Continuous Downstream Processing of Bioproducts

Resultado final

Batch and continuous chromatographic purification at microfluidic, lab and pilot scale

Report on the comparison between batch and continuous chromatographic purification of the model bioproducts at microfluidic lab and pilot scale

Mixing in microscale

Report on the experimental results of mixing in microscale for the prediction of lab and pilot scale processes

Small scale analysis

Report on analysis on very small scale

On-line estimation of product quality

Report on experimental results of online estimation of product quality

Power input and energy dissipation in miniaturized systems

Report on the determination of power input and energy dissipation in miniaturized systems.

Simulation of chromatographic behaviour for continuous DSP

Report on the simulation of chromatographic behaviour for continuous downstream processing

PAT for integrated processes

Report on use of PAT tools for the rapid development of the integrated processes

Integrated continuous processes: economic impact, drivers and future

Report on the economic impact and drivers of integrated continuous processes and how such technology can support future challenges in biopharmaceutical industry

HTS of integrated processes

Report on the use on miniaturization for the high throughput screening of integrated processes

Expanded bed technology in continuous processes

Report on the use of expanded bed technology in continuous processes including pilot scale processing

Purification of antibody in batch and continuous

Report on the experimental results of purification of antibody in batch and continuous mode

Integration of continuous downstream processes II

Report on the integration of continuous downstream processes process feasibility studies and economic validation

Integration of continuous downstream processes I

Report on the integration of continuous downstream processes development of integrated control strategies and automation

Microfluidic liquid-liquid extraction

Report on experimental results of liquidliquid extraction of industrial enzymes in a microfluidic platform

Batch and continuous extraction at microfluidic, lab and pilot scale

Report on the comparison between batch and continuous extraction of industrial enzymes at microfluidic lab and pilot scale including economic and environmental analysis

Effect of RTD on product collection

Report on the effect of residence time distribution on startup and shutdown of product collection together with mathematical algorithm for decision making aid

Supervisory Board

Supervisory Board of the network constituted.

Recruitment procedure I

Vacancies for ESR recruitment advertised.

Final and press conference

Final and press conference.

Miniaturized HTS

Training course on miniaturized HTS.

Dissemination contents/materials

Dissemination contentsmaterials produced published and available to stakeholders ie scientific community and general public via website

Policy feedback

Potential inputs for policy feedback

Website

Dedicated project website launched.

Publicaciones

White paper on high‐throughput process development for integrated continuous biomanufacturing

Autores: Mariana N. São Pedro, Tiago C. Silva, Rohan Patil, Marcel Ottens
Publicado en: Biotechnology and Bioengineering, 2021, ISSN 0006-3592
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.27757

Advanced control strategies for bioprocess chromatography: Challenges and opportunities for intensified processes and next generation products

Autores: Alexander Armstrong, Kieran Horry, Tingting Cui, Martyn Hulley, Richard Turner, Suzanne S. Farid, Stephen Goldrick, Daniel G. Bracewell
Publicado en: Journal of Chromatography A, Edición 1639, 2021, Página(s) 461914, ISSN 0021-9673
Editor: Elsevier BV
DOI: 10.1016/j.chroma.2021.461914

An integrated microfluidic device for continuous bioprocessing

Autores: Malik Abdul Wahab, C. Domingues, Ana M. Azevedo, Virginia Chu, Joao Pedro Conde, M. Raquel Aires-Barros
Publicado en: Separation and Purification Technology, Edición 332, 2024, ISSN 1383-5866
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.seppur.2023.125702

Process analytical technique (PAT) miniaturization for monoclonal antibody aggregate detection incontinuous downstream processing

Autores: São Pedro, M.N., Klijn, M.E., Eppink, M.H. and Ottens, M
Publicado en: Journal of Chemical Technology and Biotechnology, Edición 97, 2022, Página(s) 2347-2364, ISSN 0268-2575
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jctb.6920

Design of millidevices to expedite apparent solubility measurements

Autores: Maria del Carme Pons Royo; Jean-Luc Beulay; Eric Valery; Alois Jungbauer; Peter Satzer
Publicado en: Reaction Chemistry and Engineering, Edición 7 (9), 2022, Página(s) 2045 - 2053, ISSN 2058-9883
Editor: Royal Society of Chemistry
DOI: 10.1039/d2re00022a

Methodology for fast development of digital solutions in integrated continuous downstream processing

Autores: Niklas Andersson, Joaquín Gomis Fons, Madelène Isaksson, Simon Tallvod, Daniel Espinoza, Linnea Sjökvist, Gusten Zandler Andersson, Bernt Nilsson
Publicado en: Biotechnology and Bioengineering, 2023, Página(s) 10, ISSN 0006-3592
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.28501

Microchromatography integrated with impedance sensor for bioprocess optimization: Experimental and numerical study of column efficiency for evaluation of scalability

