published in: Frontier Immunology, 13, 2022, Page(s) 726153, ISSN 1664-3224
Publisher: Frontiers Media S.A
DOI: 10.3389/fimmu.2022.726153

The Potential of OMICs Technologies for the Treatment of Immune-Mediated Inflammatory Diseases

Author(s): Anchang CG, Xu C, Raimondo MG, Atreya R, Maier A, Schett G, Zaburdaev V, Rauber S, Ramming A.
Published in: Int J Mol Sci., 22(14), 2021, Page(s) 7506, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22147506

IgA subclasses have different effector functions associated with distinct glycosylation profiles

Author(s): Ulrike Steffen, Carolien A. Koeleman, Maria V. Sokolova, Holger Bang, Arnd Kleyer, Jürgen Rech, Harald Unterweger, Martin Schicht, Fabian Garreis, Jonas Hahn, Fabian T. Andes, Fabian Hartmann, Madelaine Hahn, Aparna Mahajan, Friedrich Paulsen, Markus Hoffmann, Günter Lochnit, Luis E. Muñoz, Manfred Wuhrer, David Falck, Martin Herrmann, Georg Schett
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13992-8

Aggregated neutrophil extracellular traps occlude Meibomian glands during ocular surface inflammation

Author(s): Aparna Mahajan, Lenka Hasíková, Ulrike Hampel, Anika Grüneboom, Xiaomei Shan, Irmgard Herrmann, Fabian Garreis, Felix Bock, Jasmin Knopf, Jeeshan Singh, Christine Schauer, Siddharth Mahajan, Moritz Leppkes, Friedrich Paulsen, Ursula Schlötzer-Schrehardt, Veit Krenn, Anselm Jünemann, Bettina Hohberger, Georg Schett, Martin Herrmann, Luis E. Muñoz
Published in: The Ocular Surface, 20, 2021, Page(s) 1-12, ISSN 1542-0124
Publisher: Ethis Communications
DOI: 10.1016/j.jtos.2020.12.005

CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus.

Author(s): Mougiakakos D, Krönke G, Völkl S, Kretschmann S, Aigner M, Kharboutli S, Böltz S, Manger B, Mackensen A, Schett G.
Published in: New England Journal of Medicine, 385(6), 2021, Page(s) 567-569, ISSN 1533-4406
Publisher: Massachusetts Medical Society
DOI: 10.1056/nejmc2107725

Bone Mass, Bone Microstructure and Biomechanics in Patients with Hand Osteoarthritis

Author(s): David Simon, Koray Tascilar, Sara Unbehend, Sara Bayat, Andreas Berlin, Anna‐Maria Liphardt, Timo Meinderink, Juergen Rech, Axel J Hueber, Georg Schett, Arnd Kleyer
Published in: Journal of Bone and Mineral Research, 35/9, 2020, Page(s) 1695-1702, ISSN 0884-0431
Publisher: American Society for Bone and Mineral Research
DOI: 10.1002/jbmr.4046

Bone microstructure and volumetric bone mineral density in patients with hyperuricemia with and without psoriasis

Author(s): D. Simon, J. Haschka, C. Muschitz, A. Kocijan, A. Baierl, A. Kleyer, G. Schett, S. Kapiotis, H. Resch, M. Sticherling, J. Rech, R. Kocijan
Published in: Osteoporosis International, 31/5, 2020, Page(s) 931-939, ISSN 0937-941X
Publisher: Springer Verlag
DOI: 10.1007/s00198-019-05160-x

Micro-structural bone changes are associated with broad-spectrum autoimmunity and predict the onset of rheumatoid arthritis.

Author(s): Simon D, Kleyer A, Bui CD, Hueber A, Bang H, Ramming A, Rech J, Schett G.
Published in: Arthritis and Rheumatology, 74(3), 2022, Page(s) 418-426, ISSN 2326-5191
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/art.41229

What Do We Really Need? Degenerating U-Net on Retinal Vessel Segmentation

Author(s): Fu, Weilin; Breininger, Katharina; Pan, Zhaoya; Maier, Andreas
Published in: arxiv.org, 5, 2020, ISSN 2331-8422
Publisher: Cornell University
DOI: 10.48550/arxiv.1911.02660

Locally renewing resident synovial macrophages provide a protective barrier for the joint

Author(s): Stephan Culemann, Anika Grüneboom, José Ángel Nicolás-Ávila, Daniela Weidner, Katrin Franziska Lämmle, Tobias Rothe, Juan A. Quintana, Philipp Kirchner, Branislav Krljanac, Martin Eberhardt, Fulvia Ferrazzi, elke Kretzschmar, Martin Schicht, Kim Fischer, Kolja Gelse, Maria Faas, René Pfeifle, Jochen A. Ackermann, Milena Pachowsky, Nina renner, David Simon, reiner F. Haseloff, Arif B. Ekic
Published in: Nature, 572, 2019, Page(s) 670–675, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1471-1

A. Higher serum levels of short-chain fatty acids are associated with non-progression to arthritis in individuals at increased risk of RA.

