Periodic Reporting for period 1 - AntiCamp (Developing proprietary antibacterial phage-based particles against Campylobacter jejuni for food decontamination)
Berichtszeitraum: 2018-12-01 bis 2020-05-31
To address the above problem, we have made use of a unique technology. This technology involves the production of proprietary phage-based particles that specifically inject any DNA, e.g. encoding antibacterial products, into the target bacteria. The particles are composed of a homogenous scaffold, and are produced in Escherichia coli. They can be easily modified to target a variety of serotypes or evolving resistant-mutants of the relevant bacteria. We managed to further optimize the delivery platform by making it more specific to certain strains. We aimed to develop phage-based particles that will be effective against Campylobacter jejuni, the most prevalent pathogen in foodborne poisonings in Europe. Several technological challenges were encountered, most of which in delivery of the plasmid into C. jejuni. However, the funding allowed us to overcome major challenges, and to significantly proceed toward developing the desired prouct.