Strengthening the Research Area of Delivery of Nucleic acid mimics (NAMS) into bacteria to fight the antibiotic crisis

Deliverables

Communication Final Report and evaluation

Final report about the communication and dissemination strategy adopted and the respective evaluation

Delivery of the report about the mentoring programme

Annual report on high impact publications

At the end of each period a report will be delivered regarding the high impact publications from the project 12 24 and 42nd month

Final Evaluation Report of Benchmarking Visits

Final report regarding he benchmark visits will be delivered

Final Staff Exchanges report including evaluation

Report about the staff exchange process including final evaluation of the process

Final Training (workshop and summer school) report, including overall evaluation (M42)

Reports of the final evaluation of the workshops and summer schools

Report on Collaboration Agreements and Results

Report of the possible new collaborations agreements between the research and industry

Website and social media sites

Project website and social media will be ready to maximize project visibility.

"International Conference at FEUP, named ""I Drug Delivery in Microbial Cells (DDMiC)"""

Organisation of an international conference related to the main topics of the project in close collaboration with the two twinning partners The conference will last three days and will be conducted on M39

Publications

Liposome-encapsulated Nucleic Acid Mimics (LipoNAMs): a potential novel diagnostic and therapeutic tool

Author(s): Moreira L, Pereira S, Guimarães N, Santos RS, Pereira C, Azevedo NF
Published in: Doctoral Congress in Engineering 2019, 2019
Publisher: Faculty of Engineering, University of Porto

Dendrimer for the delivery of antisense NAMs into bacteria

Author(s): Gomes M, Pereira S, Peng L, Santos RS, Azevedo NF.
Published in: 3rd SPLC-CRS Young Scientists Virtual Meeting, 2021
Publisher: SPLC-CRS

Application of agent-based modelling to simulate ribosome translation

Author(s): Magalhães BT, Santos RS, Lourenço A, Azevedo NF.
Published in: Doctoral Congress in Engineering 2021, 2021
Publisher: Faculty of Engineering, University of Porto

Oligonucleotides against bacterial infections: the Delivery Vector’s choice

Author(s): Santos RS
Published in: 13th International Conference and Workshop on Biological Barriers, 2020
Publisher: CRS

Immunoliposomes to Deliver Therapeutic Oligonucleotides in Bacteria.

Author(s): Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF.
Published in: World Microbe Forum 2021, 2021
Publisher: AFM/FEMS

Delivery of oligonucleotides in bacteria by liposomes

Author(s): Santos R, Dakwar G, Zagato E, Brans T, Figueiredo C, Azevedo N, De Smedt SC, Braeckmans K.
Published in: DelNAM Workshop 2, 2019
Publisher: DelNAM

Delivery of nucleic acid mimics into bacteria as novel theranostics of infections

Author(s): Santos RS, Pereira S, Moreira L, Gomes M, Guimarães N, Peng L, De Smedt SC, Braeckmans K, Azevedo N
Published in: 2021 CRS Virtual Annual Meeting, 2021
Publisher: CRS

Nucleic Acid Mimics As Alternatives To Small-molecule Antibiotics: The Delivery Vector's Choice

Author(s): Santos RS.
Published in: World Microbe Forum 2021, 2021
Publisher: ASM/FEMS

Self-assembling dendrimers as NAM delivery systems into bacteria

Author(s): Gomes M, Resende I, Pereira S, Peng L, Santos RS, Azevedo NF
Published in: 1st Drug Delivery in Microbial Cells Conference, 2021
Publisher: DelNAM

Effect of lipid concentration on the delivery efficiency of liposome-encapsulated nucleic acid mimics (LipoNAMs) on Escherichia coli.

Author(s): Moreira L, Pereira S, Guimarães N, Santos RS, Pereira C, Azevedo NF.
Published in: 29th ECCMID, 2019
Publisher: ESCMID

Delivery of nucleic acid mimics (NAMs) by liposomes into Gram-negative and Gram-positive bacteria.

