Deliverables Documents, reports (16) Batch and continuous chromatographic purification at microfluidic, lab and pilot scale Report on the comparison between batch and continuous chromatographic purification of the model bioproducts at microfluidic lab and pilot scale Mixing in microscale Report on the experimental results of mixing in microscale for the prediction of lab and pilot scale processes Small scale analysis Report on analysis on very small scale On-line estimation of product quality Report on experimental results of online estimation of product quality Power input and energy dissipation in miniaturized systems Report on the determination of power input and energy dissipation in miniaturized systems. Simulation of chromatographic behaviour for continuous DSP Report on the simulation of chromatographic behaviour for continuous downstream processing PAT for integrated processes Report on use of PAT tools for the rapid development of the integrated processes Integrated continuous processes: economic impact, drivers and future Report on the economic impact and drivers of integrated continuous processes and how such technology can support future challenges in biopharmaceutical industry HTS of integrated processes Report on the use on miniaturization for the high throughput screening of integrated processes Expanded bed technology in continuous processes Report on the use of expanded bed technology in continuous processes including pilot scale processing Purification of antibody in batch and continuous Report on the experimental results of purification of antibody in batch and continuous mode Integration of continuous downstream processes II Report on the integration of continuous downstream processes process feasibility studies and economic validation Integration of continuous downstream processes I Report on the integration of continuous downstream processes development of integrated control strategies and automation Microfluidic liquid-liquid extraction Report on experimental results of liquidliquid extraction of industrial enzymes in a microfluidic platform Batch and continuous extraction at microfluidic, lab and pilot scale Report on the comparison between batch and continuous extraction of industrial enzymes at microfluidic lab and pilot scale including economic and environmental analysis Effect of RTD on product collection Report on the effect of residence time distribution on startup and shutdown of product collection together with mathematical algorithm for decision making aid Other (2) Supervisory Board Supervisory Board of the network constituted. Recruitment procedure I Vacancies for ESR recruitment advertised. Websites, patent fillings, videos etc. (3) Dissemination contents/materials Dissemination contentsmaterials produced published and available to stakeholders ie scientific community and general public via website Policy feedback Potential inputs for policy feedback Website Dedicated project website launched. Publications Peer reviewed articles (30) White paper on high‐throughput process development for integrated continuous biomanufacturing Author(s): Mariana N. São Pedro, Tiago C. Silva, Rohan Patil, Marcel Ottens Published in: Biotechnology and Bioengineering, 2021, ISSN 0006-3592 Publisher: Wiley - V C H Verlag GmbbH & Co. DOI: 10.1002/bit.27757 Advanced control strategies for bioprocess chromatography: Challenges and opportunities for intensified processes and next generation products Author(s): Alexander Armstrong, Kieran Horry, Tingting Cui, Martyn Hulley, Richard Turner, Suzanne S. Farid, Stephen Goldrick, Daniel G. Bracewell Published in: Journal of Chromatography A, Issue 1639, 2021, Page(s) 461914, ISSN 0021-9673 Publisher: Elsevier BV DOI: 10.1016/j.chroma.2021.461914 An integrated microfluidic device for continuous bioprocessing Author(s): Malik Abdul Wahab, C. Domingues, Ana M. Azevedo, Virginia Chu, Joao Pedro Conde, M. Raquel Aires-Barros Published in: Separation and Purification Technology, Issue 332, 2024, ISSN 1383-5866 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.seppur.2023.125702 Process analytical technique (PAT) miniaturization for monoclonal antibody aggregate detection incontinuous downstream processing Author(s): São Pedro, M.N., Klijn, M.E., Eppink, M.H. and Ottens, M Published in: Journal of Chemical Technology and Biotechnology, Issue 97, 2022, Page(s) 2347-2364, ISSN 0268-2575 Publisher: John Wiley & Sons Inc. DOI: 10.1002/jctb.6920 Design of millidevices to expedite apparent solubility measurements Author(s): Maria del Carme Pons Royo; Jean-Luc Beulay; Eric Valery; Alois Jungbauer; Peter Satzer Published in: Reaction Chemistry and Engineering, Issue 7 (9), 2022, Page(s) 2045 - 2053, ISSN 