Deliverables Documents, reports (3) Report on the Individual Career Plans Report about the research progress Report on lectures series Websites, patent fillings, videos etc. (1) Webpage Publications Peer reviewed articles (30) Direct Cu-mediated aromatic 18F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging. Author(s): Rocío García-Vázquez; Umberto Maria Battisti; Jesper Tranekjær Jørgensen; Vladimir Shalgunov; Lars Hvass; Daniel L. Stares; Ida Nymann Petersen; François Crestey; Andreas Löffler; Dennis Svatunek; Jesper L. Kristensen; Hannes Mikula; Andreas Kjaer; Matthias M. Herth Published in: Chemical Science, Issue 12, 2021, Page(s) 11668-11675, ISSN 2041-6539 Publisher: Royal Society of Chemistry DOI: 10.1039/d1sc02789a The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier Author(s): Sara Lopes van den Broek, Dag Sehlin, Jens V. Andersen, Blanca I. Aldana, Natalie Beschörner, Maiken Nedergaard, Gitte M. Knudsen, Stina Syvänen and Matthias M. Herth Published in: Frontiers in Nuclear Medicine, 2022, ISSN 2673-8880 Publisher: Frontiers in Nuclear Medicine DOI: 10.3389/fnume.2022.1001722 Synergistic Experimental and Computational Investigation of theBioorthogonal Reactivity of Substituted Aryltetrazines Author(s): Umberto M. Battisti, Rocío García-Vázquez, Dennis Svatunek, Barbara Herrmann, Andreas Löffler, Hannes Mikula, and Matthias Manfred Herth Published in: Bioconjugate Chemistry, Issue 33, issue 4, 2022, Page(s) 608-6024, ISSN 1520-4812 Publisher: American Chemical Society DOI: 10.1021/acs.bioconjchem.2c00042 Transport of nanomedicines across the blood-brain barrier:Challenges and opportunities for imaging and therapy Author(s): Sara Lopes van den Broek; Vladimir Shalgunov; Matthias M. Herth Published in: van den Broek , S L , Shalgunov , V & Herth , M M 2022 , ' Transport of nanomedicines across the blood-brain barrier : Challenges and opportunities for imaging and therapy ' , Biomaterials Advances , vol. 141 , 213125 . https://doi.org/10.1016/j.bioadv.2022.213125, Issue 3, 2022, ISSN 2772-9516 Publisher: Elsevier DOI: 10.1016/j.bioadv.2022.213125 Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo Author(s): Dr. Christian B. M. Poulie, Dr. Emanuel Sporer, Lars Hvass, Dr. Jesper T. Jørgensen, Dr. Paul J. Kempen, Dr. Sara I. Lopes van den Broek, Dr. Vladimir Shalgunov, Prof. Dr. Andreas Kjaer, Dr. Andreas I. Jensen, Prof. Dr. Matthias M. Herth Published in: Chemistry, Issue Volume28, Issue61, 2022, ISSN 1521-3765 Publisher: Chemistry Europe DOI: 10.1002/chem.202201847 Pretargeted imaging beyond the blood–brain barrier Author(s): Vladimir Shalgunov, Sara Lopes van den Broek, Ida Vang Andersen, a Rocío García Vázquez, Nakul Ravi Raval, Mikael Palner, Yuki Mori, Gabriela Schäfer, Barbara Herrmann, Hannes Mikula, Natalie Beschorner, Maiken Nedergaard, Stina Syvänen, Matthias Barz, Gitte Moos Knudsen, Umberto Maria Battisti and Matthias Manfred Herth Published in: RSC Medicinal Chemistry, Issue 1, 2023, ISSN 2632-8682 Publisher: Royal Society of Chemistry DOI: 10.1039/d2md00360k The role of neuroimaging in Parkinson's disease. Author(s): Natasha Shalina Rajani Bidesi; Ida Vang Andersen; Albert D. Windhorst; Vladimir Shalgunov; Matthias M. Herth Published in: Journal of Neurochemistry, Issue 14714159, 2021, Page(s) 660-689, ISSN 1471-4159 Publisher: Wiley DOI: 10.1111/jnc.15516 A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain Author(s): Nakul Ravi Raval; Annette Johansen; Lene Lundgaard Donovan; Nídia Fernandez Ros; Brice