Advancing osteoporosis medicine by observing bone microstructure and remodelling using a four-dimensional nanoscope

Publications

Neutrophil Extracellular Traps Promote the Development and Growth of Human Salivary Stones.

Author(s): Schapher M, Koch M, Weidner D, Scholz M, Wirtz S, Mahajan A, Herrmann I, Singh J, Knopf J, Leppkes M, Schauer C, Grüneboom A, Alexiou C, Schett G, Iro H, Muñoz LE, Herrmann M.
Published in: Cells, Issue 9(9), 2020, Page(s) 2139, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9092139

Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells

Author(s): Bergmann C, Müller F, Distler JHW, Györfi AH, Völkl S, Aigner M, Kretschmann S, Reimann H, Harrer T, Bayerl N, Boeltz S, Wirsching A, Taubmann J, Rösler W, Spriewald B, Wacker J, Atzinger A, Uder M, Kuwert T, Mackensen A, Schett G.
Published in: Annals of Rheumatic Disease, 2023, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/ard-2023-223952

Secukinumab leads to shifts from stage-based towards response-based disease clusters—comparative data from very early and established psoriatic arthritis

Author(s): Eleni Kampylafka, Koray Tascilar, Veronika Lerchen, Christina Linz, Maria Sokolova, Ana Zekovic, Arnd Kleyer, David Simon, Jürgen Rech, Michael Sticherling, Georg Schett, Axel J. Hueber
Published in: Arthritis Research & Therapy, Issue 22/1, 2020, ISSN 1478-6362
Publisher: BMC part of Springer Nature SharedIt
DOI: 10.1186/s13075-020-02268-y

Author(s): Anna‐Maria Liphardt, Eva Manger, Sonja Liehr, Lisa Bieniek, Arnd Kleyer, David Simon, Koray Tascilar, Michael Sticherling, Jürgen Rech, Georg Schett, Axel J. Hueber
Published in: ACR Open Rheumatology, Issue 2/12, 2020, Page(s) 734-740, ISSN 2578-5745
Publisher: Wiley Online Libary
DOI: 10.1002/acr2.11196

Additional file 5 of A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Author(s): Sokolova, Maria; Simon, David; Nas, Kemal; Zaiss, Mario; Yubin Luo; Zhao, Yi; JÃ¼rgen Rech; Schett, Georg
Published in: Arthritis Research & Therapy, Issue 2, 2020, Page(s) 26, ISSN 1478-6354
Publisher: BioMed Central
DOI: 10.6084/m9.figshare.11846322.v1

Patients with COVID-19: in the dark-NETs of neutrophils.

Author(s): Ackermann M, Anders HJ, Bilyy R, Bowlin GL, Daniel C, De Lorenzo R, Egeblad M, Henneck T, Hidalgo A, Hoffmann M, Hohberger B, Kanthi Y, Kaplan MJ, Knight JS, Knopf J, Kolaczkowska E, Kubes P, Leppkes M, Mahajan A, Manfredi AA, Maueröder C, Maugeri N, Mitroulis I, Muñoz LE, Narasaraju T, Naschberger E, Neeli I, Ng LG, Radic MZ, Ritis K, Rovere-Querini P, Schapher M, Schauer C, Simon HU, Singh J,
Published in: Cell Death Differ, Issue 28(11), 2021, Page(s) 3125-3139, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-021-00805-z

Chronic Systemic Infection of Mice with Leishmania infantum Leads to Increased Bone Mass.

Author(s): Lai C, Heinemann J, Schleicher U, Schett G, Bogdan C, Bozec A, Soulat D.
Published in: Journal of Bone Mineral Research, 2023, ISSN 0884-0431
Publisher: American Society for Bone and Mineral Research
DOI: 10.1002/jbmr.4733

Epithelial HIF2α expression induces intestinal barrier dysfunction and exacerbation of arthritis.

Author(s): Wen J, Lyu P, Stolzer I, Xu J, Gießl A, Lin Z, Andreev D, Kachler K, Song R, Meng X, Cao S, Guggino G, Ciccia F, Günther C, Schett G, Bozec A.
Published in: Annals of Rheumatic Disease, 2022, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-222035

A network of trans-cortical capillaries as mainstay for blood circulation in long bones

Author(s): Anika Grüneboom, Ibrahim Hawwari, Daniela Weidner, Stephan Culemann, Sylvia Müller, Sophie Henneberg, Alexandra Brenzel, Simon Merz, Lea Bornemann, Kristina Zec, Manuela Wuelling, Lasse Kling, Mike Hasenberg, Sylvia Voortmann, Stefanie Lang, Wolfgang Baum, Alexandra Ohs, Oliver Kraff, Harald H. Quick, Marcus Jäger, Stefan Landgraeber, Marcel Dudda, Renzo Danuser, Jens V. Stein, Manfred Rohde, K
Published in: Nature Metabolism, Issue 1/2, 2019, Page(s) 236-250, ISSN 2522-5812
Publisher: Nature Research
DOI: 10.1038/s42255-018-0016-5

Increased Type H Blood Vessels Precedes Pathological Osteogenesis And Inflammation In Experimental Spondyloarthritis.

Author(s): Kaaij MH, van Hamburg JP, van Rooijen CCN, Grüneboom A, Kan YY, Pots D, Schett G, van Ruijven LJ, van Duivenvoorde LM, Huitema LFA, Baeten DLP, Tas SW.
Published in: Arthritis Rheumatology, 2023, ISSN 2326-5205
Publisher: Wiley-Blackwell
DOI: 10.1002/art.42449

Performance of a Handheld Ultrasound Device to Assess Articular and Periarticular Pathologies in Patients with Inflammatory Arthritis.

Author(s): Corte G, Bayat S, Tascilar K, Valor-Mendez L, Schuster L, Knitza J, Fagni F, Schett G, Kleyer A, Simon D.
Published in: Diagnostics, Issue 11(7), 2021, Page(s) 1139, ISSN 2075-4418
Publisher: MDPI AG, 2011
DOI: 10.3390/diagnostics11071139

Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis

Author(s): Jule Taubmann, Brenda Krishnacoumar, Christina Böhm, Maria Faas, Dorothea I. H. Müller, Susanne Adam, Cornelia Stoll, Martin Böttcher, Dimitrios Mougiakakos, Uwe Sonnewald, Jörg Hofmann, Georg Schett, Gerhard Krönke, Carina Scholtysek
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-77892-4

Technical Note: PYRO‐NN: Python reconstruction operators in neural networks

Author(s): Christopher Syben, Markus Michen, Bernhard Stimpel, Stephan Seitz, Stefan Ploner, Andreas K. Maier
Published in: Medical Physics, Issue 46/11, 2019, Page(s) 5110-5115, ISSN 0094-2405
Publisher: American Association of Physicists in Medicine
DOI: 10.1002/mp.13753

Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis

Author(s): Darja Andreev, Mengdan Liu, Katerina Kachler, Mireia Llerins Perez, Philipp Kirchner, Julia Kölle, Andreas Gießl, Simon Rauber, Rui Song, Oliver Aust, Anika Grüneboom, Arnd Kleyer, Juan D Cañete, Arif Ekici, Andreas Ramming, Susetta Finotto, Georg Schett, Aline Bozec
Published in: Annals of the Rheumatic Diseases, Issue 80/4, 2021, Page(s) 451-468, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-218902

Butyrophilin 2a2 (Btn2a2) expression on thymic epithelial cells promotes central T cell tolerance and prevents autoimmune disease.

