Advancing osteoporosis medicine by observing bone microstructure and remodelling using a four-dimensional nanoscope

Pubblicazioni

Neutrophil Extracellular Traps Promote the Development and Growth of Human Salivary Stones.

Autori: Schapher M, Koch M, Weidner D, Scholz M, Wirtz S, Mahajan A, Herrmann I, Singh J, Knopf J, Leppkes M, Schauer C, Grüneboom A, Alexiou C, Schett G, Iro H, Muñoz LE, Herrmann M.
Pubblicato in: Cells, Numero 9(9), 2020, Pagina/e 2139, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells9092139

Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells

Autori: Bergmann C, Müller F, Distler JHW, Györfi AH, Völkl S, Aigner M, Kretschmann S, Reimann H, Harrer T, Bayerl N, Boeltz S, Wirsching A, Taubmann J, Rösler W, Spriewald B, Wacker J, Atzinger A, Uder M, Kuwert T, Mackensen A, Schett G.
Pubblicato in: Annals of Rheumatic Disease, 2023, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/ard-2023-223952

Secukinumab leads to shifts from stage-based towards response-based disease clusters—comparative data from very early and established psoriatic arthritis

Autori: Eleni Kampylafka, Koray Tascilar, Veronika Lerchen, Christina Linz, Maria Sokolova, Ana Zekovic, Arnd Kleyer, David Simon, Jürgen Rech, Michael Sticherling, Georg Schett, Axel J. Hueber
Pubblicato in: Arthritis Research & Therapy, Numero 22/1, 2020, ISSN 1478-6362
Editore: BMC part of Springer Nature SharedIt
DOI: 10.1186/s13075-020-02268-y

Autori: Anna‐Maria Liphardt, Eva Manger, Sonja Liehr, Lisa Bieniek, Arnd Kleyer, David Simon, Koray Tascilar, Michael Sticherling, Jürgen Rech, Georg Schett, Axel J. Hueber
Pubblicato in: ACR Open Rheumatology, Numero 2/12, 2020, Pagina/e 734-740, ISSN 2578-5745
Editore: Wiley Online Libary
DOI: 10.1002/acr2.11196

Additional file 5 of A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Autori: Sokolova, Maria; Simon, David; Nas, Kemal; Zaiss, Mario; Yubin Luo; Zhao, Yi; JÃ¼rgen Rech; Schett, Georg
Pubblicato in: Arthritis Research & Therapy, Numero 2, 2020, Pagina/e 26, ISSN 1478-6354
Editore: BioMed Central
DOI: 10.6084/m9.figshare.11846322.v1

Patients with COVID-19: in the dark-NETs of neutrophils.

Autori: Ackermann M, Anders HJ, Bilyy R, Bowlin GL, Daniel C, De Lorenzo R, Egeblad M, Henneck T, Hidalgo A, Hoffmann M, Hohberger B, Kanthi Y, Kaplan MJ, Knight JS, Knopf J, Kolaczkowska E, Kubes P, Leppkes M, Mahajan A, Manfredi AA, Maueröder C, Maugeri N, Mitroulis I, Muñoz LE, Narasaraju T, Naschberger E, Neeli I, Ng LG, Radic MZ, Ritis K, Rovere-Querini P, Schapher M, Schauer C, Simon HU, Singh J,
Pubblicato in: Cell Death Differ, Numero 28(11), 2021, Pagina/e 3125-3139, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-021-00805-z

Chronic Systemic Infection of Mice with Leishmania infantum Leads to Increased Bone Mass.

Autori: Lai C, Heinemann J, Schleicher U, Schett G, Bogdan C, Bozec A, Soulat D.
Pubblicato in: Journal of Bone Mineral Research, 2023, ISSN 0884-0431
Editore: American Society for Bone and Mineral Research
DOI: 10.1002/jbmr.4733

Epithelial HIF2α expression induces intestinal barrier dysfunction and exacerbation of arthritis.

Autori: Wen J, Lyu P, Stolzer I, Xu J, Gießl A, Lin Z, Andreev D, Kachler K, Song R, Meng X, Cao S, Guggino G, Ciccia F, Günther C, Schett G, Bozec A.
Pubblicato in: Annals of Rheumatic Disease, 2022, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-222035

A network of trans-cortical capillaries as mainstay for blood circulation in long bones

Autori: Anika Grüneboom, Ibrahim Hawwari, Daniela Weidner, Stephan Culemann, Sylvia Müller, Sophie Henneberg, Alexandra Brenzel, Simon Merz, Lea Bornemann, Kristina Zec, Manuela Wuelling, Lasse Kling, Mike Hasenberg, Sylvia Voortmann, Stefanie Lang, Wolfgang Baum, Alexandra Ohs, Oliver Kraff, Harald H. Quick, Marcus Jäger, Stefan Landgraeber, Marcel Dudda, Renzo Danuser, Jens V. Stein, Manfred Rohde, K
Pubblicato in: Nature Metabolism, Numero 1/2, 2019, Pagina/e 236-250, ISSN 2522-5812
Editore: Nature Research
DOI: 10.1038/s42255-018-0016-5

Increased Type H Blood Vessels Precedes Pathological Osteogenesis And Inflammation In Experimental Spondyloarthritis.