Author(s): Martinsson K, Dürholz K, Schett G, Zaiss MM, Kastbom A.
Published in: Annals of the Rheumatic Diseases, 81(3), 2022, Page(s) 445-447, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-221386

Micro-cantilever testing of diamond - silicon carbide interfaces in silicon carbide bonded diamond materials produced by reactive silicon infiltration

Author(s): J. Ast; Björn Matthey; P. Herre; Sören Höhn; Mathias Herrmann; Silke Christiansen
Published in: Open Ceramics, 8(4), 2021, Page(s) 100176, ISSN 2666-5395
Publisher: Oxford: Elsevier Ltd
DOI: 10.1016/j.oceram.2021.100176

Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion

Author(s): David Simon, Koray Tascilar, Gerhard Krönke, Arnd Kleyer, Mario M. Zaiss, Franz Heppt, Christine Meder, Raja Atreya, Entcho Klenske, Peter Dietrich, Abdullah Abdullah, Thorsten Kliem, Giulia Corte, Harriet Morf, Moritz Leppkes, Andreas E. Kremer, Andreas Ramming, Milena Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Clara Maier, Axel J. Hueber, Karin Manger, Bernhard Manger, Caro
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17703-6

Learning with Known Operators reduces Maximum Training Error Bounds

Author(s): Maier, Andreas K.; Syben, Christopher; Stimpel, Bernhard; Würfl, Tobias; Hoffmann, Mathis; Schebesch, Frank; Fu, Weilin; Mill, Leonid; Kling, Lasse; Christiansen, Silke
Published in: Nature machine intelligence, 1, 2020, Page(s) 373–380, ISSN 2522-5839
Publisher: Nature Research
DOI: 10.1038/s42256-019-0077-5

IgA2 Antibodies against SARS-CoV-2 Correlate with NET Formation and Fatal Outcome in Severely Diseased COVID-19 Patients

Author(s): Léonie A. N. Staats, Hella Pfeiffer, Jasmin Knopf, Aylin Lindemann, Julia Fürst, Andreas E. Kremer, Holger Hackstein, Markus F. Neurath, Luis E. Muñoz, Susanne Achenbach, Moritz Leppkes, Martin Herrmann, Georg Schett, Ulrike Steffen
Published in: Cells, 9/12, 2020, Page(s) 2676, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9122676

Why remission is not enough: underlying disease mechanisms in RA that prevent cure.

Author(s): Georg Schett; Yoshiya Tanaka; John D. Isaacs; John D. Isaacs
Published in: Nature Reviews Rheumatology, 23, 2021, Page(s) 135–144, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/s41584-020-00543-5

Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging

Author(s): Christian Schmidkonz, Simon Rauber, Armin Atzinger, Rahul Agarwal, Theresa Ida Götz, Alina Soare, Michael Cordes, Olaf Prante, Christina Bergmann, Arnd Kleyer, Philipp Ritt, Simone Maschauer, Peter Hennig, Johannes Toms, Markus Köhner, Bernhard Manger, John H Stone, Uwe Haberkorn, Tobias Baeuerle, Jörg H W Distler, Abbas Agaimy, Torsten Kuwert, Georg Schett, Andreas Ramming
Published in: Annals of the Rheumatic Diseases, 79/11, 2020, Page(s) 1485-1491, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-217408

AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9.

