Strengthening the Research Area of Delivery of Nucleic acid mimics (NAMS) into bacteria to fight the antibiotic crisis

Informations projet

DelNAM

N° de convention de subvention: 810685

DOI

10.3030/810685

Projet clôturé

Date de signature de la CE 6 Juillet 2018

Date de début 1 Août 2018

Date de fin 31 Janvier 2022

Financé au titre de

• Twinning of research institutions

Coût total

€ 960 853,75

Contribution de l’UE

€ 960 853,75

Coordonné par

UNIVERSIDADE DO PORTO
Portugal

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (7)

Communication Final Report and evaluation

Final report about the communication and dissemination strategy adopted and the respective evaluation

Mentoring Final Report AND Evaluation

Delivery of the report about the mentoring programme

Annual report on high impact publications

At the end of each period a report will be delivered regarding the high impact publications from the project 12 24 and 42nd month

Final Evaluation Report of Benchmarking Visits

Final report regarding he benchmark visits will be delivered

Final Staff Exchanges report including evaluation

Report about the staff exchange process including final evaluation of the process

Final Training (workshop and summer school) report, including overall evaluation (M42)

Reports of the final evaluation of the workshops and summer schools

Report on Collaboration Agreements and Results

Report of the possible new collaborations agreements between the research and industry

Websites, patent fillings, videos etc. (2)

Website and social media sites

Project website and social media will be ready to maximize project visibility.

"International Conference at FEUP, named ""I Drug Delivery in Microbial Cells (DDMiC)"""

Organisation of an international conference related to the main topics of the project in close collaboration with the two twinning partners The conference will last three days and will be conducted on M39

Publications

Conference proceedings (26)

Liposome-encapsulated Nucleic Acid Mimics (LipoNAMs): a potential novel diagnostic and therapeutic tool

Auteurs: Moreira L, Pereira S, Guimarães N, Santos RS, Pereira C, Azevedo NF
Publié dans: Doctoral Congress in Engineering 2019, 2019
Éditeur: Faculty of Engineering, University of Porto

Dendrimer for the delivery of antisense NAMs into bacteria

Auteurs: Gomes M, Pereira S, Peng L, Santos RS, Azevedo NF.
Publié dans: 3rd SPLC-CRS Young Scientists Virtual Meeting, 2021
Éditeur: SPLC-CRS

Application of agent-based modelling to simulate ribosome translation

Auteurs: Magalhães BT, Santos RS, Lourenço A, Azevedo NF.
Publié dans: Doctoral Congress in Engineering 2021, 2021
Éditeur: Faculty of Engineering, University of Porto

Oligonucleotides against bacterial infections: the Delivery Vector’s choice

Auteurs: Santos RS
Publié dans: 13th International Conference and Workshop on Biological Barriers, 2020
Éditeur: CRS

Immunoliposomes to Deliver Therapeutic Oligonucleotides in Bacteria.

Auteurs: Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF.
Publié dans: World Microbe Forum 2021, 2021
Éditeur: AFM/FEMS

Delivery of oligonucleotides in bacteria by liposomes

Auteurs: Santos R, Dakwar G, Zagato E, Brans T, Figueiredo C, Azevedo N, De Smedt SC, Braeckmans K.
Publié dans: DelNAM Workshop 2, 2019
Éditeur: DelNAM

Delivery of nucleic acid mimics into bacteria as novel theranostics of infections

Auteurs: Santos RS, Pereira S, Moreira L, Gomes M, Guimarães N, Peng L, De Smedt SC, Braeckmans K, Azevedo N
Publié dans: 2021 CRS Virtual Annual Meeting, 2021
Éditeur: CRS

Nucleic Acid Mimics As Alternatives To Small-molecule Antibiotics: The Delivery Vector's Choice

Auteurs: Santos RS.
Publié dans: World Microbe Forum 2021, 2021
Éditeur: ASM/FEMS

Self-assembling dendrimers as NAM delivery systems into bacteria

Auteurs: Gomes M, Resende I, Pereira S, Peng L, Santos RS, Azevedo NF
Publié dans: 1st Drug Delivery in Microbial Cells Conference, 2021
Éditeur: DelNAM

Effect of lipid concentration on the delivery efficiency of liposome-encapsulated nucleic acid mimics (LipoNAMs) on Escherichia coli.

