Descrizione del progetto
Diagnostica innovativa della funzione endoteliale
Le cellule endoteliali rivestono l’interno dei vasi sanguigni e linfatici e formano una barriera tra i vasi e i tessuti, controllando il flusso di sostanze. Prove sempre più numerose indicano che le cellule endoteliali sono le principali responsabili di molte malattie, il che rende necessario lo sviluppo di nuovi strumenti diagnostici. L’obiettivo del progetto LOGIC LAB, finanziato dall’UE, è fornire un metodo unico per identificare la disfunzione endoteliale. Il consorzio formerà giovani ricercatori nello sviluppo di sensori multiplex di analiti in grado di fornire una visione più completa della complessità dei tessuti endoteliali. L’intero concetto si fonda sul rilevamento logico molecolare che, al riconoscimento di uno stimolo esterno, è capace di eseguire operazioni logiche e di fornire una risposta.
Obiettivo
A dysfunction of cells lining the inner walls of blood vessels, i.e. the endothelium, is the primary cause of many lifestyle related diseases. According to the WHO, those diseases accounted for 60% of all deaths worldwide in 2005. Tailor-made diagnostic tools for early and reliable identification of endothelial dysfunction are urgently needed both in fundamental research and clinical routine, respectively.
The Marie Skłodowska-Curie action LOGIC LAB objects to develop and characterize innovative molecular logic gates that can be applied as advanced diagnostic tools for parallel analyte sensing in live mammalian cells. Thereby, providing a unique method to discover endothelial dysfunction and the onset of diseases much easier and earlier than so far.
LOGIC LAB creates a multi-faceted and multi-sectoral research environment for the next generation of scientists in order to establish a novel type of molecular logic sensors that reliably operate in biological media – a crucial requirement for their application i.e. as rapid and easy-to-handle tools for intracellular diagnostics.
With excellent cross-disciplinary scientific and complementary training provided in the network, we aim to educate highly-skilled young scientists in the fields of chemistry, physics and biology, who will significantly strengthen the international research community in the domain of molecular logic sensing. Thus, in the long term, LOGIC LAB aims to finally bridge the gap between lab bench and biological or medical practice. It is this gap, that so far prevents a wide-ranging use of existing molecular logic gates e.g. for the diagnosis of lifestyle-associated diseases.
Campo scientifico
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Meccanismo di finanziamento
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinatore
07745 Jena
Germania