Strengthening the Research Area of Delivery of Nucleic acid mimics (NAMS) into bacteria to fight the antibiotic crisis

Informacje na temat projektu

DelNAM

Identyfikator umowy o grant: 810685

DOI

10.3030/810685

Projekt został zamknięty

Data podpisania przez KE 6 Lipca 2018

Data rozpoczęcia 1 Sierpnia 2018

Data zakończenia 31 Stycznia 2022

Finansowanie w ramach

• Twinning of research institutions

Koszt całkowity

€ 960 853,75

Wkład UE

€ 960 853,75

Koordynowany przez

UNIVERSIDADE DO PORTO
Portugal

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (7)

Communication Final Report and evaluation

Final report about the communication and dissemination strategy adopted and the respective evaluation

Mentoring Final Report AND Evaluation

Delivery of the report about the mentoring programme

Annual report on high impact publications

At the end of each period a report will be delivered regarding the high impact publications from the project 12 24 and 42nd month

Final Evaluation Report of Benchmarking Visits

Final report regarding he benchmark visits will be delivered

Final Staff Exchanges report including evaluation

Report about the staff exchange process including final evaluation of the process

Final Training (workshop and summer school) report, including overall evaluation (M42)

Reports of the final evaluation of the workshops and summer schools

Report on Collaboration Agreements and Results

Report of the possible new collaborations agreements between the research and industry

Websites, patent fillings, videos etc. (2)

Website and social media sites

Project website and social media will be ready to maximize project visibility.

"International Conference at FEUP, named ""I Drug Delivery in Microbial Cells (DDMiC)"""

Organisation of an international conference related to the main topics of the project in close collaboration with the two twinning partners The conference will last three days and will be conducted on M39

Publikacje

Conference proceedings (26)

Liposome-encapsulated Nucleic Acid Mimics (LipoNAMs): a potential novel diagnostic and therapeutic tool

Autorzy: Moreira L, Pereira S, Guimarães N, Santos RS, Pereira C, Azevedo NF
Opublikowane w: Doctoral Congress in Engineering 2019, 2019
Wydawca: Faculty of Engineering, University of Porto

Dendrimer for the delivery of antisense NAMs into bacteria

Autorzy: Gomes M, Pereira S, Peng L, Santos RS, Azevedo NF.
Opublikowane w: 3rd SPLC-CRS Young Scientists Virtual Meeting, 2021
Wydawca: SPLC-CRS

Application of agent-based modelling to simulate ribosome translation

Autorzy: Magalhães BT, Santos RS, Lourenço A, Azevedo NF.
Opublikowane w: Doctoral Congress in Engineering 2021, 2021
Wydawca: Faculty of Engineering, University of Porto

Oligonucleotides against bacterial infections: the Delivery Vector’s choice

Autorzy: Santos RS
Opublikowane w: 13th International Conference and Workshop on Biological Barriers, 2020
Wydawca: CRS

Immunoliposomes to Deliver Therapeutic Oligonucleotides in Bacteria.

Autorzy: Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF.
Opublikowane w: World Microbe Forum 2021, 2021
Wydawca: AFM/FEMS

Delivery of oligonucleotides in bacteria by liposomes

Autorzy: Santos R, Dakwar G, Zagato E, Brans T, Figueiredo C, Azevedo N, De Smedt SC, Braeckmans K.
Opublikowane w: DelNAM Workshop 2, 2019
Wydawca: DelNAM

Delivery of nucleic acid mimics into bacteria as novel theranostics of infections

Autorzy: Santos RS, Pereira S, Moreira L, Gomes M, Guimarães N, Peng L, De Smedt SC, Braeckmans K, Azevedo N
Opublikowane w: 2021 CRS Virtual Annual Meeting, 2021
Wydawca: CRS

Nucleic Acid Mimics As Alternatives To Small-molecule Antibiotics: The Delivery Vector's Choice

Autorzy: Santos RS.
Opublikowane w: World Microbe Forum 2021, 2021
Wydawca: ASM/FEMS

Self-assembling dendrimers as NAM delivery systems into bacteria

Autorzy: Gomes M, Resende I, Pereira S, Peng L, Santos RS, Azevedo NF
Opublikowane w: 1st Drug Delivery in Microbial Cells Conference, 2021
Wydawca: DelNAM

Effect of lipid concentration on the delivery efficiency of liposome-encapsulated nucleic acid mimics (LipoNAMs) on Escherichia coli.

