Project description
Discovery of a novel disease-causing mechanism for pancreatic oncogenesis
The molecular mechanisms that give rise to pancreatic cancer remain elusive with hardly any targeted therapies available today. The working hypothesis of the EU-funded pHioniC project is that the pancreas has a unique acidic environment that may facilitate pancreatic cancer initiation and progression. The alkaline pancreatic juice secreted to neutralise the acidic chyme that arrives from the stomach induces temporal changes in pH levels which may drive oncogenic mutations. Researchers will map the pancreatic pH landscape and investigate the mechanism by which it can influence disease progression. Moreover, they will explore potential pH interventions to alter the disease course.
Fields of science
Keywords
Programme(s)
Coordinator
48149 Muenster
Germany
See on map
Participants (11)
OX1 2JD Oxford
See on map
1165 Kobenhavn
See on map
70121 Bari
See on map
50121 Florence
See on map
59000 Lille
See on map
80025 Amiens
See on map
80539 Munchen
See on map
24118 Kiel
See on map
4032 Debrecen
See on map
Participation ended
2573 HT 'S-gravenhage
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
68526 Ladenburg
See on map
Partners (5)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
73100 Lecce
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
37073 Gottingen
See on map
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
35122 Padova
See on map
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
3015 GD Rotterdam
See on map
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
10124 Torino
See on map