Auteurs: Moreira L, Pereira S, Guimarães N, Santos RS, Pereira C, Azevedo NF.
Publié dans: 29th ECCMID, 2019
Éditeur: ESCMID

Delivery of nucleic acid mimics (NAMs) by liposomes into Gram-negative and Gram-positive bacteria.

Auteurs: Pereira S, Santos RS, Moreira L, Guimarães N, Azevedo NF, Braeckmans K, De Smedt SC.
Publié dans: 29th ECCMID, 2019
Éditeur: ESCMID

Delivery of nucleic acid mimics (NAMs) in bacteria towards fighting antimicrobial resistance.

Auteurs: Santos R, Pereira S, De Smedt S, Braeckmans K, Azevedo NF.
Publié dans: BioNano-20, 2020
Éditeur: BioNano-20

DelNAM – fighting the crisis of bacterial resistance to antibiotics.

Auteurs: Santos RS, Wengel J, Braeckmans K, De Smedt SC, Azevedo NF.
Publié dans: NanoMed Europe 2019, 2019
Éditeur: ETPN Association

Liposome-encapsulated nucleic acid mimics for the delivery of oligonucleotides into bacteria.

Auteurs: Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF.
Publié dans: 2019 CRS Annual Meeting & Exposition, 2019
Éditeur: CRS

Delivery of nucleic acid mimics (NAMs) in bacteria mediated by lipoplexes.

Auteurs: Pereira S, Santos RS, Moreira L, Zhang H, Guimarães N, Remaut K, Azevedo NF, Braeckmans K, de Smedt SC.
Publié dans: XIIIth Spanish-Portuguese Conference on Controlled Drug Delivery, 2020
Éditeur: SPLC-CRS

Delivery of nucleic acid mimics to target Helicobacter pylori infections – the effect of biological barriers.

Auteurs: Santos RS, Dakwar GR, Zagato E, Brans T, Figueiredo C, Azevedo NF, De Smedt SC, Braeckmans K.
Publié dans: XIIIth Spanish-Portuguese Conference on Controlled Drug Delivery, 2020
Éditeur: SPLC-CRS

Interaction of cationic liposomes with Gram-negative and Gram-positive bacteria.

Auteurs: Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF.
Publié dans: XIIIth Spanish-Portuguese Conference on Controlled Drug Delivery, 2020
Éditeur: SPLC-CRS

Immunoliposome for the delivery of therapeutic oligonucleotides into bacteria.

Auteurs: Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF.
Publié dans: ASM Microbe 2020, 2020
Éditeur: ASM

Delivery of nucleic acid mimics (NAMs) in bacteria mediated by lipoplexes.

Auteurs: Pereira S, Santos RS, Moreira L, Zhang H, Guimarães N, Remaut K, Azevedo NF, Braeckmans K, De Smedt SC.
Publié dans: ASM Microbe 2020, 2020
Éditeur: ASM

Surface-functionalized liposomes to deliver therapeutic nucleic acids in Escherichia coli

Auteurs: Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF.
Publié dans: 32nd ECCMID, 2021
Éditeur: ECCMID

Intracellular delivery of nucleic acid mimics in bacteria to treat infections

Auteurs: Santos RS
Publié dans: 3rd SPLC-CRS Young Scientists Virtual Meeting, 2021
Éditeur: SPLC-CRS

Interaction of lipoplexes with Gram-negative and Gram-positive bacteria: Towards delivery of nucleic acid mimics (NAMs)

Auteurs: Pereira S, Santos RS, Moreira L, Guimarães N, Azevedo NF, Braeckmans K, De Smedt SC
Publié dans: DelNAM Workshop 2, 2019
Éditeur: DelNAM

Analysing the Diffusion of NAMs in the Cytoplasm of E. coli by FRAP

Auteurs: Magalhães BT, Bläßle A, Santos RS, Azevedo NF
Publié dans: 1st Drug Delivery in Microbial Cells Conference, 2021
Éditeur: DelNAM

Nucleic acid mimics delivery into bacteria: fighting antibiotic resistance

Auteurs: Guimarães N.
Publié dans: 1st Drug Delivery in Microbial Cells Conference, 2021
Éditeur: DelNAM