Ozenne; Hanne D. Hansen; Gitte M. Knudsen Published in: International Journal of Molecular Sciences, Issue Vol 22, Iss 835, 2021, Page(s) p 835, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms22020835 Direct Cu-mediated aromatic 18F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging. Author(s): Rocío García-Vázquez; Umberto Maria Battisti; Jesper Tranekjær Jørgensen; Vladimir Shalgunov; Lars Hvass; Daniel L. Stares; Ida Nymann Petersen; François Crestey; Andreas Löffler; Dennis Svatunek; Jesper L. Kristensen; Hannes Mikula; Andreas Kjaer; Matthias M. Herth Published in: Chemical Science, Issue 20416539, 2021, Page(s) 11668-11675, ISSN 2041-6539 Publisher: Royal Society of Chemistry DOI: 10.1039/d1sc02789a In vivo imaging of synaptic density with [11C]UCB-J PET in two mouse models of neurodegenerative disease Author(s): Mengfei Xiong, Sahar Roshanbin, Johanna Rokka, Eva Schlein, Martin Ingelsson, Dag Sehlin, Jonas Eriksson, Stina Syvänen Published in: Neuroimage, Issue 239:118302, 2021, ISSN 1053-8119 Publisher: Academic Press DOI: 10.1016/j.neuroimage.2021.118302 Evaluation of the α-synuclein PET radiotracer (d3)-[11C]MODAG-001 in pigs Author(s): Nakul Ravi Raval, Clara Aabye Madsen, Vladimir Shalgunov, Arafat Nasser, Umberto Maria Battisti, Emily Eufaula Beaman, Morten Juhl, Louise Møller Jørgensen, Matthias Manfred Herth, Hanne Demant Hansen, Pontus Plavén-Sigray, Gitte Moos Knudsen Published in: Nuclear Medicine and Biology, 2022, ISSN 0969-8051 Publisher: Elsevier BV DOI: 10.1016/j.nucmedbio.2022.08.001 An in vivo Pig Model for Testing Novel Positron Emission Tomography Radioligands Targeting Cerebral Protein Aggregates Author(s): Nakul Ravi Raval, Arafat Nasser, Clara Aabye Madsen, Natalie Beschorner, Emily Eufaula Beaman, Morten Juhl, Szabolcs Lehel, Mikael Palner, Claus Svarer, Pontus Plavén-Sigray, Louise Møller Jørgensen, Gitte Moos Knudsen Published in: Frontiers in Neuroscience, Issue Volume 16 - 2022, 2022, ISSN 1662-453X Publisher: Frontiers DOI: 10.3389/fnins.2022.847074 Advancing 89Zr-immuno-PET in neuroscience with a bispecific anti-amyloid-beta monoclonal antibody – the choice of chelator is essential Author(s): Wuensche, Thomas E.; Stergiou, Natascha; Mes, Iris; Verlaan, Mariska; Schreurs, Maxime; Kooijman, Esther J. M.; Janssen, Bart; Windhorst, Albert D.; Jensen, Allan; Asuni, Ayodeji A.; Bang-Andersen, Benny; van Dongen, Guus A. M. S.; Beaino, Wissam; Vugts, Danielle J. Published in: Wuensche , T E , Stergiou , N , Mes , I , Verlaan , M , Schreurs , M , Kooijman , E J M , Janssen , B , Windhorst , A D , Jensen , A , Asuni , A A , Bang-Andersen , B , van Dongen , G A M S , Beaino , W & Vugts , D J 2022 , ' Advancing 89Zr-immuno-PET in neuroscience with a bispecific anti-amyloid-beta monoclonal antibody – the choice of chelator is essential ' , Theranostics , vol. 12 , no. 16, Issue 7, 2022, Page(s) 7067-7079, ISSN 1838-7640 Publisher: Ivyspring International Publisher DOI: 10.7150/thno.73509 Insights into Elution of Anion Exchange Cartridges: Opening the Path toward Aliphatic 18F-Radiolabeling of Base-Sensitive Tracers. Author(s): Klas Bratteby; Vladimir Shalgunov; Umberto Maria Battisti; Ida Nyman Petersen; Sara Lopes van den Broek; Tomas Ohlsson; Nic Gillings; Maria Erlandsson; Matthias M. Herth Published in: ACS Pharmacology & Translational Science, Issue 4, 2021, Page(s) 1556-1566, ISSN 2575-9108 Publisher: American Chemical Society DOI: 10.1021/acsptsci.1c00133 Alpha-Synuclein PET Tracer Development—An Overview about