Resultado final Documents, reports (1) pHioniC website pHioniC website, social media presence Publicaciones Peer reviewed articles (65) Design of New Potent and Selective Thiophene-Based KV1.3 Inhibitors and Their Potential for Anticancer Activity Autores: Špela Gubič; Louise Antonia Hendrickx; Xiaoyi Shi; Žan Toplak; Štefan Možina; Kenny M. Van Theemsche; Ernesto Lopes Pinheiro-Junior; Steve Peigneur; Alain J. Labro; Luis A. Pardo; Jan Tytgat; Tihomir Tomašič; Lucija Peterlin Mašič Publicado en: Cancers, Issue 14(11), 2595, 2023, ISSN 2072-6694 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers14112595 3D Pharmacophore-Based Discovery of Novel KV10.1 Inhibitors with Antiproliferative Activity Autores: Žan Toplak, Louise Antonia Hendrickx, Špela Gubič, Štefan Možina, Bojana Žegura, Alja Štern, Matjaž Novak, Xiaoyi Shi, Steve Peigneur, Jan Tytgat, Tihomir Tomašič, Luis A. Pardo, Lucija Peterlin Mašič Publicado en: Cancers, Issue 13/6, 2021, Page(s) 1244, ISSN 2072-6694 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers13061244 Lottini T.; Duranti C.; Iorio J.; Martinelli M.; Colasurdo R.; D’Alessandro F.N.; Buonamici M.; Coppola S.; Devescovi V.; La Vaccara V.; Coppola A.; Coppola R.; Lastraioli E.; Arcangeli A. Autores: Combination Therapy with a Bispecific Antibody Targeting the hERG1/β1 Integrin Complex and Gemcitabine in Pancreatic Ductal Adenocarcinoma Publicado en: Cancers, Issue 15, 7, 2013, 2023, ISSN 2072-6694 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers15072013 pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology Autores: Zoltán Pethő, Karolina Najder, Tiago Carvalho, Roisin McMorrow, Luca Matteo Todesca, Micol Rugi, Etmar Bulk, Alan Chan, Clemens W. G. M. Löwik, Stephan J. Reshkin, Albrecht Schwab Publicado en: Cancers, Issue 12/9, 2020, Page(s) 2484, ISSN 2072-6694 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers12092484 Permeability and driving force: why is difficult to control glycolytic flux by blocking lactate transporters? Autores: Blaszczak W, Swietach P Publicado en: Oncotarget, Issue 14, 2023, Page(s) 51-52, ISSN 1949-2553 Editor: Impact Journals DOI: 10.18632/oncotarget.28351 Cancer Cell Acid Adaptation Gene Expression Response Is Correlated to Tumor-Specific Tissue Expression Profiles and Patient Survival Autores: Jiayi Yao, Dominika Czaplinska, Renata Ialchina, Julie Schnipper, Bin Liu, Albin Sandelin, Stine Falsig Pedersen Publicado en: Cancers, Issue 12/8, 2020, Page(s) 2183, ISSN 2072-6694 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers12082183 Targeting the Stromal Pro-Tumoral Hyaluronan-CD44 Pathway in Pancreatic Cancer Autores: Tomas Koltai, Stephan Joel Reshkin, Tiago M. A. Carvalho, Rosa A. Cardone Publicado en: International Journal of Molecular Sciences, Issue 22/8, 2021, Page(s) 3953, ISSN 1422-0067 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms22083953 Increased demand for FAD synthesis in differentiated and stem pancreatic cancer cells is accomplished by modulating FLAD1 gene expression: the inhibitory effect of Chicago Sky Blue Autores: Nisco A, Carvalho TMA, Tolomeo nM, Di Molfetta D, Leone P, Galluccio M, Medina M, Indiveri C, Reshkin SJ, Cardone RA, Barile M Publicado en: The FEBS Journal, 2023, ISSN 1742-464X Editor: Blackwell Publishing Inc. DOI: 10.1111/febs.16881 The Transcriptional Landscape of BRAF Wild Type Metastatic Melanoma: A Pilot Study Autores: Elena Lastraioli; Federico Alessandro Ruffinatti; Giacomo Bagni; Luca Visentin; Francesco di Costanzo; Luca Munaron; Annarosa