Autori: Kaaij MH, van Hamburg JP, van Rooijen CCN, Grüneboom A, Kan YY, Pots D, Schett G, van Ruijven LJ, van Duivenvoorde LM, Huitema LFA, Baeten DLP, Tas SW.
Pubblicato in: Arthritis Rheumatology, 2023, ISSN 2326-5205
Editore: Wiley-Blackwell
DOI: 10.1002/art.42449

Performance of a Handheld Ultrasound Device to Assess Articular and Periarticular Pathologies in Patients with Inflammatory Arthritis.

Autori: Corte G, Bayat S, Tascilar K, Valor-Mendez L, Schuster L, Knitza J, Fagni F, Schett G, Kleyer A, Simon D.
Pubblicato in: Diagnostics, Numero 11(7), 2021, Pagina/e 1139, ISSN 2075-4418
Editore: MDPI AG, 2011
DOI: 10.3390/diagnostics11071139

Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis

Autori: Jule Taubmann, Brenda Krishnacoumar, Christina Böhm, Maria Faas, Dorothea I. H. Müller, Susanne Adam, Cornelia Stoll, Martin Böttcher, Dimitrios Mougiakakos, Uwe Sonnewald, Jörg Hofmann, Georg Schett, Gerhard Krönke, Carina Scholtysek
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-77892-4

Technical Note: PYRO‐NN: Python reconstruction operators in neural networks

Autori: Christopher Syben, Markus Michen, Bernhard Stimpel, Stephan Seitz, Stefan Ploner, Andreas K. Maier
Pubblicato in: Medical Physics, Numero 46/11, 2019, Pagina/e 5110-5115, ISSN 0094-2405
Editore: American Association of Physicists in Medicine
DOI: 10.1002/mp.13753

Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis

Autori: Darja Andreev, Mengdan Liu, Katerina Kachler, Mireia Llerins Perez, Philipp Kirchner, Julia Kölle, Andreas Gießl, Simon Rauber, Rui Song, Oliver Aust, Anika Grüneboom, Arnd Kleyer, Juan D Cañete, Arif Ekici, Andreas Ramming, Susetta Finotto, Georg Schett, Aline Bozec
Pubblicato in: Annals of the Rheumatic Diseases, Numero 80/4, 2021, Pagina/e 451-468, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-218902

Butyrophilin 2a2 (Btn2a2) expression on thymic epithelial cells promotes central T cell tolerance and prevents autoimmune disease.

Autori: Frech M, Danzer H, Uchil P, Azizov V, Schmid E, Schälter F, Dürholz K, Mauro D, Rauber S, Muñoz L, Taher L, Ciccia F, Schober K, Irla M, Sarter K, Schett G, Zaiss MM.
Pubblicato in: Journal of Autoimmunity, 2021, ISSN 0896-8411
Editore: Academic Press
DOI: 10.1016/j.jaut.2023.103071

The Transcription Factor FRA-1/AP-1 Controls Lipocalin-2 Expression and Inflammation in Sepsis Model.

Autori: Cao S, Schnelzer A, Hannemann N, Schett G, Soulat D, Bozec A.
Pubblicato in: Frontiers of Immunology, Numero 12, 2021, Pagina/e 701675, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.701675

Why remission is not enough: underlying disease mechanisms in RA that prevent cure

Autori: Georg Schett, Yoshiya Tanaka, John D. Isaacs
Pubblicato in: Nature Reviews Rheumatology, Numero 17/3, 2021, Pagina/e 135-144, ISSN 1759-4790
Editore: Nature Publishing Group
DOI: 10.1038/s41584-020-00543-5

Non-invasive metabolic profiling of inflammation in joints and entheses by multispectral optoacoustic tomography.

Autori: Tascilar K, Fagni F, Kleyer A, Bayat S, Heidemann R, Steiger F, Krönke G, Bohr D, Ramming A, Hartmann F, Klett D, Federle A, Regensburger AP, Wagner AL, Knieling F, Neurath MF, Schett G, Waldner M, Simon D.
Pubblicato in: Rheumatology, 2023, ISSN 1462-0324
Editore: Oxford University Press
DOI: 10.1093/rheumatology/keac346

DL-based inpainting for metal artifact reduction for cone beam CT using metal path length information

Autori: Tristan M. Gottschalk, Andreas Maier, Florian Kordon, Björn W. Kreher
Pubblicato in: Medical Physics, 2022, ISSN 2473-4209
Editore: Wiley
DOI: 10.1002/mp.15909

Humoral and Cellular Immune Responses to SARS-CoV-2 Infection and Vaccination in Autoimmune Disease Patients With B Cell Depletion.