Author(s): Pereira S, Santos RS, Moreira L, Guimarães N, Azevedo NF, Braeckmans K, De Smedt SC.
Published in: 29th ECCMID, 2019
Publisher: ESCMID

Delivery of nucleic acid mimics (NAMs) in bacteria towards fighting antimicrobial resistance.

Author(s): Santos R, Pereira S, De Smedt S, Braeckmans K, Azevedo NF.
Published in: BioNano-20, 2020
Publisher: BioNano-20

DelNAM – fighting the crisis of bacterial resistance to antibiotics.

Author(s): Santos RS, Wengel J, Braeckmans K, De Smedt SC, Azevedo NF.
Published in: NanoMed Europe 2019, 2019
Publisher: ETPN Association

Liposome-encapsulated nucleic acid mimics for the delivery of oligonucleotides into bacteria.

Author(s): Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF.
Published in: 2019 CRS Annual Meeting & Exposition, 2019
Publisher: CRS

Delivery of nucleic acid mimics (NAMs) in bacteria mediated by lipoplexes.

Author(s): Pereira S, Santos RS, Moreira L, Zhang H, Guimarães N, Remaut K, Azevedo NF, Braeckmans K, de Smedt SC.
Published in: XIIIth Spanish-Portuguese Conference on Controlled Drug Delivery, 2020
Publisher: SPLC-CRS

Delivery of nucleic acid mimics to target Helicobacter pylori infections – the effect of biological barriers.

Author(s): Santos RS, Dakwar GR, Zagato E, Brans T, Figueiredo C, Azevedo NF, De Smedt SC, Braeckmans K.
Published in: XIIIth Spanish-Portuguese Conference on Controlled Drug Delivery, 2020
Publisher: SPLC-CRS

Interaction of cationic liposomes with Gram-negative and Gram-positive bacteria.

Author(s): Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF.
Published in: XIIIth Spanish-Portuguese Conference on Controlled Drug Delivery, 2020
Publisher: SPLC-CRS

Immunoliposome for the delivery of therapeutic oligonucleotides into bacteria.

Author(s): Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF.
Published in: ASM Microbe 2020, 2020
Publisher: ASM

Delivery of nucleic acid mimics (NAMs) in bacteria mediated by lipoplexes.

Author(s): Pereira S, Santos RS, Moreira L, Zhang H, Guimarães N, Remaut K, Azevedo NF, Braeckmans K, De Smedt SC.
Published in: ASM Microbe 2020, 2020
Publisher: ASM

Surface-functionalized liposomes to deliver therapeutic nucleic acids in Escherichia coli

Author(s): Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF.
Published in: 32nd ECCMID, 2021
Publisher: ECCMID

Intracellular delivery of nucleic acid mimics in bacteria to treat infections

Author(s): Santos RS
Published in: 3rd SPLC-CRS Young Scientists Virtual Meeting, 2021
Publisher: SPLC-CRS

Interaction of lipoplexes with Gram-negative and Gram-positive bacteria: Towards delivery of nucleic acid mimics (NAMs)

Author(s): Pereira S, Santos RS, Moreira L, Guimarães N, Azevedo NF, Braeckmans K, De Smedt SC
Published in: DelNAM Workshop 2, 2019
Publisher: DelNAM

Analysing the Diffusion of NAMs in the Cytoplasm of E. coli by FRAP

Author(s): Magalhães BT, Bläßle A, Santos RS, Azevedo NF
Published in: 1st Drug Delivery in Microbial Cells Conference, 2021
Publisher: DelNAM

Nucleic acid mimics delivery into bacteria: fighting antibiotic resistance

Author(s): Guimarães N.
Published in: 1st Drug Delivery in Microbial Cells Conference, 2021
Publisher: DelNAM

Dendrimer for antisense NAMs delivery into bacteria

Author(s): Gomes M, Pereira S, Peng L, Santos RS, Azevedo NF.
Published in: 2021 CRS Virtual Annual Meeting, 2021
Publisher: CRS

