pH and Ion Transport in Pancreatic Cancer

Deliverables

Documents, reports (1)

pHioniC website

pHioniC website, social media presence

Publications

Peer reviewed articles (19)

3D Pharmacophore-Based Discovery of Novel KV10.1 Inhibitors with Antiproliferative Activity

Author(s): Žan Toplak, Louise Antonia Hendrickx, Špela Gubič, Štefan Možina, Bojana Žegura, Alja Štern, Matjaž Novak, Xiaoyi Shi, Steve Peigneur, Jan Tytgat, Tihomir Tomašič, Luis A. Pardo, Lucija Peterlin Mašič
Published in: Cancers, 13/6, 2021, Page(s) 1244, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13061244

pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology

Author(s): Zoltán Pethő, Karolina Najder, Tiago Carvalho, Roisin McMorrow, Luca Matteo Todesca, Micol Rugi, Etmar Bulk, Alan Chan, Clemens W. G. M. Löwik, Stephan J. Reshkin, Albrecht Schwab
Published in: Cancers, 12/9, 2020, Page(s) 2484, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12092484

Cancer Cell Acid Adaptation Gene Expression Response Is Correlated to Tumor-Specific Tissue Expression Profiles and Patient Survival

Author(s): Jiayi Yao, Dominika Czaplinska, Renata Ialchina, Julie Schnipper, Bin Liu, Albin Sandelin, Stine Falsig Pedersen
Published in: Cancers, 12/8, 2020, Page(s) 2183, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12082183

Targeting the Stromal Pro-Tumoral Hyaluronan-CD44 Pathway in Pancreatic Cancer

Author(s): Tomas Koltai, Stephan Joel Reshkin, Tiago M. A. Carvalho, Rosa A. Cardone
Published in: International Journal of Molecular Sciences, 22/8, 2021, Page(s) 3953, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22083953

The Vacuolar H+ ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells

Author(s): Mette Flinck, Sofie Hagelund, Andrej Gorbatenko, Marc Severin, Elena Pedraz-Cuesta, Ivana Novak, Christian Stock, Stine Falsig Pedersen
Published in: Cells, 9/2, 2020, Page(s) 465, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9020465

Ion Channels Orchestrate Pancreatic Ductal Adenocarcinoma Progression and Therapy

Author(s): Verena Hofschröer, Karolina Najder, Micol Rugi, Rayhana Bouazzi, Marco Cozzolino, Annarosa Arcangeli, Gyorgy Panyi, Albrecht Schwab
Published in: Frontiers in Pharmacology, 11, 2021, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.586599

Ca2+ Signalling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression

Author(s): Madelaine Magalì Audero, Natalia Prevarskaya, Alessandra Fiorio Pla
Published in: Int J Mol Sci, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23137377

Role of the Intracellular Sodium Homeostasis in Chemotaxis of Activated Murine Neutrophils

Author(s): Karolina Najder, Micol Rugi, Mégane Lebel, Julia Schröder, Leonie Oster, Sandra Schimmelpfennig, Sarah Sargin, Zoltán Pethő, Etmar Bulk, Albrecht Schwab
Published in: Frontiers in Immunology, 11, 2020, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.02124

Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production.

Author(s): Blaszczak W, Williams H, Swietach P
Published in: Br J Cancer, 2022, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-022-01910-7

Ion Channel Signature in Healthy Pancreas and Pancreatic Ductal Adenocarcinoma

Author(s): Julie Schnipper, Isabelle Dhennin-Duthille, Ahmed Ahidouch, Halima Ouadid-Ahidouch
Published in: Frontiers in Pharmacology, 11, 2020, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.568993

Cost-Effective Real-Time Metabolic Profiling of Cancer Cell Lines for Plate-Based Assays

Author(s): Wiktoria Blaszczak, Zhengchu Tan, Pawel Swietach
Published in: Chemosensors, 9/6, 2021, Page(s) 139, ISSN 2227-9040
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/chemosensors9060139

What do cellular responses to acidity tell us about cancer?

Author(s): Blaszczak W, Swietach P
Published in: Cancer Metastasis Rev, 2021, ISSN 1573-7233
Publisher: Springer Nature
DOI: 10.1007/s10555-021-10005-3

Monitoring Immune Cell Function Through Optical Imaging: a Review Highlighting Transgenic Mouse Models

Author(s): Chintan Chawda, Roisin McMorrow, Natasa Gaspar, Giorgia Zambito & Laura Mezzanotte
Published in: Molecular Imaging and Biology, 2021, ISSN 1860-2002
Publisher: Springer Nature
DOI: 10.1007/s11307-021-01662-5

Tumor Microenvironment Features and Chemoresistance in Pancreatic Ductal Adenocarcinoma: Insights into Targeting Physicochemical Barriers and Metabolism as Therapeutic Approaches

Author(s): Tiago M A Carvalho, Daria Di Molfetta, Maria Raffaella Greco, Tomas Koltai, Khalid O Alfarouk, Stephan J Reshkin, Rosa A Cardone
Published in: Cancers, 13(23), 2021, Page(s) 6135, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13236135

A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells

Author(s): Franziska Hartung, Thomas Krüwel, Xiaoyi Shi, Klaus Pfizenmaier, Roland Kontermann, Patrick Chames, Frauke Alves, Luis A. Pardo
Published in: Frontiers in Pharmacology, 11, 2020, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.00686

Glycan-Based Near-infrared Fluorescent (NIRF) Imaging of Gastrointestinal Tumors: a Preclinical Proof-of-Concept In Vivo Study

Author(s): Ruben D. Houvast, Victor M. Baart, Shadhvi S. Bhairosingh, Robert A. Cordfunke, Jia Xin Chua, Mireille Vankemmelbeke, Tina Parsons, Peter J. K. Kuppen, Lindy G. Durrant, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Published in: Molecular Imaging and Biology, 2020, ISSN 1536-1632
Publisher: Elsevier BV
DOI: 10.1007/s11307-020-01522-8

Purinergic Signaling in Pancreas—From Physiology to Therapeutic Strategies in Pancreatic Cancer

Author(s): Ivana Novak, Haoran Yu, Lara Magni, Ganga Deshar
Published in: International Journal of Molecular Sciences, 21/22, 2020, Page(s) 8781, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21228781

Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment

Author(s): Žan Toplak, Louise A. Hendrickx, Reham Abdelaziz, Xiaoyi Shi, Steve Peigneur, Tihomir Tomašič, Jan Tytgat, Lucija Peterlin‐Mašič, Luis A. Pardo
Published in: Medicinal Research Reviews, 2021, ISSN 0198-6325
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/med.21808

Extracellular Matrix Composition Modulates the Responsiveness of Differentiated and Stem Pancreatic Cancer Cells to Lipophilic Derivate of Gemcitabine

Author(s): Stefania Forciniti, Elisa Dalla Pozza, Maria Raffaella Greco, Tiago Miguel Amaral Carvalho, Barbara Rolando, Giulia Ambrosini, Cristian Andres Carmona-Carmona, Raffaella Pacchiana, Daria Di Molfetta, Massimo Donadelli, Silvia Arpicco, Marta Palmieri, Stephan Joel Reshkin, Ilaria Dando, Rosa Angela Cardone
Published in: International Journal of Molecular Sciences, 22/1, 2021, Page(s) 29, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22010029