pH and Ion Transport in Pancreatic Cancer

Risultati finali

Interaction with general public

Interaction with patient groups, media coverage, Science Night, Open Days

International Conferences

International Conferences (months 10, 44)

High school students

Teasers for high school students

Promotion of drug repurposing

Address health care policy makers to promote drug repurposing

Doctoral degrees

All ESRs obtain their doctoral degrees (month 56)

Teaching

Teaching ion transport in oncology to students

Summer Schools

Summer Schools 1–3 (months 10, 20,33)

Publications

Presenting results to the scientific/industrial community through publications,conferences

pHioniC website

pHioniC website, social media presence

Pubblicazioni

Design of New Potent and Selective Thiophene-Based KV1.3 Inhibitors and Their Potential for Anticancer Activity

Autori: Špela Gubič; Louise Antonia Hendrickx; Xiaoyi Shi; Žan Toplak; Štefan Možina; Kenny M. Van Theemsche; Ernesto Lopes Pinheiro-Junior; Steve Peigneur; Alain J. Labro; Luis A. Pardo; Jan Tytgat; Tihomir Tomašič; Lucija Peterlin Mašič
Pubblicato in: Cancers, Numero 14(11), 2595, 2023, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14112595

3D Pharmacophore-Based Discovery of Novel KV10.1 Inhibitors with Antiproliferative Activity

Autori: Žan Toplak, Louise Antonia Hendrickx, Špela Gubič, Štefan Možina, Bojana Žegura, Alja Štern, Matjaž Novak, Xiaoyi Shi, Steve Peigneur, Jan Tytgat, Tihomir Tomašič, Luis A. Pardo, Lucija Peterlin Mašič
Pubblicato in: Cancers, Numero 13/6, 2021, Pagina/e 1244, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13061244

Lottini T.; Duranti C.; Iorio J.; Martinelli M.; Colasurdo R.; D’Alessandro F.N.; Buonamici M.; Coppola S.; Devescovi V.; La Vaccara V.; Coppola A.; Coppola R.; Lastraioli E.; Arcangeli A.

Autori: Combination Therapy with a Bispecific Antibody Targeting the hERG1/β1 Integrin Complex and Gemcitabine in Pancreatic Ductal Adenocarcinoma
Pubblicato in: Cancers, Numero 15, 7, 2013, 2023, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15072013

pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology

Autori: Zoltán Pethő, Karolina Najder, Tiago Carvalho, Roisin McMorrow, Luca Matteo Todesca, Micol Rugi, Etmar Bulk, Alan Chan, Clemens W. G. M. Löwik, Stephan J. Reshkin, Albrecht Schwab
Pubblicato in: Cancers, Numero 12/9, 2020, Pagina/e 2484, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12092484

Permeability and driving force: why is difficult to control glycolytic flux by blocking lactate transporters?

Autori: Blaszczak W, Swietach P
Pubblicato in: Oncotarget, Numero 14, 2023, Pagina/e 51-52, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.28351

Cancer Cell Acid Adaptation Gene Expression Response Is Correlated to Tumor-Specific Tissue Expression Profiles and Patient Survival

Autori: Jiayi Yao, Dominika Czaplinska, Renata Ialchina, Julie Schnipper, Bin Liu, Albin Sandelin, Stine Falsig Pedersen
Pubblicato in: Cancers, Numero 12/8, 2020, Pagina/e 2183, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12082183

Targeting the Stromal Pro-Tumoral Hyaluronan-CD44 Pathway in Pancreatic Cancer

Autori: Tomas Koltai, Stephan Joel Reshkin, Tiago M. A. Carvalho, Rosa A. Cardone
Pubblicato in: International Journal of Molecular Sciences, Numero 22/8, 2021, Pagina/e 3953, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22083953

Increased demand for FAD synthesis in differentiated and stem pancreatic cancer cells is accomplished by modulating FLAD1 gene expression: the inhibitory effect of Chicago Sky Blue

Autori: Nisco A, Carvalho TMA, Tolomeo nM, Di Molfetta D, Leone P, Galluccio M, Medina M, Indiveri C, Reshkin SJ, Cardone RA, Barile M
Pubblicato in: The FEBS Journal, 2023, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.16881