Autori: Simon D, Tascilar K, Schmidt K, Manger B, Weckwerth L, Sokolova M, Bucci L, Fagni F, Manger K, Schuch F, Ronneberger M, Hueber A, Steffen U, Mielenz D, Herrmann M, Harrer T, Kleyer A, Krönke G, Schett G.
Pubblicato in: Arthritis & Rheumatology, Numero 74(1), 2022, Pagina/e 33-37, ISSN 2326-5191
Editore: John Wiley and Sons Ltd
DOI: 10.1002/art.41914

Aggregated neutrophil extracellular traps occlude Meibomian glands during ocular surface inflammation

Autori: Aparna Mahajan; Lenka Hasíková; Ulrike Hampel; Anika Grüneboom; Xiaomei Shan; Irmgard Herrmann; Fabian Garreis; Felix Bock; Jasmin Knopf; Jeeshan Singh; Christine Schauer; Siddharth Mahajan; Moritz Leppkes; Friedrich Paulsen; Ursula Schlötzer-Schrehardt; Veit Krenn; Anselm Jünemann; Bettina Hohberger; Georg Schett; Martin Herrmann; Luis E. Muñoz
Pubblicato in: Ocular Surface, Numero 2, 2020, Pagina/e 1-12, ISSN 1542-0124
Editore: Ethis Communications
DOI: 10.1016/j.jtos.2020.12.005

Antibodies against citrullinated proteins of IgA isotype are associated with progression to rheumatoid arthritis in individuals at-risk.

Autori: Sokolova MV, Hartmann F, Sieghart D, Bang H, Steiner G, Kleyer A, Schett G, Steffen U
Pubblicato in: Rheumatic & Musculoskeletal Disease Open, 2023, ISSN 2056-5933
Editore: BMJ Publishing Group Ltd
DOI: 10.1136/rmdopen-2022-002705

DeepNAPSI multi-reader nail psoriasis prediction using deep learning.

Autori: Folle L, Fenzl P, Fagni F, Thies M, Christlein V, Meder C, Simon D, Minnopoulou I, Sticherling M, Schett G, Maier A, Kleyer A.
Pubblicato in: Science Report, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-32440-8

Impact of cytokine inhibitor therapy on the prevalence, seroconversion rate and longevity of the humoral immune response against SARS-CoV-2 in an unvaccinated cohort.

Autori: Simon D, Tascilar K, Kleyer A, Fagni F, Krönke G, Meder C, Dietrich P, Orlemann T, Kliem T, Mößner J, Liphardt AM, Schönau V, Bohr D, Schuster L, Hartmann F, Leppkes M, Ramming A, Pachowsky M, Schuch F, Ronneberger M, Kleinert S, Hueber AJ, Manger K, Manger B, Atreya R, Berking C, Sticherling M, Neurath MF, Schett G.
Pubblicato in: Athritis & Rheumatology, Numero 74(5), 2022, Pagina/e 783-790, ISSN 2326-5205
Editore: John Wiley and Sons Ltd
DOI: 10.1002/art.42035

Is Medical Chest X-ray Data Anonymous?

Autori: Packhäuser, Kai; Gündel, Sebastian; Münster, Nicolas; Syben, Christopher; Christlein, Vincent; Maier, Andreas
Pubblicato in: arxiv.org, Numero 1, 2021, ISSN 2331-8422
Editore: Cornell University

RETRO study group. Advanced machine learning for predicting individual risk of flares in rheumatoid arthritis patients tapering biologic drugs.

Autori: Vodencarevic A, Tascilar K, Hartmann F, Reiser M, Hueber AJ, Haschka J, Bayat S, Meinderink T, Knitza J, Mendez L, Hagen M, Krönke G, Rech J, Manger B, Kleyer A, Zimmermann-Rittereiser M, Schett G, Simon D.
Pubblicato in: Arthritis Research & Therapy, Numero 23(1), 2021, Pagina/e 67, ISSN 1478-6362
Editore: BioMed Central
DOI: 10.1186/s13075-021-02439-5

Synthetic Image Rendering Solves Annotation Problem in Deep Learning Nanoparticle Segmentation

Autori: Leonid Mill, David Wolff, Nele Gerrits, Patrick Philipp, Lasse Kling, Florian Vollnhals, Andrew Ignatenko, Christian Jaremenko, Yixing Huang, Olivier De Castro, Jean‐Nicolas Audinot, Inge Nelissen, Tom Wirtz, Andreas Maier, Silke Christiansen
Pubblicato in: Small Methods, 2021, Pagina/e 2100223, ISSN 2366-9608
Editore: Wiley
DOI: 10.1002/smtd.202100223

Precision of handheld multispectral optoacoustic tomography for muscle imaging

Autori: Alexandra L. Wagner, Vera Danko, Anna Federle, Daniel Klett, David Simon, Rafael Heiss, Jörg Jüngert, Michael Uder, Georg Schett, Markus F. Neurath, Joachim Woelfle, Maximilian J. Waldner, Regina Trollmann, Adrian P. Regensburger, Ferdinand Knieling
Pubblicato in: Photoacoustics, Numero In Press, Journal Pre-proof, 2020, Pagina/e 100220, ISSN 2213-5979
Editore: Elsevier GmbH
DOI: 10.1016/j.pacs.2020.100220

Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis

Autori: Andreev D, Liu M, Kachler K, Llerins Perez M, Kirchner P, Kölle J, Gießl A, Rauber S, Song R, Aust O, Grüneboom A, Kleyer A, Cañete JD, Ekici A, Ramming A, Finotto S, Schett G, Bozec A.
Pubblicato in: Annals of Rheumatic Diseases, Numero 80, 2021, Pagina/e 451-468, ISSN 1468-2060
Editore: BMJ
DOI: 10.1136/annrheumdis-2020-218902

Microbiota and metabolites in rheumatic diseases.