Autores: Amin Javidanbardan, Virginia Chu, João P. Conde, Ana M. Azevedo,
Publicado en: Journal of Chromatography A, Edición 1661, 2022, Página(s) 462678, ISSN 0021-9673
Editor: Elsevier BV
DOI: 10.1016/j.chroma.2021.462678

A fluidized-bed-riser adsorption system for continuous bioproduct recovery from crude feedstock

Autores: Herlevi L.-M., Fernandez-Lahore M., Ferreira G.
Publicado en: Biotechnology and Bioengineering, Edición 120, 10, 2023, Página(s) 2969 - 2976, ISSN 0006-3592
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.28458

Online optimization of dynamic binding capacity and productivity by model predictive control

Autores: Touraj Eslami, Martin Steinberger, Christian Csizmazia, Alois Jungbauer, Nico Lingg
Publicado en: Journal of Chromatography A, Edición Volume 1680, 13 September 2022, 463420, 2022, ISSN 0021-9673
Editor: Elsevier BV
DOI: 10.1016/j.chroma.2022.463420

Small, smaller, smallest: Miniaturization of chromatographic process development

Autores: Silva, TC, Eppink, M, Ottens, M
Publicado en: Journal of Chromatography A, Edición 1681, 2022, Página(s) 463451, ISSN 0021-9673
Editor: Elsevier BV
DOI: 10.1016/j.chroma.2022.463451

Mode and dosage time in polyethylene glycol precipitation process influences protein precipitate size and filterability

Autores: Maria del Carme Pons Royo; Jean-Luc Beulay: Eric Valery; Alois Jungbauer; Peter Satzer
Publicado en: Process Biochemistry, Edición 114, 2022, Página(s) 77-85, ISSN 1359-5113
Editor: Elsevier Applied Science
DOI: 10.1016/j.procbio.2022.01.017

Soft Sensor based on Raman Spectroscopy for the In-Line Monitoring of Metabolites and Polymer Quality in the Biomanufacturing of Polyhydroxyalkanoates

Autores: João Medeiros Garcia Alcântara; Francesco Iannacci; Massimo Morbidelli; Mattia Sponchioni
Publicado en: Journal of Biotechnology, 2023, ISSN 0168-1656
Editor: Elsevier BV
DOI: 10.1016/j.jbiotec.2023.10.005

Automation and miniaturization: enabling tools for fast, high‐throughput process development in integrated continuous biomanufacturing

Autores: Tiago Castanheira Silva, Michel Eppink, Marcel Ottens
Publicado en: Journal of Chemical Technology & Biotechnology, 2021, ISSN 0268-2575
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jctb.6792

Moving adsorption belt system for continuous bioproduct recovery utilizing composite fibrous adsorbents

Autores: Guo Y., Kangwa M., Ali W., Mayer-Gall T., Gutmann J.S., Zenneck C., Winter M., Jungbauer A., Fernandez Lahore H.M.
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 11, art. no. 1135447, 2023, ISSN 2296-4185
Editor: Frontiers Media S.A
DOI: 10.3389/fbioe.2023.1135447

Design of a microfluidic mixer channel: First steps into creating a fluorescent dye-based biosensor for mAb aggregate detection

Autores: São Pedro, M. N., Santos, M.S., Eppink M.H.M., & Ottens, M
Publicado en: Biotechnology Journal, Edición 18(1), 2023, Página(s) 2200332, ISSN 1860-7314
Editor: Wiley-VCH GmbH
DOI: 10.1002/biot.202200332

Continuous precipitation of antibodies by feeding of solid polyethylene glycol

Autores: Maria del Carme Pons Royo; Tommaso De Santis: Daniel Komuczki; Peter Satzer: Alois Jungbauer
Publicado en: Separation and Purification Technology, Edición 304, 2023, ISSN 1383-5866
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.seppur.2022.122373

Current trends in the production of biodegradable bioplastics: The case of polyhydroxyalkanoates

Autores: João Medeiros Garcia Alcântara, Francesco Distante, Giuseppe Storti, Davide Moscatelli, Massimo Morbidelli, Mattia Sponchioni
Publicado en: Biotechnology Advances, Edición 42, 2020, Página(s) 107582, ISSN 0734-9750
Editor: Elsevier BV
DOI: 10.1016/j.biotechadv.2020.107582

Characterization of hydrodynamics and volumetric power input in microtiter plates for the scale-up of downstream operations

Autores: Ignacio Montes-Serrano; Peter Satzer; Alois Jungbauer; Astrid Dürauer
Publicado en: Biotechnology and Bioengineering, Edición 119 (2), 2022, Página(s) 523 - 534, ISSN 0006-3592
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.27983

Residence time distribution in counter-current protein A affinity chromatography using an inert tracer