Engineering liposomes to deliver nucleic acids in bacteria

Author(s): Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF
Published in: 1st Drug Delivery in Microbial Cells Conference, 2021
Publisher: DelNAM

Lipoplexes to deliver oligonucleotides in gram-positive and gram-negative bacteria : towards treatment of blood infections

Author(s): Sara Pereira; Rita Sobral Santos; Luís Moreira; Nuno Guimarães; Mariana Gomes; Heyang Zhang; Katrien Remaut; Kevin Braeckmans; Stefaan De Smedt; Nuno Filipe Azevedo
Published in: Pharmaceutics, Issue 13 (7), 2021, Page(s) 989, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13070989

NickFect type of cell-penetrating peptides present enhanced efficiency for microRNA-146a delivery into dendritic cells and during skin inflammation.

Author(s): Gemma Carreras-Badosa; Julia Maslovskaja; Kapilraj Periyasamy; Egon Urgard; Kärt Padari; Helen Vaher; Liina Tserel; Maxime Gestin; Kai Kisand; Piret Arukuusk; Chenguang Lou; Ülo Langel; Jesper Wengel; Margus Pooga; Ana Rebane
Published in: Biomaterials, Issue 262 (120316), 2020, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120316

Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters.

Author(s): Barras A, Sauvage F, De Hoon I, Braeckmans K, Hua D, et al.
Published in: Nanoscale Horizons, Issue 6 (6), 2021, Page(s) 449–61, ISSN 2055-6756
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1nh00157d

Carbazole modified oligonucleotides: Synthesis, hybridization studies and fluorescence properties

Author(s): Alaa S. Gouda; Alaa S. Gouda; Łukasz Przypis; Krzysztof Walczak; Per T. Jørgensen; Jesper Wengel
Published in: Organic and Biomolecular Chemistry, Issue 18 (35), 2020, Page(s) 6935-48, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0ob01553a

Can Vitamin B12 Assist the Internalization of Antisense LNA Oligonucleotides into Bacteria?

Author(s): Pereira S, Yao R, Gomes M, Jørgensen PT, Wengel J, Azevedo NF, Santos RS
Published in: Antibiotics, Issue 10 (4), 2021, Page(s) 379, ISSN 2079-6382
Publisher: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/antibiotics10040379

Photoporation with biodegradable polydopamine nanosensitizers enables safe and efficient delivery of mRNA in human T cells

Author(s): Aranit Harizaj; Mike Wels; Laurens Raes; Stephan Stremersch; Glenn Goetgeluk; Toon Brans; Bart Vandekerckhove; Félix Sauvage; Stefaan C. De Smedt; Ine Lentacker; Kevin Braeckmans
Published in: Advanced Functional Materials, Issue 31 (28), 2021, Page(s) 2102472, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202102472

Stimuli-responsive nanobubbles for biomedical applications

Author(s): Ranhua Xiong; Ronald X. Xu; Chaobo Huang; Stefaan De Smedt; Kevin Braeckmans
Published in: Chemical Society Reviews, Issue 50 (9), 2021, Page(s) 5746–76, ISSN 1460-4744
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9cs00839j

Polyamine-Functionalized 2'-Amino-LNA in Oligonucleotides: Facile Synthesis of New Monomers and High-Affinity Binding towards ssDNA and dsDNA.

Author(s): Mathias B. Danielsen; Niels Johan Christensen; Per T. Jørgensen; Knud J. Jensen; Jesper Wengel; Chenguang Lou
Published in: Chemistry - A European Journal, Issue 27 (4), 2021, Page(s) 1416-22, ISSN 1521-3765
Publisher: John Wiley & Sons, Ltd
DOI: 10.1002/chem.202004495

Photothermal nanofibres enable safe engineering of therapeutic cells

Author(s): Xiong R, Hua D, Van Hoeck J, Berdecka D, Léger L, et al
Published in: Nature Nanotechnology, Issue 16 (11), 2021, Page(s) 1281–91, ISSN 1748-3395
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-021-00976-3