Arcangeli Publicado en: International Journal of Molecular Sciences, Issue 23; 13; 6898, 2022, ISSN 1422-0067 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms23136898 New Diarylamine KV10.1 Inhibitors and Their Anticancer Potential Autores: Špela Gubič; Žan Toplak; Xiaoyi Shi; Jaka Dernovšek; Louise Antonia Hendrickx; Ernesto Lopes Pinheiro-Junior; Steve Peigneur; Jan Tytgat; Luis A. Pardo; Lucija Peterlin Mašič; Tihomir Tomašič Publicado en: Pharmaceutics, Issue 14, 8, 1963, 2022, ISSN 1999-4923 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/pharmaceutics14091963 Acidic growth conditions promote epithelial-to-mesenchymal transitionto select more aggressive PDAC cell phenotypes in vitro Autores: Audero MM, Carvalho TMA, Ruffinatti FA, Loeck T, Yassine M, Chinigò G, Folcher A, Farfariello V, Amadori S, Vaghi C, Schwab A, Reshkin SJ, Cardone R.,Prevarskaya N, Fiorio Pla A A. Publicado en: Cancers, Issue 15, 9, 2572, 2023, ISSN 2072-6694 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers15092572 Extracellular pH Controls Chemotaxis of Neutrophil Granulocytes by Regulating Leukotriene B4 Production and Cdc42 Signaling Autores: Leonie Oster; Julia Schröder; Micol Rugi; Sandra Schimmelpfennig; Sarah Sargin; Albrecht Schwab; Karolina Najder Publicado en: The Journal of Immunology, Issue 209 (1), 2022, Page(s) 136–144, ISSN 0022-1767 Editor: American Association of Immunologists DOI: 10.4049/jimmunol.2100475 The Vacuolar H+ ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells Autores: Mette Flinck, Sofie Hagelund, Andrej Gorbatenko, Marc Severin, Elena Pedraz-Cuesta, Ivana Novak, Christian Stock, Stine Falsig Pedersen Publicado en: Cells, Issue 9/2, 2020, Page(s) 465, ISSN 2073-4409 Editor: MDPI DOI: 10.3390/cells9020465 Ion Channels Orchestrate Pancreatic Ductal Adenocarcinoma Progression and Therapy Autores: Verena Hofschröer, Karolina Najder, Micol Rugi, Rayhana Bouazzi, Marco Cozzolino, Annarosa Arcangeli, Gyorgy Panyi, Albrecht Schwab Publicado en: Frontiers in Pharmacology, Issue 11, 2021, ISSN 1663-9812 Editor: Frontiers Media S.A. DOI: 10.3389/fphar.2020.586599 The Acidic Tumor Microenvironment as a Driver of Cancer Autores: Boedtkjer E, Pedersen SF Publicado en: Annu Rev Physiol, Issue 82, 2020, Page(s) 103-126, ISSN 1545-1585 Editor: Annual Reviews DOI: 10.1146/annurev-physiol-021119-034627 Pharmacological targeting of the mitochondrial calcium dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivo Autores: Bachmann M, Rossa A, Varanita T, Fioretti B, Biasutto L, Milenkovic S, Checchetto V, Peruzzo R, Ahmad S, Patel S, Lukowksi R, Edwards M, Ceccarelli M, Gulbins E, Zoratti M, Mattarei A, Szabo I Publicado en: Cell Death Dis, 2022, Page(s) 13, 1055, ISSN 2041-4889 Editor: Nature Publishing Group DOI: 10.1038/s41419-022-05463-8 Role of pH in Regulating Cancer Pyrimidine Synthesis Autores: Alqahtani SS, Koltai T, Ibrahim ME, Bashir AHH, Alhoufie STS, Ahmed SBM, Molfetta DD, Carvalho TMA, Cardone RA, Reshkin SJ, Hifny A, Ahmed ME, Alfarouk KO Publicado en: Journal of Xenobiotics, Issue 12, 2022, Page(s) 158 - 180, ISSN 2039-4705 Editor: MDPI DOI: 10.3390/jox12030014 A Transcriptomic Approach Reveals Selective Ribosomal Remodelling in the Tumour Versus the Stromal Compartment of Metastatic Colorectal Cancer Autores: Elena Lastraioli; Federico Alessandro Ruffinatti; Francesco Di Costanzo; Cesare Sala; Luca Munaron; Annarosa Arcangeli Publicado en: Cancers, Issue 13, 16, 4188, 2021, ISSN 2072-6694 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers13164188 Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets Autores: Andersen HB, Ialchina R, Pedersen SF, Czaplinska D Publicado en: Cancer Metastasis Rev, Issue 40, 4, 2021, Page(s) 1093-1114, ISSN 0167-7659 Editor: Kluwer Academic Publishers DOI: 10.1007/s10555-021-10004-4 Ca2+ Signalling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression Autores: Madelaine Magalì Audero, Natalia Prevarskaya, Alessandra Fiorio Pla Publicado en: Int J Mol Sci, 2022, ISSN 1422-0067 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms23137377 Role of the Intracellular Sodium Homeostasis in Chemotaxis of Activated Murine Neutrophils Autores: Karolina Najder, Micol Rugi, Mégane Lebel, Julia Schröder, Leonie Oster, Sandra Schimmelpfennig, Sarah Sargin, Zoltán Pethő, Etmar Bulk, Albrecht Schwab Publicado en: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224 Editor: Frontiers Media S.A. DOI: 10.3389/fimmu.2020.02124 The Interplay between Dysregulated Ion Transport and Mitochondrial Architecture as a Dangerous Liaison in Cancer. Autores: Stine F. Pedersen; Mette Flinck; Luis A. Pardo Publicado en: International Journal of Molecular Sciences, Issue 22, 10, 5209, 2021, ISSN 1000-9035 Editor: Multidisciplinary Digital Publishing Institute DOI: 10.3390/ijms22105209 ECM composition differentially regulates intracellular and extracellular pH in normal and cancer pancreatic duct epithelial cells. Autores: Di Molfetta D, Cannone S, Greco MR, Caroppo R, Piccapane F, Carvalho TMA, Altamura C, Saltarella I, Tavares Valente D, Desaphy JF, Reshkin SJ, Cardone RA. Publicado en: Int J Mol Sci, Issue 24, 13, 2023, ISSN 1000-9035 Editor: MDPI DOI: 10.3390/ijms241310632 Biophysical and Biomechanical Effect of Low Intensity US Treatments on Pancreatic Adenocarcinoma 3D Cultures Autores: Mattia Dimitri; Claudia Duranti; Sara Aquino; Lucrezia Mazzantini; Jessica Iorio; Matteo Lulli; Martina Ricci; Lorenzo Capineri; Annarosa Arcangeli; Andrea Corvi Publicado en: Applied Sciences, Issue 12, 2, 666, 2022, ISSN 2076-3417 Editor: MDPI DOI: 10.3390/app12020666 Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production. Autores: Blaszczak W, Williams H, Swietach P Publicado en: Br J Cancer, 2022, ISSN 0007-0920 Editor: Nature Publishing Group DOI: 10.1038/s41416-022-01910-7 Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment. Autores: Žan Toplak; Louise Antonia Hendrickx; Reham Abdelaziz; Xiaoyi Shi; Steve Peigneur; Tihomir Tomašič; Jan Tytgat; Lucija Peterlin-Mašič; Luis A. Pardo Publicado en: Medicinal Research Reviews, Issue 42, 1, 2022, Page(s) 183-226, ISSN 0198-6325 Editor: John Wiley & Sons Inc. DOI: 10.1002/med.21808 Ion Channel Signature in Healthy Pancreas and Pancreatic Ductal Adenocarcinoma Autores: Julie Schnipper, Isabelle Dhennin-Duthille, Ahmed Ahidouch, Halima Ouadid-Ahidouch Publicado en: Frontiers in Pharmacology, Issue 11, 2020, ISSN 1663-9812 Editor: Frontiers Media S.A. DOI: 10.3389/fphar.2020.568993 Resistance to gemcitabine in pancreatic ductal adenocarcinoma: A physiopathologic and pharmacologic review Autores: Koltai T, Reshkin SJ, Carvalho TMA, Di Molfetta D, Greco MR, Alfarouk KO, Cardone RA. Publicado en: Cancers, Issue 14, 2486, 2022, ISSN 2072-6694 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers14102486 The A818–6 system as an in-vitro model for studying the role of the transportome in pancreatic cancer Autores: Doaa Tawfik, Angela Zaccagnino, Alexander Bernt, Monika Szczepanowski, Wolfram Klapper, Albrecht Schwab, Holger Kalthoff, Anna