PET Imaging of Alpha-Synuclein Fibril Formation

Informazioni relative al progetto

PET-AlphaSy

ID dell’accordo di sovvenzione: 813528

DOI

10.3030/813528

Progetto chiuso

Data della firma CE 30 Agosto 2018

Data di avvio 1 Settembre 2018

Data di completamento 30 Novembre 2022

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 4 100 369,95

Contributo UE

€ 4 100 369,95

Coordinato da

KOBENHAVNS UNIVERSITET
Denmark

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I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (3)

Report on the Individual Career Plans
Report about the research progress
Report on lectures series

Websites, patent fillings, videos etc. (1)

Webpage

Pubblicazioni

Peer reviewed articles (23)

Direct Cu-mediated aromatic 18F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging.

Autori: Rocío García-Vázquez; Umberto Maria Battisti; Jesper Tranekjær Jørgensen; Vladimir Shalgunov; Lars Hvass; Daniel L. Stares; Ida Nymann Petersen; François Crestey; Andreas Löffler; Dennis Svatunek; Jesper L. Kristensen; Hannes Mikula; Andreas Kjaer; Matthias M. Herth
Pubblicato in: Chemical Science, Numero 12, 2021, Pagina/e 11668-11675, ISSN 2041-6539
Editore: Royal Society of Chemistry
DOI: 10.1039/d1sc02789a

The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier

Autori: Sara Lopes van den Broek, Dag Sehlin, Jens V. Andersen, Blanca I. Aldana, Natalie Beschörner, Maiken Nedergaard, Gitte M. Knudsen, Stina Syvänen and Matthias M. Herth
Pubblicato in: Frontiers in Nuclear Medicine, 2022, ISSN 2673-8880
Editore: Frontiers in Nuclear Medicine
DOI: 10.3389/fnume.2022.1001722

Synergistic Experimental and Computational Investigation of theBioorthogonal Reactivity of Substituted Aryltetrazines

Autori: Umberto M. Battisti, Rocío García-Vázquez, Dennis Svatunek, Barbara Herrmann, Andreas Löffler, Hannes Mikula, and Matthias Manfred Herth
Pubblicato in: Bioconjugate Chemistry, Numero 33, issue 4, 2022, Pagina/e 608-6024, ISSN 1520-4812
Editore: American Chemical Society
DOI: 10.1021/acs.bioconjchem.2c00042

Transport of nanomedicines across the blood-brain barrier:Challenges and opportunities for imaging and therapy

Autori: Sara Lopes van den Broek; Vladimir Shalgunov; Matthias M. Herth
Pubblicato in: van den Broek , S L , Shalgunov , V & Herth , M M 2022 , ' Transport of nanomedicines across the blood-brain barrier : Challenges and opportunities for imaging and therapy ' , Biomaterials Advances , vol. 141 , 213125 . https://doi.org/10.1016/j.bioadv.2022.213125, Numero 3, 2022, ISSN 2772-9516
Editore: Elsevier
DOI: 10.1016/j.bioadv.2022.213125

Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo

Autori: Dr. Christian B. M. Poulie, Dr. Emanuel Sporer, Lars Hvass, Dr. Jesper T. Jørgensen, Dr. Paul J. Kempen, Dr. Sara I. Lopes van den Broek, Dr. Vladimir Shalgunov, Prof. Dr. Andreas Kjaer, Dr. Andreas I. Jensen, Prof. Dr. Matthias M. Herth
Pubblicato in: Chemistry, Numero Volume28, Numero61, 2022, ISSN 1521-3765
Editore: Chemistry Europe
DOI: 10.1002/chem.202201847

Pretargeted imaging beyond the blood–brain barrier

Autori: Vladimir Shalgunov, Sara Lopes van den Broek, Ida Vang Andersen, a Rocío García Vázquez, Nakul Ravi Raval, Mikael Palner, Yuki Mori, Gabriela Schäfer, Barbara Herrmann, Hannes Mikula, Natalie Beschorner, Maiken Nedergaard, Stina Syvänen, Matthias Barz, Gitte Moos Knudsen, Umberto Maria Battisti and Matthias Manfred Herth
Pubblicato in: RSC Medicinal Chemistry, Numero 1, 2023, ISSN 2632-8682
Editore: Royal Society of Chemistry
DOI: 10.1039/d2md00360k

The role of neuroimaging in Parkinson's disease.