Autorzy: Moreira L, Pereira S, Guimarães N, Santos RS, Pereira C, Azevedo NF.
Opublikowane w: 29th ECCMID, 2019
Wydawca: ESCMID

Delivery of nucleic acid mimics (NAMs) by liposomes into Gram-negative and Gram-positive bacteria.

Autorzy: Pereira S, Santos RS, Moreira L, Guimarães N, Azevedo NF, Braeckmans K, De Smedt SC.
Opublikowane w: 29th ECCMID, 2019
Wydawca: ESCMID

Delivery of nucleic acid mimics (NAMs) in bacteria towards fighting antimicrobial resistance.

Autorzy: Santos R, Pereira S, De Smedt S, Braeckmans K, Azevedo NF.
Opublikowane w: BioNano-20, 2020
Wydawca: BioNano-20

DelNAM – fighting the crisis of bacterial resistance to antibiotics.

Autorzy: Santos RS, Wengel J, Braeckmans K, De Smedt SC, Azevedo NF.
Opublikowane w: NanoMed Europe 2019, 2019
Wydawca: ETPN Association

Liposome-encapsulated nucleic acid mimics for the delivery of oligonucleotides into bacteria.

Autorzy: Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF.
Opublikowane w: 2019 CRS Annual Meeting & Exposition, 2019
Wydawca: CRS

Delivery of nucleic acid mimics (NAMs) in bacteria mediated by lipoplexes.

Autorzy: Pereira S, Santos RS, Moreira L, Zhang H, Guimarães N, Remaut K, Azevedo NF, Braeckmans K, de Smedt SC.
Opublikowane w: XIIIth Spanish-Portuguese Conference on Controlled Drug Delivery, 2020
Wydawca: SPLC-CRS

Delivery of nucleic acid mimics to target Helicobacter pylori infections – the effect of biological barriers.

Autorzy: Santos RS, Dakwar GR, Zagato E, Brans T, Figueiredo C, Azevedo NF, De Smedt SC, Braeckmans K.
Opublikowane w: XIIIth Spanish-Portuguese Conference on Controlled Drug Delivery, 2020
Wydawca: SPLC-CRS

Interaction of cationic liposomes with Gram-negative and Gram-positive bacteria.

Autorzy: Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF.
Opublikowane w: XIIIth Spanish-Portuguese Conference on Controlled Drug Delivery, 2020
Wydawca: SPLC-CRS

Immunoliposome for the delivery of therapeutic oligonucleotides into bacteria.

Autorzy: Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF.
Opublikowane w: ASM Microbe 2020, 2020
Wydawca: ASM

Delivery of nucleic acid mimics (NAMs) in bacteria mediated by lipoplexes.

Autorzy: Pereira S, Santos RS, Moreira L, Zhang H, Guimarães N, Remaut K, Azevedo NF, Braeckmans K, De Smedt SC.
Opublikowane w: ASM Microbe 2020, 2020
Wydawca: ASM

Surface-functionalized liposomes to deliver therapeutic nucleic acids in Escherichia coli

Autorzy: Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF.
Opublikowane w: 32nd ECCMID, 2021
Wydawca: ECCMID

Intracellular delivery of nucleic acid mimics in bacteria to treat infections

Autorzy: Santos RS
Opublikowane w: 3rd SPLC-CRS Young Scientists Virtual Meeting, 2021
Wydawca: SPLC-CRS

Interaction of lipoplexes with Gram-negative and Gram-positive bacteria: Towards delivery of nucleic acid mimics (NAMs)

Autorzy: Pereira S, Santos RS, Moreira L, Guimarães N, Azevedo NF, Braeckmans K, De Smedt SC
Opublikowane w: DelNAM Workshop 2, 2019
Wydawca: DelNAM

Analysing the Diffusion of NAMs in the Cytoplasm of E. coli by FRAP

Autorzy: Magalhães BT, Bläßle A, Santos RS, Azevedo NF
Opublikowane w: 1st Drug Delivery in Microbial Cells Conference, 2021
Wydawca: DelNAM

Nucleic acid mimics delivery into bacteria: fighting antibiotic resistance

Autorzy: Guimarães N.
Opublikowane w: 1st Drug Delivery in Microbial Cells Conference, 2021
Wydawca: DelNAM

