PET Imaging of Alpha-Synuclein Fibril Formation

Project Information

PET-AlphaSy

Grant agreement ID: 813528

DOI

10.3030/813528

Project closed

EC signature date 30 August 2018

Start date 1 September 2018

End date 30 November 2022

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 4 100 369,95

EU contribution

€ 4 100 369,95

Coordinated by

KOBENHAVNS UNIVERSITET
Denmark

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (3)

Report on the Individual Career Plans
Report about the research progress
Report on lectures series

Websites, patent fillings, videos etc. (1)

Webpage

Publications

Peer reviewed articles (23)

Direct Cu-mediated aromatic 18F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging.

Author(s): Rocío García-Vázquez; Umberto Maria Battisti; Jesper Tranekjær Jørgensen; Vladimir Shalgunov; Lars Hvass; Daniel L. Stares; Ida Nymann Petersen; François Crestey; Andreas Löffler; Dennis Svatunek; Jesper L. Kristensen; Hannes Mikula; Andreas Kjaer; Matthias M. Herth
Published in: Chemical Science, Issue 12, 2021, Page(s) 11668-11675, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc02789a

The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier

Author(s): Sara Lopes van den Broek, Dag Sehlin, Jens V. Andersen, Blanca I. Aldana, Natalie Beschörner, Maiken Nedergaard, Gitte M. Knudsen, Stina Syvänen and Matthias M. Herth
Published in: Frontiers in Nuclear Medicine, 2022, ISSN 2673-8880
Publisher: Frontiers in Nuclear Medicine
DOI: 10.3389/fnume.2022.1001722

Synergistic Experimental and Computational Investigation of theBioorthogonal Reactivity of Substituted Aryltetrazines

Author(s): Umberto M. Battisti, Rocío García-Vázquez, Dennis Svatunek, Barbara Herrmann, Andreas Löffler, Hannes Mikula, and Matthias Manfred Herth
Published in: Bioconjugate Chemistry, Issue 33, issue 4, 2022, Page(s) 608-6024, ISSN 1520-4812
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.2c00042

Transport of nanomedicines across the blood-brain barrier:Challenges and opportunities for imaging and therapy

Author(s): Sara Lopes van den Broek; Vladimir Shalgunov; Matthias M. Herth
Published in: van den Broek , S L , Shalgunov , V & Herth , M M 2022 , ' Transport of nanomedicines across the blood-brain barrier : Challenges and opportunities for imaging and therapy ' , Biomaterials Advances , vol. 141 , 213125 . https://doi.org/10.1016/j.bioadv.2022.213125, Issue 3, 2022, ISSN 2772-9516
Publisher: Elsevier
DOI: 10.1016/j.bioadv.2022.213125

Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo

Author(s): Dr. Christian B. M. Poulie, Dr. Emanuel Sporer, Lars Hvass, Dr. Jesper T. Jørgensen, Dr. Paul J. Kempen, Dr. Sara I. Lopes van den Broek, Dr. Vladimir Shalgunov, Prof. Dr. Andreas Kjaer, Dr. Andreas I. Jensen, Prof. Dr. Matthias M. Herth
Published in: Chemistry, Issue Volume28, Issue61, 2022, ISSN 1521-3765
Publisher: Chemistry Europe
DOI: 10.1002/chem.202201847

Pretargeted imaging beyond the blood–brain barrier

Author(s): Vladimir Shalgunov, Sara Lopes van den Broek, Ida Vang Andersen, a Rocío García Vázquez, Nakul Ravi Raval, Mikael Palner, Yuki Mori, Gabriela Schäfer, Barbara Herrmann, Hannes Mikula, Natalie Beschorner, Maiken Nedergaard, Stina Syvänen, Matthias Barz, Gitte Moos Knudsen, Umberto Maria Battisti and Matthias Manfred Herth
Published in: RSC Medicinal Chemistry, Issue 1, 2023, ISSN 2632-8682
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2md00360k

The role of neuroimaging in Parkinson's disease.

