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Advancing osteoporosis medicine by observing bone microstructure and remodelling using a four-dimensional nanoscope

Publications

Secukinumab leads to shifts from stage-based towards response-based disease clusters—comparative data from very early and established psoriatic arthritis

Author(s): Eleni Kampylafka, Koray Tascilar, Veronika Lerchen, Christina Linz, Maria Sokolova, Ana Zekovic, Arnd Kleyer, David Simon, Jürgen Rech, Michael Sticherling, Georg Schett, Axel J. Hueber
Published in: Arthritis Research & Therapy, Issue 22/1, 2020, ISSN 1478-6362
DOI: 10.1186/s13075-020-02268-y

A network of trans-cortical capillaries as mainstay for blood circulation in long bones

Author(s): Anika Grüneboom, Ibrahim Hawwari, Daniela Weidner, Stephan Culemann, Sylvia Müller, Sophie Henneberg, Alexandra Brenzel, Simon Merz, Lea Bornemann, Kristina Zec, Manuela Wuelling, Lasse Kling, Mike Hasenberg, Sylvia Voortmann, Stefanie Lang, Wolfgang Baum, Alexandra Ohs, Oliver Kraff, Harald H. Quick, Marcus Jäger, Stefan Landgraeber, Marcel Dudda, Renzo Danuser, Jens V. Stein, Manfred Rohde, K
Published in: Nature Metabolism, Issue 1/2, 2019, Page(s) 236-250, ISSN 2522-5812
DOI: 10.1038/s42255-018-0016-5

Technical Note: PYRO‐NN: Python reconstruction operators in neural networks

Author(s): Christopher Syben, Markus Michen, Bernhard Stimpel, Stephan Seitz, Stefan Ploner, Andreas K. Maier
Published in: Medical Physics, Issue 46/11, 2019, Page(s) 5110-5115, ISSN 0094-2405
DOI: 10.1002/mp.13753

Precision of handheld multispectral optoacoustic tomography for muscle imaging

Author(s): Alexandra L. Wagner, Vera Danko, Anna Federle, Daniel Klett, David Simon, Rafael Heiss, Jörg Jüngert, Michael Uder, Georg Schett, Markus F. Neurath, Joachim Woelfle, Maximilian J. Waldner, Regina Trollmann, Adrian P. Regensburger, Ferdinand Knieling
Published in: Photoacoustics, Issue In Press, Journal Pre-proof, 2020, Page(s) 100220, ISSN 2213-5979
DOI: 10.1016/j.pacs.2020.100220

Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin

Author(s): Darja Andreev, Mengdan Liu, Daniela Weidner, Katerina Kachler, Maria Faas, Anika Grüneboom, Ursula Schlötzer-Schrehardt, Luis E. Muñoz, Ulrike Steffen, Bettina Grötsch, Barbara Killy, Gerhard Krönke, Andreas M. Luebke, Andreas Niemeier, Falk Wehrhan, Roland Lang, Georg Schett, Aline Bozec
Published in: Journal of Clinical Investigation, Issue 130/9, 2020, Page(s) 4811-4830, ISSN 0021-9738
DOI: 10.1172/jci134214

The gut-bone axis: how bacterial metabolites bridge the distance

Author(s): Mario M. Zaiss, Rheinallt M. Jones, Georg Schett, Roberto Pacifici
Published in: Journal of Clinical Investigation, Issue 129/8, 2019, Page(s) 3018-3028, ISSN 0021-9738
DOI: 10.1172/jci128521

The ageing joint-standard age- and sex-related values of bone erosions and osteophytes in the hand joints of healthy individuals

Author(s): A. Berlin, D. Simon, K. Tascilar, C. Figueiredo, S. Bayat, S. Finzel, E. Klaus, J. Rech, A.J. Hueber, A. Kleyer, G. Schett
Published in: Osteoarthritis and Cartilage, Issue 27/7, 2019, Page(s) 1043-1047, ISSN 1063-4584
DOI: 10.1016/j.joca.2019.01.019

JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function

Author(s): Susanne Adam, Nils Simon, Ulrike Steffen, Fabian T. Andes, Carina Scholtysek, Dorothea I. H. Müller, Daniela Weidner, Darja Andreev, Arnd Kleyer, Stephan Culemann, Madelaine Hahn, Georg Schett, Gerhard Krönke, Silke Frey, Axel J. Hueber
Published in: Science Translational Medicine, Issue 12/530, 2020, Page(s) eaay4447, ISSN 1946-6234
DOI: 10.1126/scitranslmed.aay4447

Limited angle tomography for transmission X-ray microscopy using deep learning.