Author(s): Frech M, Danzer H, Uchil P, Azizov V, Schmid E, Schälter F, Dürholz K, Mauro D, Rauber S, Muñoz L, Taher L, Ciccia F, Schober K, Irla M, Sarter K, Schett G, Zaiss MM.
Published in: Journal of Autoimmunity, 2021, ISSN 0896-8411
Publisher: Academic Press
DOI: 10.1016/j.jaut.2023.103071

The Transcription Factor FRA-1/AP-1 Controls Lipocalin-2 Expression and Inflammation in Sepsis Model.

Author(s): Cao S, Schnelzer A, Hannemann N, Schett G, Soulat D, Bozec A.
Published in: Frontiers of Immunology, Issue 12, 2021, Page(s) 701675, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.701675

Why remission is not enough: underlying disease mechanisms in RA that prevent cure

Author(s): Georg Schett, Yoshiya Tanaka, John D. Isaacs
Published in: Nature Reviews Rheumatology, Issue 17/3, 2021, Page(s) 135-144, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/s41584-020-00543-5

Non-invasive metabolic profiling of inflammation in joints and entheses by multispectral optoacoustic tomography.

Author(s): Tascilar K, Fagni F, Kleyer A, Bayat S, Heidemann R, Steiger F, Krönke G, Bohr D, Ramming A, Hartmann F, Klett D, Federle A, Regensburger AP, Wagner AL, Knieling F, Neurath MF, Schett G, Waldner M, Simon D.
Published in: Rheumatology, 2023, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keac346

DL-based inpainting for metal artifact reduction for cone beam CT using metal path length information

Author(s): Tristan M. Gottschalk, Andreas Maier, Florian Kordon, Björn W. Kreher
Published in: Medical Physics, 2022, ISSN 2473-4209
Publisher: Wiley
DOI: 10.1002/mp.15909

Humoral and Cellular Immune Responses to SARS-CoV-2 Infection and Vaccination in Autoimmune Disease Patients With B Cell Depletion.

Author(s): Simon D, Tascilar K, Schmidt K, Manger B, Weckwerth L, Sokolova M, Bucci L, Fagni F, Manger K, Schuch F, Ronneberger M, Hueber A, Steffen U, Mielenz D, Herrmann M, Harrer T, Kleyer A, Krönke G, Schett G.
Published in: Arthritis & Rheumatology, Issue 74(1), 2022, Page(s) 33-37, ISSN 2326-5191
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/art.41914

Aggregated neutrophil extracellular traps occlude Meibomian glands during ocular surface inflammation

Author(s): Aparna Mahajan; Lenka Hasíková; Ulrike Hampel; Anika Grüneboom; Xiaomei Shan; Irmgard Herrmann; Fabian Garreis; Felix Bock; Jasmin Knopf; Jeeshan Singh; Christine Schauer; Siddharth Mahajan; Moritz Leppkes; Friedrich Paulsen; Ursula Schlötzer-Schrehardt; Veit Krenn; Anselm Jünemann; Bettina Hohberger; Georg Schett; Martin Herrmann; Luis E. Muñoz
Published in: Ocular Surface, Issue 2, 2020, Page(s) 1-12, ISSN 1542-0124
Publisher: Ethis Communications
DOI: 10.1016/j.jtos.2020.12.005

Antibodies against citrullinated proteins of IgA isotype are associated with progression to rheumatoid arthritis in individuals at-risk.

Author(s): Sokolova MV, Hartmann F, Sieghart D, Bang H, Steiner G, Kleyer A, Schett G, Steffen U
Published in: Rheumatic & Musculoskeletal Disease Open, 2023, ISSN 2056-5933
Publisher: BMJ Publishing Group Ltd
DOI: 10.1136/rmdopen-2022-002705

DeepNAPSI multi-reader nail psoriasis prediction using deep learning.

Author(s): Folle L, Fenzl P, Fagni F, Thies M, Christlein V, Meder C, Simon D, Minnopoulou I, Sticherling M, Schett G, Maier A, Kleyer A.
Published in: Science Report, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-32440-8

Impact of cytokine inhibitor therapy on the prevalence, seroconversion rate and longevity of the humoral immune response against SARS-CoV-2 in an unvaccinated cohort.

Author(s): Simon D, Tascilar K, Kleyer A, Fagni F, Krönke G, Meder C, Dietrich P, Orlemann T, Kliem T, Mößner J, Liphardt AM, Schönau V, Bohr D, Schuster L, Hartmann F, Leppkes M, Ramming A, Pachowsky M, Schuch F, Ronneberger M, Kleinert S, Hueber AJ, Manger K, Manger B, Atreya R, Berking C, Sticherling M, Neurath MF, Schett G.
Published in: Athritis & Rheumatology, Issue 74(5), 2022, Page(s) 783-790, ISSN 2326-5205
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/art.42035

Is Medical Chest X-ray Data Anonymous?

Author(s): Packhäuser, Kai; Gündel, Sebastian; Münster, Nicolas; Syben, Christopher; Christlein, Vincent; Maier, Andreas
Published in: arxiv.org, Issue 1, 2021, ISSN 2331-8422
Publisher: Cornell University

RETRO study group. Advanced machine learning for predicting individual risk of flares in rheumatoid arthritis patients tapering biologic drugs.

Author(s): Vodencarevic A, Tascilar K, Hartmann F, Reiser M, Hueber AJ, Haschka J, Bayat S, Meinderink T, Knitza J, Mendez L, Hagen M, Krönke G, Rech J, Manger B, Kleyer A, Zimmermann-Rittereiser M, Schett G, Simon D.
Published in: Arthritis Research & Therapy, Issue 23(1), 2021, Page(s) 67, ISSN 1478-6362
Publisher: BioMed Central
DOI: 10.1186/s13075-021-02439-5

Synthetic Image Rendering Solves Annotation Problem in Deep Learning Nanoparticle Segmentation

Author(s): Leonid Mill, David Wolff, Nele Gerrits, Patrick Philipp, Lasse Kling, Florian Vollnhals, Andrew Ignatenko, Christian Jaremenko, Yixing Huang, Olivier De Castro, Jean‐Nicolas Audinot, Inge Nelissen, Tom Wirtz, Andreas Maier, Silke Christiansen
Published in: Small Methods, 2021, Page(s) 2100223, ISSN 2366-9608
Publisher: Wiley
DOI: 10.1002/smtd.202100223

Precision of handheld multispectral optoacoustic tomography for muscle imaging

Author(s): Alexandra L. Wagner, Vera Danko, Anna Federle, Daniel Klett, David Simon, Rafael Heiss, Jörg Jüngert, Michael Uder, Georg Schett, Markus F. Neurath, Joachim Woelfle, Maximilian J. Waldner, Regina Trollmann, Adrian P. Regensburger, Ferdinand Knieling
Published in: Photoacoustics, Issue In Press, Journal Pre-proof, 2020, Page(s) 100220, ISSN 2213-5979
Publisher: Elsevier GmbH
DOI: 10.1016/j.pacs.2020.100220

Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis

Author(s): Andreev D, Liu M, Kachler K, Llerins Perez M, Kirchner P, Kölle J, Gießl A, Rauber S, Song R, Aust O, Grüneboom A, Kleyer A, Cañete JD, Ekici A, Ramming A, Finotto S, Schett G, Bozec A.
Published in: Annals of Rheumatic Diseases, Issue 80, 2021, Page(s) 451-468, ISSN 1468-2060
Publisher: BMJ
DOI: 10.1136/annrheumdis-2020-218902

Microbiota and metabolites in rheumatic diseases.

