Project description
Reinforcing Portuguese research into novel antibiotic alternatives
Antimicrobial resistance poses a serious medical threat worldwide rendering current antibiotics ineffective. Nucleic acid mimics (NAMs) represent a promising alternative to the search for new antibiotics. NAMs can be tailored against key bacterial genes, kill bacteria or restore their susceptibility to antibiotics. The aim of the EU-funded DelNAM project is to strengthen the infrastructure of the Faculty of Engineering of the University of Porto in Portugal with regards to NAMs development and nanodelivery strategies. By twinning the Faculty with EU institutions, DelNAM aims to improve the delivery strategies of NAMs across the bacterial envelope. At the same time, it will raise awareness about the problem of antimicrobial resistance.
Objective
DelNAM aims at Strengthening the Research Area of Delivery of Nucleic Acid Mimics (NAMS) into bacteria to fight the antibiotic crisis. This will be achieved by twinning the Faculty of Engineering of the University of Porto (FEUP) with outstanding EU institutions with high expertise in the areas of NAMs development and nanodelivery strategies. DelNAM will allow the development of a consolidated strategic research approach and a set of guidelines for exploitation and commercialization of the results that will have a strong regional, national and European impact. The proposal integrates synergies in complementary fields of research that include nanotechnology, synthetic chemistry, microbiology and bioprocess modelling, aiming to obtain scientific breakthroughs that can improve the global health and economy.
The objectives of this proposal are in line with the specific challenge and scope of the topic H2020-WIDESPREAD-2016-2017 of the Twinning call, addressing networking gaps and deficiencies between the research institutions of the Widening countries and internationally-leading counterparts at EU level. This challenge is addressed by twinning FEUP with 2 leading EU research institutions: University of Southern Denmark (SDU), in Odense, Denmark, a global leader in the development and invention of novel NAMs for gene therapy. They contribute with their extensive experience on the synthesis, structural studies and molecular modelling of NAMs; Ghent University (UGhent), in Belgium, an internationally-recognized laboratory for its excellence in the field of nanomedicines for the delivery of drugs and, in particular, nucleic acids. They provide decisive expertise on the design of delivery systems for nucleic acids and their behavior in native biological fluids.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules nucleic acids
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.4.b. - Twinning of research institutions
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
CSA - Coordination and support action
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-WIDESPREAD-2016-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
4099-002 PORTO
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.