Dendrimer for antisense NAMs delivery into bacteria

Autorzy: Gomes M, Pereira S, Peng L, Santos RS, Azevedo NF.
Opublikowane w: 2021 CRS Virtual Annual Meeting, 2021
Wydawca: CRS

Engineering liposomes to deliver nucleic acids in bacteria

Autorzy: Moreira L, Pereira S, Guimarães N, Santos RS, Loureiro J, Pereira C, Azevedo NF
Opublikowane w: 1st Drug Delivery in Microbial Cells Conference, 2021
Wydawca: DelNAM

Peer reviewed articles (31)

Lipoplexes to deliver oligonucleotides in gram-positive and gram-negative bacteria : towards treatment of blood infections

Autorzy: Sara Pereira; Rita Sobral Santos; Luís Moreira; Nuno Guimarães; Mariana Gomes; Heyang Zhang; Katrien Remaut; Kevin Braeckmans; Stefaan De Smedt; Nuno Filipe Azevedo
Opublikowane w: Pharmaceutics, Numer 13 (7), 2021, Strona(/y) 989, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13070989

NickFect type of cell-penetrating peptides present enhanced efficiency for microRNA-146a delivery into dendritic cells and during skin inflammation.

Autorzy: Gemma Carreras-Badosa; Julia Maslovskaja; Kapilraj Periyasamy; Egon Urgard; Kärt Padari; Helen Vaher; Liina Tserel; Maxime Gestin; Kai Kisand; Piret Arukuusk; Chenguang Lou; Ülo Langel; Jesper Wengel; Margus Pooga; Ana Rebane
Opublikowane w: Biomaterials, Numer 262 (120316), 2020, ISSN 0142-9612
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120316

Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters.

Autorzy: Barras A, Sauvage F, De Hoon I, Braeckmans K, Hua D, et al.
Opublikowane w: Nanoscale Horizons, Numer 6 (6), 2021, Strona(/y) 449–61, ISSN 2055-6756
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d1nh00157d

Carbazole modified oligonucleotides: Synthesis, hybridization studies and fluorescence properties

Autorzy: Alaa S. Gouda; Alaa S. Gouda; Łukasz Przypis; Krzysztof Walczak; Per T. Jørgensen; Jesper Wengel
Opublikowane w: Organic and Biomolecular Chemistry, Numer 18 (35), 2020, Strona(/y) 6935-48, ISSN 1477-0520
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d0ob01553a

Can Vitamin B12 Assist the Internalization of Antisense LNA Oligonucleotides into Bacteria?

Autorzy: Pereira S, Yao R, Gomes M, Jørgensen PT, Wengel J, Azevedo NF, Santos RS
Opublikowane w: Antibiotics, Numer 10 (4), 2021, Strona(/y) 379, ISSN 2079-6382
Wydawca: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/antibiotics10040379

Photoporation with biodegradable polydopamine nanosensitizers enables safe and efficient delivery of mRNA in human T cells

Autorzy: Aranit Harizaj; Mike Wels; Laurens Raes; Stephan Stremersch; Glenn Goetgeluk; Toon Brans; Bart Vandekerckhove; Félix Sauvage; Stefaan C. De Smedt; Ine Lentacker; Kevin Braeckmans
Opublikowane w: Advanced Functional Materials, Numer 31 (28), 2021, Strona(/y) 2102472, ISSN 1616-301X
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202102472

Stimuli-responsive nanobubbles for biomedical applications

Autorzy: Ranhua Xiong; Ronald X. Xu; Chaobo Huang; Stefaan De Smedt; Kevin Braeckmans
Opublikowane w: Chemical Society Reviews, Numer 50 (9), 2021, Strona(/y) 5746–76, ISSN 1460-4744
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c9cs00839j

Polyamine-Functionalized 2'-Amino-LNA in Oligonucleotides: Facile Synthesis of New Monomers and High-Affinity Binding towards ssDNA and dsDNA.