Autori: Tong Y, Marion T, Schett G, Luo Y, Liu Y.
Pubblicato in: Autoimmunity Reviews, Numero Volume 19, Numero 8, 2020, Pagina/e 102530, ISSN 1568-9972
Editore: Elsevier BV
DOI: 10.1016/j.autrev.2020.102530

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

Autori: Jasna Friščić, Martin Böttcher, Christiane Reinwald, Heiko Bruns, Benjamin Wirth, Samantha-Josefine Popp, Kellie Irene Walker, Jochen A. Ackermann, Xi Chen, Jason Turner, Honglin Zhu, Lisa Seyler, Maximilien Euler, Philipp Kirchner, René Krüger, Arif B. Ekici, Triin Major, Oliver Aust, Daniela Weidner, Anita Fischer, Fabian T. Andes, Zeljka Stanojevic, Vladimir Trajkovic, Martin Herrmann, Ad
Pubblicato in: Immunity, Numero 54/5, 2021, Pagina/e 1002-1021.e10, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2021.03.003

Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease: a prospective cohort study.

Autori: Simon D, Tascilar K, Fagni F, Kleyer A, Krönke G, Meder C, Dietrich P, Orlemann T, Mößner J, Taubmann J, Mutlu MY, Knitza J, Kemenes S, Liphardt AM, Schönau V, Bohr D, Schuster L, Hartmann F, Minopoulou I, Leppkes M, Ramming A, Pachowsky M, Schuch F, Ronneberger M, Kleinert S, Hueber AJ, Manger K, Manger B, Atreya R, Berking C, Sticherling M, Neurath MF, Schett G.
Pubblicato in: The Lancet Rheumatology, 2022, ISSN 2665-9913
Editore: Elsevier
DOI: 10.1016/s2665-9913(22)00191-6

Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin

Autori: Darja Andreev, Mengdan Liu, Daniela Weidner, Katerina Kachler, Maria Faas, Anika Grüneboom, Ursula Schlötzer-Schrehardt, Luis E. Muñoz, Ulrike Steffen, Bettina Grötsch, Barbara Killy, Gerhard Krönke, Andreas M. Luebke, Andreas Niemeier, Falk Wehrhan, Roland Lang, Georg Schett, Aline Bozec
Pubblicato in: Journal of Clinical Investigation, Numero 130/9, 2020, Pagina/e 4811-4830, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci134214

Assessment of myocardial fibrosis in patients with systemic sclerosis using [68Ga]Ga‑FAPI‑04‑PET‑CT

Autori: Treutlein C, Distler JHW, Tascilar K, Fakhouri SC, Györfi AH, Atzinger A, Matei AE, Dees C, Büttner-Herold M, Kuwert T, Prante O, Bäuerle T, Uder M, Schett G, Schmidkonz C, Bergmann C.
Pubblicato in: European Journal of Nuclear Medicine and Molecular Imaging, 2022, ISSN 1619-7070
Editore: Springer Verlag
DOI: 10.1007/s00259-022-06081-4

Calibration by differentiation – Self‐supervised calibration for X‐ray microscopy using a differentiable cone‐beam reconstruction operator

Autori: Mareike Thies; Fabian Wagner; Yixing Huang; Mingxuan Gu; Lasse Kling; Sabrina Pechmann; Oliver Aust; Anika Grüneboom; Georg Schett; Silke Christiansen; Andreas Maier
Pubblicato in: Crossref, Numero 3, 2022, ISSN 0022-2720
Editore: Blackwell Publishing Inc.
DOI: 10.17169/refubium-36666

Advanced machine learning for predicting individual risk of flares in rheumatoid arthritis patients tapering biologic drugs

Autori: Asmir Vodencarevic, Koray Tascilar, Fabian Hartmann, Michaela Reiser, Axel J. Hueber, Judith Haschka, Sara Bayat, Timo Meinderink, Johannes Knitza, Larissa Mendez, Melanie Hagen, Gerhard Krönke, Jürgen Rech, Bernhard Manger, Arnd Kleyer, Marcus Zimmermann-Rittereiser, Georg Schett, David Simon
Pubblicato in: Arthritis Research & Therapy, Numero 23/1, 2021, ISSN 1478-6362
Editore: BMC Part of Springer nature
DOI: 10.1186/s13075-021-02439-5