Dendrimer for antisense NAMs delivery into bacteria

Auteurs: Gomes M, Pereira S, Peng L, Santos RS, Azevedo NF.
Publié dans: 2021 CRS Virtual Annual Meeting, 2021
Éditeur: CRS

Engineering liposomes to deliver nucleic acids in bacteria

Auteurs: Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF
Publié dans: 1st Drug Delivery in Microbial Cells Conference, 2021
Éditeur: DelNAM

Peer reviewed articles (31)

Lipoplexes to deliver oligonucleotides in gram-positive and gram-negative bacteria : towards treatment of blood infections

Auteurs: Sara Pereira; Rita Sobral Santos; Luís Moreira; Nuno Guimarães; Mariana Gomes; Heyang Zhang; Katrien Remaut; Kevin Braeckmans; Stefaan De Smedt; Nuno Filipe Azevedo
Publié dans: Pharmaceutics, Numéro 13 (7), 2021, Page(s) 989, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13070989

NickFect type of cell-penetrating peptides present enhanced efficiency for microRNA-146a delivery into dendritic cells and during skin inflammation.

Auteurs: Gemma Carreras-Badosa; Julia Maslovskaja; Kapilraj Periyasamy; Egon Urgard; Kärt Padari; Helen Vaher; Liina Tserel; Maxime Gestin; Kai Kisand; Piret Arukuusk; Chenguang Lou; Ülo Langel; Jesper Wengel; Margus Pooga; Ana Rebane
Publié dans: Biomaterials, Numéro 262 (120316), 2020, ISSN 0142-9612
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120316

Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters.

Auteurs: Barras A, Sauvage F, De Hoon I, Braeckmans K, Hua D, et al.
Publié dans: Nanoscale Horizons, Numéro 6 (6), 2021, Page(s) 449–61, ISSN 2055-6756
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d1nh00157d

Carbazole modified oligonucleotides: Synthesis, hybridization studies and fluorescence properties

Auteurs: Alaa S. Gouda; Alaa S. Gouda; Łukasz Przypis; Krzysztof Walczak; Per T. Jørgensen; Jesper Wengel
Publié dans: Organic and Biomolecular Chemistry, Numéro 18 (35), 2020, Page(s) 6935-48, ISSN 1477-0520
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0ob01553a

Can Vitamin B12 Assist the Internalization of Antisense LNA Oligonucleotides into Bacteria?

Auteurs: Pereira S, Yao R, Gomes M, Jørgensen PT, Wengel J, Azevedo NF, Santos RS
Publié dans: Antibiotics, Numéro 10 (4), 2021, Page(s) 379, ISSN 2079-6382
Éditeur: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/antibiotics10040379

Photoporation with biodegradable polydopamine nanosensitizers enables safe and efficient delivery of mRNA in human T cells

Auteurs: Aranit Harizaj; Mike Wels; Laurens Raes; Stephan Stremersch; Glenn Goetgeluk; Toon Brans; Bart Vandekerckhove; Félix Sauvage; Stefaan C. De Smedt; Ine Lentacker; Kevin Braeckmans
Publié dans: Advanced Functional Materials, Numéro 31 (28), 2021, Page(s) 2102472, ISSN 1616-301X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202102472

Stimuli-responsive nanobubbles for biomedical applications

Auteurs: Ranhua Xiong; Ronald X. Xu; Chaobo Huang; Stefaan De Smedt; Kevin Braeckmans
Publié dans: Chemical Society Reviews, Numéro 50 (9), 2021, Page(s) 5746–76, ISSN 1460-4744
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9cs00839j

Polyamine-Functionalized 2'-Amino-LNA in Oligonucleotides: Facile Synthesis of New Monomers and High-Affinity Binding towards ssDNA and dsDNA.