The Transcriptional Landscape of BRAF Wild Type Metastatic Melanoma: A Pilot Study

Autori: Elena Lastraioli; Federico Alessandro Ruffinatti; Giacomo Bagni; Luca Visentin; Francesco di Costanzo; Luca Munaron; Annarosa Arcangeli
Pubblicato in: International Journal of Molecular Sciences, Numero 23; 13; 6898, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23136898

New Diarylamine KV10.1 Inhibitors and Their Anticancer Potential

Autori: Špela Gubič; Žan Toplak; Xiaoyi Shi; Jaka Dernovšek; Louise Antonia Hendrickx; Ernesto Lopes Pinheiro-Junior; Steve Peigneur; Jan Tytgat; Luis A. Pardo; Lucija Peterlin Mašič; Tihomir Tomašič
Pubblicato in: Pharmaceutics, Numero 14, 8, 1963, 2022, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14091963

Acidic growth conditions promote epithelial-to-mesenchymal transitionto select more aggressive PDAC cell phenotypes in vitro

Autori: Audero MM, Carvalho TMA, Ruffinatti FA, Loeck T, Yassine M, Chinigò G, Folcher A, Farfariello V, Amadori S, Vaghi C, Schwab A, Reshkin SJ, Cardone R.,Prevarskaya N, Fiorio Pla A A.
Pubblicato in: Cancers, Numero 15, 9, 2572, 2023, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15092572

Extracellular pH Controls Chemotaxis of Neutrophil Granulocytes by Regulating Leukotriene B4 Production and Cdc42 Signaling

Autori: Leonie Oster; Julia Schröder; Micol Rugi; Sandra Schimmelpfennig; Sarah Sargin; Albrecht Schwab; Karolina Najder
Pubblicato in: The Journal of Immunology, Numero 209 (1), 2022, Pagina/e 136–144, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.2100475

The Vacuolar H+ ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells

Autori: Mette Flinck, Sofie Hagelund, Andrej Gorbatenko, Marc Severin, Elena Pedraz-Cuesta, Ivana Novak, Christian Stock, Stine Falsig Pedersen
Pubblicato in: Cells, Numero 9/2, 2020, Pagina/e 465, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells9020465

Ion Channels Orchestrate Pancreatic Ductal Adenocarcinoma Progression and Therapy

Autori: Verena Hofschröer, Karolina Najder, Micol Rugi, Rayhana Bouazzi, Marco Cozzolino, Annarosa Arcangeli, Gyorgy Panyi, Albrecht Schwab
Pubblicato in: Frontiers in Pharmacology, Numero 11, 2021, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.586599

The Acidic Tumor Microenvironment as a Driver of Cancer

Autori: Boedtkjer E, Pedersen SF
Pubblicato in: Annu Rev Physiol, Numero 82, 2020, Pagina/e 103-126, ISSN 1545-1585
Editore: Annual Reviews
DOI: 10.1146/annurev-physiol-021119-034627

Pharmacological targeting of the mitochondrial calcium dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivo

Autori: Bachmann M, Rossa A, Varanita T, Fioretti B, Biasutto L, Milenkovic S, Checchetto V, Peruzzo R, Ahmad S, Patel S, Lukowksi R, Edwards M, Ceccarelli M, Gulbins E, Zoratti M, Mattarei A, Szabo I
Pubblicato in: Cell Death Dis, 2022, Pagina/e 13, 1055, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-022-05463-8

Role of pH in Regulating Cancer Pyrimidine Synthesis

Autori: Alqahtani SS, Koltai T, Ibrahim ME, Bashir AHH, Alhoufie STS, Ahmed SBM, Molfetta DD, Carvalho TMA, Cardone RA, Reshkin SJ, Hifny A, Ahmed ME, Alfarouk KO
Pubblicato in: Journal of Xenobiotics, Numero 12, 2022, Pagina/e 158 - 180, ISSN 2039-4705
Editore: MDPI
DOI: 10.3390/jox12030014

A Transcriptomic Approach Reveals Selective Ribosomal Remodelling in the Tumour Versus the Stromal Compartment of Metastatic Colorectal Cancer