Autores: Narges Lali; Peter Satzer; Alois Jungbauer
Publicado en: Journal of Chromatography A, Edición 1683, 2022, ISSN 0021-9673
Editor: Elsevier BV
DOI: 10.1016/j.chroma.2022.463530

Traceability of products and guide for batch definition in integrated continuous biomanufacturing

Autores: Narges Lali; Alois Jungbauer; Peter Satzer
Publicado en: Journal of Chemical Technology and Biotechnology, Edición 97 (9), 2022, Página(s) 2386 - 2392, ISSN 0268-2575
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jctb.6953

An automated buffer management system for small-scale continuous downstream bioprocessing

Autores: Madelène Isaksson, Joaquín Gomis-Fons, Niklas Andersson, Bernt Nilsson
Publicado en: Journal of Chromatography A, Edición 1695, 2023, ISSN 0021-9673
Editor: Elsevier BV
DOI: 10.1016/j.chroma.2023.463942

Milliscale reactors for integration of continuous precipitation and filtration

Autores: Maria del Carme Pons Royo; Ignacio Montes‐Serrano; Eric Valery; Alois Jungbauer; Peter Satzer
Publicado en: Journal of Chemical Technology and Biotechnology, Edición 97 (11), 2022, Página(s) 3183 - 3192, ISSN 1097-4660
Editor: John Wiley and Sons Ltd
DOI: 10.1002/jctb.7187

A modelling approach for volumetric power input in the microscale and its utilization for the scale-up of solid-liquid mixing systems

Autores: Ignacio Montes-Serrano: Daniel Paul Komuczki; Astrid Dürauer
Publicado en: Chemical Engineering and Processing: Process Intensification, Edición 184, 2023, ISSN 0255-2701
Editor: Elsevier BV
DOI: 10.1016/j.cep.2023.109303

Application of a fluorescent dye-based microfluidic sensor for real-time detection of mAb aggregates

Autores: São Pedro, M.N., Eppink M.H.M., & Ottens, M
Publicado en: Biotechnology Progress, Edición e3355, 2023, ISSN 8756-7938
Editor: American Chemical Society
DOI: 10.1002/btpr.3355

Productivity for free: Residence time gradients during loading increase dynamic binding capacity and productivity

Autores: Touraj Eslami, Leo A. Jakob, Peter Satzer, Gerald Ebner, Alois Jungbauer, Nico Lingg
Publicado en: Separation and Purification Technology, Edición Volume 281, 15 January 2022, 119985, 2022, ISSN 1383-5866
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.seppur.2021.119985

A Systematic Approach for Developing 3D High-Quality PDMS Microfluidic Chips Based on Micromilling Technology

Autores: Amin Javidanbardan, Ana M. Azevedo, Virginia Chu, João P. Conde
Publicado en: Micromachines, Edición 13, 2022, ISSN 2072-666X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi13010006

Design of an integrated continuous downstream process for acid-sensitive monoclonal antibodies based on a calcium-dependent Protein A ligand

Autores: Julia Scheffel, Madelène Isaksson, Joaquín Gomis-Fons , Hubert Schwarz, Niklas Andersson, Björn Norén, Anita Solbrand, Veronique Chotteau, Sophia Hober, Bernt Nilsson
Publicado en: Journal of Chromatography A, Edición 1664, 2022, Página(s) 1-18, ISSN 0021-9673
Editor: Elsevier BV
DOI: 10.1016/j.chroma.2022.462806

Megaporous monolithic adsorbents for bioproduct recovery as prepared on the basis of nonwoven fabrics

Autores: Guo Y., Ali W., Schneider A., Salma A., Mayer-Gall T., Gutmann J.S., Fernandez Lahore H.M.
Publicado en: Electrophoresis, Edición 43, issue 13-14, 2022, Página(s) 1387 - 1398, ISSN 0173-0835
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/elps.202100220

Real-time detection of mAb aggregates in an integrated downstream process

Autores: São Pedro, M.N., Isaksson, M., Gomis-Fons, J., Eppink M.H.M., Nilsson, B. & Ottens, M.
Publicado en: Biotechnology & Bioengineering, Edición 120 (10), 2023, Página(s) 2989-3000, ISSN 0006-3592
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.28466

Integrated continuous biomanufacturing on pilot scale for acid‐sensitive monoclonal antibodies

Autores: Hubert Schwarz; Joaquín Gomis‐Fons; Madelène Isaksson; Julia Scheffel; Niklas Andersson; Andreas Andersson; Andreas Castan; Anita Solbrand; Sophia Hober; Bernt Nilsson; Veronique Chotteau
Publicado en: Biotechnology and Bioengineering, Edición 3, 2022, Página(s) 1-18, ISSN 0006-3592
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.28120

Resultado final

Publicaciones

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