Intracellular delivery of oligonucleotides in Helicobacter pylori by fusogenic liposomes in the presence of gastric mucus

Author(s): Rita S. Santos, George R. Dakwar, Elisa Zagato, Toon Brans, Céu Figueiredo, Koen Raemdonck, Nuno F. Azevedo, Stefaan C. De Smedt, Kevin Braeckmans
Published in: Biomaterials, Issue 138, 2017, Page(s) 1-12, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2017.05.029

An in vitro model of catheter-associated urinary tract infections to investigate the role of uncommon bacteria on the Escherichia coli microbial consortium

Author(s): Andreia S. Azevedo, Carina Almeida, Luciana C. Gomes, Carla Ferreira, Filipe J. Mergulhão, Luís F. Melo, Nuno F. Azevedo
Published in: Biochemical Engineering Journal, Issue 118, 2017, Page(s) 64-69, ISSN 1369-703X
Publisher: Elsevier BV
DOI: 10.1016/j.bej.2016.11.013

Discriminating typical and atypical cystic fibrosis-related bacteria by multiplex PNA-FISH

Author(s): Susana P. Lopes, Daniel T. Carvalho, Maria O. Pereira, Nuno F. Azevedo
Published in: Biotechnology and Bioengineering, Issue 114/2, 2017, Page(s) 355-367, ISSN 0006-3592
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.26085

Novel strategy to detect and locate periodontal pathogens: The PNA-FISH technique

Author(s): Luzia Mendes, Rui Rocha, Andreia Sofia Azevedo, Catarina Ferreira, Mariana Henriques, Miguel Gonçalves Pinto, Nuno Filipe Azevedo
Published in: Microbiological Research, Issue 192, 2016, Page(s) 185-191, ISSN 0944-5013
Publisher: Elsevier BV
DOI: 10.1016/j.micres.2016.07.002

Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model

Author(s): Sílvia Fontenete, Marina Leite, Davie Cappoen, Rita Santos, Chris Van Ginneken, Céu Figueiredo, Jesper Wengel, Paul Cos, Nuno Filipe Azevedo
Published in: PLOS ONE, Issue 11/2, 2016, Page(s) e0148353, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0148353

Application of locked nucleic acid-based probes in fluorescence in situ hybridization

Author(s): Sílvia Fontenete, Daniel Carvalho, Nuno Guimarães, Pedro Madureira, Céu Figueiredo, Jesper Wengel, Nuno Filipe Azevedo
Published in: Applied Microbiology and Biotechnology, Issue 100/13, 2016, Page(s) 5897-5906, ISSN 0175-7598
Publisher: Springer Verlag
DOI: 10.1007/s00253-016-7429-4

Optimization of peptide nucleic acid fluorescence in situ hybridization (PNA-FISH) for the detection of bacteria: The effect of pH, dextran sulfate and probe concentration

Author(s): Rui Rocha, Rita S. Santos, Pedro Madureira, Carina Almeida, Nuno F. Azevedo
Published in: Journal of Biotechnology, Issue 226, 2016, Page(s) 1-7, ISSN 0168-1656
Publisher: Elsevier BV
DOI: 10.1016/j.jbiotec.2016.03.047

Impact of Delftia tsuruhatensis and Achromobacter xylosoxidans on Escherichia coli dual-species biofilms treated with antibiotic agents

Author(s): Andreia S. Azevedo, Carina Almeida, Bruno Pereira, Luís F. Melo, Nuno F. Azevedo
Published in: Biofouling, Issue 32/3, 2016, Page(s) 227-241, ISSN 0892-7014
Publisher: Taylor & Francis
DOI: 10.1080/08927014.2015.1124096

Prediction of melting temperatures in fluorescence in situ hybridization (FISH) procedures using thermodynamic models

Author(s): Sílvia Fontenete, Nuno Guimarães, Jesper Wengel, Nuno Filipe Azevedo
Published in: Critical Reviews in Biotechnology, 2016, Page(s) 1-12, ISSN 0738-8551
Publisher: Taylor & Francis
DOI: 10.3109/07388551.2014.993589

Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori

Author(s): Rita S Santos, George R Dakwar, Ranhua Xiong, Katrien Forier, Katrien Remaut, Stephan Stremersch, Nuno Guimarães, Sílvia Fontenete, Jesper Wengel, Marina Leite, Céu Figueiredo, Stefaan C De Smedt, Kevin Braeckmans, Nuno F Azevedo
Published in: Molecular Therapy - Nucleic Acids, Issue 4, 2015, Page(s) e269, ISSN 2162-2531
Publisher: Nature Publishing Group
DOI: 10.1038/mtna.2015.46

Towards Fluorescence In Vivo Hybridization (FIVH) Detection of H. pylori in Gastric Mucosa Using Advanced LNA Probes

Author(s): Sílvia Fontenete, Marina Leite, Nuno Guimarães, Pedro Madureira, Rui Manuel Ferreira, Céu Figueiredo, Jesper Wengel, Nuno Filipe Azevedo
Published in: PLOS ONE, Issue 10/4, 2015, Page(s) e0125494, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0125494

Detection and discrimination of biofilm populations using locked nucleic acid/2′-O-methyl-RNA fluorescence in situ hybridization (LNA/2′OMe-FISH)

Author(s): Andreia S. Azevedo, Carina Almeida, Bruno Pereira, Pedro Madureira, Jesper Wengel, Nuno F. Azevedo
Published in: Biochemical Engineering Journal, Issue 104, 2015, Page(s) 64-73, ISSN 1369-703X
Publisher: Elsevier BV
DOI: 10.1016/j.bej.2015.04.024

Mismatch discrimination in fluorescent in situ hybridization using different types of nucleic acids

Author(s): Fontenete Silvia, Barros Joana, Madureira Pedro, Figueiredo Céu, Wengel Jesper, Azevedo Nuno Filipe
Published in: Applied Microbiology and Biotechnology, Issue 99/9, 2015, Page(s) 3961-3969, ISSN 0175-7598
Publisher: Springer Verlag
DOI: 10.1007/s00253-015-6389-4

Alpha-l-Locked Nucleic Acid-Modified Antisense Oligonucleotides Induce Efficient Splice Modulation In Vitro

Author(s): Prithi Raguraman, Tao Wang, Lixia Ma, Per Trolle Jørgensen, Jesper Wengel, Rakesh N. Veedu
Published in: International Journal of Molecular Sciences, Issue 21/7, 2020, Page(s) 2434, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072434

Fluorinated Molecules and Nanotechnology: Future ‘Avengers’ against the Alzheimer’s Disease?

Author(s): Meghna Dabur, Joana A. Loureiro, Maria Carmo Pereira
Published in: International Journal of Molecular Sciences, Issue 21/8, 2020, Page(s) 2989, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21082989

Molecular interactions between Vitamin B12 and membrane models: A biophysical study for new insights into the bioavailability of Vitamin

Author(s): Maria João Ramalho, Stéphanie Andrade, Manuel A.N. Coelho, Joana A. Loureiro, Maria Carmo Pereira
Published in: Colloids and Surfaces B: Biointerfaces, Issue 194, 2020, Page(s) 111187, ISSN 0927-7765
Publisher: Elsevier BV
DOI: 10.1016/j.colsurfb.2020.111187

Novel assemblies based on oligonucleotides containing intercalating nucleic acid monomers

Author(s): Asmaa Abdelrahman, Alaa S. Gouda, Per T. Jørgensen, Jesper Wengel
Published in: Nucleosides, Nucleotides & Nucleic Acids, Issue 39/1-3, 2020, Page(s) 82-96, ISSN 1525-7770
Publisher: Marcel Dekker Inc.
DOI: 10.1080/15257770.2019.1683188

Gapmer Antisense Oligonucleotides Containing 2′,3′‐Dideoxy‐2′‐fluoro‐3′‐ C ‐hydroxymethyl‐β‐ d ‐lyxofuranosyl Nucleotides Display Site‐Specific RNase H Cleavage and Induce Gene Silencing

