Description du projet
Formation en immunométabolisme: l’avenir des stratégies antivirales
Le système immunitaire inné se trouve en première ligne contre les agents pathogènes viraux. La reprogrammation métabolique des cellules immunitaires semble influencer la réponse antivirale et inflammatoire de l’hôte aux infections virales, et constitue un nouveau domaine prometteur pour élaborer des remèdes antiviraux. Le projet INITIATE, financé par l’UE, rassemblera des experts issus du milieu académique et de l’industrie afin de proposer un programme de formation scientifique interdisciplinaire sur les interactions entre infection virale, métabolisme hôte et défense immunitaire. L’objectif est de fournir des connaissances sans précédent susceptibles d’être traduites en interventions thérapeutiques novatrices contre les infections virales, et de lutter contre les épidémies ou les pandémies à venir.
Objectif
Viral outbreaks and epidemics continue to impose high morbidity and mortality burdens in mankind and animals, emphasizing the urgent need for the continuous improvement and innovation of our antiviral strategies. The innate immune system is pivotal for effective anti-viral defences. This field is now being revolutionised by the recognition that metabolic re-programming has a major impact on the host antiviral and inflammatory response to virus infections. The development of strategies targeted to these pathways represents an exciting new frontier for antiviral remedies. To drive this emerging field of antiviral immunometabolism and its application to viral diseases, INITIATE (INnate-ImmunomeTabolIsm as Antiviral TargEt) brings together a highly complementary team of world leaders, both academic and corporate, from the historically distinct research fields of virology, innate immunity and cellular metabolism in order to train a new generation of interdisciplinary scientists. Specifically, INITIATE will deliver training on the interrelationships between viral infection, host metabolism and immune defences through related and interdependent research projects, complemented with interdisciplinary and intersectoral secondments. Local and network-wide scientific workshops will be supplemented with transferrable skill workshops devoted to academia/industry collaboration, research dissemination and translation of knowledge into novel therapeutic interventions, public engagement and a successful research environment. INITIATE will result in a new generation of creative, entrepreneurial and innovative top-level interdisciplinary researchers, who will be at the forefront of the emerging research field of ‘antiviral immunometabolism’. These scientists will be able to face the inevitable future challenges in combating viral and other diseases, and they will be highly attractive to European Life Sciences industry and academia.
Champ scientifique
Programme(s)
Régime de financement
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinateur
3015 GD Rotterdam
Pays-Bas