PET Imaging of Alpha-Synuclein Fibril Formation

Información del proyecto

PET-AlphaSy

Identificador del acuerdo de subvención: 813528

DOI

10.3030/813528

Proyecto cerrado

Fecha de la firma de la CE 30 Agosto 2018

Fecha de inicio 1 Septiembre 2018

Fecha de finalización 30 Noviembre 2022

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 4 100 369,95

Aportación de la UE

€ 4 100 369,95

Coordinado por

KOBENHAVNS UNIVERSITET
Denmark

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (3)

Report on the Individual Career Plans
Report about the research progress
Report on lectures series

Websites, patent fillings, videos etc. (1)

Webpage

Publicaciones

Peer reviewed articles (23)

Direct Cu-mediated aromatic 18F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging.

Autores: Rocío García-Vázquez; Umberto Maria Battisti; Jesper Tranekjær Jørgensen; Vladimir Shalgunov; Lars Hvass; Daniel L. Stares; Ida Nymann Petersen; François Crestey; Andreas Löffler; Dennis Svatunek; Jesper L. Kristensen; Hannes Mikula; Andreas Kjaer; Matthias M. Herth
Publicado en: Chemical Science, Edición 12, 2021, Página(s) 11668-11675, ISSN 2041-6539
Editor: Royal Society of Chemistry
DOI: 10.1039/d1sc02789a

The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier

Autores: Sara Lopes van den Broek, Dag Sehlin, Jens V. Andersen, Blanca I. Aldana, Natalie Beschörner, Maiken Nedergaard, Gitte M. Knudsen, Stina Syvänen and Matthias M. Herth
Publicado en: Frontiers in Nuclear Medicine, 2022, ISSN 2673-8880
Editor: Frontiers in Nuclear Medicine
DOI: 10.3389/fnume.2022.1001722

Synergistic Experimental and Computational Investigation of theBioorthogonal Reactivity of Substituted Aryltetrazines

Autores: Umberto M. Battisti, Rocío García-Vázquez, Dennis Svatunek, Barbara Herrmann, Andreas Löffler, Hannes Mikula, and Matthias Manfred Herth
Publicado en: Bioconjugate Chemistry, Edición 33, issue 4, 2022, Página(s) 608-6024, ISSN 1520-4812
Editor: American Chemical Society
DOI: 10.1021/acs.bioconjchem.2c00042

Transport of nanomedicines across the blood-brain barrier:Challenges and opportunities for imaging and therapy

Autores: Sara Lopes van den Broek; Vladimir Shalgunov; Matthias M. Herth
Publicado en: van den Broek , S L , Shalgunov , V & Herth , M M 2022 , ' Transport of nanomedicines across the blood-brain barrier : Challenges and opportunities for imaging and therapy ' , Biomaterials Advances , vol. 141 , 213125 . https://doi.org/10.1016/j.bioadv.2022.213125, Edición 3, 2022, ISSN 2772-9516
Editor: Elsevier
DOI: 10.1016/j.bioadv.2022.213125

Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo

Autores: Dr. Christian B. M. Poulie, Dr. Emanuel Sporer, Lars Hvass, Dr. Jesper T. Jørgensen, Dr. Paul J. Kempen, Dr. Sara I. Lopes van den Broek, Dr. Vladimir Shalgunov, Prof. Dr. Andreas Kjaer, Dr. Andreas I. Jensen, Prof. Dr. Matthias M. Herth
Publicado en: Chemistry, Edición Volume28, Edición61, 2022, ISSN 1521-3765
Editor: Chemistry Europe
DOI: 10.1002/chem.202201847

Pretargeted imaging beyond the blood–brain barrier

Autores: Vladimir Shalgunov, Sara Lopes van den Broek, Ida Vang Andersen, a Rocío García Vázquez, Nakul Ravi Raval, Mikael Palner, Yuki Mori, Gabriela Schäfer, Barbara Herrmann, Hannes Mikula, Natalie Beschorner, Maiken Nedergaard, Stina Syvänen, Matthias Barz, Gitte Moos Knudsen, Umberto Maria Battisti and Matthias Manfred Herth
Publicado en: RSC Medicinal Chemistry, Edición 1, 2023, ISSN 2632-8682
Editor: Royal Society of Chemistry
DOI: 10.1039/d2md00360k

The role of neuroimaging in Parkinson's disease.