Additional file 4 of A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Autori: Sokolova, Maria; Simon, David; Nas, Kemal; Zaiss, Mario; Yubin Luo; Zhao, Yi; JÃ¼rgen Rech; Schett, Georg
Pubblicato in: Arthritis Research & Therapy, Numero 22, 2020, Pagina/e 26, ISSN 1478-6354
Editore: BioMed Central
DOI: 10.6084/m9.figshare.11846319

Trainable Joint Bilateral Filters for Enhanced Prediction Stability in Low-dose CT

Autori: Wagner, Fabian; Thies, Mareike; Denzinger, Felix; Gu, Mingxuan; Patwari, Mayank; Ploner, Stefan; Maul, Noah; Pfaff, Laura; Huang, Yixing; Maier, Andreas
Pubblicato in: Crossref, Numero 3, 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-22530-4

The gut-bone axis: how bacterial metabolites bridge the distance

Autori: Mario M. Zaiss, Rheinallt M. Jones, Georg Schett, Roberto Pacifici
Pubblicato in: Journal of Clinical Investigation, Numero 129/8, 2019, Pagina/e 3018-3028, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci128521

Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes

Autori: Grüneboom A, Uderhardt S, Schett G
Pubblicato in: Journal of Experimental Medicine, 2023, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20220525

Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus.

Autori: Mackensen A, Müller F, Mougiakakos D, Böltz S, Wilhelm A, Aigner M, Völkl S, Simon D, Kleyer A, Munoz L, Kretschmann S, Kharboutli S, Gary R, Reimann H, Rösler W, Uderhardt S, Bang H, Herrmann M, Ekici AB, Buettner C, Habenicht KM, Winkler TH, Krönke G, Schett G.
Pubblicato in: Nature Medicine, 2022, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-022-02017-5

The ageing joint-standard age- and sex-related values of bone erosions and osteophytes in the hand joints of healthy individuals

Autori: A. Berlin, D. Simon, K. Tascilar, C. Figueiredo, S. Bayat, S. Finzel, E. Klaus, J. Rech, A.J. Hueber, A. Kleyer, G. Schett
Pubblicato in: Osteoarthritis and Cartilage, Numero 27/7, 2019, Pagina/e 1043-1047, ISSN 1063-4584
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2019.01.019

JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function

Autori: Susanne Adam, Nils Simon, Ulrike Steffen, Fabian T. Andes, Carina Scholtysek, Dorothea I. H. Müller, Daniela Weidner, Darja Andreev, Arnd Kleyer, Stephan Culemann, Madelaine Hahn, Georg Schett, Gerhard Krönke, Silke Frey, Axel J. Hueber
Pubblicato in: Science Translational Medicine, Numero 12/530, 2020, Pagina/e eaay4447, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aay4447

Limited angle tomography for transmission X-ray microscopy using deep learning.

Autori: Yixing Huang; Shengxiang Wang; Yong Guan; Andreas Maier
Pubblicato in: Journal of Synchrotron Radiation, Numero 2, 2020, Pagina/e 477-485, ISSN 1600-5775
Editore: Wiley
DOI: 10.1107/S160057752000017X

Systemic PPARγ Antagonism Reduces Metastatic Tumor Progression in Adipocyte-Rich Bone in Excess Weight Male Rodents.

Autori: Gaculenko A, Gregoric G, Popp V, Seyler L, Ringer M, Kachler K, Wu Z, Kisel W, Hofbauer C, Hofbauer LC, Uder M, Schett G, Bäuerle T, Bozec A.
Pubblicato in: Journal of Bone and Mineral Research, Numero 36(12), 2021, Pagina/e 2440-2452, ISSN 0884-0431
Editore: American Society for Bone and Mineral Research
DOI: 10.1002/jbmr.4422

Known operator learning and hybrid machine learning in medical imaging—a review of the past, the present, and the future

Autori: Andreas Maier, Harald Köstler, Marco Heisig, Patrick Krauss, Seung Hee Yang
Pubblicato in: Progress in Biomedical Engineering, Numero 4/2, 2022, ISSN 2516-1091
Editore: IOP Publishing
DOI: 10.1088/2516-1091/ac5b13

Double-Sided Graphene-Enhanced Raman Scattering and Fluorescence Quenching in Hybrid Biological Structures

Autori: George Sarau; George Sarau; Christoph Daniel; Martin Heilmann; Gerd Leuchs; Kerstin Amann; Silke Christiansen
Pubblicato in: Advanced Materials Technologies, Numero 6(9), 2021, Pagina/e pp, ISSN 2365-709X
Editore: Wiley-Blackwell
DOI: 10.1002/admt.202100385

Efficacy and safety of SARS-CoV-2 revaccination in non-responders with immune-mediated inflammatory disease.