Auteurs: Mathias B. Danielsen; Niels Johan Christensen; Per T. Jørgensen; Knud J. Jensen; Jesper Wengel; Chenguang Lou
Publié dans: Chemistry - A European Journal, Numéro 27 (4), 2021, Page(s) 1416-22, ISSN 1521-3765
Éditeur: John Wiley & Sons, Ltd
DOI: 10.1002/chem.202004495

Photothermal nanofibres enable safe engineering of therapeutic cells

Auteurs: Xiong R, Hua D, Van Hoeck J, Berdecka D, Léger L, et al
Publié dans: Nature Nanotechnology, Numéro 16 (11), 2021, Page(s) 1281–91, ISSN 1748-3395
Éditeur: Nature Publishing Group
DOI: 10.1038/s41565-021-00976-3

Intracellular delivery of oligonucleotides in Helicobacter pylori by fusogenic liposomes in the presence of gastric mucus

Auteurs: Rita S. Santos, George R. Dakwar, Elisa Zagato, Toon Brans, Céu Figueiredo, Koen Raemdonck, Nuno F. Azevedo, Stefaan C. De Smedt, Kevin Braeckmans
Publié dans: Biomaterials, Numéro 138, 2017, Page(s) 1-12, ISSN 0142-9612
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2017.05.029

An in vitro model of catheter-associated urinary tract infections to investigate the role of uncommon bacteria on the Escherichia coli microbial consortium

Auteurs: Andreia S. Azevedo, Carina Almeida, Luciana C. Gomes, Carla Ferreira, Filipe J. Mergulhão, Luís F. Melo, Nuno F. Azevedo
Publié dans: Biochemical Engineering Journal, Numéro 118, 2017, Page(s) 64-69, ISSN 1369-703X
Éditeur: Elsevier BV
DOI: 10.1016/j.bej.2016.11.013

Discriminating typical and atypical cystic fibrosis-related bacteria by multiplex PNA-FISH

Auteurs: Susana P. Lopes, Daniel T. Carvalho, Maria O. Pereira, Nuno F. Azevedo
Publié dans: Biotechnology and Bioengineering, Numéro 114/2, 2017, Page(s) 355-367, ISSN 0006-3592
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.26085

Novel strategy to detect and locate periodontal pathogens: The PNA-FISH technique

Auteurs: Luzia Mendes, Rui Rocha, Andreia Sofia Azevedo, Catarina Ferreira, Mariana Henriques, Miguel Gonçalves Pinto, Nuno Filipe Azevedo
Publié dans: Microbiological Research, Numéro 192, 2016, Page(s) 185-191, ISSN 0944-5013
Éditeur: Elsevier BV
DOI: 10.1016/j.micres.2016.07.002

Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model

Auteurs: Sílvia Fontenete, Marina Leite, Davie Cappoen, Rita Santos, Chris Van Ginneken, Céu Figueiredo, Jesper Wengel, Paul Cos, Nuno Filipe Azevedo
Publié dans: PLOS ONE, Numéro 11/2, 2016, Page(s) e0148353, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0148353

Application of locked nucleic acid-based probes in fluorescence in situ hybridization

Auteurs: Sílvia Fontenete, Daniel Carvalho, Nuno Guimarães, Pedro Madureira, Céu Figueiredo, Jesper Wengel, Nuno Filipe Azevedo
Publié dans: Applied Microbiology and Biotechnology, Numéro 100/13, 2016, Page(s) 5897-5906, ISSN 0175-7598
Éditeur: Springer Verlag
DOI: 10.1007/s00253-016-7429-4

Optimization of peptide nucleic acid fluorescence in situ hybridization (PNA-FISH) for the detection of bacteria: The effect of pH, dextran sulfate and probe concentration

Auteurs: Rui Rocha, Rita S. Santos, Pedro Madureira, Carina Almeida, Nuno F. Azevedo
Publié dans: Journal of Biotechnology, Numéro 226, 2016, Page(s) 1-7, ISSN 0168-1656
Éditeur: Elsevier BV
DOI: 10.1016/j.jbiotec.2016.03.047

Impact of Delftia tsuruhatensis and Achromobacter xylosoxidans on Escherichia coli dual-species biofilms treated with antibiotic agents

Auteurs: Andreia S. Azevedo, Carina Almeida, Bruno Pereira, Luís F. Melo, Nuno F. Azevedo
Publié dans: Biofouling, Numéro 32/3, 2016, Page(s) 227-241, ISSN 0892-7014
Éditeur: Taylor & Francis
DOI: 10.1080/08927014.2015.1124096

Prediction of melting temperatures in fluorescence in situ hybridization (FISH) procedures using thermodynamic models