Author(s): Tong Y, Marion T, Schett G, Luo Y, Liu Y.
Published in: Autoimmunity Reviews, Issue Volume 19, Issue 8, 2020, Page(s) 102530, ISSN 1568-9972
Publisher: Elsevier BV
DOI: 10.1016/j.autrev.2020.102530

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

Author(s): Jasna Friščić, Martin Böttcher, Christiane Reinwald, Heiko Bruns, Benjamin Wirth, Samantha-Josefine Popp, Kellie Irene Walker, Jochen A. Ackermann, Xi Chen, Jason Turner, Honglin Zhu, Lisa Seyler, Maximilien Euler, Philipp Kirchner, René Krüger, Arif B. Ekici, Triin Major, Oliver Aust, Daniela Weidner, Anita Fischer, Fabian T. Andes, Zeljka Stanojevic, Vladimir Trajkovic, Martin Herrmann, Ad
Published in: Immunity, Issue 54/5, 2021, Page(s) 1002-1021.e10, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2021.03.003

Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease: a prospective cohort study.

Author(s): Simon D, Tascilar K, Fagni F, Kleyer A, Krönke G, Meder C, Dietrich P, Orlemann T, Mößner J, Taubmann J, Mutlu MY, Knitza J, Kemenes S, Liphardt AM, Schönau V, Bohr D, Schuster L, Hartmann F, Minopoulou I, Leppkes M, Ramming A, Pachowsky M, Schuch F, Ronneberger M, Kleinert S, Hueber AJ, Manger K, Manger B, Atreya R, Berking C, Sticherling M, Neurath MF, Schett G.
Published in: The Lancet Rheumatology, 2022, ISSN 2665-9913
Publisher: Elsevier
DOI: 10.1016/s2665-9913(22)00191-6

Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin

Author(s): Darja Andreev, Mengdan Liu, Daniela Weidner, Katerina Kachler, Maria Faas, Anika Grüneboom, Ursula Schlötzer-Schrehardt, Luis E. Muñoz, Ulrike Steffen, Bettina Grötsch, Barbara Killy, Gerhard Krönke, Andreas M. Luebke, Andreas Niemeier, Falk Wehrhan, Roland Lang, Georg Schett, Aline Bozec
Published in: Journal of Clinical Investigation, Issue 130/9, 2020, Page(s) 4811-4830, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci134214

Assessment of myocardial fibrosis in patients with systemic sclerosis using [68Ga]Ga‑FAPI‑04‑PET‑CT

Author(s): Treutlein C, Distler JHW, Tascilar K, Fakhouri SC, Györfi AH, Atzinger A, Matei AE, Dees C, Büttner-Herold M, Kuwert T, Prante O, Bäuerle T, Uder M, Schett G, Schmidkonz C, Bergmann C.
Published in: European Journal of Nuclear Medicine and Molecular Imaging, 2022, ISSN 1619-7070
Publisher: Springer Verlag
DOI: 10.1007/s00259-022-06081-4

Calibration by differentiation – Self‐supervised calibration for X‐ray microscopy using a differentiable cone‐beam reconstruction operator

Author(s): Mareike Thies; Fabian Wagner; Yixing Huang; Mingxuan Gu; Lasse Kling; Sabrina Pechmann; Oliver Aust; Anika Grüneboom; Georg Schett; Silke Christiansen; Andreas Maier
Published in: Crossref, Issue 3, 2022, ISSN 0022-2720
Publisher: Blackwell Publishing Inc.
DOI: 10.17169/refubium-36666

Advanced machine learning for predicting individual risk of flares in rheumatoid arthritis patients tapering biologic drugs

Author(s): Asmir Vodencarevic, Koray Tascilar, Fabian Hartmann, Michaela Reiser, Axel J. Hueber, Judith Haschka, Sara Bayat, Timo Meinderink, Johannes Knitza, Larissa Mendez, Melanie Hagen, Gerhard Krönke, Jürgen Rech, Bernhard Manger, Arnd Kleyer, Marcus Zimmermann-Rittereiser, Georg Schett, David Simon
Published in: Arthritis Research & Therapy, Issue 23/1, 2021, ISSN 1478-6362
Publisher: BMC Part of Springer nature
DOI: 10.1186/s13075-021-02439-5

Additional file 4 of A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Author(s): Sokolova, Maria; Simon, David; Nas, Kemal; Zaiss, Mario; Yubin Luo; Zhao, Yi; JÃ¼rgen Rech; Schett, Georg
Published in: Arthritis Research & Therapy, Issue 22, 2020, Page(s) 26, ISSN 1478-6354
Publisher: BioMed Central
DOI: 10.6084/m9.figshare.11846319

Trainable Joint Bilateral Filters for Enhanced Prediction Stability in Low-dose CT

Author(s): Wagner, Fabian; Thies, Mareike; Denzinger, Felix; Gu, Mingxuan; Patwari, Mayank; Ploner, Stefan; Maul, Noah; Pfaff, Laura; Huang, Yixing; Maier, Andreas
Published in: Crossref, Issue 3, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-22530-4

The gut-bone axis: how bacterial metabolites bridge the distance

Author(s): Mario M. Zaiss, Rheinallt M. Jones, Georg Schett, Roberto Pacifici
Published in: Journal of Clinical Investigation, Issue 129/8, 2019, Page(s) 3018-3028, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci128521

Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes

Author(s): Grüneboom A, Uderhardt S, Schett G
Published in: Journal of Experimental Medicine, 2023, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20220525

Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus.

Author(s): Mackensen A, Müller F, Mougiakakos D, Böltz S, Wilhelm A, Aigner M, Völkl S, Simon D, Kleyer A, Munoz L, Kretschmann S, Kharboutli S, Gary R, Reimann H, Rösler W, Uderhardt S, Bang H, Herrmann M, Ekici AB, Buettner C, Habenicht KM, Winkler TH, Krönke G, Schett G.
Published in: Nature Medicine, 2022, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-022-02017-5

The ageing joint-standard age- and sex-related values of bone erosions and osteophytes in the hand joints of healthy individuals

Author(s): A. Berlin, D. Simon, K. Tascilar, C. Figueiredo, S. Bayat, S. Finzel, E. Klaus, J. Rech, A.J. Hueber, A. Kleyer, G. Schett
Published in: Osteoarthritis and Cartilage, Issue 27/7, 2019, Page(s) 1043-1047, ISSN 1063-4584
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2019.01.019

JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function

Author(s): Susanne Adam, Nils Simon, Ulrike Steffen, Fabian T. Andes, Carina Scholtysek, Dorothea I. H. Müller, Daniela Weidner, Darja Andreev, Arnd Kleyer, Stephan Culemann, Madelaine Hahn, Georg Schett, Gerhard Krönke, Silke Frey, Axel J. Hueber
Published in: Science Translational Medicine, Issue 12/530, 2020, Page(s) eaay4447, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aay4447

Limited angle tomography for transmission X-ray microscopy using deep learning.

Author(s): Yixing Huang; Shengxiang Wang; Yong Guan; Andreas Maier
Published in: Journal of Synchrotron Radiation, Issue 2, 2020, Page(s) 477-485, ISSN 1600-5775
Publisher: Wiley
DOI: 10.1107/S160057752000017X

Systemic PPARγ Antagonism Reduces Metastatic Tumor Progression in Adipocyte-Rich Bone in Excess Weight Male Rodents.