Current Efforts Author(s): Špela Korat; Natasha Shalina Rajani Bidesi; Federica Bonanno; Adriana di Nanni; Anh Nguyên Nhât Hoàng; Kristina Herfert; Andreas Maurer; Umberto Maria Battisti; Gregory D. Bowden; David Thonon; Danielle J. Vugts; Albert D. Windhorst; Matthias M. Herth Published in: Pharmaceuticals, Issue 5, Vol 14, 2021, Page(s) p 847, ISSN 1424-8247 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ph14090847 [11C]Carboxylated tetrazines for facile labeling of trans-cyclooctene-functionalized PeptoBrushes Author(s): Rocío García‐Vázquez; Umberto Maria Battisti; Vladimir Shalgunov; Gabriela Schäfer; Matthias Barz; Matthias Manfred Herth Published in: Macromolecular Rapid Communications, Issue Vol. 43, Issue 12, 2022, ISSN 1521-3927 Publisher: Wiley DOI: 10.1002/marc.202100655 A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain Author(s): Nakul Ravi Raval; Annette Johansen; Annette Johansen; Lene Lundgaard Donovan; Lene Lundgaard Donovan; Nídia Fernandez Ros; Brice Ozenne; Brice Ozenne; Hanne D. Hansen; Hanne D. Hansen; Gitte M. Knudsen; Gitte M. Knudsen Published in: International Journal of Molecular Sciences, Vol 22, Iss 835, p 835 (2021), Issue 4, 2021, Page(s) 835, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms22020835 Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging Author(s): Eva Schlein; Stina Syvänen; Johanna Rokka; Tobias Gustavsson; Raffaella Rossin; Marc Robillard; Jonas Eriksson; Dag Sehlin Published in: Molecular Pharmaceutics, Issue 19, 2022, Page(s) 4111-4122, ISSN 1543-8384 Publisher: American Chemical Society DOI: 10.1021/acs.molpharmaceut.2c00536 Alpha-Synuclein PET Tracer Development—An Overview about Current Efforts Author(s): Špela Korat; Natasha Shalina Rajani Bidesi; Federica Bonanno; Adriana di Nanni; Anh Nguyên Nhât Hoàng; Kristina Herfert; Andreas Maurer; Umberto Maria Battisti; Gregory D. Bowden; David Thonon; Danielle J. Vugts; Albert D. Windhorst; Matthias M. Herth Published in: Pharmaceuticals, Issue 14248247, 2021, ISSN 1424-8247 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ph14090847 Pretargeted Imaging beyond the Blood–Brain Barrier—Utopia or Feasible? Author(s): Sara Lopes van den Broek,Vladimir Shalgunov,Rocío García Vázquez, Natalie Beschorner D, Natasha S. R. Bidesi, Maiken Nedergaard, Gitte M. Knudsen, Dag Sehlin, Stina Syvänen, Matthias M. Herth Published in: Pharmaceuticals, Issue 15(10), 1191, 2022, ISSN 1424-8247 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ph15101191 [11C]MODAG-001-towards a PET tracer targeting α-synuclein aggregates Author(s): Laura Kuebler, Sabrina Buss, Andrei Leonov, Sergey Ryazanov, Felix Schmidt, Andreas Maurer; Daniel Weckbecker, Anne M Landau, Thea P Lillethorup, Daniel Bleher, Ran Sing Saw, Bernd J Pichler, Christian Griesinger, Armin Giese, Kristina Herfert Published in: European Journal of Nuclear Medicine and Molecular Imaging, Issue 48, 2021, Page(s) 1759-1772, ISSN 1619-7070 Publisher: Springer Verlag DOI: 10.1007/s00259-020-05133-x Synergistic Experimental and Computational Investigation of the Bioorthogonal Reactivity of Substituted Aryltetrazines Author(s): Umberto Maria Battisti; Rocío García-Vázquez; Dennis Svatunek; Barbara Herrmann; Andreas Löffler; Hannes Mikula; Matthias M. Herth Published in: Bioconjugate Chemistry, Issue 15204812, 2022, Page(s) 608-624, ISSN 1520-4812 Publisher: American Chemical Society DOI: 10.26434/chemrxiv-2021-2kn3l Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins Author(s): Dr. Natasha Shalina