Trauzold Publicado en: BMC Cancer, Issue 20, 2020, Page(s) 264, ISSN 1471-2407 Editor: BioMed Central DOI: 10.1186/s12885-020-06773-w Extracellular Matrix Collagen I Differentially Regulates the Metabolic Plasticity of Pancreatic Ductal Adenocarcinoma Parenchymal Cell and Cancer Stem Cell Autores: Tavares-Valente D, Cannone S, Greco MR, Carvalho TMA, Baltazar F, Queirós O, Agrimi G, Reshkin SJ, Cardone RA Publicado en: Cancers, Issue 15, 3868, 2023, ISSN 2072-6694 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers15153868 Acid-base homeostasis orchestrated by NHE1 defines pancreatic stellate cell phenotype in pancreatic cancer Autores: Pethő Z, Najder K, Stephanie Beel S, Fels B, Neumann I, Schimmelpfennig S, Sargin S, Wolters M, Grantins K, Wardelmann E, Mitkovski M, Oeckinghaus A, Schwab A Publicado en: J Clin Invest Insight, Issue in press, 2023, ISSN 2379-3708 Editor: American Society for Clinical Investigation DOI: 10.1172/jci.insight.170928 The context-dependent role of the Na+/Ca2+-exchanger (NCX) in pancreatic stellate cell migration Autores: Loeck T, Rugi M, Todesca LM, Soret B, Neumann I, Schimmelpfennig S, Najder K, Pethő Z, Farfariello V, Prevarskaya N, Schwab A Publicado en: Pflügers Arch, 2023, ISSN 0031-6768 Editor: Springer Verlag DOI: 10.1007/s00424-023-02847-3 Cost-Effective Real-Time Metabolic Profiling of Cancer Cell Lines for Plate-Based Assays Autores: Wiktoria Blaszczak, Zhengchu Tan, Pawel Swietach Publicado en: Chemosensors, Issue 9/6, 2021, Page(s) 139, ISSN 2227-9040 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/chemosensors9060139 What do cellular responses to acidity tell us about cancer? Autores: Blaszczak W, Swietach P Publicado en: Cancer Metastasis Rev, 2021, ISSN 1573-7233 Editor: Springer Nature DOI: 10.1007/s10555-021-10005-3 Protonation of Piezo1 Impairs Cell-Matrix Interactions of Pancreatic Stellate Cells Autores: Kuntze, A. (Anna); Goetsch, O. (Ole); Fels, B. (Benedikt); Najder, K. (Karolina); Unger, A. (Andreas); Wilhelmi, M. (Marianne); Sargin, S. (Sarah); Schimmelpfennig, S. (Sandra); Neumann, I. (Ilka); Schwab, A. (Albrecht); Pethő, Z. (Zoltan) Publicado en: Frontiers in Physiology, Issue 11, 89, 2020, ISSN 1664-042X Editor: Frontiers Research Foundation DOI: 10.3389/fphys.2020.00089 Prognostic role of hERG1 Potassium Channels in Neuroendocrine Tumours of the Ileum and Pancreas Autores: Jessica Iorio; Lorenzo Antonuzzo; Emanuela Scarpi; Massimo D’Amico; Claudia Duranti; Luca Messerini; Clotilde Sparano; Damiano Caputo; Daniele Lavacchi; Domenico Borzomati; Alice Antonelli; Lorenzo Nibid; Giuseppe Perrone; Alessandro Coppola; Roberto Coppola; Francesco di Costanzo; Elena Lastraioli; Annarosa Arcangeli Publicado en: International Journal of Molecular Sciences, Issue 23, 18, 10623, 2022, ISSN 1661-6596 Editor: MDPI DOI: 10.3390/ijms231810623 Immunosuppressive effects of new thiophene-based KV1.3 inhibitors Autores: Gubič Š, Montalbano A, Sala C, Becchetti A, Hendrickx LA, Van Theemsche KM, Pinheiro-Junior EL, Altadonna GC, Peigneur S, Ilaš J, Labro AJ, Pardo LA, Tytgat J, Tomašič T, Arcangeli A, Peterlin Mašič L Publicado en: European Journal of Medicinal Chemistry, 2023, Page(s) 115561, ISSN 0223-5234 Editor: Elsevier BV DOI: 10.1016/j.ejmech.2023.115561 Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles Autores: Laura Somodi, Ildikó Beke Debreceni, Gréta Kis, Marco Cozzolino, János Kappelmayer, Miklós Antal, György Panyi, Helga Bárdos, Nicola J. Mutch, László Muszbek Publicado en: Journal of Thrombosis