Author(s): Gaculenko A, Gregoric G, Popp V, Seyler L, Ringer M, Kachler K, Wu Z, Kisel W, Hofbauer C, Hofbauer LC, Uder M, Schett G, Bäuerle T, Bozec A.
Published in: Journal of Bone and Mineral Research, Issue 36(12), 2021, Page(s) 2440-2452, ISSN 0884-0431
Publisher: American Society for Bone and Mineral Research
DOI: 10.1002/jbmr.4422

Known operator learning and hybrid machine learning in medical imaging—a review of the past, the present, and the future

Author(s): Andreas Maier, Harald Köstler, Marco Heisig, Patrick Krauss, Seung Hee Yang
Published in: Progress in Biomedical Engineering, Issue 4/2, 2022, ISSN 2516-1091
Publisher: IOP Publishing
DOI: 10.1088/2516-1091/ac5b13

Double-Sided Graphene-Enhanced Raman Scattering and Fluorescence Quenching in Hybrid Biological Structures

Author(s): George Sarau; George Sarau; Christoph Daniel; Martin Heilmann; Gerd Leuchs; Kerstin Amann; Silke Christiansen
Published in: Advanced Materials Technologies, Issue 6(9), 2021, Page(s) pp, ISSN 2365-709X
Publisher: Wiley-Blackwell
DOI: 10.1002/admt.202100385

Efficacy and safety of SARS-CoV-2 revaccination in non-responders with immune-mediated inflammatory disease.

Author(s): Simon D, Tascilar K, Fagni F, Schmidt K, Krönke G, Kleyer A, Ramming A, Schoenau V, Bohr D, Knitza J, Harrer T, Manger K, Manger B, Schett G.
Published in: Annal of the Rheumatic Diseases, Issue 36(12), 2021, Page(s) 2440-2452, ISSN 1468-2060
Publisher: J Bone Miner Res.
DOI: 10.1136/annrheumdis-2021-221554

Rheumatic?-A Digital Diagnostic Decision Support Tool for Individuals Suspecting Rheumatic Diseases: A Multicenter Pilot Validation Study.

Author(s): Knevel R, Knitza J, Hensvold A, Circiumaru A, Bruce T, Evans S, Maarseveen T, Maurits M, Beaart-van de Voorde L, Simon D, Kleyer A, Johannesson M, Schett G, Huizinga T, Svanteson S, Lindfors A, Klareskog L, Catrina A.
Published in: Frontier Medicine, 2022, ISSN 2095-0225
Publisher: Frontier Media SA
DOI: 10.3389/fmed.2022.774945

Methotrexate hampers immunogenicity to BNT162b2 mRNA COVID-19 vaccine in immune-mediated inflammatory disease.

Author(s): Haberman RH, Herati R, Simon D, Samanovic M, Blank RB, Tuen M, Koralov SB, Atreya R, Tascilar K, Allen JR, Castillo R, Cornelius AR, Rackoff P, Solomon G, Adhikari S, Azar N, Rosenthal P, Izmirly P, Samuels J, Golden B, Reddy SM, Neurath MF, Abramson SB, Schett G, Mulligan MJ, Scher JU.
Published in: Annal of the Rheumatic Diseases, Issue 80(10), 2021, Page(s) 1339-1344, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220597

Will We Ever Have Conscious Machines?

Author(s): Patrick Krauss, Andreas Maier
Published in: Frontiers in Computational Neuroscience, Issue 14, 2020, ISSN 1662-5188
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncom.2020.556544

Efficacy and drug persistence of baricitinib monotherapy is similar to combination therapy in patients with active RA: a prospective observational study.

Author(s): Bayat S, Tascilar K, Bohr D, Krönke G, Simon D, Knitza J, Hartmann F, Schett G, Kleyer A.
Published in: Rheumatic & Musculoskeletal Disease Open, 2022, ISSN 2056-5933
Publisher: BMJ Publishing Group Ltd
DOI: 10.1136/rmdopen-2022-002674

Mobile Health Usage, Preferences, Barriers, and eHealth Literacy in Rheumatology: Patient Survey Study

Author(s): Johannes Knitza, David Simon, Antonia Lambrecht, Christina Raab, Koray Tascilar, Melanie Hagen, Arnd Kleyer, Sara Bayat, Adrian Derungs, Oliver Amft, Georg Schett, Axel J Hueber
Published in: JMIR mHealth and uHealth, Issue 8/8, 2020, Page(s) e19661, ISSN 2291-5222
Publisher: Europe PMC
DOI: 10.2196/19661

Ultralow-parameter denoising: Trainable bilateral filter layers in computed tomography.

Author(s): Fabian Wagner; Mareike Thies; Mingxuan Gu; Yixing Huang; Sabrina Pechmann; Mayank Patwari; Stefan Ploner; Oliver Aust; Stefan Uderhardt; Georg Schett; Silke Christiansen; Andreas Maier
Published in: Crossref, Issue 4, 2022, ISSN 2473-4209
Publisher: Medical Physics
DOI: 10.48550/arxiv.2201.10345

Analysis of Hand Joint Space Morphology in Women and Men with Hereditary Hemochromatosis.

Author(s): Heilmeier U, Burghardt AJ, Tse JJ, Kapoor P, Stok KS, Manske S, Voll RE, Schett G, Finzel S.
Published in: Calcified Tissue International, 2023, ISSN 0171-967X
Publisher: Springer Verlag
DOI: 10.1007/s00223-022-01050-3

Glaucoma classification in 3 x 3 mm en face macular scans using deep learning in a different plexus

Author(s): Julia Schottenhamml; Tobias Würfl; Sophia Mardin; Stefan B. Ploner; Lennart Husvogt; Bettina Hohberger; Robert Lämmer; Christian Y. Mardin; Andreas Maier
Published in: Biomed Opt Express, Issue 2, 2021, Page(s) 7434-7444, ISSN 2156-7085
Publisher: The Optical Society
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Neutralizing monoclonal antibodies against SARS-CoV-2 for COVID-19 pneumonia in a rituximab treated patient with systemic sclerosis-A case report and literature review.

Author(s): Yalcin Mutlu M, Taubmann J, Wacker J, Tascilar K, Fagni F, Gerner M, Klett D, Schett G, Manger B, Simon D.
Published in: Frontiers in molecular medicine and therapeutics, 2022, ISSN 2771-7720
Publisher: Frontiers Media SA
DOI: 10.3389/fmed.2022.934169

Advanced neural networks for classification of MRI in psoriatic arthritis, seronegative, and seropositive rheumatoid arthritis

Author(s): Lukas Folle, Sara Bayat, Arnd Kleyer, Filippo Fagni, Lorenz A Kapsner, Maja Schlereth, Timo Meinderink, Katharina Breininger, Koray Tascilar, Gerhard Krönke, Michael Uder, Michael Sticherling, Sebastian Bickelhaupt, Georg Schett, Andreas Maier, Frank Roemer, David Simon
Published in: Rheumatology, 2022, ISSN 1462-0332
Publisher: Oxford Academic
DOI: 10.1093/rheumatology/keac197

Hypoxia Promotes Neutrophil Survival After Acute Myocardial Infarction.