Autorzy: Mathias B. Danielsen; Niels Johan Christensen; Per T. Jørgensen; Knud J. Jensen; Jesper Wengel; Chenguang Lou
Opublikowane w: Chemistry - A European Journal, Numer 27 (4), 2021, Strona(/y) 1416-22, ISSN 1521-3765
Wydawca: John Wiley & Sons, Ltd
DOI: 10.1002/chem.202004495

Photothermal nanofibres enable safe engineering of therapeutic cells

Autorzy: Xiong R, Hua D, Van Hoeck J, Berdecka D, Léger L, et al
Opublikowane w: Nature Nanotechnology, Numer 16 (11), 2021, Strona(/y) 1281–91, ISSN 1748-3395
Wydawca: Nature Publishing Group
DOI: 10.1038/s41565-021-00976-3

Intracellular delivery of oligonucleotides in Helicobacter pylori by fusogenic liposomes in the presence of gastric mucus

Autorzy: Rita S. Santos, George R. Dakwar, Elisa Zagato, Toon Brans, Céu Figueiredo, Koen Raemdonck, Nuno F. Azevedo, Stefaan C. De Smedt, Kevin Braeckmans
Opublikowane w: Biomaterials, Numer 138, 2017, Strona(/y) 1-12, ISSN 0142-9612
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2017.05.029

An in vitro model of catheter-associated urinary tract infections to investigate the role of uncommon bacteria on the Escherichia coli microbial consortium

Autorzy: Andreia S. Azevedo, Carina Almeida, Luciana C. Gomes, Carla Ferreira, Filipe J. Mergulhão, Luís F. Melo, Nuno F. Azevedo
Opublikowane w: Biochemical Engineering Journal, Numer 118, 2017, Strona(/y) 64-69, ISSN 1369-703X
Wydawca: Elsevier BV
DOI: 10.1016/j.bej.2016.11.013

Discriminating typical and atypical cystic fibrosis-related bacteria by multiplex PNA-FISH

Autorzy: Susana P. Lopes, Daniel T. Carvalho, Maria O. Pereira, Nuno F. Azevedo
Opublikowane w: Biotechnology and Bioengineering, Numer 114/2, 2017, Strona(/y) 355-367, ISSN 0006-3592
Wydawca: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.26085

Novel strategy to detect and locate periodontal pathogens: The PNA-FISH technique

Autorzy: Luzia Mendes, Rui Rocha, Andreia Sofia Azevedo, Catarina Ferreira, Mariana Henriques, Miguel Gonçalves Pinto, Nuno Filipe Azevedo
Opublikowane w: Microbiological Research, Numer 192, 2016, Strona(/y) 185-191, ISSN 0944-5013
Wydawca: Elsevier BV
DOI: 10.1016/j.micres.2016.07.002

Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model

Autorzy: Sílvia Fontenete, Marina Leite, Davie Cappoen, Rita Santos, Chris Van Ginneken, Céu Figueiredo, Jesper Wengel, Paul Cos, Nuno Filipe Azevedo
Opublikowane w: PLOS ONE, Numer 11/2, 2016, Strona(/y) e0148353, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0148353

Application of locked nucleic acid-based probes in fluorescence in situ hybridization

Autorzy: Sílvia Fontenete, Daniel Carvalho, Nuno Guimarães, Pedro Madureira, Céu Figueiredo, Jesper Wengel, Nuno Filipe Azevedo
Opublikowane w: Applied Microbiology and Biotechnology, Numer 100/13, 2016, Strona(/y) 5897-5906, ISSN 0175-7598
Wydawca: Springer Verlag
DOI: 10.1007/s00253-016-7429-4

Optimization of peptide nucleic acid fluorescence in situ hybridization (PNA-FISH) for the detection of bacteria: The effect of pH, dextran sulfate and probe concentration

Autorzy: Rui Rocha, Rita S. Santos, Pedro Madureira, Carina Almeida, Nuno F. Azevedo
Opublikowane w: Journal of Biotechnology, Numer 226, 2016, Strona(/y) 1-7, ISSN 0168-1656
Wydawca: Elsevier BV
DOI: 10.1016/j.jbiotec.2016.03.047

Impact of Delftia tsuruhatensis and Achromobacter xylosoxidans on Escherichia coli dual-species biofilms treated with antibiotic agents

Autorzy: Andreia S. Azevedo, Carina Almeida, Bruno Pereira, Luís F. Melo, Nuno F. Azevedo
Opublikowane w: Biofouling, Numer 32/3, 2016, Strona(/y) 227-241, ISSN 0892-7014
Wydawca: Taylor & Francis
DOI: 10.1080/08927014.2015.1124096

Prediction of melting temperatures in fluorescence in situ hybridization (FISH) procedures using thermodynamic models