and Haemostasis, Issue 2022;20, 2022, Page(s) 1223–1235, ISSN 1538-7836 Editor: Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis DOI: 10.1111/jth.15668 Transcriptomic data of bevacizumab-adapted colorectal adenocarcinoma cells HCT-116 Autores: Sala Cesare; Lottini Tiziano; Lastraioli Elena; Ruffinatti Federico Alessandro; Visentin Luca; Arcangeli Annarosa Publicado en: Data Brief, Issue 48: 109069, 2023, ISSN 2352-3409 Editor: Elsevier BV DOI: 10.1016/j.dib.2023.109069 Impact of Extracellular pH on Apoptotic and Non-Apoptotic TRAIL-Induced Signaling in Pancreatic Ductal Adenocarcinoma Cells Autores: Hagelund S, Trauzold A Publicado en: Front Cell Dev Biol, Issue 10: 768579, 2022, ISSN 2296-634X Editor: Frontiers DOI: 10.3389/fcell.2022.768579 Acid Adaptation Promotes TRPC1 Plasma Membrane Localization Leading to Pancreatic Ductal Adenocarcinoma Cell Proliferation and Migration through Ca2+ Entry and Interaction with PI3K/CaM Autores: Schnipper J, Kouba S, Hague F, Girault A, Telliez MS, Guénin S, Ahidouch A, Pedersen SF, Ouadid-Ahidouch H Publicado en: Cancers, Issue 14, 19, 4946, 2022, ISSN 2072-6694 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers14194946 Synergistic effects of agonists and two-pore-domain potassium channels on secretory responses of human pancreatic duct cells Capan-1. Autores: Sørensen CE, Trauzold A, Christensen N, Tawfik D., Szczepanowski M, Novak, I Publicado en: Pflügers Archiv - European Journal of Physiology, Issue 475, 3, 2023, Page(s) 361-379, ISSN 1432-2013 Editor: Springer Nature Verlag DOI: 10.1007/s00424-022-02782-9 KV11.1 Potassium Channel and the Na+/H+ Antiporter NHE1 Modulate Adhesion-Dependent Intracellular pH in Colorectal Cancer Cells Autores: Iorio J.; Duranti C.; Lottini T.; Lastraioli E.; Bagni G.; Becchetti A.; Arcangeli A. Publicado en: Frontiers in Pharmacology, Issue 11, 848, 2020, ISSN 1663-9812 Editor: Frontiers Media S.A. DOI: 10.3389/fphar.2020.00848 Monitoring Immune Cell Function Through Optical Imaging: a Review Highlighting Transgenic Mouse Models Autores: Chintan Chawda, Roisin McMorrow, Natasa Gaspar, Giorgia Zambito & Laura Mezzanotte Publicado en: Molecular Imaging and Biology, 2021, ISSN 1860-2002 Editor: Springer Nature DOI: 10.1007/s11307-021-01662-5 hERG1 Potassium Channel Expression in Colorectal Adenomas: Comparison with Other Preneoplastic Lesions of the Gastrointestinal Tract Autores: Lastraioli E.; Iorio J.; Petrelli F.; Tomezzoli A.; Battista S.; Ambrosio M.R.; Chiudinelli M.; De Salvatore F.; Messerini L.; Villanacci V.; Saragoni L.; Arcangeli A. Publicado en: Current Issues in Molecular Biology, Issue 44, 3, 2022, Page(s) 1326-1331, ISSN 1467-3037 Editor: Caister Academic Press DOI: 10.3390/cimb44030089 Harnessing the hERG1/b1 integrin complex via a novel bispecific single-chain antibody: An effective strategy against solid cancers Autores: Duranti C.; Iorio J.; Lottini T.; Lastraioli E.; Crescioli S.; Bagni G.; Lulli M.; Capitani C.; Bouazzi R.; Stefanini M.; Carraresi L.; Iamele L.; De Jonge H.; Arcangeli A. Publicado en: Molecular Cancer Therapeutics, Issue 20, 8, 2021, Page(s) 1338-1350, ISSN 1535-7163 Editor: American Association for Cancer Research DOI: 10.1158/1535-7163.mct-20-1111 The TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca2+-Independent Manner Autores: Schnipper J, Kouba S, Hague F, Girault A, Rybarczyk P, Telliez MS, Guénin S, Tebbakha R, Sevestre H, Ahidouch A, Pedersen SF, Ouadid-Ahidouch H Publicado en: Int J Mol Sci, Issue 23, 14, 7923, 2022, ISSN 1422-0067 