Author(s): Dölling M, Eckstein M, Singh J, Schauer C, Schoen J, Shan X, Bozec A, Knopf J, Schett G, Muñoz LE, Herrmann M.
Published in: Frontier Immunology, Issue 13, 2022, Page(s) 726153, ISSN 1664-3224
Publisher: Frontiers Media S.A
DOI: 10.3389/fimmu.2022.726153

The Potential of OMICs Technologies for the Treatment of Immune-Mediated Inflammatory Diseases

Author(s): Anchang CG, Xu C, Raimondo MG, Atreya R, Maier A, Schett G, Zaburdaev V, Rauber S, Ramming A.
Published in: Int J Mol Sci., Issue 22(14), 2021, Page(s) 7506, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22147506

Moonlighting chromatin: when DNA escapes nuclear control

Author(s): Singh J, Boettcher M, Dölling M, Heuer A, Hohberger B, Leppkes M, Naschberger E, Schapher M, Schauer C, Schoen J, Stürzl M, Vitkov L, Wang H, Zlatar L, Schett GA, Pisetsky DS, Liu ML, Herrmann M, Knopf J.
Published in: Cell Death & Differentiation, 2023, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-023-01124-1

IgA subclasses have different effector functions associated with distinct glycosylation profiles

Author(s): Ulrike Steffen, Carolien A. Koeleman, Maria V. Sokolova, Holger Bang, Arnd Kleyer, Jürgen Rech, Harald Unterweger, Martin Schicht, Fabian Garreis, Jonas Hahn, Fabian T. Andes, Fabian Hartmann, Madelaine Hahn, Aparna Mahajan, Friedrich Paulsen, Markus Hoffmann, Günter Lochnit, Luis E. Muñoz, Manfred Wuhrer, David Falck, Martin Herrmann, Georg Schett
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13992-8

Aggregated neutrophil extracellular traps occlude Meibomian glands during ocular surface inflammation

Author(s): Aparna Mahajan, Lenka Hasíková, Ulrike Hampel, Anika Grüneboom, Xiaomei Shan, Irmgard Herrmann, Fabian Garreis, Felix Bock, Jasmin Knopf, Jeeshan Singh, Christine Schauer, Siddharth Mahajan, Moritz Leppkes, Friedrich Paulsen, Ursula Schlötzer-Schrehardt, Veit Krenn, Anselm Jünemann, Bettina Hohberger, Georg Schett, Martin Herrmann, Luis E. Muñoz
Published in: The Ocular Surface, Issue 20, 2021, Page(s) 1-12, ISSN 1542-0124
Publisher: Ethis Communications
DOI: 10.1016/j.jtos.2020.12.005

CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus.

Author(s): Mougiakakos D, Krönke G, Völkl S, Kretschmann S, Aigner M, Kharboutli S, Böltz S, Manger B, Mackensen A, Schett G.
Published in: New England Journal of Medicine, Issue 385(6), 2021, Page(s) 567-569, ISSN 1533-4406
Publisher: Massachusetts Medical Society
DOI: 10.1056/nejmc2107725

Bone Mass, Bone Microstructure and Biomechanics in Patients with Hand Osteoarthritis

Author(s): David Simon, Koray Tascilar, Sara Unbehend, Sara Bayat, Andreas Berlin, Anna‐Maria Liphardt, Timo Meinderink, Juergen Rech, Axel J Hueber, Georg Schett, Arnd Kleyer
Published in: Journal of Bone and Mineral Research, Issue 35/9, 2020, Page(s) 1695-1702, ISSN 0884-0431
Publisher: American Society for Bone and Mineral Research
DOI: 10.1002/jbmr.4046

Bone microstructure and volumetric bone mineral density in patients with hyperuricemia with and without psoriasis

Author(s): D. Simon, J. Haschka, C. Muschitz, A. Kocijan, A. Baierl, A. Kleyer, G. Schett, S. Kapiotis, H. Resch, M. Sticherling, J. Rech, R. Kocijan
Published in: Osteoporosis International, Issue 31/5, 2020, Page(s) 931-939, ISSN 0937-941X
Publisher: Springer Verlag
DOI: 10.1007/s00198-019-05160-x

Imaging in inflammatory arthritis: progress towards precision medicine.

Author(s): Minopoulou I, Kleyer A, Yalcin-Mutlu M, Fagni F, Kemenes S, Schmidkonz C, Atzinger A, Pachowsky M, Engel K, Folle L, Roemer F, Waldner M, D'Agostino MA, Schett G, Simon D.
Published in: Nature Review of Rheumatology, 2022, Page(s) 650-665, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/s41584-023-01016-1

Micro-structural bone changes are associated with broad-spectrum autoimmunity and predict the onset of rheumatoid arthritis.

Author(s): Simon D, Kleyer A, Bui CD, Hueber A, Bang H, Ramming A, Rech J, Schett G.
Published in: Arthritis and Rheumatology, Issue 74(3), 2022, Page(s) 418-426, ISSN 2326-5191
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/art.41229

What Do We Really Need? Degenerating U-Net on Retinal Vessel Segmentation

Author(s): Fu, Weilin; Breininger, Katharina; Pan, Zhaoya; Maier, Andreas
Published in: arxiv.org, Issue 5, 2020, ISSN 2331-8422
Publisher: Cornell University
DOI: 10.48550/arxiv.1911.02660

Locally renewing resident synovial macrophages provide a protective barrier for the joint

Author(s): Stephan Culemann, Anika Grüneboom, José Ángel Nicolás-Ávila, Daniela Weidner, Katrin Franziska Lämmle, Tobias Rothe, Juan A. Quintana, Philipp Kirchner, Branislav Krljanac, Martin Eberhardt, Fulvia Ferrazzi, elke Kretzschmar, Martin Schicht, Kim Fischer, Kolja Gelse, Maria Faas, René Pfeifle, Jochen A. Ackermann, Milena Pachowsky, Nina renner, David Simon, reiner F. Haseloff, Arif B. Ekic
Published in: Nature, Issue 572, 2019, Page(s) 670–675, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1471-1

A. Higher serum levels of short-chain fatty acids are associated with non-progression to arthritis in individuals at increased risk of RA.

Author(s): Martinsson K, Dürholz K, Schett G, Zaiss MM, Kastbom A.
Published in: Annals of the Rheumatic Diseases, Issue 81(3), 2022, Page(s) 445-447, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-221386

Micro-cantilever testing of diamond - silicon carbide interfaces in silicon carbide bonded diamond materials produced by reactive silicon infiltration

Author(s): J. Ast; Björn Matthey; P. Herre; Sören Höhn; Mathias Herrmann; Silke Christiansen
Published in: Open Ceramics, Issue 8(4), 2021, Page(s) 100176, ISSN 2666-5395
Publisher: Oxford: Elsevier Ltd
DOI: 10.1016/j.oceram.2021.100176

Concise report: a minimal-invasive method to retrieve and identify entheseal tissue from psoriatic arthritis patients.

Author(s): Pachowsky ML, Raimondo MG, Xu C, Rauber S, Tascilar K, Labinsky H, Vogg M, Aziz Saad MS, Simon D, Rech J, Soare A, Braeuer L, Kleyer A, Schett G, Ramming A.
Published in: Annals of Rheumatic Disease, 2022, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-222061

Gradient-based geometry learning for fan-beam CT reconstruction

Author(s): Mareike Thies, Fabian Wagner, Noah Maul, Lukas Folle, Manuela Meier, Maximilian Rohleder, Linda-Sophie Schneider, Laura Pfaff, Mingxuan Gu, Jonas Utz, Felix Denzinger, Michael Manhart, Andreas Maier
Published in: Physics in Medicine and Biology, 2023, ISSN 0031-9155
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6560/acf90e

Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion

Author(s): David Simon, Koray Tascilar, Gerhard Krönke, Arnd Kleyer, Mario M. Zaiss, Franz Heppt, Christine Meder, Raja Atreya, Entcho Klenske, Peter Dietrich, Abdullah Abdullah, Thorsten Kliem, Giulia Corte, Harriet Morf, Moritz Leppkes, Andreas E. Kremer, Andreas Ramming, Milena Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Clara Maier, Axel J. Hueber, Karin Manger, Bernhard Manger, Caro
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17703-6

Effects of casirivimab/imdevimab on systemic and mucosal immunity against SARS-CoV-2 in B-cell depleted patients with autoimmune rheumatic diseases refractory to vaccination.