Autori: Natasha Shalina Rajani Bidesi; Ida Vang Andersen; Albert D. Windhorst; Vladimir Shalgunov; Matthias M. Herth
Pubblicato in: Journal of Neurochemistry, Numero 14714159, 2021, Pagina/e 660-689, ISSN 1471-4159
Editore: Wiley
DOI: 10.1111/jnc.15516

A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain

Autori: Nakul Ravi Raval; Annette Johansen; Lene Lundgaard Donovan; Nídia Fernandez Ros; Brice Ozenne; Hanne D. Hansen; Gitte M. Knudsen
Pubblicato in: International Journal of Molecular Sciences, Numero Vol 22, Iss 835, 2021, Pagina/e p 835, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020835

In vivo imaging of synaptic density with [11C]UCB-J PET in two mouse models of neurodegenerative disease

Autori: Mengfei Xiong, Sahar Roshanbin, Johanna Rokka, Eva Schlein, Martin Ingelsson, Dag Sehlin, Jonas Eriksson, Stina Syvänen
Pubblicato in: Neuroimage, Numero 239:118302, 2021, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2021.118302

Evaluation of the α-synuclein PET radiotracer (d3)-[11C]MODAG-001 in pigs

Autori: Nakul Ravi Raval, Clara Aabye Madsen, Vladimir Shalgunov, Arafat Nasser, Umberto Maria Battisti, Emily Eufaula Beaman, Morten Juhl, Louise Møller Jørgensen, Matthias Manfred Herth, Hanne Demant Hansen, Pontus Plavén-Sigray, Gitte Moos Knudsen
Pubblicato in: Nuclear Medicine and Biology, 2022, ISSN 0969-8051
Editore: Elsevier BV
DOI: 10.1016/j.nucmedbio.2022.08.001

An in vivo Pig Model for Testing Novel Positron Emission Tomography Radioligands Targeting Cerebral Protein Aggregates

Autori: Nakul Ravi Raval, Arafat Nasser, Clara Aabye Madsen, Natalie Beschorner, Emily Eufaula Beaman, Morten Juhl, Szabolcs Lehel, Mikael Palner, Claus Svarer, Pontus Plavén-Sigray, Louise Møller Jørgensen, Gitte Moos Knudsen
Pubblicato in: Frontiers in Neuroscience, Numero Volume 16 - 2022, 2022, ISSN 1662-453X
Editore: Frontiers
DOI: 10.3389/fnins.2022.847074

Advancing 89Zr-immuno-PET in neuroscience with a bispecific anti-amyloid-beta monoclonal antibody – the choice of chelator is essential

Autori: Wuensche, Thomas E.; Stergiou, Natascha; Mes, Iris; Verlaan, Mariska; Schreurs, Maxime; Kooijman, Esther J. M.; Janssen, Bart; Windhorst, Albert D.; Jensen, Allan; Asuni, Ayodeji A.; Bang-Andersen, Benny; van Dongen, Guus A. M. S.; Beaino, Wissam; Vugts, Danielle J.
Pubblicato in: Wuensche , T E , Stergiou , N , Mes , I , Verlaan , M , Schreurs , M , Kooijman , E J M , Janssen , B , Windhorst , A D , Jensen , A , Asuni , A A , Bang-Andersen , B , van Dongen , G A M S , Beaino , W & Vugts , D J 2022 , ' Advancing 89Zr-immuno-PET in neuroscience with a bispecific anti-amyloid-beta monoclonal antibody – the choice of chelator is essential ' , Theranostics , vol. 12 , no. 16, Numero 7, 2022, Pagina/e 7067-7079, ISSN 1838-7640
Editore: Ivyspring International Publisher
DOI: 10.7150/thno.73509

Insights into Elution of Anion Exchange Cartridges: Opening the Path toward Aliphatic 18F-Radiolabeling of Base-Sensitive Tracers.

Autori: Klas Bratteby; Vladimir Shalgunov; Umberto Maria Battisti; Ida Nyman Petersen; Sara Lopes van den Broek; Tomas Ohlsson; Nic Gillings; Maria Erlandsson; Matthias M. Herth
Pubblicato in: ACS Pharmacology & Translational Science, Numero 4, 2021, Pagina/e 1556-1566, ISSN 2575-9108
Editore: American Chemical Society
DOI: 10.1021/acsptsci.1c00133

Alpha-Synuclein PET Tracer Development—An Overview about Current Efforts

Autori: Špela Korat; Natasha Shalina Rajani Bidesi; Federica Bonanno; Adriana di Nanni; Anh Nguyên Nhât Hoàng; Kristina Herfert; Andreas Maurer; Umberto Maria Battisti; Gregory D. Bowden; David Thonon; Danielle J. Vugts; Albert D. Windhorst; Matthias M. Herth
Pubblicato in: Pharmaceuticals, Numero 5, Vol 14, 2021, Pagina/e p 847, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14090847

[11C]Carboxylated tetrazines for facile labeling of trans-cyclooctene-functionalized PeptoBrushes

Autori: Rocío García‐Vázquez; Umberto Maria Battisti; Vladimir Shalgunov; Gabriela Schäfer; Matthias Barz; Matthias Manfred Herth
Pubblicato in: Macromolecular Rapid Communications, Numero Vol. 43, Numero 12, 2022, ISSN 1521-3927
Editore: Wiley
DOI: 10.1002/marc.202100655

Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

Autori: Eva Schlein; Stina Syvänen; Johanna Rokka; Tobias Gustavsson; Raffaella Rossin; Marc Robillard; Jonas Eriksson; Dag Sehlin
Pubblicato in: Molecular Pharmaceutics, Numero 19, 2022, Pagina/e 4111-4122, ISSN 1543-8384
Editore: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.2c00536

Pretargeted Imaging beyond the Blood–Brain Barrier—Utopia or Feasible?