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms23147923 Tumor Microenvironment Features and Chemoresistance in Pancreatic Ductal Adenocarcinoma: Insights into Targeting Physicochemical Barriers and Metabolism as Therapeutic Approaches Autores: Carvalho TMA, Di Molfetta D, Greco MR, Koltai T, Alfarouk KO, Reshkin SJ, Cardone RA Publicado en: Cancers, Issue 13(23), 2021, Page(s) 6135, ISSN 2072-6694 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers13236135 A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells Autores: Franziska Hartung, Thomas Krüwel, Xiaoyi Shi, Klaus Pfizenmaier, Roland Kontermann, Patrick Chames, Frauke Alves, Luis A. Pardo Publicado en: Frontiers in Pharmacology, Issue 11, 2020, ISSN 1663-9812 Editor: Frontiers Media S.A. DOI: 10.3389/fphar.2020.00686 Glycan-Based Near-infrared Fluorescent (NIRF) Imaging of Gastrointestinal Tumors: a Preclinical Proof-of-Concept In Vivo Study Autores: Ruben D. Houvast, Victor M. Baart, Shadhvi S. Bhairosingh, Robert A. Cordfunke, Jia Xin Chua, Mireille Vankemmelbeke, Tina Parsons, Peter J. K. Kuppen, Lindy G. Durrant, Alexander L. Vahrmeijer, Cornelis F. M. Sier Publicado en: Molecular Imaging and Biology, 2020, ISSN 1536-1632 Editor: Elsevier BV DOI: 10.1007/s11307-020-01522-8 Expression and purification of a novel single-chain diabody (scDb-hERG1/β1) from Pichia pastoris transformants Autores: Duranti C.; Lastraioli E.; Iorio J.; Capitani C.; Carraresi L.; Gonnelli L.; Arcangeli A. Publicado en: Protein Expression and Purification, Issue 184, 105879, 2021, ISSN 1046-5928 Editor: Academic Press DOI: 10.1016/j.pep.2021.105879 Generation of an orthotopic xenograft of pancreatic cancer cells by ultrasound-guided injection Autores: Lottini T.; Buonamici M.; Duranti C.; Arcangeli A. Publicado en: Journal of Visualized Experiments, Issue 177, 2021, Page(s) e63123, ISSN 1940-087X Editor: MYJoVE Corporation DOI: 10.3791/63123 Discovery of K$_V$1.3 ion channel inhibitors Autores: Gubič, Špela; Hendrickx, Louise Antonia; Toplak, Žan; Sterle, Maša; Peigneur, Steve; Tomašič, Tihomir; Pardo, Luis A.; Tytgat, Jan; Zega, Anamarija; Peterlin-Mašič, Lucija Publicado en: Medicinal research reviews, Issue 41, 4, 2021, Page(s) 2423-2473, ISSN 0198-6325 Editor: John Wiley & Sons Inc. DOI: 10.1002/med.21800 The Voltage-Gated Hv1 H+ Channel Is Expressed in Tumor-Infiltrating Myeloid-Derived Suppressor Cells Autores: Marco Cozzolino, Adrienn Gyöngyösi, Eva Korpos, Peter Gogolak, Muhammad Umair Naseem, Judit Kállai, Arpad Lanyi and Gyorgy Panyi Publicado en: International Journal of Molecular Sciences, Issue 2023 (24), 6216, 2023, ISSN 1422-0067 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms24076216 Purinergic Signaling in Pancreas—From Physiology to Therapeutic Strategies in Pancreatic Cancer Autores: Ivana Novak, Haoran Yu, Lara Magni, Ganga Deshar Publicado en: International Journal of Molecular Sciences, Issue 21/22, 2020, Page(s) 8781, ISSN 1422-0067 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms21228781 Whole body bioluminescence imaging of T-cell response in PDAC models Autores: McMorrow R, Zambito G, Nigg A, Lila K, van den Bosch T, Lowik C, Mezzanotte L Publicado en: Front Immunol, 2023, ISSN 1664-3224 Editor: Frontiers DOI: 10.3389/fimmu.2023.1207533 Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment Autores: Žan Toplak, Louise A. Hendrickx, Reham Abdelaziz, Xiaoyi Shi, Steve Peigneur, Tihomir Tomašič, Jan Tytgat, Lucija Peterlin‐Mašič, Luis A. Pardo Publicado en: Medicinal Research