Author(s): Fagni F, Schmidt K, Bohr D, Valor-Méndez L, Hartmann F, Tascilar K, Manger K, Manger B, Kleyer A, Simon D, Schett G, Harrer T.
Published in: Rheumatic & Musuloskeletal Disease Open, 2022, ISSN 2056-5933
Publisher: BMJ Publishing Group Ltd
DOI: 10.1136/rmdopen-2022-002323

Learning with Known Operators reduces Maximum Training Error Bounds

Author(s): Maier, Andreas K.; Syben, Christopher; Stimpel, Bernhard; Würfl, Tobias; Hoffmann, Mathis; Schebesch, Frank; Fu, Weilin; Mill, Leonid; Kling, Lasse; Christiansen, Silke
Published in: Nature machine intelligence, Issue 1, 2020, Page(s) 373–380, ISSN 2522-5839
Publisher: Nature Research
DOI: 10.1038/s42256-019-0077-5

IgA2 Antibodies against SARS-CoV-2 Correlate with NET Formation and Fatal Outcome in Severely Diseased COVID-19 Patients

Author(s): Léonie A. N. Staats, Hella Pfeiffer, Jasmin Knopf, Aylin Lindemann, Julia Fürst, Andreas E. Kremer, Holger Hackstein, Markus F. Neurath, Luis E. Muñoz, Susanne Achenbach, Moritz Leppkes, Martin Herrmann, Georg Schett, Ulrike Steffen
Published in: Cells, Issue 9/12, 2020, Page(s) 2676, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9122676

Why remission is not enough: underlying disease mechanisms in RA that prevent cure.

Author(s): Georg Schett; Yoshiya Tanaka; John D. Isaacs; John D. Isaacs
Published in: Nature Reviews Rheumatology, Issue 23, 2021, Page(s) 135–144, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/s41584-020-00543-5

Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging

Author(s): Christian Schmidkonz, Simon Rauber, Armin Atzinger, Rahul Agarwal, Theresa Ida Götz, Alina Soare, Michael Cordes, Olaf Prante, Christina Bergmann, Arnd Kleyer, Philipp Ritt, Simone Maschauer, Peter Hennig, Johannes Toms, Markus Köhner, Bernhard Manger, John H Stone, Uwe Haberkorn, Tobias Baeuerle, Jörg H W Distler, Abbas Agaimy, Torsten Kuwert, Georg Schett, Andreas Ramming
Published in: Annals of the Rheumatic Diseases, Issue 79/11, 2020, Page(s) 1485-1491, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-217408

Deep learning-based patient re-identification is able to exploit the biometric nature of medical chest X-ray data

Author(s): Kai Packhäuser, Sebastian Gündel, Nicolas Münster, Christopher Syben, Vincent Christlein, Andreas Maier
Published in: Scientific Reports, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-19045-3

AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9.

Author(s): Vergarajauregui S, Becker R, Steffen U, Sharkova M, Esser T, Petzold J, Billing F, Kapiloff MS, Schett G, Thievessen I, Engel FB.
Published in: eLife, Issue 9, 2020, Page(s) 61669, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.61669

SARS-CoV-2 vaccination responses in untreated, conventionally treated and anticytokine-treated patients with immune-mediated inflammatory diseases

Author(s): David Simon, Koray Tascilar, Filippo Fagni, Gerhard Krönke, Arnd Kleyer, Christine Meder, Raja Atreya, Moritz Leppkes, Andreas E Kremer, Andreas Ramming, Milena L Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Axel J Hueber, Karin Manger, Bernhard Manger, Carola Berking, Michael Sticherling, Markus F Neurath, Georg Schett
Published in: Annals of the Rheumatic Diseases, 2021, Page(s) annrheumdis-2021-220461, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220461

Structural entheseal lesions in patients with psoriasis are associated with an increased risk of progression to psoriatic arthritis

Author(s): David Simon, Koray Tascilar, Arnd Kleyer, Sara Bayat, Eleni Kampylafka, Maria Sokolova, Ana Zekovic, Axel J Hueber, Jürgen Rech, Louis Schuster, Klaus Engel, Michael Sticherling, Georg Schett
Published in: Arthritis & Rheumatology, 2020, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.41239

A Detailed Analysis of the Association between Urate Deposition and Erosions and Osteophytes in Gout

Author(s): Caroline Pecherstorfer, David Simon, Sara Unbehend, Hanna Ellmann, Matthias Englbrecht, Fabian Hartmann, Camille Figueiredo, Axel Hueber, Judith Haschka, Roland Kocijan, Arnd Kleyer, Georg Schett, Jürgen Rech, Sara Bayat
Published in: ACR Open Rheumatology, Issue 2/10, 2020, Page(s) 565-572, ISSN 2578-5745
Publisher: Wiley
DOI: 10.1002/acr2.11172

Vascular occlusion by neutrophil extracellular traps in COVID-19

Author(s): Moritz Leppkes, Jasmin Knopf, Elisabeth Naschberger, Aylin Lindemann, Jeeshan Singh, Irmgard Herrmann, Michael Stürzl, Léonie Staats, Aparna Mahajan, Christine Schauer, Anita N. Kremer, Simon Völkl, Kerstin Amann, Katja Evert, Christina Falkeis, Andreas Wehrfritz, Ralf J. Rieker, Arndt Hartmann, Andreas E. Kremer, Markus F. Neurath, Luis E. Muñoz, Georg Schett, Martin Herrmann
Published in: EBioMedicine, Issue 58, 2020, Page(s) 102925, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2020.102925

Effect of disease-modifying anti-rheumatic drugs on bone structure and strength in psoriatic arthritis patients

Author(s): David Simon, Arnd Kleyer, Sara Bayat, Koray Tascilar, Eleni Kampylafka, Timo Meinderink, Louis Schuster, Ramona Petrov, Anna-Maria Liphardt, Juergen Rech, Georg Schett, Axel J. Hueber
Published in: Arthritis Research & Therapy, Issue 21/1, 2019, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-019-1938-3

Additional file 1 of Advanced machine learning for predicting individual risk of flares in rheumatoid arthritis patients tapering biologic drugs

Author(s): Vodencarevic, Asmir; Tascilar, Koray; Hartmann, Fabian; Reiser, Michaela; Hueber, Axel J.; Haschka, Judith; Bayat, Sara; Meinderink, Timo; Knitza, Johannes; Mendez, Larissa; Hagen, Melanie; Krönke, Gerhard; Rech, Jürgen; Manger, Bernhard; Kleyer, Arnd; Zimmermann-Rittereiser, Marcus; Schett, Georg; Simon, David
Published in: Arthritis Research & Therapy, Issue 23(1), 2021, Page(s) 67, ISSN 1478-6354
Publisher: BioMed Central
DOI: 10.6084/m9.figshare.14130926.v1

IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation.

Author(s): Faas M, Ipseiz N, Ackermann J, Culemann S, Grüneboom A, Schröder F, Rothe T, Scholtysek C, Eberhardt M, Böttcher M, Kirchner P, Stoll C, Ekici A, Fuchs M, Kunz M, Weigmann B, Wirtz S, Lang R, Hofmann J, Vera J, Voehringer D, Michelucci A, Mougiakakos D, Uderhardt S, Schett G, Krönke G.
Published in: Immunity, Issue 54(11), 2021, Page(s) 2531-2546, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2021.09.010

Murine Metatarsus Bone and Joint Collagen-I Fiber Morphologies and Networks Studied With SHG Multiphoton Imaging.

Author(s): Vielreicher M, Bozec A, Schett G, Friedrich O.
Published in: Frontier Bioengeeniering Biotechnology, Issue 9, 2021, Page(s) 608383, ISSN 2296-4185
Publisher: Frontiers Media S.A.
DOI: 10.3389/fbioe.2021.608383

Biomechanical stress in the context of competitive sports training triggers enthesitis.