Autori: Elena Lastraioli; Federico Alessandro Ruffinatti; Francesco Di Costanzo; Cesare Sala; Luca Munaron; Annarosa Arcangeli
Pubblicato in: Cancers, Numero 13, 16, 4188, 2021, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13164188

Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets

Autori: Andersen HB, Ialchina R, Pedersen SF, Czaplinska D
Pubblicato in: Cancer Metastasis Rev, Numero 40, 4, 2021, Pagina/e 1093-1114, ISSN 0167-7659
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10555-021-10004-4

Ca2+ Signalling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression

Autori: Madelaine Magalì Audero, Natalia Prevarskaya, Alessandra Fiorio Pla
Pubblicato in: Int J Mol Sci, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23137377

Role of the Intracellular Sodium Homeostasis in Chemotaxis of Activated Murine Neutrophils

Autori: Karolina Najder, Micol Rugi, Mégane Lebel, Julia Schröder, Leonie Oster, Sandra Schimmelpfennig, Sarah Sargin, Zoltán Pethő, Etmar Bulk, Albrecht Schwab
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.02124

The Interplay between Dysregulated Ion Transport and Mitochondrial Architecture as a Dangerous Liaison in Cancer.

Autori: Stine F. Pedersen; Mette Flinck; Luis A. Pardo
Pubblicato in: International Journal of Molecular Sciences, Numero 22, 10, 5209, 2021, ISSN 1000-9035
Editore: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/ijms22105209

ECM composition differentially regulates intracellular and extracellular pH in normal and cancer pancreatic duct epithelial cells.

Autori: Di Molfetta D, Cannone S, Greco MR, Caroppo R, Piccapane F, Carvalho TMA, Altamura C, Saltarella I, Tavares Valente D, Desaphy JF, Reshkin SJ, Cardone RA.
Pubblicato in: Int J Mol Sci, Numero 24, 13, 2023, ISSN 1000-9035
Editore: MDPI
DOI: 10.3390/ijms241310632

Biophysical and Biomechanical Effect of Low Intensity US Treatments on Pancreatic Adenocarcinoma 3D Cultures

Autori: Mattia Dimitri; Claudia Duranti; Sara Aquino; Lucrezia Mazzantini; Jessica Iorio; Matteo Lulli; Martina Ricci; Lorenzo Capineri; Annarosa Arcangeli; Andrea Corvi
Pubblicato in: Applied Sciences, Numero 12, 2, 666, 2022, ISSN 2076-3417
Editore: MDPI
DOI: 10.3390/app12020666

Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production.

Autori: Blaszczak W, Williams H, Swietach P
Pubblicato in: Br J Cancer, 2022, ISSN 0007-0920
Editore: Nature Publishing Group
DOI: 10.1038/s41416-022-01910-7

Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment.

Autori: Žan Toplak; Louise Antonia Hendrickx; Reham Abdelaziz; Xiaoyi Shi; Steve Peigneur; Tihomir Tomašič; Jan Tytgat; Lucija Peterlin-Mašič; Luis A. Pardo
Pubblicato in: Medicinal Research Reviews, Numero 42, 1, 2022, Pagina/e 183-226, ISSN 0198-6325
Editore: John Wiley & Sons Inc.
DOI: 10.1002/med.21808

Ion Channel Signature in Healthy Pancreas and Pancreatic Ductal Adenocarcinoma

Autori: Julie Schnipper, Isabelle Dhennin-Duthille, Ahmed Ahidouch, Halima Ouadid-Ahidouch
Pubblicato in: Frontiers in Pharmacology, Numero 11, 2020, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.568993

Resistance to gemcitabine in pancreatic ductal adenocarcinoma: A physiopathologic and pharmacologic review

Autori: Koltai T, Reshkin SJ, Carvalho TMA, Di Molfetta D, Greco MR, Alfarouk KO, Cardone RA.
Pubblicato in: Cancers, Numero 14, 2486, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14102486

The A818–6 system as an in-vitro model for studying the role of the transportome in pancreatic cancer