Author(s): Vergarajauregui S, Becker R, Steffen U, Sharkova M, Esser T, Petzold J, Billing F, Kapiloff MS, Schett G, Thievessen I, Engel FB.
Published in: eLife, 9, 2020, Page(s) 61669, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.61669

SARS-CoV-2 vaccination responses in untreated, conventionally treated and anticytokine-treated patients with immune-mediated inflammatory diseases

Author(s): David Simon, Koray Tascilar, Filippo Fagni, Gerhard Krönke, Arnd Kleyer, Christine Meder, Raja Atreya, Moritz Leppkes, Andreas E Kremer, Andreas Ramming, Milena L Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Axel J Hueber, Karin Manger, Bernhard Manger, Carola Berking, Michael Sticherling, Markus F Neurath, Georg Schett
Published in: Annals of the Rheumatic Diseases, 2021, Page(s) annrheumdis-2021-220461, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220461

Structural entheseal lesions in patients with psoriasis are associated with an increased risk of progression to psoriatic arthritis

Author(s): David Simon, Koray Tascilar, Arnd Kleyer, Sara Bayat, Eleni Kampylafka, Maria Sokolova, Ana Zekovic, Axel J Hueber, Jürgen Rech, Louis Schuster, Klaus Engel, Michael Sticherling, Georg Schett
Published in: Arthritis & Rheumatology, 2020, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.41239

A Detailed Analysis of the Association between Urate Deposition and Erosions and Osteophytes in Gout

Author(s): Caroline Pecherstorfer, David Simon, Sara Unbehend, Hanna Ellmann, Matthias Englbrecht, Fabian Hartmann, Camille Figueiredo, Axel Hueber, Judith Haschka, Roland Kocijan, Arnd Kleyer, Georg Schett, Jürgen Rech, Sara Bayat
Published in: ACR Open Rheumatology, 2/10, 2020, Page(s) 565-572, ISSN 2578-5745
Publisher: Wiley
DOI: 10.1002/acr2.11172

Vascular occlusion by neutrophil extracellular traps in COVID-19

Author(s): Moritz Leppkes, Jasmin Knopf, Elisabeth Naschberger, Aylin Lindemann, Jeeshan Singh, Irmgard Herrmann, Michael Stürzl, Léonie Staats, Aparna Mahajan, Christine Schauer, Anita N. Kremer, Simon Völkl, Kerstin Amann, Katja Evert, Christina Falkeis, Andreas Wehrfritz, Ralf J. Rieker, Arndt Hartmann, Andreas E. Kremer, Markus F. Neurath, Luis E. Muñoz, Georg Schett, Martin Herrmann
Published in: EBioMedicine, 58, 2020, Page(s) 102925, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2020.102925

Effect of disease-modifying anti-rheumatic drugs on bone structure and strength in psoriatic arthritis patients

Author(s): David Simon, Arnd Kleyer, Sara Bayat, Koray Tascilar, Eleni Kampylafka, Timo Meinderink, Louis Schuster, Ramona Petrov, Anna-Maria Liphardt, Juergen Rech, Georg Schett, Axel J. Hueber
Published in: Arthritis Research & Therapy, 21/1, 2019, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-019-1938-3

Additional file 1 of Advanced machine learning for predicting individual risk of flares in rheumatoid arthritis patients tapering biologic drugs

Author(s): Vodencarevic, Asmir; Tascilar, Koray; Hartmann, Fabian; Reiser, Michaela; Hueber, Axel J.; Haschka, Judith; Bayat, Sara; Meinderink, Timo; Knitza, Johannes; Mendez, Larissa; Hagen, Melanie; Krönke, Gerhard; Rech, Jürgen; Manger, Bernhard; Kleyer, Arnd; Zimmermann-Rittereiser, Marcus; Schett, Georg; Simon, David
Published in: Arthritis Research & Therapy, 23(1), 2021, Page(s) 67, ISSN 1478-6354
Publisher: BioMed Central
DOI: 10.6084/m9.figshare.14130926.v1

IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation.

Author(s): Faas M, Ipseiz N, Ackermann J, Culemann S, Grüneboom A, Schröder F, Rothe T, Scholtysek C, Eberhardt M, Böttcher M, Kirchner P, Stoll C, Ekici A, Fuchs M, Kunz M, Weigmann B, Wirtz S, Lang R, Hofmann J, Vera J, Voehringer D, Michelucci A, Mougiakakos D, Uderhardt S, Schett G, Krönke G.
Published in: Immunity, 54(11), 2021, Page(s) 2531-2546, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2021.09.010

Murine Metatarsus Bone and Joint Collagen-I Fiber Morphologies and Networks Studied With SHG Multiphoton Imaging.

Author(s): Vielreicher M, Bozec A, Schett G, Friedrich O.
Published in: Frontier Bioengeeniering Biotechnology, 9, 2021, Page(s) 608383, ISSN 2296-4185
Publisher: Frontiers Media S.A.
DOI: 10.3389/fbioe.2021.608383

Biomechanical stress in the context of competitive sports training triggers enthesitis.