Author(s): Natasha Shalina Rajani Bidesi; Ida Vang Andersen; Albert D. Windhorst; Vladimir Shalgunov; Matthias M. Herth
Published in: Journal of Neurochemistry, Issue 14714159, 2021, Page(s) 660-689, ISSN 1471-4159
Publisher: Wiley
DOI: 10.1111/jnc.15516

A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain

Author(s): Nakul Ravi Raval; Annette Johansen; Lene Lundgaard Donovan; Nídia Fernandez Ros; Brice Ozenne; Hanne D. Hansen; Gitte M. Knudsen
Published in: International Journal of Molecular Sciences, Issue Vol 22, Iss 835, 2021, Page(s) p 835, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020835

In vivo imaging of synaptic density with [11C]UCB-J PET in two mouse models of neurodegenerative disease

Author(s): Mengfei Xiong, Sahar Roshanbin, Johanna Rokka, Eva Schlein, Martin Ingelsson, Dag Sehlin, Jonas Eriksson, Stina Syvänen
Published in: Neuroimage, Issue 239:118302, 2021, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2021.118302

Evaluation of the α-synuclein PET radiotracer (d3)-[11C]MODAG-001 in pigs

Author(s): Nakul Ravi Raval, Clara Aabye Madsen, Vladimir Shalgunov, Arafat Nasser, Umberto Maria Battisti, Emily Eufaula Beaman, Morten Juhl, Louise Møller Jørgensen, Matthias Manfred Herth, Hanne Demant Hansen, Pontus Plavén-Sigray, Gitte Moos Knudsen
Published in: Nuclear Medicine and Biology, 2022, ISSN 0969-8051
Publisher: Elsevier BV
DOI: 10.1016/j.nucmedbio.2022.08.001

An in vivo Pig Model for Testing Novel Positron Emission Tomography Radioligands Targeting Cerebral Protein Aggregates

Author(s): Nakul Ravi Raval, Arafat Nasser, Clara Aabye Madsen, Natalie Beschorner, Emily Eufaula Beaman, Morten Juhl, Szabolcs Lehel, Mikael Palner, Claus Svarer, Pontus Plavén-Sigray, Louise Møller Jørgensen, Gitte Moos Knudsen
Published in: Frontiers in Neuroscience, Issue Volume 16 - 2022, 2022, ISSN 1662-453X
Publisher: Frontiers
DOI: 10.3389/fnins.2022.847074

Advancing 89Zr-immuno-PET in neuroscience with a bispecific anti-amyloid-beta monoclonal antibody – the choice of chelator is essential

Author(s): Wuensche, Thomas E.; Stergiou, Natascha; Mes, Iris; Verlaan, Mariska; Schreurs, Maxime; Kooijman, Esther J. M.; Janssen, Bart; Windhorst, Albert D.; Jensen, Allan; Asuni, Ayodeji A.; Bang-Andersen, Benny; van Dongen, Guus A. M. S.; Beaino, Wissam; Vugts, Danielle J.
Published in: Wuensche , T E , Stergiou , N , Mes , I , Verlaan , M , Schreurs , M , Kooijman , E J M , Janssen , B , Windhorst , A D , Jensen , A , Asuni , A A , Bang-Andersen , B , van Dongen , G A M S , Beaino , W & Vugts , D J 2022 , ' Advancing 89Zr-immuno-PET in neuroscience with a bispecific anti-amyloid-beta monoclonal antibody – the choice of chelator is essential ' , Theranostics , vol. 12 , no. 16, Issue 7, 2022, Page(s) 7067-7079, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.73509

Insights into Elution of Anion Exchange Cartridges: Opening the Path toward Aliphatic 18F-Radiolabeling of Base-Sensitive Tracers.

Author(s): Klas Bratteby; Vladimir Shalgunov; Umberto Maria Battisti; Ida Nyman Petersen; Sara Lopes van den Broek; Tomas Ohlsson; Nic Gillings; Maria Erlandsson; Matthias M. Herth
Published in: ACS Pharmacology & Translational Science, Issue 4, 2021, Page(s) 1556-1566, ISSN 2575-9108
Publisher: American Chemical Society
DOI: 10.1021/acsptsci.1c00133

Alpha-Synuclein PET Tracer Development—An Overview about Current Efforts

Author(s): Špela Korat; Natasha Shalina Rajani Bidesi; Federica Bonanno; Adriana di Nanni; Anh Nguyên Nhât Hoàng; Kristina Herfert; Andreas Maurer; Umberto Maria Battisti; Gregory D. Bowden; David Thonon; Danielle J. Vugts; Albert D. Windhorst; Matthias M. Herth
Published in: Pharmaceuticals, Issue 5, Vol 14, 2021, Page(s) p 847, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14090847

[11C]Carboxylated tetrazines for facile labeling of trans-cyclooctene-functionalized PeptoBrushes

Author(s): Rocío García‐Vázquez; Umberto Maria Battisti; Vladimir Shalgunov; Gabriela Schäfer; Matthias Barz; Matthias Manfred Herth
Published in: Macromolecular Rapid Communications, Issue Vol. 43, Issue 12, 2022, ISSN 1521-3927
Publisher: Wiley
DOI: 10.1002/marc.202100655

Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

Author(s): Eva Schlein; Stina Syvänen; Johanna Rokka; Tobias Gustavsson; Raffaella Rossin; Marc Robillard; Jonas Eriksson; Dag Sehlin
Published in: Molecular Pharmaceutics, Issue 19, 2022, Page(s) 4111-4122, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.2c00536

Pretargeted Imaging beyond the Blood–Brain Barrier—Utopia or Feasible?