Reviews, 2021, ISSN 0198-6325 Editor: John Wiley & Sons Inc. DOI: 10.1002/med.21808 Extracellular Matrix Composition Modulates the Responsiveness of Differentiated and Stem Pancreatic Cancer Cells to Lipophilic Derivate of Gemcitabine Autores: Stefania Forciniti, Elisa Dalla Pozza, Maria Raffaella Greco, Tiago Miguel Amaral Carvalho, Barbara Rolando, Giulia Ambrosini, Cristian Andres Carmona-Carmona, Raffaella Pacchiana, Daria Di Molfetta, Massimo Donadelli, Silvia Arpicco, Marta Palmieri, Stephan Joel Reshkin, Ilaria Dando, Rosa Angela Cardone Publicado en: International Journal of Molecular Sciences, Issue 22/1, 2021, Page(s) 29, ISSN 1422-0067 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms22010029 The Interaction between hERG1 and β1 Integrins Modulates hERG1 Current in Different Pathological Cell Models Autores: Chioccioli Altadonna G.; Montalbano A.; Iorio J.; Becchetti A.; Arcangeli A.; Duranti C. Publicado en: Membranes, Issue 12, 11, 1162, 2022, ISSN 2077-0375 Editor: Molecular Diversity Preservation International DOI: 10.3390/membranes12111162 Cancer Associated Fibroblast (CAF) Regulation of PDAC Parenchymal (CPC) and CSC Phenotypes Is Modulated by ECM Composition Autores: Cannone S, Greco MR, Carvalho TMA, Guizouarn H, Soriani O, Di Molfetta D, Tomasini R, Zeeberg K, Reshkin SJ, Cardone RA Publicado en: Cancers, Issue 14, 3737, 2022, ISSN 2072-6694 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers14153737 The role of potassium channels in tumours of the gastrointestinal tract: a focus on the human ether-à-go-go related gene 1 channels Autores: Arcangeli A.; Duranti C.; Iorio J.; Lastraioli E. Publicado en: Journal of Physiology, Issue 601, 9, 2023, Page(s) 1597-1610, ISSN 0022-3751 Editor: Blackwell Publishing Inc. DOI: 10.1113/jp282310 Crosstalk between tumor acidosis, p53 and extracellular matrix regulates pancreatic cancer aggressiveness. Autores: Czaplinska D, Ialchina R, Andersen HB, Yao J, Stigliani A, Dannesboe J, Flinck M, Chen X, Mitrega J, Gnosa SP, Dmytriyeva O, Alves F, Napp J, Sandelin A, Pedersen SF Publicado en: Int J Cancer, Issue 152, 6, 2023, Page(s) 1210-1225, ISSN 0020-7136 Editor: John Wiley & Sons Inc. DOI: 10.1002/ijc.34367 CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH Autores: Michl J, Wang Y, Monterisi S, Blaszczak W, Beveridge R, Bridges EM, Koth J, Bodmer WF, Swietach P Publicado en: Cell Reports, Issue 38, 10, 110493, 2022, ISSN 2211-1247 Editor: Cell Press DOI: 10.1016/j.celrep.2022.110493 Endogenous TRAIL-R4 critically impacts apoptotic and non-apoptotic TRAIL-induced signaling in cancer cells Autores: Rambow AC, Aschenbach I, Hagelund S, Tawfik D, Gundlach JP, Weiße S, Maass N, Trauzold A Publicado en: Front Cell Dev Biol, Issue 10: 942718, 2022, ISSN 2296-634X Editor: Frontiers DOI: 10.3389/fcell.2022.942718 Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2. Autores: Michl J, Monterisi S, White B, Blaszczak W, Hulikova A, Abdullayeva G, Bridges E, Yin Z, Bodmer WF, Swietach P. Publicado en: Cell Reports, Issue 42, 6, 112601, 2023, ISSN 2211-1247 Editor: Cell Press DOI: 10.1016/j.celrep.2023.112601 Book chapters (1) Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression. Autores: Ouadid-Ahidouch H, Morjani H, Schnipper J, Girault A, Ahidouch A Publicado en: Rev Physiol Biochem Pharmacol, Issue 181, 2021, Page(s) 1-38, ISSN 1617-5786 Editor: Springer DOI: 10.1007/112_2020_19 Buscando datos de OpenAIRE... Se ha producido un error en la búsqueda de datos de OpenAIRE No hay resultados disponibles
