Project description
European training programme on chromatin dynamics and DNA repair mechanisms
Cells possess a battery of DNA repair mechanisms ensuring the genome’s stability and its transmission to progeny. Defects in DNA repair mechanisms are associated with health complications ranging from developmental abnormalities to the onset of neurodegeneration, cancer and age-related diseases. DNA repair factors play additional roles in such processes as nucleosome remodelling, chromatin and RNA biogenesis, and the transcription activation of genes involved in cell proliferation. Funded by the Marie Skłodowska-Curie Actions programme, the aDDRess project aims to establish a European research training platform in the field of chromatin dynamics and DNA damage response. The objective is to create a dedicated network for high-quality training of young researchers, covering subjects from basic mechanisms to translational research applications.
Objective
Defects in DNA repair trigger a number of devastating health complications ranging from developmental abnormalities to the premature onset of age-related diseases, including the metabolic syndrome, neurodegeneration and cancer. To counteract genome instability, cells have evolved a battery of DNA repair mechanisms ensuring that their genome remains functionally intact and is faithfully transmitted to progeny. Recent work reveals that DNA repair factors play additional roles in vital biological processes, including nucleosome remodeling, chromatin architecture, RNA biogenesis or the transcription activation of genes involved in cellular reprogramming and growth. These recent discoveries have pushed the DNA repair field forward and towards new grounds requiring a series of sophisticated functional and multidisciplinary approaches. Based on these novel scientific paths, we have carefully designed the “aDDRess” consortium on the basis of past excellence of the individual participants and their relevance to the proposed field. The action addresses a major research topic i.e. DNA damage in development and disease with great socioeconomic impact in Europe and direct relevance to human health. The objectives of the program are:
i. to create a European research platform of excellence in the field of DNA repair by integrating research from basic mechanisms to translational research applications,
ii. to establish a Network dedicated to the high-quality training of ESRs promoting their independent careers and future employment prospects,
iii. to transform our current successful, long-term collaborations into a stronger intellectual network and build durable links between the participating labs and the industry (SMEs). Understanding the relevance of genome maintenance pathways to human health will shed light onto the causal mechanisms of rare and widespread life-threatening diseases, including cancer.
Fields of science
Programme(s)
Coordinator
70013 Irakleio
Greece
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Participants (13)
20139 Milano
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80539 Muenchen
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17177 Stockholm
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1066 CX Amsterdam
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50937 Koeln
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1015 Lausanne
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75006 Paris
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75794 Paris
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1165 Kobenhavn
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602 00 Brno
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Participation ended
38700 La Tronche
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
0374 OSLO
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
33100 Tampere
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partners (5)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
34136 Trieste
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
50931 Koln
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
74100 Rethimno
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
1211 Geneve
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
70013 Heraklion
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