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pH and Ion Transport in Pancreatic Cancer

Objective

pHioniC brings together highly synergistic expertise, research and training facilities to investigate pancreatic ductal adenocarcinoma (PDAC), a frequent and aggressive cancer that is still incurable. The programme’s central hypothesis has a strong grounding in the physiology of the exocrine pancreas. Secretion of the alkaline pancreatic juice, normally associated with digestion, leads to acidifications of the pancreas stroma resulting in an acid adaptation of pancreatic cells. We are first to propose that this adaptation facilitates PDAC initiation and progression by selecting for more aggressive phenotypes in interplay with PDAC driver mutations. pHioniC will:
(i) develop models (e.g. pancreas-/PDAC-specific pH-indicator mouse) to map the pH landscape in the normal and diseased pancreas,
(ii) characterize the impact of the acidic microenvironment in PDAC development and
(iii) design bespoke approaches to the treatment of PDAC that exploit the unique physiology of the pancreas and utilize a combination of nanocarrier and antibody technology for targeting.
Thereby, pHioniC provides an innovative interdisciplinary and intersectoral training for ESRs at the forefront of oncological research.
pHioniC comprises excellent complementary basic-research, clinical, and in silico laboratories that provided the seed discoveries for this novel concept, and industrial partners with a track record in therapeutic and diagnostic development in oncology. This highly synergistic team combines the state-of-the-art research tools and translational opportunities needed to meet the most ambitious doctoral programmes. pHioniC training for ESRs covers the fields of ion transport, oncology, imaging, bioinformatics and antibody technology, and is complemented by extensive transferable skills and personalised training elements. pHioniC will establish a lasting contribution towards European doctoral training beyond the lifetime of the project.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/mutation
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology
  • /social sciences/social and economic geography/transport
  • /medical and health sciences/basic medicine/physiology

Call for proposal

H2020-MSCA-ITN-2018
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Address
Schlossplatz 2
48149 Muenster
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 252 788,40

Participants (11)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 303 172,56
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 892 566
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italy
EU contribution
€ 261 499,68
Address
Piazza Umberto I 1
70121 Bari
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
EU contribution
€ 261 499,68
Address
Piazza San Marco 4
50121 Florence
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE LILLE
France
EU contribution
€ 274 802,04
Address
42 Rue Paul Duez
59800 Lille
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE PICARDIE JULES VERNE
France
EU contribution
€ 274 802,04
Address
Chemin Du Thil
80025 Amiens
Activity type
Higher or Secondary Education Establishments
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 505 576,80
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Germany
EU contribution
€ 252 788,40
Address
Olshausenstrasse 40
24118 Kiel
Activity type
Higher or Secondary Education Establishments
DEBRECENI EGYETEM
Hungary
EU contribution
€ 229 715,28
Address
Egyetem Ter 1
4032 Debrecen
Activity type
Higher or Secondary Education Establishments
PERCUROS BV
Netherlands
EU contribution
€ 265 619,88
Address
Plesmanlaan 1
2333 BZ Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HEIDELBERG PHARMA RESEARCH GMBH
Germany
EU contribution
€ 252 788,40
Address
Schriesheimer Strasse 101
68526 Ladenburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (5)

TYPEONE S.R.L.
Italy
Address
Via Per Monteroni 1
73100 Lecce
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GEORG-AUGUST-UNIVERSITAT GOTTINGENSTIFTUNG OFFENTLICHEN RECHTS
Germany
Address
Wilhelmsplatz 1
37073 Gottingen
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
Address
Via 8 Febbraio 2
35122 Padova
Activity type
Higher or Secondary Education Establishments
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI TORINO
Italy
Address
Via Giuseppe Verdi 8
10124 Torino
Activity type
Higher or Secondary Education Establishments