Auteurs: Sílvia Fontenete, Nuno Guimarães, Jesper Wengel, Nuno Filipe Azevedo
Publié dans: Critical Reviews in Biotechnology, 2016, Page(s) 1-12, ISSN 0738-8551
Éditeur: Taylor & Francis
DOI: 10.3109/07388551.2014.993589

Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori

Auteurs: Rita S Santos, George R Dakwar, Ranhua Xiong, Katrien Forier, Katrien Remaut, Stephan Stremersch, Nuno Guimarães, Sílvia Fontenete, Jesper Wengel, Marina Leite, Céu Figueiredo, Stefaan C De Smedt, Kevin Braeckmans, Nuno F Azevedo
Publié dans: Molecular Therapy - Nucleic Acids, Numéro 4, 2015, Page(s) e269, ISSN 2162-2531
Éditeur: Nature Publishing Group
DOI: 10.1038/mtna.2015.46

Towards Fluorescence In Vivo Hybridization (FIVH) Detection of H. pylori in Gastric Mucosa Using Advanced LNA Probes

Auteurs: Sílvia Fontenete, Marina Leite, Nuno Guimarães, Pedro Madureira, Rui Manuel Ferreira, Céu Figueiredo, Jesper Wengel, Nuno Filipe Azevedo
Publié dans: PLOS ONE, Numéro 10/4, 2015, Page(s) e0125494, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0125494

Detection and discrimination of biofilm populations using locked nucleic acid/2′-O-methyl-RNA fluorescence in situ hybridization (LNA/2′OMe-FISH)

Auteurs: Andreia S. Azevedo, Carina Almeida, Bruno Pereira, Pedro Madureira, Jesper Wengel, Nuno F. Azevedo
Publié dans: Biochemical Engineering Journal, Numéro 104, 2015, Page(s) 64-73, ISSN 1369-703X
Éditeur: Elsevier BV
DOI: 10.1016/j.bej.2015.04.024

Mismatch discrimination in fluorescent in situ hybridization using different types of nucleic acids

Auteurs: Fontenete Silvia, Barros Joana, Madureira Pedro, Figueiredo Céu, Wengel Jesper, Azevedo Nuno Filipe
Publié dans: Applied Microbiology and Biotechnology, Numéro 99/9, 2015, Page(s) 3961-3969, ISSN 0175-7598
Éditeur: Springer Verlag
DOI: 10.1007/s00253-015-6389-4

Alpha-l-Locked Nucleic Acid-Modified Antisense Oligonucleotides Induce Efficient Splice Modulation In Vitro

Auteurs: Prithi Raguraman, Tao Wang, Lixia Ma, Per Trolle Jørgensen, Jesper Wengel, Rakesh N. Veedu
Publié dans: International Journal of Molecular Sciences, Numéro 21/7, 2020, Page(s) 2434, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072434

Fluorinated Molecules and Nanotechnology: Future ‘Avengers’ against the Alzheimer’s Disease?

Auteurs: Meghna Dabur, Joana A. Loureiro, Maria Carmo Pereira
Publié dans: International Journal of Molecular Sciences, Numéro 21/8, 2020, Page(s) 2989, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21082989

Molecular interactions between Vitamin B12 and membrane models: A biophysical study for new insights into the bioavailability of Vitamin

Auteurs: Maria João Ramalho, Stéphanie Andrade, Manuel A.N. Coelho, Joana A. Loureiro, Maria Carmo Pereira
Publié dans: Colloids and Surfaces B: Biointerfaces, Numéro 194, 2020, Page(s) 111187, ISSN 0927-7765
Éditeur: Elsevier BV
DOI: 10.1016/j.colsurfb.2020.111187

Novel assemblies based on oligonucleotides containing intercalating nucleic acid monomers

Auteurs: Asmaa Abdelrahman, Alaa S. Gouda, Per T. Jørgensen, Jesper Wengel
Publié dans: Nucleosides, Nucleotides & Nucleic Acids, Numéro 39/1-3, 2020, Page(s) 82-96, ISSN 1525-7770
Éditeur: Marcel Dekker Inc.
DOI: 10.1080/15257770.2019.1683188

Gapmer Antisense Oligonucleotides Containing 2′,3′‐Dideoxy‐2′‐fluoro‐3′‐ C ‐hydroxymethyl‐β‐ d ‐lyxofuranosyl Nucleotides Display Site‐Specific RNase H Cleavage and Induce Gene Silencing