Autori: Simon D, Tascilar K, Fagni F, Schmidt K, Krönke G, Kleyer A, Ramming A, Schoenau V, Bohr D, Knitza J, Harrer T, Manger K, Manger B, Schett G.
Pubblicato in: Annal of the Rheumatic Diseases, Numero 36(12), 2021, Pagina/e 2440-2452, ISSN 1468-2060
Editore: J Bone Miner Res.
DOI: 10.1136/annrheumdis-2021-221554

Rheumatic?-A Digital Diagnostic Decision Support Tool for Individuals Suspecting Rheumatic Diseases: A Multicenter Pilot Validation Study.

Autori: Knevel R, Knitza J, Hensvold A, Circiumaru A, Bruce T, Evans S, Maarseveen T, Maurits M, Beaart-van de Voorde L, Simon D, Kleyer A, Johannesson M, Schett G, Huizinga T, Svanteson S, Lindfors A, Klareskog L, Catrina A.
Pubblicato in: Frontier Medicine, 2022, ISSN 2095-0225
Editore: Frontier Media SA
DOI: 10.3389/fmed.2022.774945

Methotrexate hampers immunogenicity to BNT162b2 mRNA COVID-19 vaccine in immune-mediated inflammatory disease.

Autori: Haberman RH, Herati R, Simon D, Samanovic M, Blank RB, Tuen M, Koralov SB, Atreya R, Tascilar K, Allen JR, Castillo R, Cornelius AR, Rackoff P, Solomon G, Adhikari S, Azar N, Rosenthal P, Izmirly P, Samuels J, Golden B, Reddy SM, Neurath MF, Abramson SB, Schett G, Mulligan MJ, Scher JU.
Pubblicato in: Annal of the Rheumatic Diseases, Numero 80(10), 2021, Pagina/e 1339-1344, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220597

Will We Ever Have Conscious Machines?

Autori: Patrick Krauss, Andreas Maier
Pubblicato in: Frontiers in Computational Neuroscience, Numero 14, 2020, ISSN 1662-5188
Editore: Frontiers Research Foundation
DOI: 10.3389/fncom.2020.556544

Efficacy and drug persistence of baricitinib monotherapy is similar to combination therapy in patients with active RA: a prospective observational study.

Autori: Bayat S, Tascilar K, Bohr D, Krönke G, Simon D, Knitza J, Hartmann F, Schett G, Kleyer A.
Pubblicato in: Rheumatic & Musculoskeletal Disease Open, 2022, ISSN 2056-5933
Editore: BMJ Publishing Group Ltd
DOI: 10.1136/rmdopen-2022-002674

Mobile Health Usage, Preferences, Barriers, and eHealth Literacy in Rheumatology: Patient Survey Study

Autori: Johannes Knitza, David Simon, Antonia Lambrecht, Christina Raab, Koray Tascilar, Melanie Hagen, Arnd Kleyer, Sara Bayat, Adrian Derungs, Oliver Amft, Georg Schett, Axel J Hueber
Pubblicato in: JMIR mHealth and uHealth, Numero 8/8, 2020, Pagina/e e19661, ISSN 2291-5222
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The Potential of OMICs Technologies for the Treatment of Immune-Mediated Inflammatory Diseases

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Bone Mass, Bone Microstructure and Biomechanics in Patients with Hand Osteoarthritis

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Micro-structural bone changes are associated with broad-spectrum autoimmunity and predict the onset of rheumatoid arthritis.

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Learning with Known Operators reduces Maximum Training Error Bounds

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IgA2 Antibodies against SARS-CoV-2 Correlate with NET Formation and Fatal Outcome in Severely Diseased COVID-19 Patients

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Why remission is not enough: underlying disease mechanisms in RA that prevent cure.

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Deep learning-based patient re-identification is able to exploit the biometric nature of medical chest X-ray data

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AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9.

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SARS-CoV-2 vaccination responses in untreated, conventionally treated and anticytokine-treated patients with immune-mediated inflammatory diseases

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Structural entheseal lesions in patients with psoriasis are associated with an increased risk of progression to psoriatic arthritis

Autori: David Simon, Koray Tascilar, Arnd Kleyer, Sara Bayat, Eleni Kampylafka, Maria Sokolova, Ana Zekovic, Axel J Hueber, Jürgen Rech, Louis Schuster, Klaus Engel, Michael Sticherling, Georg Schett
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A Detailed Analysis of the Association between Urate Deposition and Erosions and Osteophytes in Gout

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Effect of disease-modifying anti-rheumatic drugs on bone structure and strength in psoriatic arthritis patients

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IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation.

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Murine Metatarsus Bone and Joint Collagen-I Fiber Morphologies and Networks Studied With SHG Multiphoton Imaging.

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Biomechanical stress in the context of competitive sports training triggers enthesitis.

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Successful Generation of CD19 Chimeric Antigen Receptor T Cells from Patients with Advanced Systemic Lupus Erythematosus.

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“Keep it simple, scholar”: an experimental analysis of few-parameter segmentation networks for retinal vessels in fundus imaging

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Inflammatory activation of the FcγR and IFNγR pathways co-influences the differentiation and activity of osteoclasts.