Author(s): Simon D, Kleyer A, Bayat S, Knitza J, Valor-Mendez L, Schweiger M, Schett G, Tascilar K, Hueber AJ.
Published in: Arthritis Research & Therapy, 23(1), 2021, Page(s) 172, ISSN 1478-6362
Publisher: Biomed Central
DOI: 10.1186/s13075-021-02530-x

“Keep it simple, scholar”: an experimental analysis of few-parameter segmentation networks for retinal vessels in fundus imaging

Author(s): Weilin Fu, Katharina Breininger, Roman Schaffert, Zhaoya Pan, Andreas Maier
Published in: International Journal of Computer Assisted Radiology and Surgery, 16/6, 2021, Page(s) 967-978, ISSN 1861-6410
Publisher: Springer Verlag
DOI: 10.1007/s11548-021-02340-1

Complexes Induce Neutrophil Extracellular Trap Formation More Potently Than IgG Complexes.

Author(s): Gimpel AK, Maccataio A, Unterweger H, Sokolova MV, Schett G, Steffen U.
Published in: Frontier Immunology, 12, 2022, Page(s) 761816, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.761816

Deep Learning-Based Classification of Inflammatory Arthritis by Identification of Joint Shape Patterns—How Neural Networks Can Tell Us Where to “Deep Dive” Clinically

Author(s): Lukas Folle, David Simon, Koray Tascilar, Gerhard Krönke, Anna-Maria Liphardt, Andreas Maier, Georg Schett, Arnd Kleyer
Published in: Frontiers in Medicine, 2022, ISSN 2296-858X
Publisher: Frontiers Media
DOI: 10.3389/fmed.2022.850552

Additional file 3 of A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Author(s): Sokolova, Maria; Simon, David; Nas, Kemal; Zaiss, Mario; Yubin Luo; Zhao, Yi; JÃ¼rgen Rech; Schett, Georg
Published in: Arthritis Research & Therapy, 4, 2020, Page(s) 26, ISSN 1478-6354
Publisher: BioMed Central
DOI: 10.6084/m9.figshare.11846310

Next-generation imaging of the skeletal system and its blood supply

Author(s): Anika Grüneboom, Lasse Kling, Silke Christiansen, Leonid Mill, Andreas Maier, Klaus Engelke, Harald H. Quick, Georg Schett, Matthias Gunzer
Published in: Nature Reviews Rheumatology, 15/9, 2019, Page(s) 533-549, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/s41584-019-0274-y

PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass

Author(s): Dorothea I. H. Müller, Cornelia Stoll, Katrin Palumbo-Zerr, Christina Böhm, Brenda Krishnacoumar, Natacha Ipseiz, Jule Taubmann, Max Zimmermann, Martin Böttcher, Dimitrios Mougiakakos, Jan Tuckermann, Farida Djouad, Georg Schett, Carina Scholtysek, Gerhard Krönke
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-65305-5

COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses.

Author(s): Fagni F, Simon D, Tascilar K, Schoenau V, Sticherling M, Neurath MF, Schett G.
Published in: Lancet Rheumatology, 3(10), 2021, Page(s) e724-e736, ISSN 2665-9913
Publisher: Lancet Publishing Group
DOI: 10.1016/s2665-9913(21)00247-2

Does methotrexate influence COVID-19 infection? Case series and mechanistic data.

Author(s): Schälter F, Dürholz K, Bucci L, Burmester G, Caporali R, Figuereido C, Cobra JF, Manger B, Zaiss MM, Schett G.
Published in: Arthritis Research & Therapy, 23(1), 2021, Page(s) 166, ISSN 1478-6362
Publisher: BioMed Central
DOI: 10.1186/s13075-021-02464-4

A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Author(s): Maria V. Sokolova, David Simon, Kemal Nas, Mario M. Zaiss, Yubin Luo, Yi Zhao, Jürgen Rech, Georg Schett
Published in: Arthritis Research & Therapy, 22/1, 2020, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-020-2111-8

The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption.