2058-9883 Publisher: Royal Society of Chemistry DOI: 10.1039/d2re00022a Methodology for fast development of digital solutions in integrated continuous downstream processing Author(s): Niklas Andersson, Joaquín Gomis Fons, Madelène Isaksson, Simon Tallvod, Daniel Espinoza, Linnea Sjökvist, Gusten Zandler Andersson, Bernt Nilsson Published in: Biotechnology and Bioengineering, 2023, Page(s) 10, ISSN 0006-3592 Publisher: Wiley - V C H Verlag GmbbH & Co. DOI: 10.1002/bit.28501 Microchromatography integrated with impedance sensor for bioprocess optimization: Experimental and numerical study of column efficiency for evaluation of scalability Author(s): Amin Javidanbardan, Virginia Chu, João P. Conde, Ana M. Azevedo, Published in: Journal of Chromatography A, Issue 1661, 2022, Page(s) 462678, ISSN 0021-9673 Publisher: Elsevier BV DOI: 10.1016/j.chroma.2021.462678 A fluidized-bed-riser adsorption system for continuous bioproduct recovery from crude feedstock Author(s): Herlevi L.-M., Fernandez-Lahore M., Ferreira G. Published in: Biotechnology and Bioengineering, Issue 120, 10, 2023, Page(s) 2969 - 2976, ISSN 0006-3592 Publisher: Wiley - V C H Verlag GmbbH & Co. DOI: 10.1002/bit.28458 Online optimization of dynamic binding capacity and productivity by model predictive control Author(s): Touraj Eslami, Martin Steinberger, Christian Csizmazia, Alois Jungbauer, Nico Lingg Published in: Journal of Chromatography A, Issue Volume 1680, 13 September 2022, 463420, 2022, ISSN 0021-9673 Publisher: Elsevier BV DOI: 10.1016/j.chroma.2022.463420 Small, smaller, smallest: Miniaturization of chromatographic process development Author(s): Silva, TC, Eppink, M, Ottens, M Published in: Journal of Chromatography A, Issue 1681, 2022, Page(s) 463451, ISSN 0021-9673 Publisher: Elsevier BV DOI: 10.1016/j.chroma.2022.463451 Mode and dosage time in polyethylene glycol precipitation process influences protein precipitate size and filterability Author(s): Maria del Carme Pons Royo; Jean-Luc Beulay: Eric Valery; Alois Jungbauer; Peter Satzer Published in: Process Biochemistry, Issue 114, 2022, Page(s) 77-85, ISSN 1359-5113 Publisher: Elsevier Applied Science DOI: 10.1016/j.procbio.2022.01.017 Soft Sensor based on Raman Spectroscopy for the In-Line Monitoring of Metabolites and Polymer Quality in the Biomanufacturing of Polyhydroxyalkanoates Author(s): João Medeiros Garcia Alcântara; Francesco Iannacci; Massimo Morbidelli; Mattia Sponchioni Published in: Journal of Biotechnology, 2023, ISSN 0168-1656 Publisher: Elsevier BV DOI: 10.1016/j.jbiotec.2023.10.005 Automation and miniaturization: enabling tools for fast, high‐throughput process development in integrated continuous biomanufacturing Author(s): Tiago Castanheira Silva, Michel Eppink, Marcel Ottens Published in: Journal of Chemical Technology & Biotechnology, 2021, ISSN 0268-2575 Publisher: John Wiley & Sons Inc. DOI: 10.1002/jctb.6792 Moving adsorption belt system for continuous bioproduct recovery utilizing composite fibrous adsorbents Author(s): Guo Y., Kangwa M., Ali W., Mayer-Gall T., Gutmann J.S., Zenneck C., Winter M., Jungbauer A., Fernandez Lahore H.M. Published in: Frontiers in Bioengineering and Biotechnology, Issue 11, art. no. 1135447, 2023, ISSN 2296-4185 Publisher: Frontiers Media S.A DOI: 10.3389/fbioe.2023.1135447 Design of a microfluidic mixer channel: First steps into creating a fluorescent dye-based biosensor for mAb aggregate detection Author(s): São Pedro, M. N., Santos, M.S., Eppink M.H.M., & Ottens, M Published in: Biotechnology Journal, Issue 18(1), 2023, Page(s) 2200332, ISSN 1860-7314 Publisher: Wiley-VCH GmbH DOI: 10.1002/biot.202200332 Continuous precipitation of antibodies by feeding of solid polyethylene glycol Author(s): Maria del Carme Pons Royo; Tommaso De Santis: Daniel Komuczki; Peter Satzer: Alois Jungbauer Published in: Separation and Purification Technology, Issue 304, 2023, ISSN 1383-5866 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.seppur.2022.122373 Current trends in the production of biodegradable bioplastics: The case of polyhydroxyalkanoates Author(s): João Medeiros Garcia Alcântara, Francesco Distante, Giuseppe Storti, Davide Moscatelli, Massimo Morbidelli, Mattia Sponchioni Published in: Biotechnology Advances, Issue 42, 2020, Page(s) 107582, ISSN 0734-9750 Publisher: Elsevier BV DOI: 10.1016/j.biotechadv.2020.107582 Characterization of hydrodynamics and volumetric power input in microtiter plates for the scale-up of downstream operations Author(s): Ignacio Montes-Serrano; Peter Satzer; Alois Jungbauer; Astrid Dürauer Published in: Biotechnology and Bioengineering, Issue 119 (2), 2022, Page(s) 523 - 534, ISSN 0006-3592 Publisher: Wiley - V C H Verlag GmbbH & Co. DOI: 