Descripción del proyecto
Nueva información sobre las alteraciones novedosas de la topología de la cromatina
La alteración de la regulación génica en los seres humanos se produce de forma natural con la edad y se asocia a varias enfermedades. A fin de desarrollar herramientas de diagnóstico y métodos terapéuticos, es necesario caracterizar la forma en que la organización tridimensional de la cromatina afecta a la regulación génica en muchos trastornos. En el proyecto ChromDesign, financiado con fondos europeos, se formará a trece investigadores noveles para que trabajen con expertos europeos en biología de la cromatina, genómica tridimensional y diseño de investigaciones a fin de identificar nuevas alteraciones en la topología de la cromatina responsables de disfunciones celulares. El equipo del proyecto investigará cómo el genoma se organiza en tres dimensiones a lo largo del tiempo y de qué modo la organización tridimensional está relacionada con la regulación génica en la salud y la enfermedad para desarrollar nuevas herramientas de diagnóstico, comunicar los resultados de investigación a través de juegos de herramientas específicos e identificar dianas terapéuticas innovadoras.
Objetivo
ChromDesign is an innovative and interdisciplinary network of 10 European academic and private institutions that will characterize how 3D chromatin organization affects gene regulation during cellular differentiation and in several human disorders. We will train 13 Early Stage Researchers (ESR), equipping them with the skills, knowledge, expertise, and enthusiasm necessary to develop successful future careers in the biomedical field (in academia or the private sector). Together with European experts in chromatin biology, 3D genomics, and research design, these ESRs will work towards the goal of identifying novel alterations in chromatin topology responsible for cellular malfunctions to: i) develop new diagnostic tools, ii) effectively communicate research results through specific toolkits; and iii) identify novel therapeutic targets with the potential to be exploited as treatments.
Alteration of gene regulation occurs naturally during aging and underlies several human diseases. Its better characterization requires a deeper understanding of the spatial organization of the genome. We will investigate how the genome organizes in 3D over time, and how the 3D organization is related to gene regulation in health and disease. We will use and develop technologies in imaging, cell biology, genomics, and computational modelling and will focus on translating our results into clinical applications. ESRs will thereby receive training with state-of-the-art technologies in distinct research areas and in modules with theoretical and hands-on sessions on transferable skills: entrepreneurship, management, communication, and outreach.
ChromDesign comprises 6 work packages: WP1–4 address the 4 main areas of chromatin biology and 3D genomics; WP5 applies the knowledge obtained from WPs1–4 into translational research; WP6 develops (with a dedicated ESR) a set of design toolkits for communicating results to scientists, the public, and schools; and WP7 ensures quality training for ESRs.
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
08003 Barcelona
España