Descripción del proyecto
Diagnóstico innovador de la función endotelial
Las células endoteliales recubren el interior de los vasos sanguíneos y linfáticos y forman una barrera entre los vasos y los tejidos, controlando el flujo de sustancias. Numerosas pruebas sugieren que las células endoteliales son las principales responsables de diferentes enfermedades, lo cual requiere el desarrollo de nuevas herramientas de diagnóstico. El objetivo del proyecto LOGIC-LAB, financiado con fondos europeos, es proporcionar un método innovador para identificar la disfunción endotelial. El consorcio formará a jóvenes investigadores en el desarrollo de sensores de analitos múltiples que pueden ofrecer una visión más integral de la complejidad de los tejidos endoteliales. El concepto se basa en la detección lógica molecular que, al detectar un estímulo externo, tiene la capacidad de realizar operaciones lógicas y proporcionar una respuesta.
Objetivo
A dysfunction of cells lining the inner walls of blood vessels, i.e. the endothelium, is the primary cause of many lifestyle related diseases. According to the WHO, those diseases accounted for 60% of all deaths worldwide in 2005. Tailor-made diagnostic tools for early and reliable identification of endothelial dysfunction are urgently needed both in fundamental research and clinical routine, respectively.
The Marie Skłodowska-Curie action LOGIC LAB objects to develop and characterize innovative molecular logic gates that can be applied as advanced diagnostic tools for parallel analyte sensing in live mammalian cells. Thereby, providing a unique method to discover endothelial dysfunction and the onset of diseases much easier and earlier than so far.
LOGIC LAB creates a multi-faceted and multi-sectoral research environment for the next generation of scientists in order to establish a novel type of molecular logic sensors that reliably operate in biological media – a crucial requirement for their application i.e. as rapid and easy-to-handle tools for intracellular diagnostics.
With excellent cross-disciplinary scientific and complementary training provided in the network, we aim to educate highly-skilled young scientists in the fields of chemistry, physics and biology, who will significantly strengthen the international research community in the domain of molecular logic sensing. Thus, in the long term, LOGIC LAB aims to finally bridge the gap between lab bench and biological or medical practice. It is this gap, that so far prevents a wide-ranging use of existing molecular logic gates e.g. for the diagnosis of lifestyle-associated diseases.
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
07745 Jena
Alemania