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Joint Training and Research Program on Chromatin Dynamics and the DNA Damage Response

Objective

Defects in DNA repair trigger a number of devastating health complications ranging from developmental abnormalities to the premature onset of age-related diseases, including the metabolic syndrome, neurodegeneration and cancer. To counteract genome instability, cells have evolved a battery of DNA repair mechanisms ensuring that their genome remains functionally intact and is faithfully transmitted to progeny. Recent work reveals that DNA repair factors play additional roles in vital biological processes, including nucleosome remodeling, chromatin architecture, RNA biogenesis or the transcription activation of genes involved in cellular reprogramming and growth. These recent discoveries have pushed the DNA repair field forward and towards new grounds requiring a series of sophisticated functional and multidisciplinary approaches. Based on these novel scientific paths, we have carefully designed the “aDDRess” consortium on the basis of past excellence of the individual participants and their relevance to the proposed field. The action addresses a major research topic i.e. DNA damage in development and disease with great socioeconomic impact in Europe and direct relevance to human health. The objectives of the program are:
i. to create a European research platform of excellence in the field of DNA repair by integrating research from basic mechanisms to translational research applications,
ii. to establish a Network dedicated to the high-quality training of ESRs promoting their independent careers and future employment prospects,
iii. to transform our current successful, long-term collaborations into a stronger intellectual network and build durable links between the participating labs and the industry (SMEs). Understanding the relevance of genome maintenance pathways to human health will shed light onto the causal mechanisms of rare and widespread life-threatening diseases, including cancer.

Coordinator

IDRYMA TECHNOLOGIAS KAI EREVNAS
Net EU contribution
€ 486 035,28
Address
N Plastira Str 100
70013 Irakleio
Greece
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Ηράκλειο Κρήτη Νησιά Αιγαίου

Participants (13)

IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE
Italy
Net EU contribution
€ 261 499,68
Address
Via Adamello 16
20139 Milano
Activity type
Research Organisations
Non-EU contribution
€ 0,00
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
Net EU contribution
€ 252 788,40
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 281 982,96
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands
Net EU contribution
€ 265 619,88
Address
Plesmanlaan 121
1066 CX Amsterdam
Activity type
Research Organisations
Non-EU contribution
€ 0,00
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
Net EU contribution
€ 252 788,40
Address
Kerpener Strasse 62
50937 Koeln
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Net EU contribution
€ 281 276,64
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
UNIVERSITE PARIS CITE
France
Net EU contribution
€ 274 802,04
Address
85 Bd Saint Germain
75006 Paris
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Ile-de-France Ile-de-France Paris
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 274 802,04
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
KOBENHAVNS UNIVERSITET
Denmark
Net EU contribution
€ 297 522,00
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FAKULTNI NEMOCNICE U SV. ANNY V BRNE
Czechia
Net EU contribution
€ 234 871,56
Address
Pekarska 53
656 91 Brno
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
LXREPAIR
France
Net EU contribution
€ 274 802,04
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
5 Avenue Du Grand Sablon Biopolis
38700 La Tronche
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Auvergne-Rhône-Alpes Rhône-Alpes Isère
 
NORGENOTECH AS
Norway
Net EU contribution
€ 292 342,32
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Ullernchausseén 64
0374 Oslo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
GENEVIA TECHNOLOGIES OY
Finland
Net EU contribution
€ 280 805,76
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Hameenkatu 14 C 33
33100 Tampere
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Manner-Suomi Länsi-Suomi Pirkanmaa
 

Partners (5)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE
Italy
Net EU contribution
€ 0,00
Address
Via Bonomea 265
34136 Trieste
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSITAT ZU KOLN
Germany
Net EU contribution
€ 0,00
Address
Albertus Magnus Platz
50931 Koln
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

PANEPISTIMIO KRITIS
Greece
Net EU contribution
€ 0,00
Address
University Campus Gallos
74100 Rethimno
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Ρέθυμνο Κρήτη Νησιά Αιγαίου
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSITE DE GENEVE
Switzerland
Net EU contribution
€ 0,00
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Schweiz/Suisse/Svizzera Région lémanique Genève
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

ETAIRIA DIACHIRISIS KAI ANAPTIXIS EPISTIMONIKOU KAI TECHNOLOGIKOU PARKOU KRITIS AE
Greece
Net EU contribution
€ 0,00
Address
Nikolaou Plastira 100 Vasilika Vouton
70013 Heraklion
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Ηράκλειο Κρήτη Νησιά Αιγαίου