Author(s): Simon D, Kleyer A, Bayat S, Knitza J, Valor-Mendez L, Schweiger M, Schett G, Tascilar K, Hueber AJ.
Published in: Arthritis Research & Therapy, Issue 23(1), 2021, Page(s) 172, ISSN 1478-6362
Publisher: Biomed Central
DOI: 10.1186/s13075-021-02530-x

Successful Generation of CD19 Chimeric Antigen Receptor T Cells from Patients with Advanced Systemic Lupus Erythematosus.

Author(s): Kretschmann S, Völkl S, Reimann H, Krönke G, Schett G, Achenbach S, Lutzny-Geier G, Müller F, Mougiakakos D, Dingfelder J, Flamann C, Hanssens L, Gary R, Mackensen A, Aigner M.
Published in: Transplantation and Cellular Therapy, 2023, ISSN 2666-6375
Publisher: Elsevier
DOI: 10.1016/j.jtct.2022.10.004

“Keep it simple, scholar”: an experimental analysis of few-parameter segmentation networks for retinal vessels in fundus imaging

Author(s): Weilin Fu, Katharina Breininger, Roman Schaffert, Zhaoya Pan, Andreas Maier
Published in: International Journal of Computer Assisted Radiology and Surgery, Issue 16/6, 2021, Page(s) 967-978, ISSN 1861-6410
Publisher: Springer Verlag
DOI: 10.1007/s11548-021-02340-1

Inflammatory activation of the FcγR and IFNγR pathways co-influences the differentiation and activity of osteoclasts.

Author(s): Groetsch B, Schachtschabel E, Tripal P, Schmid B, Smith AS, Schett G, Bozec A.
Published in: Frontier Immunology, 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.958974

Complexes Induce Neutrophil Extracellular Trap Formation More Potently Than IgG Complexes.

Author(s): Gimpel AK, Maccataio A, Unterweger H, Sokolova MV, Schett G, Steffen U.
Published in: Frontier Immunology, Issue 12, 2022, Page(s) 761816, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.761816

A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19

Author(s): Singh J, Herrmann I, Mahajan A, Schauer C, Shan X, Hartmann A, Rieker RJ, Evert K, Falkeis C, Naschberger E, von Stillfried S, Boor P, Muñoz LE, Schett G, Herrmann M, Knopf J.
Published in: International Journal of Molecular Science, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232315126

Deep Learning-Based Classification of Inflammatory Arthritis by Identification of Joint Shape Patterns—How Neural Networks Can Tell Us Where to “Deep Dive” Clinically

Author(s): Lukas Folle, David Simon, Koray Tascilar, Gerhard Krönke, Anna-Maria Liphardt, Andreas Maier, Georg Schett, Arnd Kleyer
Published in: Frontiers in Medicine, 2022, ISSN 2296-858X
Publisher: Frontiers Media
DOI: 10.3389/fmed.2022.850552

Additional file 3 of A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Author(s): Sokolova, Maria; Simon, David; Nas, Kemal; Zaiss, Mario; Yubin Luo; Zhao, Yi; JÃ¼rgen Rech; Schett, Georg
Published in: Arthritis Research & Therapy, Issue 4, 2020, Page(s) 26, ISSN 1478-6354
Publisher: BioMed Central
DOI: 10.6084/m9.figshare.11846310

Next-generation imaging of the skeletal system and its blood supply

Author(s): Anika Grüneboom, Lasse Kling, Silke Christiansen, Leonid Mill, Andreas Maier, Klaus Engelke, Harald H. Quick, Georg Schett, Matthias Gunzer
Published in: Nature Reviews Rheumatology, Issue 15/9, 2019, Page(s) 533-549, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/s41584-019-0274-y

PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass

Author(s): Dorothea I. H. Müller, Cornelia Stoll, Katrin Palumbo-Zerr, Christina Böhm, Brenda Krishnacoumar, Natacha Ipseiz, Jule Taubmann, Max Zimmermann, Martin Böttcher, Dimitrios Mougiakakos, Jan Tuckermann, Farida Djouad, Georg Schett, Carina Scholtysek, Gerhard Krönke
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-65305-5

Deep learning for terahertz image denoising in nondestructive historical document analysis

Author(s): Balaka Dutta, Konstantin Root, Ingrid Ullmann, Fabian Wagner, Martin Mayr, Mathias Seuret, Mareike Thies, Daniel Stromer, Vincent Christlein, Jan Schür, Andreas Maier, Yixing Huang
Published in: Scientific Reports, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-26957-7

COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses.

Author(s): Fagni F, Simon D, Tascilar K, Schoenau V, Sticherling M, Neurath MF, Schett G.
Published in: Lancet Rheumatology, Issue 3(10), 2021, Page(s) e724-e736, ISSN 2665-9913
Publisher: Lancet Publishing Group
DOI: 10.1016/s2665-9913(21)00247-2

Does methotrexate influence COVID-19 infection? Case series and mechanistic data.

Author(s): Schälter F, Dürholz K, Bucci L, Burmester G, Caporali R, Figuereido C, Cobra JF, Manger B, Zaiss MM, Schett G.
Published in: Arthritis Research & Therapy, Issue 23(1), 2021, Page(s) 166, ISSN 1478-6362
Publisher: BioMed Central
DOI: 10.1186/s13075-021-02464-4

A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Author(s): Maria V. Sokolova, David Simon, Kemal Nas, Mario M. Zaiss, Yubin Luo, Yi Zhao, Jürgen Rech, Georg Schett
Published in: Arthritis Research & Therapy, Issue 22/1, 2020, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-020-2111-8

Microbiota-Derived Propionate Modulates Megakaryopoiesis and Platelet Function.

Author(s): Dürholz K, Schmid E, Frech M, Azizov V, Otterbein N, Lucas S, Rauh M, Schett G, Bruns H, Zaiss MM.
Published in: Frontiers Immunology, 2022, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2022.908174

The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption.

Author(s): Andes FT, Adam S, Hahn M, Aust O, Frey S, Grueneboom A, Nitschke L, Schett G, Steffen U.
Published in: Bone, Issue 143, 2020, Page(s) 115665, ISSN 8756-3282
Publisher: Elsevier BV
DOI: 10.1016/j.bone.2020.115665

Learned cone-beam CT reconstruction using neural ordinary differential equations

Author(s): Mareike Thies, Fabian Wagner, Mingxuan Gu, Lukas Folle, Lina Felsner, Andreas Maier
Published in: Proceedings 7th International Conference on Image Formation in X-Ray Computed Tomography, Issue Volume 12304, 2022
Publisher: SPIE
DOI: 10.1117/12.2646442

On the Benefit of Dual-Domain Denoising in a Self-Supervised Low-Dose CT Setting

Author(s): Fabian Wagner; Mareike Thies; Laura Pfaff; Oliver Aust; Sabrina Pechmann; Daniela Weidner; Noah Maul; Maximilian Rohleder; Mingxuan Gu; Jonas Utz; Felix Denzinger; Andreas Maier
Published in: 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI), 2023
Publisher: IEEE
DOI: 10.1109/isbi53787.2023.10230511

Cavity Segmentation in X-ray Microscopy Scans of Mouse Tibiae

Author(s): Mingxuan Gu, Mareike Thies, Fabian Wagner, Sabrina Pechmann, Oliver Aust, Daniela Weidner, Georgiana Neag, Zhaoya Pan, Jonas Utz, Georg Schett, Silke Christiansen, Stefan Uderhardt, Andreas Maier
Published in: Bildverarbeitung für die Medizin 2023, 2023
Publisher: Springer
DOI: 10.1007/978-3-658-41657-7_56