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Complexes Induce Neutrophil Extracellular Trap Formation More Potently Than IgG Complexes.

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A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19

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Deep Learning-Based Classification of Inflammatory Arthritis by Identification of Joint Shape Patterns—How Neural Networks Can Tell Us Where to “Deep Dive” Clinically

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Additional file 3 of A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

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Next-generation imaging of the skeletal system and its blood supply

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PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass

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Deep learning for terahertz image denoising in nondestructive historical document analysis

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COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses.

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Does methotrexate influence COVID-19 infection? Case series and mechanistic data.

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A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Autori: Maria V. Sokolova, David Simon, Kemal Nas, Mario M. Zaiss, Yubin Luo, Yi Zhao, Jürgen Rech, Georg Schett
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Microbiota-Derived Propionate Modulates Megakaryopoiesis and Platelet Function.

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The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption.

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Learned cone-beam CT reconstruction using neural ordinary differential equations

Autori: Mareike Thies, Fabian Wagner, Mingxuan Gu, Lukas Folle, Lina Felsner, Andreas Maier
Pubblicato in: Proceedings 7th International Conference on Image Formation in X-Ray Computed Tomography, Numero Volume 12304, 2022
Editore: SPIE
DOI: 10.1117/12.2646442

On the Benefit of Dual-Domain Denoising in a Self-Supervised Low-Dose CT Setting

Autori: Fabian Wagner; Mareike Thies; Laura Pfaff; Oliver Aust; Sabrina Pechmann; Daniela Weidner; Noah Maul; Maximilian Rohleder; Mingxuan Gu; Jonas Utz; Felix Denzinger; Andreas Maier
Pubblicato in: 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI), 2023
Editore: IEEE
DOI: 10.1109/isbi53787.2023.10230511

Cavity Segmentation in X-ray Microscopy Scans of Mouse Tibiae

Autori: Mingxuan Gu, Mareike Thies, Fabian Wagner, Sabrina Pechmann, Oliver Aust, Daniela Weidner, Georgiana Neag, Zhaoya Pan, Jonas Utz, Georg Schett, Silke Christiansen, Stefan Uderhardt, Andreas Maier
Pubblicato in: Bildverarbeitung für die Medizin 2023, 2023
Editore: Springer
DOI: 10.1007/978-3-658-41657-7_56

Noise2Contrast: Multi-contrast Fusion Enables Self-supervised Tomographic Image Denoising

Autori: Fabian Wagner, Mareike Thies, Laura Pfaff, Noah Maul, Sabrina Pechmann, Mingxuan Gu, Jonas Utz, Oliver Aust, Daniela Weidner, Georgiana Neag, Stefan Uderhardt, Jang-Hwan Choi, Andreas Maier
Pubblicato in: Information Processing in Medical Imaging 2023, 2023
Editore: Springer
DOI: 10.1007/978-3-031-34048-2_59

Robust Multi-Contrast Mri Denoising Using Trainable Bilateral Filters Without Noise-Free Targets

Autori: Laura Pfaff; Fabian Wagner; Julian Hossbach; Elisabeth Preuhs; Noah Maul; Mareike Thies; Felix Denzinger; Dominik Nickel; Tobias Wuerfl; Andreas Maier
Pubblicato in: 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI), 2023
Editore: IEEE
DOI: 10.1109/isbi53787.2023.10230627

Deep Learning-Based Anonymization of Chest Radiographs: A Utility-Preserving Measure for Patient Privacy

Autori: Kai Packhäuser, Sebastian Gündel, Florian Thamm, Felix Denzinger, Andreas Maier
Pubblicato in: Medical Image Computing and Computer Assisted Intervention – MICCAI 2023, 2023
Editore: Springer
DOI: 10.1007/978-3-031-43898-1_26

Geometric Constraints Enable Self-Supervised Sinogram Inpainting in Sparse-View Tomography

Autori: Fabian Wagner, Mareike Thies, Noah Maul, Laura Pfaff, Oliver Aust, Sabrina Pechmann, Christopher Syben, Andreas Maier
Pubblicato in: 17th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine (Fully3D), 2023
Editore: Fully3d

Focus on Content not Noise: Improving Image Generation for Nuclei Segmentation by Suppressing Steganography in CycleGAN

Autori: Jonas Utz, Tobias Weise, Maja Schlereth, Fabian Wagner, Mareike Thies, Mingxuan Gu, Stefan Uderhardt, Katharina Breininger
Pubblicato in: Proceedings of the IEEE/CVF International Conference on Computer Vision (ICCV) Workshops, 2023
Editore: CVF

Generation of Anonymous Chest Radiographs Using Latent Diffusion Models for Training Thoracic Abnormality Classification Systems

Autori: Kai Packhäuser; Lukas Folle; Florian Thamm; Andreas Maier
Pubblicato in: 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI), 2023
Editore: IEEE
DOI: 10.1109/isbi53787.2023.10230346

