Objective
pHioniC brings together highly synergistic expertise, research and training facilities to investigate pancreatic ductal adenocarcinoma (PDAC), a frequent and aggressive cancer that is still incurable. The programme’s central hypothesis has a strong grounding in the physiology of the exocrine pancreas. Secretion of the alkaline pancreatic juice, normally associated with digestion, leads to acidifications of the pancreas stroma resulting in an acid adaptation of pancreatic cells. We are first to propose that this adaptation facilitates PDAC initiation and progression by selecting for more aggressive phenotypes in interplay with PDAC driver mutations. pHioniC will:
(i) develop models (e.g. pancreas-/PDAC-specific pH-indicator mouse) to map the pH landscape in the normal and diseased pancreas,
(ii) characterize the impact of the acidic microenvironment in PDAC development and
(iii) design bespoke approaches to the treatment of PDAC that exploit the unique physiology of the pancreas and utilize a combination of nanocarrier and antibody technology for targeting.
Thereby, pHioniC provides an innovative interdisciplinary and intersectoral training for ESRs at the forefront of oncological research.
pHioniC comprises excellent complementary basic-research, clinical, and in silico laboratories that provided the seed discoveries for this novel concept, and industrial partners with a track record in therapeutic and diagnostic development in oncology. This highly synergistic team combines the state-of-the-art research tools and translational opportunities needed to meet the most ambitious doctoral programmes. pHioniC training for ESRs covers the fields of ion transport, oncology, imaging, bioinformatics and antibody technology, and is complemented by extensive transferable skills and personalised training elements. pHioniC will establish a lasting contribution towards European doctoral training beyond the lifetime of the project.
Fields of science
Programme(s)
Funding Scheme
MSCA-ITN-ETN - European Training NetworksCoordinator
48149 Muenster
Germany
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Participants (11)
OX1 2JD Oxford
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1165 Kobenhavn
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70121 Bari
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50121 Florence
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59000 Lille
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80025 Amiens
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80539 Munchen
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24118 Kiel
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4032 Debrecen
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2573 HT 'S-gravenhage
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
68526 Ladenburg
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Partners (5)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
73100 Lecce
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
37073 Gottingen
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
35122 Padova
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
3015 GD Rotterdam
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
10124 Torino
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