Author(s): Sara Lopes van den Broek,Vladimir Shalgunov,Rocío García Vázquez, Natalie Beschorner D, Natasha S. R. Bidesi, Maiken Nedergaard, Gitte M. Knudsen, Dag Sehlin, Stina Syvänen, Matthias M. Herth
Published in: Pharmaceuticals, Issue 15(10), 1191, 2022, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15101191

[11C]MODAG-001-towards a PET tracer targeting α-synuclein aggregates

Author(s): Laura Kuebler, Sabrina Buss, Andrei Leonov, Sergey Ryazanov, Felix Schmidt, Andreas Maurer; Daniel Weckbecker, Anne M Landau, Thea P Lillethorup, Daniel Bleher, Ran Sing Saw, Bernd J Pichler, Christian Griesinger, Armin Giese, Kristina Herfert
Published in: European Journal of Nuclear Medicine and Molecular Imaging, Issue 48, 2021, Page(s) 1759-1772, ISSN 1619-7070
Publisher: Springer Verlag
DOI: 10.1007/s00259-020-05133-x

Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins

Author(s): Dr. Natasha Shalina Radjani Bidesi, Dr. Umberto Maria Battisti, Dr. Sara Lopes van de Broek, Dr. Vladimir Shalgunov, Dr. Anne-Mette Dall, Dr. Jesper Bøggild Kristensen, Prof. Dag Sehlin, Prof. Stina Syvänen, Prof. Gitte Moos Knudsen, Prof. Matthias Manfred Herth
Published in: ChemBioChem, Issue Volume23, Issue23, 2022, ISSN 1439-7633
Publisher: Chemistry Europe
DOI: 10.1002/cbic.202200539

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Author(s): Rebecca Faresjö; Gillian Bonvicini; Xiaotian T. Fang; Ximena Aguilar; Dag Sehlin; Stina Syvänen
Published in: Fluids and Barriers of the CNS, Issue Vol 18, Iss 1, 2021, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-021-00257-0

Improved synthesis of SV2A targeting radiotracer [11C]UCB-J

Author(s): Johanna Rokka, Eva Schlein, Jonas Eriksson
Published in: EJNMMI Radiopharmacy and Chemistry, Issue 4/1, 2019, ISSN 2365-421X
Publisher: Springer Open
DOI: 10.1186/s41181-019-0080-5

Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease

Author(s): Nakul Ravi Raval; Nakul Ravi Raval; Frederik Gudmundsen; Morten Juhl; Ida Vang Andersen; Ida Vang Andersen; Nikolaj Speth; Annesofie Videbæk; Ida Nymann Petersen; Jens D. Mikkelsen; Jens D. Mikkelsen; Patrick M. Fisher; Matthias M. Herth; Matthias M. Herth; Pontus Plavén-Sigray; Gitte M. Knudsen; Gitte M. Knudsen; Mikael Palner; Mikael Palner; Mikael Palner
Published in: Frontiers in Synaptic Neuroscience, Issue vol. 13 , 715811, 2022, Page(s) 1663-3563, ISSN 1663-3563
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnsyn.2021.715811

α-Synuclein Radiotracer Development andIn VivoImaging: RecentAdvancements and New Perspectives

Author(s): Obada M. Alzghool, MSc,1,2*Guus van Dongen, PhD,1Elsmarieke van de Giessen, PhD,1Linda Schoonmade, MSc,3and Wissam Beaino, PhD
Published in: Movement disorders, Issue Volume37, Issue 5, 2022, Page(s) 936-948, ISSN 1531-8257
Publisher: Wiley
DOI: 10.1002/mds.28984

Other (1)

Additional file 1 of Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Author(s): Faresjö, Rebecca; Bonvicini, Gillian; Fang, Xiaotian T.; Aguilar, Ximena; Sehlin, Dag; Syvänen, Stina
Published in: Fluids Barriers CNS 18, 26 (2021), Issue 14, 2021, Page(s) 26, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.6084/m9.figshare.14722064.v1