Project description
Discovery of a novel disease-causing mechanism for pancreatic oncogenesis
The molecular mechanisms that give rise to pancreatic cancer remain elusive with hardly any targeted therapies available today. The working hypothesis of the EU-funded pHioniC project is that the pancreas has a unique acidic environment that may facilitate pancreatic cancer initiation and progression. The alkaline pancreatic juice secreted to neutralise the acidic chyme that arrives from the stomach induces temporal changes in pH levels which may drive oncogenic mutations. Researchers will map the pancreatic pH landscape and investigate the mechanism by which it can influence disease progression. Moreover, they will explore potential pH interventions to alter the disease course.
Fields of science
Programme(s)
Funding Scheme
MSCA-ITN-ETN - European Training NetworksCoordinator
48149 Muenster
Germany
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Participants (11)
OX1 2JD Oxford
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1165 Kobenhavn
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70121 Bari
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50121 Florence
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59000 Lille
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80025 Amiens
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80539 Munchen
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24118 Kiel
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4032 Debrecen
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2573 HT 'S-gravenhage
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
68526 Ladenburg
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Partners (5)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
73100 Lecce
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
37073 Gottingen
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
35122 Padova
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
3015 GD Rotterdam
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
10124 Torino
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