Autori: Doaa Tawfik, Angela Zaccagnino, Alexander Bernt, Monika Szczepanowski, Wolfram Klapper, Albrecht Schwab, Holger Kalthoff, Anna Trauzold
Pubblicato in: BMC Cancer, Numero 20, 2020, Pagina/e 264, ISSN 1471-2407
Editore: BioMed Central
DOI: 10.1186/s12885-020-06773-w

Extracellular Matrix Collagen I Differentially Regulates the Metabolic Plasticity of Pancreatic Ductal Adenocarcinoma Parenchymal Cell and Cancer Stem Cell

Autori: Tavares-Valente D, Cannone S, Greco MR, Carvalho TMA, Baltazar F, Queirós O, Agrimi G, Reshkin SJ, Cardone RA
Pubblicato in: Cancers, Numero 15, 3868, 2023, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15153868

Acid-base homeostasis orchestrated by NHE1 defines pancreatic stellate cell phenotype in pancreatic cancer

Autori: Pethő Z, Najder K, Stephanie Beel S, Fels B, Neumann I, Schimmelpfennig S, Sargin S, Wolters M, Grantins K, Wardelmann E, Mitkovski M, Oeckinghaus A, Schwab A
Pubblicato in: J Clin Invest Insight, Numero in press, 2023, ISSN 2379-3708
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.170928

The context-dependent role of the Na+/Ca2+-exchanger (NCX) in pancreatic stellate cell migration

Autori: Loeck T, Rugi M, Todesca LM, Soret B, Neumann I, Schimmelpfennig S, Najder K, Pethő Z, Farfariello V, Prevarskaya N, Schwab A
Pubblicato in: Pflügers Arch, 2023, ISSN 0031-6768
Editore: Springer Verlag
DOI: 10.1007/s00424-023-02847-3

Cost-Effective Real-Time Metabolic Profiling of Cancer Cell Lines for Plate-Based Assays

Autori: Wiktoria Blaszczak, Zhengchu Tan, Pawel Swietach
Pubblicato in: Chemosensors, Numero 9/6, 2021, Pagina/e 139, ISSN 2227-9040
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/chemosensors9060139

What do cellular responses to acidity tell us about cancer?

Autori: Blaszczak W, Swietach P
Pubblicato in: Cancer Metastasis Rev, 2021, ISSN 1573-7233
Editore: Springer Nature
DOI: 10.1007/s10555-021-10005-3

Protonation of Piezo1 Impairs Cell-Matrix Interactions of Pancreatic Stellate Cells

Autori: Kuntze, A. (Anna); Goetsch, O. (Ole); Fels, B. (Benedikt); Najder, K. (Karolina); Unger, A. (Andreas); Wilhelmi, M. (Marianne); Sargin, S. (Sarah); Schimmelpfennig, S. (Sandra); Neumann, I. (Ilka); Schwab, A. (Albrecht); Pethő, Z. (Zoltan)
Pubblicato in: Frontiers in Physiology, Numero 11, 89, 2020, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00089

Prognostic role of hERG1 Potassium Channels in Neuroendocrine Tumours of the Ileum and Pancreas

Autori: Jessica Iorio; Lorenzo Antonuzzo; Emanuela Scarpi; Massimo D’Amico; Claudia Duranti; Luca Messerini; Clotilde Sparano; Damiano Caputo; Daniele Lavacchi; Domenico Borzomati; Alice Antonelli; Lorenzo Nibid; Giuseppe Perrone; Alessandro Coppola; Roberto Coppola; Francesco di Costanzo; Elena Lastraioli; Annarosa Arcangeli
Pubblicato in: International Journal of Molecular Sciences, Numero 23, 18, 10623, 2022, ISSN 1661-6596
Editore: MDPI
DOI: 10.3390/ijms231810623

Immunosuppressive effects of new thiophene-based KV1.3 inhibitors

Autori: Gubič Š, Montalbano A, Sala C, Becchetti A, Hendrickx LA, Van Theemsche KM, Pinheiro-Junior EL, Altadonna GC, Peigneur S, Ilaš J, Labro AJ, Pardo LA, Tytgat J, Tomašič T, Arcangeli A, Peterlin Mašič L
Pubblicato in: European Journal of Medicinal Chemistry, 2023, Pagina/e 115561, ISSN 0223-5234
Editore: Elsevier BV
DOI: 10.1016/j.ejmech.2023.115561

Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles

Autori: Laura Somodi, Ildikó Beke Debreceni, Gréta Kis, Marco Cozzolino, János Kappelmayer, Miklós Antal, György Panyi, Helga Bárdos, Nicola J. Mutch, László Muszbek
Pubblicato in: Journal of Thrombosis and Haemostasis, Numero 2022;20, 2022, Pagina/e 1223–1235, ISSN 1538-7836
Editore: Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis
DOI: 10.1111/jth.15668

Transcriptomic data of bevacizumab-adapted colorectal adenocarcinoma cells HCT-116

Autori: Sala Cesare; Lottini Tiziano; Lastraioli Elena; Ruffinatti Federico Alessandro; Visentin Luca; Arcangeli Annarosa
Pubblicato in: Data Brief, Numero 48: 109069, 2023, ISSN 2352-3409
Editore: Elsevier BV
DOI: 10.1016/j.dib.2023.109069

Impact of Extracellular pH on Apoptotic and Non-Apoptotic TRAIL-Induced Signaling in Pancreatic Ductal Adenocarcinoma Cells

Autori: Hagelund S, Trauzold A
Pubblicato in: Front Cell Dev Biol, Numero 10: 768579, 2022, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2022.768579

Acid Adaptation Promotes TRPC1 Plasma Membrane Localization Leading to Pancreatic Ductal Adenocarcinoma Cell Proliferation and Migration through Ca2+ Entry and Interaction with PI3K/CaM

Autori: Schnipper J, Kouba S, Hague F, Girault A, Telliez MS, Guénin S, Ahidouch A, Pedersen SF, Ouadid-Ahidouch H
Pubblicato in: Cancers, Numero 14, 19, 4946, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14194946

Synergistic effects of agonists and two-pore-domain potassium channels on secretory responses of human pancreatic duct cells Capan-1.

Autori: Sørensen CE, Trauzold A, Christensen N, Tawfik D., Szczepanowski M, Novak, I
Pubblicato in: Pflügers Archiv - European Journal of Physiology, Numero 475, 3, 2023, Pagina/e 361-379, ISSN 1432-2013
Editore: Springer Nature Verlag
DOI: 10.1007/s00424-022-02782-9

KV11.1 Potassium Channel and the Na+/H+ Antiporter NHE1 Modulate Adhesion-Dependent Intracellular pH in Colorectal Cancer Cells

Autori: Iorio J.; Duranti C.; Lottini T.; Lastraioli E.; Bagni G.; Becchetti A.; Arcangeli A.
Pubblicato in: Frontiers in Pharmacology, Numero 11, 848, 2020, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.00848

Monitoring Immune Cell Function Through Optical Imaging: a Review Highlighting Transgenic Mouse Models

Autori: Chintan Chawda, Roisin McMorrow, Natasa Gaspar, Giorgia Zambito & Laura Mezzanotte
Pubblicato in: Molecular Imaging and Biology, 2021, ISSN 1860-2002
Editore: Springer Nature
DOI: 10.1007/s11307-021-01662-5

hERG1 Potassium Channel Expression in Colorectal Adenomas: Comparison with Other Preneoplastic Lesions of the Gastrointestinal Tract

Autori: Lastraioli E.; Iorio J.; Petrelli F.; Tomezzoli A.; Battista S.; Ambrosio M.R.; Chiudinelli M.; De Salvatore F.; Messerini L.; Villanacci V.; Saragoni L.; Arcangeli A.
Pubblicato in: Current Numeros in Molecular Biology, Numero 44, 3, 2022, Pagina/e 1326-1331, ISSN 1467-3037
Editore: Caister Academic Press
DOI: 10.3390/cimb44030089

Harnessing the hERG1/b1 integrin complex via a novel bispecific single-chain antibody: An effective strategy against solid cancers