Noise2Contrast: Multi-contrast Fusion Enables Self-supervised Tomographic Image Denoising

Author(s): Fabian Wagner, Mareike Thies, Laura Pfaff, Noah Maul, Sabrina Pechmann, Mingxuan Gu, Jonas Utz, Oliver Aust, Daniela Weidner, Georgiana Neag, Stefan Uderhardt, Jang-Hwan Choi, Andreas Maier
Published in: Information Processing in Medical Imaging 2023, 2023
Publisher: Springer
DOI: 10.1007/978-3-031-34048-2_59

Robust Multi-Contrast Mri Denoising Using Trainable Bilateral Filters Without Noise-Free Targets

Author(s): Laura Pfaff; Fabian Wagner; Julian Hossbach; Elisabeth Preuhs; Noah Maul; Mareike Thies; Felix Denzinger; Dominik Nickel; Tobias Wuerfl; Andreas Maier
Published in: 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI), 2023
Publisher: IEEE
DOI: 10.1109/isbi53787.2023.10230627

Deep Learning-Based Anonymization of Chest Radiographs: A Utility-Preserving Measure for Patient Privacy

Author(s): Kai Packhäuser, Sebastian Gündel, Florian Thamm, Felix Denzinger, Andreas Maier
Published in: Medical Image Computing and Computer Assisted Intervention – MICCAI 2023, 2023
Publisher: Springer
DOI: 10.1007/978-3-031-43898-1_26

Geometric Constraints Enable Self-Supervised Sinogram Inpainting in Sparse-View Tomography

Author(s): Fabian Wagner, Mareike Thies, Noah Maul, Laura Pfaff, Oliver Aust, Sabrina Pechmann, Christopher Syben, Andreas Maier
Published in: 17th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine (Fully3D), 2023
Publisher: Fully3d

Focus on Content not Noise: Improving Image Generation for Nuclei Segmentation by Suppressing Steganography in CycleGAN

Author(s): Jonas Utz, Tobias Weise, Maja Schlereth, Fabian Wagner, Mareike Thies, Mingxuan Gu, Stefan Uderhardt, Katharina Breininger
Published in: Proceedings of the IEEE/CVF International Conference on Computer Vision (ICCV) Workshops, 2023
Publisher: CVF

Generation of Anonymous Chest Radiographs Using Latent Diffusion Models for Training Thoracic Abnormality Classification Systems

Author(s): Kai Packhäuser; Lukas Folle; Florian Thamm; Andreas Maier
Published in: 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI), 2023
Publisher: IEEE
DOI: 10.1109/isbi53787.2023.10230346

Optimizing CT Scan Geometries With and Without Gradients

Author(s): Mareike Thies, Fabian Wagner, Noah Maul, Laura Pfaff, Linda-Sophie Schneider, Christopher Syben, Andreas Maier
Published in: 17th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine (Fully3D), 2023
Publisher: Fully3d

Lesson Learnt: Modularization of Deep Networks Allow Cross-Modality Reuse

Author(s): Fu, Weilin; Husvogt, Lennart; Maier, Stefan Ploner James G. Fujimoto Andreas
Published in: Bildverarbeitung für die Medizin 2020. Informatik aktuell., Issue 2, 2020, Page(s) 274-279
Publisher: Springer Vieweg
DOI: 10.1007/978-3-658-29267-6

Bildverarbeitung für die Medizin 2021 - Proceedings, German Workshop on Medical Image Computing, Regensburg, March 7-9, 2021

Author(s): Yixing Huang, Leonid Mill, Robert Stoll, Lasse Kling, Oliver Aust, Fabian Wagner, Anika Gruneboom, Georg Schett, Silke Christiansen, Andreas Maier
Published in: Semi-permeable Filters for Interior Region of InterestDose Reduction in X-ray Microscopy, 2021, Page(s) 61-66, ISBN 978-3-658-33198-6
Publisher: Springer Fachmedien Wiesbaden GmbH
DOI: 10.1007/978-3-658-33198-6

Monte Carlo Dose Simulation for In-Vivo X-Ray Nanoscopy

Author(s): Fabian Wagner, Mareike Thies, Marek Karolczak, Sabrina Pechmann, Yixing Huang, Mingxuan Gu, Lasse Kling, Daniela Weidner, Oliver Aust, Georg Schett, Silke Christiansen, Andreas Maier
Published in: Bildverarbeitung für die Medizin, 2022
Publisher: Springer
DOI: 10.1007/978-3-658-36932-3_22

Towards In-Vivo X-Ray Nanoscopy - Acquisition Parameters vs. Image Quality

Author(s): Leonid Mill, Lasse Kling, Anika Grüneboom, Georg Schett, Silke Christiansen, Andreas Maier
Published in: Bildverarbeitung für die Medizin 2019 - Algorithmen – Systeme – Anwendungen. Proceedings des Workshops vom 17. bis 19. März 2019 in Lübeck, 2019, Page(s) 251-256, ISBN 978-3-658-25325-7
Publisher: Springer Fachmedien Wiesbaden
DOI: 10.1007/978-3-658-25326-4_56

Towards In-Vivo X-Ray Nanoscopy - The Effect of Motion on Image Quality

Author(s): Leonid Mill, Bastian Bier, Christopher Syben, Lasse Kling, Anika Klingberg, Silke Christiansen, Georg Schett, Andreas Maier
Published in: Bildverarbeitung für die Medizin 2018 - Algorithmen - Systeme - Anwendungen. Proceedings des Workshops vom 11. bis 13. März 2018 in Erlangen, 2018, Page(s) 115-120, ISBN 978-3-662-56536-0
Publisher: Springer Berlin Heidelberg
DOI: 10.1007/978-3-662-56537-7_40

Degenerating U-Net on Retinal Vessel Segmentation - What Do We Really Need?

Author(s): Weilin Fu, Katharina Breininger, Zhaoya Pan, Andreas Maier
Published in: Bildverarbeitung für die Medizin 2020 - Algorithmen – Systeme – Anwendungen. Proceedings des Workshops vom 15. bis 17. März 2020 in Berlin, 2020, Page(s) 33-38, ISBN 978-3-658-29266-9
Publisher: Springer Fachmedien Wiesbaden
DOI: 10.1007/978-3-658-29267-6_7

Few-shot Unsupervised Domain Adaptation for Multi-modal Cardiac Image Segmentation

Author(s): Mingxuan Gu, Sulaiman Vesal, Ronak Kosti, Andreas Maier
Published in: Bildverarbeitung für die Medizin, 2022
Publisher: Springer
DOI: 10.1007/978-3-658-36932-3_5

Towards Mouse Bone X-ray Microscopy Scan Simulation

Author(s): Weilin Fu, Leonid Mill, Stephan Seitz, Tobias Geimer, Lasse Kling, Dennis Possart, Silke Christiansen, Andreas Maier
Published in: Bildverarbeitung für die Medizin 2021 - Proceedings, German Workshop on Medical Image Computing, Regensburg, March 7-9, 2021, 2021, Page(s) 128-133, ISBN 978-3-658-33197-9
Publisher: Springer Fachmedien Wiesbaden
DOI: 10.1007/978-3-658-33198-6_32

Degenerating U-Net on Retinal Vessel Segmentation

Author(s): Fu, Weilin; Breininger, Katharina; Pan, Zhaoya; Maier, Andreas
Published in: Informatik aktuell, Issue 1, 2020, Page(s) 33-38, ISBN 978-3-658-29266-6
Publisher: Springer Vieweg
DOI: 10.1007/978-3-658-29266-6

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