Descrizione del progetto
Il lavoro di squadra apre la strada alla scoperta e all’applicazione di innovative proteine nella biologia sintetica
Il rapido sviluppo di tecniche per lo studio delle molecole coinvolte nei processi cellulari sta conducendo a informazioni scientifiche nuove e significative. In particolare, la biologia sintetica apre la strada a innovative applicazioni di grande rilevanza socioeconomica, tra cui l’ambito dell’energia verde. Con il sostegno del programma di azioni Marie Skłodowska-Curie, il progetto RNAct sta formando una nuova generazione di ricercatori nella progettazione di innovative proteine leganti l’RNA per la bioanalisi e la biologia sintetica. I ricercatori in fase iniziale di carriera si uniscono in coppie per insegnarsi a vicenda il calcolo e la sperimentazione e collaborano con partner accademici e industriali per partecipare ad attività di innovazione, accelerando il progresso in settori importanti per la bioeconomia europea.
Obiettivo
RNAct creates an integrated and multidisciplinary training and research programme for 10 broadly employable ESRs with versatile computational and experimental skills. The RNAct research aim is the design of novel RNA recognition motif (RRM) proteins for exploitation in synthetic biology and bio-analytics. This is achieved through a design cycle that starts with computational approaches at the sequence and structure levels of proteins and RNA, in order to select amino acid positions and mutations for large-scale phage display experiments with RNA screening. Viable RRMs will be further investigated at the atomic level with integrative structural biology approaches, and will be applied in synthetic biology, to post-transcriptionally regulate fatty acid processing via RRMs, and in bio-analytics, to detect RNA in-cell and design RNA biochips. The RNAct training will provide ESR-tailored research and education-based training in both topical content and transversal skills. All ESRs will experience both academic and industrial environments, and will be exposed to both computation and experiment at the peer level via an ESR 'buddy' system. The ESRs will be actively involved in, and responsible for, information dissemination and communication for the RNAct project, and will have to opportunity to participate in innovation activities. This will enable the ESRs to constructively contribute to the European bio-economy in both academic and industrial settings.
Campo scientifico
- natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acids
- natural sciencesbiological sciencessynthetic biology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- natural sciencesbiological sciencesgeneticsRNA
- engineering and technologyother engineering and technologiesmicrotechnologymolecular engineering
Parole chiave
Programma(i)
Argomento(i)
Meccanismo di finanziamento
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinatore
1050 Bruxelles / Brussel
Belgio