Autori: Duranti C.; Iorio J.; Lottini T.; Lastraioli E.; Crescioli S.; Bagni G.; Lulli M.; Capitani C.; Bouazzi R.; Stefanini M.; Carraresi L.; Iamele L.; De Jonge H.; Arcangeli A.
Pubblicato in: Molecular Cancer Therapeutics, Numero 20, 8, 2021, Pagina/e 1338-1350, ISSN 1535-7163
Editore: American Association for Cancer Research
DOI: 10.1158/1535-7163.mct-20-1111

The TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca2+-Independent Manner

Autori: Schnipper J, Kouba S, Hague F, Girault A, Rybarczyk P, Telliez MS, Guénin S, Tebbakha R, Sevestre H, Ahidouch A, Pedersen SF, Ouadid-Ahidouch H
Pubblicato in: Int J Mol Sci, Numero 23, 14, 7923, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23147923

Tumor Microenvironment Features and Chemoresistance in Pancreatic Ductal Adenocarcinoma: Insights into Targeting Physicochemical Barriers and Metabolism as Therapeutic Approaches

Autori: Carvalho TMA, Di Molfetta D, Greco MR, Koltai T, Alfarouk KO, Reshkin SJ, Cardone RA
Pubblicato in: Cancers, Numero 13(23), 2021, Pagina/e 6135, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13236135

A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells

Autori: Franziska Hartung, Thomas Krüwel, Xiaoyi Shi, Klaus Pfizenmaier, Roland Kontermann, Patrick Chames, Frauke Alves, Luis A. Pardo
Pubblicato in: Frontiers in Pharmacology, Numero 11, 2020, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.00686

Expression and purification of a novel single-chain diabody (scDb-hERG1/β1) from Pichia pastoris transformants

Autori: Duranti C.; Lastraioli E.; Iorio J.; Capitani C.; Carraresi L.; Gonnelli L.; Arcangeli A.
Pubblicato in: Protein Expression and Purification, Numero 184, 105879, 2021, ISSN 1046-5928
Editore: Academic Press
DOI: 10.1016/j.pep.2021.105879

Generation of an orthotopic xenograft of pancreatic cancer cells by ultrasound-guided injection

Autori: Lottini T.; Buonamici M.; Duranti C.; Arcangeli A.
Pubblicato in: Journal of Visualized Experiments, Numero 177, 2021, Pagina/e e63123, ISSN 1940-087X
Editore: MYJoVE Corporation
DOI: 10.3791/63123

Discovery of K$_V$1.3 ion channel inhibitors

Autori: Gubič, Špela; Hendrickx, Louise Antonia; Toplak, Žan; Sterle, Maša; Peigneur, Steve; Tomašič, Tihomir; Pardo, Luis A.; Tytgat, Jan; Zega, Anamarija; Peterlin-Mašič, Lucija
Pubblicato in: Medicinal research reviews, Numero 41, 4, 2021, Pagina/e 2423-2473, ISSN 0198-6325
Editore: John Wiley & Sons Inc.
DOI: 10.1002/med.21800

The Voltage-Gated Hv1 H+ Channel Is Expressed in Tumor-Infiltrating Myeloid-Derived Suppressor Cells

Autori: Marco Cozzolino, Adrienn Gyöngyösi, Eva Korpos, Peter Gogolak, Muhammad Umair Naseem, Judit Kállai, Arpad Lanyi and Gyorgy Panyi
Pubblicato in: International Journal of Molecular Sciences, Numero 2023 (24), 6216, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24076216

Purinergic Signaling in Pancreas—From Physiology to Therapeutic Strategies in Pancreatic Cancer

Autori: Ivana Novak, Haoran Yu, Lara Magni, Ganga Deshar
Pubblicato in: International Journal of Molecular Sciences, Numero 21/22, 2020, Pagina/e 8781, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21228781

Whole body bioluminescence imaging of T-cell response in PDAC models

Autori: McMorrow R, Zambito G, Nigg A, Lila K, van den Bosch T, Lowik C, Mezzanotte L
Pubblicato in: Front Immunol, 2023, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2023.1207533

Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment

Autori: Žan Toplak, Louise A. Hendrickx, Reham Abdelaziz, Xiaoyi Shi, Steve Peigneur, Tihomir Tomašič, Jan Tytgat, Lucija Peterlin‐Mašič, Luis A. Pardo
Pubblicato in: Medicinal Research Reviews, 2021, ISSN 0198-6325
Editore: John Wiley & Sons Inc.
DOI: 10.1002/med.21808

Extracellular Matrix Composition Modulates the Responsiveness of Differentiated and Stem Pancreatic Cancer Cells to Lipophilic Derivate of Gemcitabine

Autori: Stefania Forciniti, Elisa Dalla Pozza, Maria Raffaella Greco, Tiago Miguel Amaral Carvalho, Barbara Rolando, Giulia Ambrosini, Cristian Andres Carmona-Carmona, Raffaella Pacchiana, Daria Di Molfetta, Massimo Donadelli, Silvia Arpicco, Marta Palmieri, Stephan Joel Reshkin, Ilaria Dando, Rosa Angela Cardone
Pubblicato in: International Journal of Molecular Sciences, Numero 22/1, 2021, Pagina/e 29, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22010029

The Interaction between hERG1 and β1 Integrins Modulates hERG1 Current in Different Pathological Cell Models

Autori: Chioccioli Altadonna G.; Montalbano A.; Iorio J.; Becchetti A.; Arcangeli A.; Duranti C.
Pubblicato in: Membranes, Numero 12, 11, 1162, 2022, ISSN 2077-0375
Editore: Molecular Diversity Preservation International
DOI: 10.3390/membranes12111162

Cancer Associated Fibroblast (CAF) Regulation of PDAC Parenchymal (CPC) and CSC Phenotypes Is Modulated by ECM Composition

Autori: Cannone S, Greco MR, Carvalho TMA, Guizouarn H, Soriani O, Di Molfetta D, Tomasini R, Zeeberg K, Reshkin SJ, Cardone RA
Pubblicato in: Cancers, Numero 14, 3737, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14153737

The role of potassium channels in tumours of the gastrointestinal tract: a focus on the human ether-à-go-go related gene 1 channels

Autori: Arcangeli A.; Duranti C.; Iorio J.; Lastraioli E.
Pubblicato in: Journal of Physiology, Numero 601, 9, 2023, Pagina/e 1597-1610, ISSN 0022-3751
Editore: Blackwell Publishing Inc.
DOI: 10.1113/jp282310

Crosstalk between tumor acidosis, p53 and extracellular matrix regulates pancreatic cancer aggressiveness.

Autori: Czaplinska D, Ialchina R, Andersen HB, Yao J, Stigliani A, Dannesboe J, Flinck M, Chen X, Mitrega J, Gnosa SP, Dmytriyeva O, Alves F, Napp J, Sandelin A, Pedersen SF
Pubblicato in: Int J Cancer, Numero 152, 6, 2023, Pagina/e 1210-1225, ISSN 0020-7136
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34367

CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH

Autori: Michl J, Wang Y, Monterisi S, Blaszczak W, Beveridge R, Bridges EM, Koth J, Bodmer WF, Swietach P
Pubblicato in: Cell Reports, Numero 38, 10, 110493, 2022, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2022.110493

Endogenous TRAIL-R4 critically impacts apoptotic and non-apoptotic TRAIL-induced signaling in cancer cells

Autori: Rambow AC, Aschenbach I, Hagelund S, Tawfik D, Gundlach JP, Weiße S, Maass N, Trauzold A
Pubblicato in: Front Cell Dev Biol, Numero 10: 942718, 2022, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2022.942718

Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2.

Autori: Michl J, Monterisi S, White B, Blaszczak W, Hulikova A, Abdullayeva G, Bridges E, Yin Z, Bodmer WF, Swietach P.
Pubblicato in: Cell Reports, Numero 42, 6, 112601, 2023, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2023.112601

Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression.

Autori: Ouadid-Ahidouch H, Morjani H, Schnipper J, Girault A, Ahidouch A
Pubblicato in: Rev Physiol Biochem Pharmacol, Numero 181, 2021, Pagina/e 1-38, ISSN 1617-5786
Editore: Springer
DOI: 10.1007/112_2020_19

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