Auteurs: Mathias B. Danielsen, Chenguang Lou, Jolanta Lisowiec‐Wachnicka, Anna Pasternak, Per T. Jørgensen, Jesper Wengel
Publié dans: Chemistry – A European Journal, Numéro 26/6, 2020, Page(s) 1368-1379, ISSN 0947-6539
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201904540

Nanomaterials and molecular transporters to overcome the bacterial envelope barrier: Towards advanced delivery of antibiotics

Auteurs: Rita S. Santos, Céu Figueiredo, Nuno F. Azevedo, Kevin Braeckmans, Stefaan C. De Smedt
Publié dans: Advanced Drug Delivery Reviews, Numéro 136-137, 2018, Page(s) 28-48, ISSN 0169-409X
Éditeur: Elsevier BV
DOI: 10.1016/j.addr.2017.12.010

Macrophage reprogramming into a pro-healing phenotype by siRNA delivered with LBL assembled nanocomplexes for wound healing applications

Auteurs: Sharifiaghdam M, Shaabani E, Sharifiaghdam Z, De Keersmaecker H, Lucas B, Lammens J, et al.
Publié dans: Nanoscale, Numéro 13 (36), 2021, Page(s) 15445–63, ISSN 2040-3364
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d1nr03830c

The dawn of mRNA vaccines: The COVID-19 case

Auteurs: Verbeke R, Lentacker I, De Smedt SC, Dewitte H.
Publié dans: Journal of Controlled Release, Numéro 333, 2021, Page(s) 511–20, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2021.03.043

Vaccinia Virus Protein B18R: Influence on mRNA Immunogenicity and Translation upon Non-Viral Delivery in Different Ocular Cell Types

Auteurs: Minnaert AK, Devoldere J, Peynshaert K, Vercruysse L, De Smedt SC, Remaut K
Publié dans: Pharmaceutics, Numéro 13 (1), 2021, Page(s) 74, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13010074

Book chapters (4)

Delivery of Oligonucleotides into Bacteria by Fusogenic Liposomes. In: Fluorescence In-Situ Hybridization (FISH) for Microbial Cells.

Auteurs: Pereira S, Santos RS, Moreira L, Guimarães N, Braeckmans K, De Smedt SC, Azevedo NF
Publié dans: Methods in Molecular Biology, Numéro 2246, 2021, Page(s) 87–96, ISBN 978-1-0716-1115-9
Éditeur: Humana
DOI: 10.1007/978-1-0716-1115-9_6

An Introduction to Fluorescence in situ Hybridization in Microorganisms. In: Fluorescence In-Situ Hybridization (FISH) for Microbial Cells.

Auteurs: Almeida C, Azevedo NF
Publié dans: Methods in Molecular Biology, Numéro 2246, 2021, Page(s) 1–15, ISBN 978-1-0716-1115-9
Éditeur: Humana
DOI: 10.1007/978-1-0716-1115-9_1

Computational Resources and Strategies to Construct Single-Molecule Models of FISH. In: Fluorescence In-Situ Hybridization (FISH) for Microbial Cells.

Auteurs: Magalhães BT, Santos RS, Azevedo NF, Lourenço A
Publié dans: Methods in Molecular Biology, Numéro 2246, 2021, Page(s) 317–30, ISBN 978-1-0716-1115-9
Éditeur: Humana
DOI: 10.1007/978-1-0716-1115-9_21

Albumin-Binding Fatty Acid–Modified Gapmer Antisense Oligonucleotides for Modulation of Pharmacokinetics. In: Gapmers.

Auteurs: Cai Y, Lou C, Wengel J, Howard KA.
Publié dans: Methods in Molecular Biology, Numéro 2176, 2020, Page(s) 163–74, ISBN 978-1-0716-0770-8
Éditeur: Humana
DOI: 10.1007/978-1-0716-0771-8_12

Thesis and dissertations (2)

Delivery of nucleic acid mimics into bacteria as a novel method to treat infections

Auteurs: Pereira S.
Publié dans: 2021
Éditeur: FEUP

Design and application of nucleic acid mimics oligonucleotides (NAMs) in combination with nanoparticles for detection and/or growth inhibition of microorganisms

Auteurs: Moreira L.
Publié dans: 2022
Éditeur: FEUP