Autorzy: Sílvia Fontenete, Nuno Guimarães, Jesper Wengel, Nuno Filipe Azevedo
Opublikowane w: Critical Reviews in Biotechnology, 2016, Strona(/y) 1-12, ISSN 0738-8551
Wydawca: Taylor & Francis
DOI: 10.3109/07388551.2014.993589

Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori

Autorzy: Rita S Santos, George R Dakwar, Ranhua Xiong, Katrien Forier, Katrien Remaut, Stephan Stremersch, Nuno Guimarães, Sílvia Fontenete, Jesper Wengel, Marina Leite, Céu Figueiredo, Stefaan C De Smedt, Kevin Braeckmans, Nuno F Azevedo
Opublikowane w: Molecular Therapy - Nucleic Acids, Numer 4, 2015, Strona(/y) e269, ISSN 2162-2531
Wydawca: Nature Publishing Group
DOI: 10.1038/mtna.2015.46

Towards Fluorescence In Vivo Hybridization (FIVH) Detection of H. pylori in Gastric Mucosa Using Advanced LNA Probes

Autorzy: Sílvia Fontenete, Marina Leite, Nuno Guimarães, Pedro Madureira, Rui Manuel Ferreira, Céu Figueiredo, Jesper Wengel, Nuno Filipe Azevedo
Opublikowane w: PLOS ONE, Numer 10/4, 2015, Strona(/y) e0125494, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0125494

Detection and discrimination of biofilm populations using locked nucleic acid/2′-O-methyl-RNA fluorescence in situ hybridization (LNA/2′OMe-FISH)

Autorzy: Andreia S. Azevedo, Carina Almeida, Bruno Pereira, Pedro Madureira, Jesper Wengel, Nuno F. Azevedo
Opublikowane w: Biochemical Engineering Journal, Numer 104, 2015, Strona(/y) 64-73, ISSN 1369-703X
Wydawca: Elsevier BV
DOI: 10.1016/j.bej.2015.04.024

Mismatch discrimination in fluorescent in situ hybridization using different types of nucleic acids

Autorzy: Fontenete Silvia, Barros Joana, Madureira Pedro, Figueiredo Céu, Wengel Jesper, Azevedo Nuno Filipe
Opublikowane w: Applied Microbiology and Biotechnology, Numer 99/9, 2015, Strona(/y) 3961-3969, ISSN 0175-7598
Wydawca: Springer Verlag
DOI: 10.1007/s00253-015-6389-4

Alpha-l-Locked Nucleic Acid-Modified Antisense Oligonucleotides Induce Efficient Splice Modulation In Vitro

Autorzy: Prithi Raguraman, Tao Wang, Lixia Ma, Per Trolle Jørgensen, Jesper Wengel, Rakesh N. Veedu
Opublikowane w: International Journal of Molecular Sciences, Numer 21/7, 2020, Strona(/y) 2434, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072434

Fluorinated Molecules and Nanotechnology: Future ‘Avengers’ against the Alzheimer’s Disease?

Autorzy: Meghna Dabur, Joana A. Loureiro, Maria Carmo Pereira
Opublikowane w: International Journal of Molecular Sciences, Numer 21/8, 2020, Strona(/y) 2989, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21082989

Molecular interactions between Vitamin B12 and membrane models: A biophysical study for new insights into the bioavailability of Vitamin

Autorzy: Maria João Ramalho, Stéphanie Andrade, Manuel A.N. Coelho, Joana A. Loureiro, Maria Carmo Pereira
Opublikowane w: Colloids and Surfaces B: Biointerfaces, Numer 194, 2020, Strona(/y) 111187, ISSN 0927-7765
Wydawca: Elsevier BV
DOI: 10.1016/j.colsurfb.2020.111187

Novel assemblies based on oligonucleotides containing intercalating nucleic acid monomers

Autorzy: Asmaa Abdelrahman, Alaa S. Gouda, Per T. Jørgensen, Jesper Wengel
Opublikowane w: Nucleosides, Nucleotides & Nucleic Acids, Numer 39/1-3, 2020, Strona(/y) 82-96, ISSN 1525-7770
Wydawca: Marcel Dekker Inc.
DOI: 10.1080/15257770.2019.1683188

Gapmer Antisense Oligonucleotides Containing 2′,3′‐Dideoxy‐2′‐fluoro‐3′‐ C ‐hydroxymethyl‐β‐ d ‐lyxofuranosyl Nucleotides Display Site‐Specific RNase H Cleavage and Induce Gene Silencing