Optimizing CT Scan Geometries With and Without Gradients

Autori: Mareike Thies, Fabian Wagner, Noah Maul, Laura Pfaff, Linda-Sophie Schneider, Christopher Syben, Andreas Maier
Pubblicato in: 17th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine (Fully3D), 2023
Editore: Fully3d

Lesson Learnt: Modularization of Deep Networks Allow Cross-Modality Reuse

Autori: Fu, Weilin; Husvogt, Lennart; Maier, Stefan Ploner James G. Fujimoto Andreas
Pubblicato in: Bildverarbeitung für die Medizin 2020. Informatik aktuell., Numero 2, 2020, Pagina/e 274-279
Editore: Springer Vieweg
DOI: 10.1007/978-3-658-29267-6

Bildverarbeitung für die Medizin 2021 - Proceedings, German Workshop on Medical Image Computing, Regensburg, March 7-9, 2021

Autori: Yixing Huang, Leonid Mill, Robert Stoll, Lasse Kling, Oliver Aust, Fabian Wagner, Anika Gruneboom, Georg Schett, Silke Christiansen, Andreas Maier
Pubblicato in: Semi-permeable Filters for Interior Region of InterestDose Reduction in X-ray Microscopy, 2021, Pagina/e 61-66, ISBN 978-3-658-33198-6
Editore: Springer Fachmedien Wiesbaden GmbH
DOI: 10.1007/978-3-658-33198-6

Monte Carlo Dose Simulation for In-Vivo X-Ray Nanoscopy

Autori: Fabian Wagner, Mareike Thies, Marek Karolczak, Sabrina Pechmann, Yixing Huang, Mingxuan Gu, Lasse Kling, Daniela Weidner, Oliver Aust, Georg Schett, Silke Christiansen, Andreas Maier
Pubblicato in: Bildverarbeitung für die Medizin, 2022
Editore: Springer
DOI: 10.1007/978-3-658-36932-3_22

Towards In-Vivo X-Ray Nanoscopy - Acquisition Parameters vs. Image Quality

Autori: Leonid Mill, Lasse Kling, Anika Grüneboom, Georg Schett, Silke Christiansen, Andreas Maier
Pubblicato in: Bildverarbeitung für die Medizin 2019 - Algorithmen – Systeme – Anwendungen. Proceedings des Workshops vom 17. bis 19. März 2019 in Lübeck, 2019, Pagina/e 251-256, ISBN 978-3-658-25325-7
Editore: Springer Fachmedien Wiesbaden
DOI: 10.1007/978-3-658-25326-4_56

Towards In-Vivo X-Ray Nanoscopy - The Effect of Motion on Image Quality

Autori: Leonid Mill, Bastian Bier, Christopher Syben, Lasse Kling, Anika Klingberg, Silke Christiansen, Georg Schett, Andreas Maier
Pubblicato in: Bildverarbeitung für die Medizin 2018 - Algorithmen - Systeme - Anwendungen. Proceedings des Workshops vom 11. bis 13. März 2018 in Erlangen, 2018, Pagina/e 115-120, ISBN 978-3-662-56536-0
Editore: Springer Berlin Heidelberg
DOI: 10.1007/978-3-662-56537-7_40

Degenerating U-Net on Retinal Vessel Segmentation - What Do We Really Need?

Autori: Weilin Fu, Katharina Breininger, Zhaoya Pan, Andreas Maier
Pubblicato in: Bildverarbeitung für die Medizin 2020 - Algorithmen – Systeme – Anwendungen. Proceedings des Workshops vom 15. bis 17. März 2020 in Berlin, 2020, Pagina/e 33-38, ISBN 978-3-658-29266-9
Editore: Springer Fachmedien Wiesbaden
DOI: 10.1007/978-3-658-29267-6_7

Few-shot Unsupervised Domain Adaptation for Multi-modal Cardiac Image Segmentation

Autori: Mingxuan Gu, Sulaiman Vesal, Ronak Kosti, Andreas Maier
Pubblicato in: Bildverarbeitung für die Medizin, 2022
Editore: Springer
DOI: 10.1007/978-3-658-36932-3_5

Towards Mouse Bone X-ray Microscopy Scan Simulation

Autori: Weilin Fu, Leonid Mill, Stephan Seitz, Tobias Geimer, Lasse Kling, Dennis Possart, Silke Christiansen, Andreas Maier
Pubblicato in: Bildverarbeitung für die Medizin 2021 - Proceedings, German Workshop on Medical Image Computing, Regensburg, March 7-9, 2021, 2021, Pagina/e 128-133, ISBN 978-3-658-33197-9
Editore: Springer Fachmedien Wiesbaden
DOI: 10.1007/978-3-658-33198-6_32

Degenerating U-Net on Retinal Vessel Segmentation

Autori: Fu, Weilin; Breininger, Katharina; Pan, Zhaoya; Maier, Andreas
Pubblicato in: Informatik aktuell, Numero 1, 2020, Pagina/e 33-38, ISBN 978-3-658-29266-6
Editore: Springer Vieweg
DOI: 10.1007/978-3-658-29266-6

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