Author(s): Yixing Huang; Shengxiang Wang; Yong Guan; Andreas Maier
Published in: Journal of Synchrotron Radiation, Issue 2, 2020, Page(s) 477-485, ISSN 1600-5775
DOI: 10.1107/S160057752000017X

IgA subclasses have different effector functions associated with distinct glycosylation profiles

Author(s): Ulrike Steffen, Carolien A. Koeleman, Maria V. Sokolova, Holger Bang, Arnd Kleyer, Jürgen Rech, Harald Unterweger, Martin Schicht, Fabian Garreis, Jonas Hahn, Fabian T. Andes, Fabian Hartmann, Madelaine Hahn, Aparna Mahajan, Friedrich Paulsen, Markus Hoffmann, Günter Lochnit, Luis E. Muñoz, Manfred Wuhrer, David Falck, Martin Herrmann, Georg Schett
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-019-13992-8

Bone microstructure and volumetric bone mineral density in patients with hyperuricemia with and without psoriasis

Author(s): D. Simon, J. Haschka, C. Muschitz, A. Kocijan, A. Baierl, A. Kleyer, G. Schett, S. Kapiotis, H. Resch, M. Sticherling, J. Rech, R. Kocijan
Published in: Osteoporosis International, Issue 31/5, 2020, Page(s) 931-939, ISSN 0937-941X
DOI: 10.1007/s00198-019-05160-x

Locally renewing resident synovial macrophages provide a protective barrier for the joint

Author(s): Stephan Culemann, Anika Grüneboom, José Ángel Nicolás-Ávila, Daniela Weidner, Katrin Franziska Lämmle, Tobias Rothe, Juan A. Quintana, Philipp Kirchner, Branislav Krljanac, Martin eberhardt, Fulvia Ferrazzi, elke Kretzschmar, Martin Schicht, Kim Fischer, Kolja Gelse, Maria Faas, rené Pfeifle, Jochen A. Ackermann, Milena Pachowsky, Nina renner, David Simon, reiner F. Haseloff, Arif B. ekic
Published in: Nature, Issue 572, 2019, Page(s) 670–675, ISSN 2041-1723
DOI: 10.1038/s41586-019-1471-1

Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion

Author(s): David Simon, Koray Tascilar, Gerhard Krönke, Arnd Kleyer, Mario M. Zaiss, Franz Heppt, Christine Meder, Raja Atreya, Entcho Klenske, Peter Dietrich, Abdullah Abdullah, Thorsten Kliem, Giulia Corte, Harriet Morf, Moritz Leppkes, Andreas E. Kremer, Andreas Ramming, Milena Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Clara Maier, Axel J. Hueber, Karin Manger, Bernhard Manger, Caro
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-17703-6

Learning with Known Operators reduces Maximum Training Error Bounds

Author(s): Maier, Andreas K.; Syben, Christopher; Stimpel, Bernhard; Würfl, Tobias; Hoffmann, Mathis; Schebesch, Frank; Fu, Weilin; Mill, Leonid; Kling, Lasse; Christiansen, Silke
Published in: Nature machine intelligence, Issue 1, 2020, Page(s) 373–380, ISSN 2522-5839
DOI: 10.1038/s42256-019-0077-5

Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging

Author(s): Christian Schmidkonz, Simon Rauber, Armin Atzinger, Rahul Agarwal, Theresa Ida Götz, Alina Soare, Michael Cordes, Olaf Prante, Christina Bergmann, Arnd Kleyer, Philipp Ritt, Simone Maschauer, Peter Hennig, Johannes Toms, Markus Köhner, Bernhard Manger, John H Stone, Uwe Haberkorn, Tobias Baeuerle, Jörg H W Distler, Abbas Agaimy, Torsten Kuwert, Georg Schett, Andreas Ramming
Published in: Annals of the Rheumatic Diseases, Issue 79/11, 2020, Page(s) 1485-1491, ISSN 0003-4967
DOI: 10.1136/annrheumdis-2020-217408

Structural entheseal lesions in patients with psoriasis are associated with an increased risk of progression to psoriatic arthritis

Author(s): David Simon, Koray Tascilar, Arnd Kleyer, Sara Bayat, Eleni Kampylafka, Maria Sokolova, Ana Zekovic, Axel J Hueber, Jürgen Rech, Louis Schuster, Klaus Engel, Michael Sticherling, Georg Schett
Published in: Arthritis & Rheumatology, 02020, ISSN 2326-5191
DOI: 10.1002/art.41239

A Detailed Analysis of the Association between Urate Deposition and Erosions and Osteophytes in Gout

Author(s): Caroline Pecherstorfer, David Simon, Sara Unbehend, Hanna Ellmann, Matthias Englbrecht, Fabian Hartmann, Camille Figueiredo, Axel Hueber, Judith Haschka, Roland Kocijan, Arnd Kleyer, Georg Schett, Jürgen Rech, Sara Bayat
Published in: ACR Open Rheumatology, Issue 2/10, 2020, Page(s) 565-572, ISSN 2578-5745
DOI: 10.1002/acr2.11172

Vascular occlusion by neutrophil extracellular traps in COVID-19

Author(s): Moritz Leppkes, Jasmin Knopf, Elisabeth Naschberger, Aylin Lindemann, Jeeshan Singh, Irmgard Herrmann, Michael Stürzl, Léonie Staats, Aparna Mahajan, Christine Schauer, Anita N. Kremer, Simon Völkl, Kerstin Amann, Katja Evert, Christina Falkeis, Andreas Wehrfritz, Ralf J. Rieker, Arndt Hartmann, Andreas E. Kremer, Markus F. Neurath, Luis E. Muñoz, Georg Schett, Martin Herrmann
Published in: EBioMedicine, Issue 58, 2020, Page(s) 102925, ISSN 2352-3964
DOI: 10.1016/j.ebiom.2020.102925

Effect of disease-modifying anti-rheumatic drugs on bone structure and strength in psoriatic arthritis patients

Author(s): David Simon, Arnd Kleyer, Sara Bayat, Koray Tascilar, Eleni Kampylafka, Timo Meinderink, Louis Schuster, Ramona Petrov, Anna-Maria Liphardt, Juergen Rech, Georg Schett, Axel J. Hueber
Published in: Arthritis Research & Therapy, Issue 21/1, 2019, ISSN 1478-6362
DOI: 10.1186/s13075-019-1938-3

Next-generation imaging of the skeletal system and its blood supply

Author(s): Anika Grüneboom, Lasse Kling, Silke Christiansen, Leonid Mill, Andreas Maier, Klaus Engelke, Harald H. Quick, Georg Schett, Matthias Gunzer
Published in: Nature Reviews Rheumatology, Issue 15/9, 2019, Page(s) 533-549, ISSN 1759-4790
DOI: 10.1038/s41584-019-0274-y

PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass

Author(s): Dorothea I. H. Müller, Cornelia Stoll, Katrin Palumbo-Zerr, Christina Böhm, Brenda Krishnacoumar, Natacha Ipseiz, Jule Taubmann, Max Zimmermann, Martin Böttcher, Dimitrios Mougiakakos, Jan Tuckermann, Farida Djouad, Georg Schett, Carina Scholtysek, Gerhard Krönke
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
DOI: 10.1038/s41598-020-65305-5

A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Author(s): Maria V. Sokolova, David Simon, Kemal Nas, Mario M. Zaiss, Yubin Luo, Yi Zhao, Jürgen Rech, Georg Schett
Published in: Arthritis Research & Therapy, Issue 22/1, 2020, ISSN 1478-6362
DOI: 10.1186/s13075-020-2111-8