Description du projet
Un programme de formation sur des organoïdes innovants dans le cadre de l’étude des infections virales
Les approches courantes de l’étude des infections virales recourent notamment à des modèles animaux et à des cultures cellulaires en 2D. Dans le cas des infections virales humaines, cependant, les effets en aval et secondaires causés par les virus ne peuvent pas être entièrement étudiés via ces modèles. Financé par le programme Actions Marie Skłodowska-Curie, le projet OrganoVIR développera un réseau de formation à la recherche afin d’étudier les infections virales humaines dans des cultures cellulaires 3D (organoïdes). Son objectif est d’imposer les organoïdes humains en tant que modèles supérieurs permettant d’étudier la pathogenèse virale et de tester les antiviraux, à la place des modèles animaux. Ce programme formera les jeunes chercheurs aux aspects scientifiques et techniques des organoïdes dans le cadre de la recherche sur les virus, ainsi qu’aux aspects financiers, éthiques, commerciaux et juridiques de la technologie des organoïdes.
Objectif
OrganoVIR (Organoids for Virus Research) will train young researchers (ESRs) in the field of organoids and virology. Human viral infection studies lack suitable experimental models as animal models or conventional 2-dimensional (2D) cell cultures do not translate to human infection. OrganoVIR makes use of the breakthrough in the culturing of primary human cells into 3D cultures (organoids). Within this ETN programme, organoids will be used for the first time to study human viral infections in their natural environment.
OrganoVIR includes leading partners in virology and organoid technology covering 7 academic institutes, 3 life science companies, 1 organoid technology private company, 2 non-profit organisations, a national public health institute and a business school originating from 8 countries.
The aim is to introduce and establish human organoids as superior models for viral pathogenesis studies and antiviral testing, thus replacing animal models and reducing animal use. OrganoVIR provides a full package ETN programme for ESRs to learn the science of innovative 3D culture systems for virus research as well as financial, commercial, ethical, communicative, policy and dissemination aspects for optimal valorization. The projects are intensified by significant secondments at commercial, governmental and non-profit partner institutes.
OrganoVIR provides:
- High-ranked scientific and technical training in an interdisciplinary, intersectoral and international top research project
- Training in transferrable managerial skills, including a pre-MBA
- Implementation of innovative organoid technology for viral pathogenesis studies and antiviral development
- Innovation in organoid technology by co-culture design and high throughput screening.
OrganoVIR combines frontier research with an innovative training programme in a complementary network, certifying high impact scientists.
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinateur
1105AZ Amsterdam
Pays-Bas