Author(s): Andes FT, Adam S, Hahn M, Aust O, Frey S, Grueneboom A, Nitschke L, Schett G, Steffen U.
Published in: Bone, 143, 2020, Page(s) 115665, ISSN 8756-3282
Publisher: Elsevier BV
DOI: 10.1016/j.bone.2020.115665

Monte Carlo Dose Simulation for In-Vivo X-Ray Nanoscopy

Author(s): Fabian Wagner, Mareike Thies, Marek Karolczak, Sabrina Pechmann, Yixing Huang, Mingxuan Gu, Lasse Kling, Daniela Weidner, Oliver Aust, Georg Schett, Silke Christiansen, Andreas Maier
Published in: Bildverarbeitung für die Medizin, 2022
Publisher: Springer
DOI: 10.1007/978-3-658-36932-3_22

Towards In-Vivo X-Ray Nanoscopy - Acquisition Parameters vs. Image Quality

Author(s): Leonid Mill, Lasse Kling, Anika Grüneboom, Georg Schett, Silke Christiansen, Andreas Maier
Published in: Bildverarbeitung für die Medizin 2019 - Algorithmen – Systeme – Anwendungen. Proceedings des Workshops vom 17. bis 19. März 2019 in Lübeck, 2019, Page(s) 251-256, ISBN 978-3-658-25325-7
Publisher: Springer Fachmedien Wiesbaden
DOI: 10.1007/978-3-658-25326-4_56

Towards In-Vivo X-Ray Nanoscopy - The Effect of Motion on Image Quality

Author(s): Leonid Mill, Bastian Bier, Christopher Syben, Lasse Kling, Anika Klingberg, Silke Christiansen, Georg Schett, Andreas Maier
Published in: Bildverarbeitung für die Medizin 2018 - Algorithmen - Systeme - Anwendungen. Proceedings des Workshops vom 11. bis 13. März 2018 in Erlangen, 2018, Page(s) 115-120, ISBN 978-3-662-56536-0
Publisher: Springer Berlin Heidelberg
DOI: 10.1007/978-3-662-56537-7_40

Degenerating U-Net on Retinal Vessel Segmentation - What Do We Really Need?

Author(s): Weilin Fu, Katharina Breininger, Zhaoya Pan, Andreas Maier
Published in: Bildverarbeitung für die Medizin 2020 - Algorithmen – Systeme – Anwendungen. Proceedings des Workshops vom 15. bis 17. März 2020 in Berlin, 2020, Page(s) 33-38, ISBN 978-3-658-29266-9
Publisher: Springer Fachmedien Wiesbaden
DOI: 10.1007/978-3-658-29267-6_7

Few-shot Unsupervised Domain Adaptation for Multi-modal Cardiac Image Segmentation

Author(s): Mingxuan Gu, Sulaiman Vesal, Ronak Kosti, Andreas Maier
Published in: Bildverarbeitung für die Medizin, 2022
Publisher: Springer
DOI: 10.1007/978-3-658-36932-3_5

Towards Mouse Bone X-ray Microscopy Scan Simulation

Author(s): Weilin Fu, Leonid Mill, Stephan Seitz, Tobias Geimer, Lasse Kling, Dennis Possart, Silke Christiansen, Andreas Maier
Published in: Bildverarbeitung für die Medizin 2021 - Proceedings, German Workshop on Medical Image Computing, Regensburg, March 7-9, 2021, 2021, Page(s) 128-133, ISBN 978-3-658-33197-9
Publisher: Springer Fachmedien Wiesbaden
DOI: 10.1007/978-3-658-33198-6_32

Degenerating U-Net on Retinal Vessel Segmentation

Author(s): Fu, Weilin; Breininger, Katharina; Pan, Zhaoya; Maier, Andreas
Published in: Informatik aktuell, 1, 2020, Page(s) 33-38, ISBN 978-3-658-29266-6
Publisher: Springer Vieweg
DOI: 10.1007/978-3-658-29266-6

Bildverarbeitung für die Medizin 2021 - Proceedings, German Workshop on Medical Image Computing, Regensburg, March 7-9, 2021

Author(s): Yixing Huang, Leonid Mill, Robert Stoll, Lasse Kling, Oliver Aust, Fabian Wagner, Anika Gruneboom, Georg Schett, Silke Christiansen, Andreas Maier
Published in: Semi-permeable Filters for Interior Region of InterestDose Reduction in X-ray Microscopy, 2021, Page(s) 61-66, ISBN 978-3-658-33198-6
Publisher: Springer Fachmedien Wiesbaden GmbH
DOI: 10.1007/978-3-658-33198-6

Datasets

Additional file 1 of A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Author(s): Sokolova, Maria; Simon, David; Nas, Kemal; Zaiss, Mario; Yubin Luo; Zhao, Yi; JÃ¼rgen Rech; Schett, Georg
Published in: figshare

Additional file 2 of A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Author(s): Sokolova, Maria; Simon, David; Nas, Kemal; Zaiss, Mario; Yubin Luo; Zhao, Yi; JÃ¼rgen Rech; Schett, Georg
Published in: figshare

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