Autorzy: Mathias B. Danielsen, Chenguang Lou, Jolanta Lisowiec‐Wachnicka, Anna Pasternak, Per T. Jørgensen, Jesper Wengel
Opublikowane w: Chemistry – A European Journal, Numer 26/6, 2020, Strona(/y) 1368-1379, ISSN 0947-6539
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201904540

Nanomaterials and molecular transporters to overcome the bacterial envelope barrier: Towards advanced delivery of antibiotics

Autorzy: Rita S. Santos, Céu Figueiredo, Nuno F. Azevedo, Kevin Braeckmans, Stefaan C. De Smedt
Opublikowane w: Advanced Drug Delivery Reviews, Numer 136-137, 2018, Strona(/y) 28-48, ISSN 0169-409X
Wydawca: Elsevier BV
DOI: 10.1016/j.addr.2017.12.010

Macrophage reprogramming into a pro-healing phenotype by siRNA delivered with LBL assembled nanocomplexes for wound healing applications

Autorzy: Sharifiaghdam M, Shaabani E, Sharifiaghdam Z, De Keersmaecker H, Lucas B, Lammens J, et al.
Opublikowane w: Nanoscale, Numer 13 (36), 2021, Strona(/y) 15445–63, ISSN 2040-3364
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d1nr03830c

The dawn of mRNA vaccines: The COVID-19 case

Autorzy: Verbeke R, Lentacker I, De Smedt SC, Dewitte H.
Opublikowane w: Journal of Controlled Release, Numer 333, 2021, Strona(/y) 511–20, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2021.03.043

Vaccinia Virus Protein B18R: Influence on mRNA Immunogenicity and Translation upon Non-Viral Delivery in Different Ocular Cell Types

Autorzy: Minnaert AK, Devoldere J, Peynshaert K, Vercruysse L, De Smedt SC, Remaut K
Opublikowane w: Pharmaceutics, Numer 13 (1), 2021, Strona(/y) 74, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13010074

Book chapters (4)

Delivery of Oligonucleotides into Bacteria by Fusogenic Liposomes. In: Fluorescence In-Situ Hybridization (FISH) for Microbial Cells.

Autorzy: Pereira S, Santos RS, Moreira L, Guimarães N, Braeckmans K, De Smedt SC, Azevedo NF
Opublikowane w: Methods in Molecular Biology, Numer 2246, 2021, Strona(/y) 87–96, ISBN 978-1-0716-1115-9
Wydawca: Humana
DOI: 10.1007/978-1-0716-1115-9_6

An Introduction to Fluorescence in situ Hybridization in Microorganisms. In: Fluorescence In-Situ Hybridization (FISH) for Microbial Cells.

Autorzy: Almeida C, Azevedo NF
Opublikowane w: Methods in Molecular Biology, Numer 2246, 2021, Strona(/y) 1–15, ISBN 978-1-0716-1115-9
Wydawca: Humana
DOI: 10.1007/978-1-0716-1115-9_1

Computational Resources and Strategies to Construct Single-Molecule Models of FISH. In: Fluorescence In-Situ Hybridization (FISH) for Microbial Cells.

Autorzy: Magalhães BT, Santos RS, Azevedo NF, Lourenço A
Opublikowane w: Methods in Molecular Biology, Numer 2246, 2021, Strona(/y) 317–30, ISBN 978-1-0716-1115-9
Wydawca: Humana
DOI: 10.1007/978-1-0716-1115-9_21

Albumin-Binding Fatty Acid–Modified Gapmer Antisense Oligonucleotides for Modulation of Pharmacokinetics. In: Gapmers.

Autorzy: Cai Y, Lou C, Wengel J, Howard KA.
Opublikowane w: Methods in Molecular Biology, Numer 2176, 2020, Strona(/y) 163–74, ISBN 978-1-0716-0770-8
Wydawca: Humana
DOI: 10.1007/978-1-0716-0771-8_12

Thesis and dissertations (2)

Delivery of nucleic acid mimics into bacteria as a novel method to treat infections

Autorzy: Pereira S.
Opublikowane w: 2021
Wydawca: FEUP

Design and application of nucleic acid mimics oligonucleotides (NAMs) in combination with nanoparticles for detection and/or growth inhibition of microorganisms

Autorzy: Moreira L.
Opublikowane w: 2022
Wydawca: FEUP