Autores: Natasha Shalina Rajani Bidesi; Ida Vang Andersen; Albert D. Windhorst; Vladimir Shalgunov; Matthias M. Herth
Publicado en: Journal of Neurochemistry, Edición 14714159, 2021, Página(s) 660-689, ISSN 1471-4159
Editor: Wiley
DOI: 10.1111/jnc.15516

A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain

Autores: Nakul Ravi Raval; Annette Johansen; Lene Lundgaard Donovan; Nídia Fernandez Ros; Brice Ozenne; Hanne D. Hansen; Gitte M. Knudsen
Publicado en: International Journal of Molecular Sciences, Edición Vol 22, Iss 835, 2021, Página(s) p 835, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020835

In vivo imaging of synaptic density with [11C]UCB-J PET in two mouse models of neurodegenerative disease

Autores: Mengfei Xiong, Sahar Roshanbin, Johanna Rokka, Eva Schlein, Martin Ingelsson, Dag Sehlin, Jonas Eriksson, Stina Syvänen
Publicado en: Neuroimage, Edición 239:118302, 2021, ISSN 1053-8119
Editor: Academic Press
DOI: 10.1016/j.neuroimage.2021.118302

Evaluation of the α-synuclein PET radiotracer (d3)-[11C]MODAG-001 in pigs

Autores: Nakul Ravi Raval, Clara Aabye Madsen, Vladimir Shalgunov, Arafat Nasser, Umberto Maria Battisti, Emily Eufaula Beaman, Morten Juhl, Louise Møller Jørgensen, Matthias Manfred Herth, Hanne Demant Hansen, Pontus Plavén-Sigray, Gitte Moos Knudsen
Publicado en: Nuclear Medicine and Biology, 2022, ISSN 0969-8051
Editor: Elsevier BV
DOI: 10.1016/j.nucmedbio.2022.08.001

An in vivo Pig Model for Testing Novel Positron Emission Tomography Radioligands Targeting Cerebral Protein Aggregates

Autores: Nakul Ravi Raval, Arafat Nasser, Clara Aabye Madsen, Natalie Beschorner, Emily Eufaula Beaman, Morten Juhl, Szabolcs Lehel, Mikael Palner, Claus Svarer, Pontus Plavén-Sigray, Louise Møller Jørgensen, Gitte Moos Knudsen
Publicado en: Frontiers in Neuroscience, Edición Volume 16 - 2022, 2022, ISSN 1662-453X
Editor: Frontiers
DOI: 10.3389/fnins.2022.847074

Advancing 89Zr-immuno-PET in neuroscience with a bispecific anti-amyloid-beta monoclonal antibody – the choice of chelator is essential

Autores: Wuensche, Thomas E.; Stergiou, Natascha; Mes, Iris; Verlaan, Mariska; Schreurs, Maxime; Kooijman, Esther J. M.; Janssen, Bart; Windhorst, Albert D.; Jensen, Allan; Asuni, Ayodeji A.; Bang-Andersen, Benny; van Dongen, Guus A. M. S.; Beaino, Wissam; Vugts, Danielle J.
Publicado en: Wuensche , T E , Stergiou , N , Mes , I , Verlaan , M , Schreurs , M , Kooijman , E J M , Janssen , B , Windhorst , A D , Jensen , A , Asuni , A A , Bang-Andersen , B , van Dongen , G A M S , Beaino , W & Vugts , D J 2022 , ' Advancing 89Zr-immuno-PET in neuroscience with a bispecific anti-amyloid-beta monoclonal antibody – the choice of chelator is essential ' , Theranostics , vol. 12 , no. 16, Edición 7, 2022, Página(s) 7067-7079, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.73509

Insights into Elution of Anion Exchange Cartridges: Opening the Path toward Aliphatic 18F-Radiolabeling of Base-Sensitive Tracers.

Autores: Klas Bratteby; Vladimir Shalgunov; Umberto Maria Battisti; Ida Nyman Petersen; Sara Lopes van den Broek; Tomas Ohlsson; Nic Gillings; Maria Erlandsson; Matthias M. Herth
Publicado en: ACS Pharmacology & Translational Science, Edición 4, 2021, Página(s) 1556-1566, ISSN 2575-9108
Editor: American Chemical Society
DOI: 10.1021/acsptsci.1c00133

Alpha-Synuclein PET Tracer Development—An Overview about Current Efforts

Autores: Špela Korat; Natasha Shalina Rajani Bidesi; Federica Bonanno; Adriana di Nanni; Anh Nguyên Nhât Hoàng; Kristina Herfert; Andreas Maurer; Umberto Maria Battisti; Gregory D. Bowden; David Thonon; Danielle J. Vugts; Albert D. Windhorst; Matthias M. Herth
Publicado en: Pharmaceuticals, Edición 5, Vol 14, 2021, Página(s) p 847, ISSN 1424-8247
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14090847

[11C]Carboxylated tetrazines for facile labeling of trans-cyclooctene-functionalized PeptoBrushes

Autores: Rocío García‐Vázquez; Umberto Maria Battisti; Vladimir Shalgunov; Gabriela Schäfer; Matthias Barz; Matthias Manfred Herth
Publicado en: Macromolecular Rapid Communications, Edición Vol. 43, Edición 12, 2022, ISSN 1521-3927
Editor: Wiley
DOI: 10.1002/marc.202100655

Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

Autores: Eva Schlein; Stina Syvänen; Johanna Rokka; Tobias Gustavsson; Raffaella Rossin; Marc Robillard; Jonas Eriksson; Dag Sehlin
Publicado en: Molecular Pharmaceutics, Edición 19, 2022, Página(s) 4111-4122, ISSN 1543-8384
Editor: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.2c00536

Pretargeted Imaging beyond the Blood–Brain Barrier—Utopia or Feasible?