Autori: Sara Lopes van den Broek,Vladimir Shalgunov,Rocío García Vázquez, Natalie Beschorner D, Natasha S. R. Bidesi, Maiken Nedergaard, Gitte M. Knudsen, Dag Sehlin, Stina Syvänen, Matthias M. Herth
Pubblicato in: Pharmaceuticals, Numero 15(10), 1191, 2022, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15101191

[11C]MODAG-001-towards a PET tracer targeting α-synuclein aggregates

Autori: Laura Kuebler, Sabrina Buss, Andrei Leonov, Sergey Ryazanov, Felix Schmidt, Andreas Maurer; Daniel Weckbecker, Anne M Landau, Thea P Lillethorup, Daniel Bleher, Ran Sing Saw, Bernd J Pichler, Christian Griesinger, Armin Giese, Kristina Herfert
Pubblicato in: European Journal of Nuclear Medicine and Molecular Imaging, Numero 48, 2021, Pagina/e 1759-1772, ISSN 1619-7070
Editore: Springer Verlag
DOI: 10.1007/s00259-020-05133-x

Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins

Autori: Dr. Natasha Shalina Radjani Bidesi, Dr. Umberto Maria Battisti, Dr. Sara Lopes van de Broek, Dr. Vladimir Shalgunov, Dr. Anne-Mette Dall, Dr. Jesper Bøggild Kristensen, Prof. Dag Sehlin, Prof. Stina Syvänen, Prof. Gitte Moos Knudsen, Prof. Matthias Manfred Herth
Pubblicato in: ChemBioChem, Numero Volume23, Numero23, 2022, ISSN 1439-7633
Editore: Chemistry Europe
DOI: 10.1002/cbic.202200539

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Autori: Rebecca Faresjö; Gillian Bonvicini; Xiaotian T. Fang; Ximena Aguilar; Dag Sehlin; Stina Syvänen
Pubblicato in: Fluids and Barriers of the CNS, Numero Vol 18, Iss 1, 2021, ISSN 2045-8118
Editore: BioMed Central
DOI: 10.1186/s12987-021-00257-0

Improved synthesis of SV2A targeting radiotracer [11C]UCB-J

Autori: Johanna Rokka, Eva Schlein, Jonas Eriksson
Pubblicato in: EJNMMI Radiopharmacy and Chemistry, Numero 4/1, 2019, ISSN 2365-421X
Editore: Springer Open
DOI: 10.1186/s41181-019-0080-5

Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease

Autori: Nakul Ravi Raval; Nakul Ravi Raval; Frederik Gudmundsen; Morten Juhl; Ida Vang Andersen; Ida Vang Andersen; Nikolaj Speth; Annesofie Videbæk; Ida Nymann Petersen; Jens D. Mikkelsen; Jens D. Mikkelsen; Patrick M. Fisher; Matthias M. Herth; Matthias M. Herth; Pontus Plavén-Sigray; Gitte M. Knudsen; Gitte M. Knudsen; Mikael Palner; Mikael Palner; Mikael Palner
Pubblicato in: Frontiers in Synaptic Neuroscience, Numero vol. 13 , 715811, 2022, Pagina/e 1663-3563, ISSN 1663-3563
Editore: Frontiers Research Foundation
DOI: 10.3389/fnsyn.2021.715811

α-Synuclein Radiotracer Development andIn VivoImaging: RecentAdvancements and New Perspectives

Autori: Obada M. Alzghool, MSc,1,2*Guus van Dongen, PhD,1Elsmarieke van de Giessen, PhD,1Linda Schoonmade, MSc,3and Wissam Beaino, PhD
Pubblicato in: Movement disorders, Numero Volume37, Numero 5, 2022, Pagina/e 936-948, ISSN 1531-8257
Editore: Wiley
DOI: 10.1002/mds.28984

Other (1)

Additional file 1 of Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Autori: Faresjö, Rebecca; Bonvicini, Gillian; Fang, Xiaotian T.; Aguilar, Ximena; Sehlin, Dag; Syvänen, Stina
Pubblicato in: Fluids Barriers CNS 18, 26 (2021), Numero 14, 2021, Pagina/e 26, ISSN 2045-8118
Editore: BioMed Central
DOI: 10.6084/m9.figshare.14722064.v1