Author(s): Mathias B. Danielsen, Chenguang Lou, Jolanta Lisowiec‐Wachnicka, Anna Pasternak, Per T. Jørgensen, Jesper Wengel
Published in: Chemistry – A European Journal, Issue 26/6, 2020, Page(s) 1368-1379, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201904540

Nanomaterials and molecular transporters to overcome the bacterial envelope barrier: Towards advanced delivery of antibiotics

Author(s): Rita S. Santos, Céu Figueiredo, Nuno F. Azevedo, Kevin Braeckmans, Stefaan C. De Smedt
Published in: Advanced Drug Delivery Reviews, Issue 136-137, 2018, Page(s) 28-48, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2017.12.010

Macrophage reprogramming into a pro-healing phenotype by siRNA delivered with LBL assembled nanocomplexes for wound healing applications

Author(s): Sharifiaghdam M, Shaabani E, Sharifiaghdam Z, De Keersmaecker H, Lucas B, Lammens J, et al.
Published in: Nanoscale, Issue 13 (36), 2021, Page(s) 15445–63, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1nr03830c

The dawn of mRNA vaccines: The COVID-19 case

Author(s): Verbeke R, Lentacker I, De Smedt SC, Dewitte H.
Published in: Journal of Controlled Release, Issue 333, 2021, Page(s) 511–20, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2021.03.043

Vaccinia Virus Protein B18R: Influence on mRNA Immunogenicity and Translation upon Non-Viral Delivery in Different Ocular Cell Types

Author(s): Minnaert AK, Devoldere J, Peynshaert K, Vercruysse L, De Smedt SC, Remaut K
Published in: Pharmaceutics, Issue 13 (1), 2021, Page(s) 74, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13010074

Delivery of Oligonucleotides into Bacteria by Fusogenic Liposomes. In: Fluorescence In-Situ Hybridization (FISH) for Microbial Cells.

Author(s): Pereira S, Santos RS, Moreira L, Guimarães N, Braeckmans K, De Smedt SC, Azevedo NF
Published in: Methods in Molecular Biology, Issue 2246, 2021, Page(s) 87–96, ISBN 978-1-0716-1115-9
Publisher: Humana
DOI: 10.1007/978-1-0716-1115-9_6

An Introduction to Fluorescence in situ Hybridization in Microorganisms. In: Fluorescence In-Situ Hybridization (FISH) for Microbial Cells.

Author(s): Almeida C, Azevedo NF
Published in: Methods in Molecular Biology, Issue 2246, 2021, Page(s) 1–15, ISBN 978-1-0716-1115-9
Publisher: Humana
DOI: 10.1007/978-1-0716-1115-9_1

Computational Resources and Strategies to Construct Single-Molecule Models of FISH. In: Fluorescence In-Situ Hybridization (FISH) for Microbial Cells.

Author(s): Magalhães BT, Santos RS, Azevedo NF, Lourenço A
Published in: Methods in Molecular Biology, Issue 2246, 2021, Page(s) 317–30, ISBN 978-1-0716-1115-9
Publisher: Humana
DOI: 10.1007/978-1-0716-1115-9_21

Albumin-Binding Fatty Acid–Modified Gapmer Antisense Oligonucleotides for Modulation of Pharmacokinetics. In: Gapmers.

Author(s): Cai Y, Lou C, Wengel J, Howard KA.
Published in: Methods in Molecular Biology, Issue 2176, 2020, Page(s) 163–74, ISBN 978-1-0716-0770-8
Publisher: Humana
DOI: 10.1007/978-1-0716-0771-8_12

Delivery of nucleic acid mimics into bacteria as a novel method to treat infections

Author(s): Pereira S.
Published in: 2021
Publisher: FEUP

Design and application of nucleic acid mimics oligonucleotides (NAMs) in combination with nanoparticles for detection and/or growth inhibition of microorganisms

Author(s): Moreira L.
Published in: 2022
Publisher: FEUP

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