10.1002/bit.27983 Residence time distribution in counter-current protein A affinity chromatography using an inert tracer Author(s): Narges Lali; Peter Satzer; Alois Jungbauer Published in: Journal of Chromatography A, Issue 1683, 2022, ISSN 0021-9673 Publisher: Elsevier BV DOI: 10.1016/j.chroma.2022.463530 Traceability of products and guide for batch definition in integrated continuous biomanufacturing Author(s): Narges Lali; Alois Jungbauer; Peter Satzer Published in: Journal of Chemical Technology and Biotechnology, Issue 97 (9), 2022, Page(s) 2386 - 2392, ISSN 0268-2575 Publisher: John Wiley & Sons Inc. DOI: 10.1002/jctb.6953 An automated buffer management system for small-scale continuous downstream bioprocessing Author(s): Madelène Isaksson, Joaquín Gomis-Fons, Niklas Andersson, Bernt Nilsson Published in: Journal of Chromatography A, Issue 1695, 2023, ISSN 0021-9673 Publisher: Elsevier BV DOI: 10.1016/j.chroma.2023.463942 Milliscale reactors for integration of continuous precipitation and filtration Author(s): Maria del Carme Pons Royo; Ignacio Montes‐Serrano; Eric Valery; Alois Jungbauer; Peter Satzer Published in: Journal of Chemical Technology and Biotechnology, Issue 97 (11), 2022, Page(s) 3183 - 3192, ISSN 1097-4660 Publisher: John Wiley and Sons Ltd DOI: 10.1002/jctb.7187 A modelling approach for volumetric power input in the microscale and its utilization for the scale-up of solid-liquid mixing systems Author(s): Ignacio Montes-Serrano: Daniel Paul Komuczki; Astrid Dürauer Published in: Chemical Engineering and Processing: Process Intensification, Issue 184, 2023, ISSN 0255-2701 Publisher: Elsevier BV DOI: 10.1016/j.cep.2023.109303 Application of a fluorescent dye-based microfluidic sensor for real-time detection of mAb aggregates Author(s): São Pedro, M.N., Eppink M.H.M., & Ottens, M Published in: Biotechnology Progress, Issue e3355, 2023, ISSN 8756-7938 Publisher: American Chemical Society DOI: 10.1002/btpr.3355 Productivity for free: Residence time gradients during loading increase dynamic binding capacity and productivity Author(s): Touraj Eslami, Leo A. Jakob, Peter Satzer, Gerald Ebner, Alois Jungbauer, Nico Lingg Published in: Separation and Purification Technology, Issue Volume 281, 15 January 2022, 119985, 2022, ISSN 1383-5866 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.seppur.2021.119985 A Systematic Approach for Developing 3D High-Quality PDMS Microfluidic Chips Based on Micromilling Technology Author(s): Amin Javidanbardan, Ana M. Azevedo, Virginia Chu, João P. Conde Published in: Micromachines, Issue 13, 2022, ISSN 2072-666X Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/mi13010006 Design of an integrated continuous downstream process for acid-sensitive monoclonal antibodies based on a calcium-dependent Protein A ligand Author(s): Julia Scheffel, Madelène Isaksson, Joaquín Gomis-Fons , Hubert Schwarz, Niklas Andersson, Björn Norén, Anita Solbrand, Veronique Chotteau, Sophia Hober, Bernt Nilsson Published in: Journal of Chromatography A, Issue 1664, 2022, Page(s) 1-18, ISSN 0021-9673 Publisher: Elsevier BV DOI: 10.1016/j.chroma.2022.462806 Megaporous monolithic adsorbents for bioproduct recovery as prepared on the basis of nonwoven fabrics Author(s): Guo Y., Ali W., Schneider A., Salma A., Mayer-Gall T., Gutmann J.S., Fernandez Lahore H.M. Published in: Electrophoresis, Issue 43, issue 13-14, 2022, Page(s) 1387 - 1398, ISSN 0173-0835 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/elps.202100220 Real-time detection of mAb aggregates in an integrated downstream process Author(s): São Pedro, M.N., Isaksson, M., Gomis-Fons, J., Eppink M.H.M., Nilsson, B. & Ottens, M. Published in: Biotechnology & Bioengineering, Issue 120 (10), 2023, Page(s) 2989-3000, ISSN 0006-3592 Publisher: Wiley - V C H Verlag GmbbH & Co. DOI: 10.1002/bit.28466 Integrated continuous biomanufacturing on pilot scale for acid‐sensitive monoclonal antibodies Author(s): Hubert Schwarz; Joaquín Gomis‐Fons; Madelène Isaksson; Julia Scheffel; Niklas Andersson; Andreas Andersson; Andreas Castan; Anita Solbrand; Sophia Hober; Bernt Nilsson; Veronique Chotteau Published in: Biotechnology and Bioengineering, Issue 3, 2022, Page(s) 1-18, ISSN 0006-3592 Publisher: Wiley - V C H Verlag GmbbH & Co. DOI: 10.1002/bit.28120 Intellectual Property Rights Other (2) APPARATUS AND METHOD FOR REMOVING PROTEINS TAKEN UP IN A CARRIER LIQUID Application/Publication number: WO 2022207907A1 Date: 2021-04-01 Applicant(s): CONSTRUCTOR UNIVERSITY BREMEN GGMBH Apparatus and method for the purification of biomolecules Application/Publication number: WO 2022083901 Date: 2021-06-15 Applicant(s): NOVASEP PROCESS Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