Radjani Bidesi, Dr. Umberto Maria Battisti, Dr. Sara Lopes van de Broek, Dr. Vladimir Shalgunov, Dr. Anne-Mette Dall, Dr. Jesper Bøggild Kristensen, Prof. Dag Sehlin, Prof. Stina Syvänen, Prof. Gitte Moos Knudsen, Prof. Matthias Manfred Herth Published in: ChemBioChem, Issue Volume23, Issue23, 2022, ISSN 1439-7633 Publisher: Chemistry Europe DOI: 10.1002/cbic.202200539 [11C]Carboxylated tetrazines for facile labeling of trans-cyclooctene-functionalized PeptoBrushes Author(s): Rocío García‐Vázquez; Umberto Maria Battisti; Vladimir Shalgunov; Gabriela Schäfer; Matthias Barz; Matthias Manfred Herth Published in: Macromolecular Rapid Communications, Issue 15213927, 2021, ISSN 1521-3927 Publisher: Wiley DOI: 10.1002/marc.202100655 Insights into Elution of Anion Exchange Cartridges: Opening the Path toward Aliphatic 18F-Radiolabeling of Base-Sensitive Tracers. Author(s): Klas Bratteby; Vladimir Shalgunov; Umberto Maria Battisti; Ida Nyman Petersen; Sara Lopes van den Broek; Tomas Ohlsson; Nic Gillings; Maria Erlandsson; Matthias M. Herth Published in: ACS Pharmacology & Translational Science, Issue 25759108, 2021, Page(s) 1556-1566, ISSN 2575-9108 Publisher: American Chemical Society DOI: 10.26434/chemrxiv.14229491.v1 Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size Author(s): Rebecca Faresjö; Gillian Bonvicini; Xiaotian T. Fang; Ximena Aguilar; Dag Sehlin; Stina Syvänen Published in: Fluids and Barriers of the CNS, Issue Vol 18, Iss 1, 2021, ISSN 2045-8118 Publisher: BioMed Central DOI: 10.1186/s12987-021-00257-0 Improved synthesis of SV2A targeting radiotracer [11C]UCB-J Author(s): Johanna Rokka, Eva Schlein, Jonas Eriksson Published in: EJNMMI Radiopharmacy and Chemistry, Issue 4/1, 2019, ISSN 2365-421X Publisher: Springer Open DOI: 10.1186/s41181-019-0080-5 Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size Author(s): Rebecca Faresjö; Gillian Bonvicini; Xiaotian T. Fang; Ximena Aguilar; Dag Sehlin; Stina Syvänen Published in: Fluids and Barriers of the CNS, Issue Vol 18, Iss 1, 2021, Page(s) 1-15, ISSN 2045-8118 Publisher: BioMed Central DOI: 10.1186/s12987-021-00257-0 Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease Author(s): Nakul Ravi Raval; Nakul Ravi Raval; Frederik Gudmundsen; Morten Juhl; Ida Vang Andersen; Ida Vang Andersen; Nikolaj Speth; Annesofie Videbæk; Ida Nymann Petersen; Jens D. Mikkelsen; Jens D. Mikkelsen; Patrick M. Fisher; Matthias M. Herth; Matthias M. Herth; Pontus Plavén-Sigray; Gitte M. Knudsen; Gitte M. Knudsen; Mikael Palner; Mikael Palner; Mikael Palner Published in: Frontiers in Synaptic Neuroscience, Issue vol. 13 , 715811, 2022, Page(s) 1663-3563, ISSN 1663-3563 Publisher: Frontiers Research Foundation DOI: 10.3389/fnsyn.2021.715811 α-Synuclein Radiotracer Development andIn VivoImaging: RecentAdvancements and New Perspectives Author(s): Obada M. Alzghool, MSc,1,2*Guus van Dongen, PhD,1Elsmarieke van de Giessen, PhD,1Linda Schoonmade, MSc,3and Wissam Beaino, PhD Published in: Movement disorders, Issue Volume37, Issue 5, 2022, Page(s) 936-948, ISSN 1531-8257 Publisher: Wiley DOI: 10.1002/mds.28984 Other (1) Additional file 1 of Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size Author(s): Faresjö, Rebecca; Bonvicini, Gillian; Fang, Xiaotian T.; Aguilar, Ximena; Sehlin, Dag; Syvänen, Stina Published in: Fluids Barriers CNS 18, 26 (2021), Issue 14, 2021, Page(s) 26, ISSN 2045-8118 Publisher: BioMed Central DOI: 10.6084/m9.figshare.14722064.v1 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