Autores: Sara Lopes van den Broek,Vladimir Shalgunov,Rocío García Vázquez, Natalie Beschorner D, Natasha S. R. Bidesi, Maiken Nedergaard, Gitte M. Knudsen, Dag Sehlin, Stina Syvänen, Matthias M. Herth
Publicado en: Pharmaceuticals, Edición 15(10), 1191, 2022, ISSN 1424-8247
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15101191

[11C]MODAG-001-towards a PET tracer targeting α-synuclein aggregates

Autores: Laura Kuebler, Sabrina Buss, Andrei Leonov, Sergey Ryazanov, Felix Schmidt, Andreas Maurer; Daniel Weckbecker, Anne M Landau, Thea P Lillethorup, Daniel Bleher, Ran Sing Saw, Bernd J Pichler, Christian Griesinger, Armin Giese, Kristina Herfert
Publicado en: European Journal of Nuclear Medicine and Molecular Imaging, Edición 48, 2021, Página(s) 1759-1772, ISSN 1619-7070
Editor: Springer Verlag
DOI: 10.1007/s00259-020-05133-x

Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins

Autores: Dr. Natasha Shalina Radjani Bidesi, Dr. Umberto Maria Battisti, Dr. Sara Lopes van de Broek, Dr. Vladimir Shalgunov, Dr. Anne-Mette Dall, Dr. Jesper Bøggild Kristensen, Prof. Dag Sehlin, Prof. Stina Syvänen, Prof. Gitte Moos Knudsen, Prof. Matthias Manfred Herth
Publicado en: ChemBioChem, Edición Volume23, Edición23, 2022, ISSN 1439-7633
Editor: Chemistry Europe
DOI: 10.1002/cbic.202200539

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Autores: Rebecca Faresjö; Gillian Bonvicini; Xiaotian T. Fang; Ximena Aguilar; Dag Sehlin; Stina Syvänen
Publicado en: Fluids and Barriers of the CNS, Edición Vol 18, Iss 1, 2021, ISSN 2045-8118
Editor: BioMed Central
DOI: 10.1186/s12987-021-00257-0

Improved synthesis of SV2A targeting radiotracer [11C]UCB-J

Autores: Johanna Rokka, Eva Schlein, Jonas Eriksson
Publicado en: EJNMMI Radiopharmacy and Chemistry, Edición 4/1, 2019, ISSN 2365-421X
Editor: Springer Open
DOI: 10.1186/s41181-019-0080-5

Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease

Autores: Nakul Ravi Raval; Nakul Ravi Raval; Frederik Gudmundsen; Morten Juhl; Ida Vang Andersen; Ida Vang Andersen; Nikolaj Speth; Annesofie Videbæk; Ida Nymann Petersen; Jens D. Mikkelsen; Jens D. Mikkelsen; Patrick M. Fisher; Matthias M. Herth; Matthias M. Herth; Pontus Plavén-Sigray; Gitte M. Knudsen; Gitte M. Knudsen; Mikael Palner; Mikael Palner; Mikael Palner
Publicado en: Frontiers in Synaptic Neuroscience, Edición vol. 13 , 715811, 2022, Página(s) 1663-3563, ISSN 1663-3563
Editor: Frontiers Research Foundation
DOI: 10.3389/fnsyn.2021.715811

α-Synuclein Radiotracer Development andIn VivoImaging: RecentAdvancements and New Perspectives

Autores: Obada M. Alzghool, MSc,1,2*Guus van Dongen, PhD,1Elsmarieke van de Giessen, PhD,1Linda Schoonmade, MSc,3and Wissam Beaino, PhD
Publicado en: Movement disorders, Edición Volume37, Edición 5, 2022, Página(s) 936-948, ISSN 1531-8257
Editor: Wiley
DOI: 10.1002/mds.28984

Other (1)

Additional file 1 of Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Autores: Faresjö, Rebecca; Bonvicini, Gillian; Fang, Xiaotian T.; Aguilar, Ximena; Sehlin, Dag; Syvänen, Stina
Publicado en: Fluids Barriers CNS 18, 26 (2021), Edición 14, 2021, Página(s) 26, ISSN 2045-8118
Editor: BioMed Central
DOI: 10.6084/m9.figshare.14722064.v1