Project description DEENESFRITPL Producing 100 high added value compounds from the shikimate pathway Chemical synthesis is often difficult and usually results in undesired by-products. While nature can provide many products, their very low concentrations make extraction costly. Conversely, microbial production is a well-established process for compounds that are host-produced or have fully characterised biosynthetic pathways. However, major screenings are required for the efficient production of target compounds derived from nature in industrial applications. With this in mind, the EU-funded SHIKIFACTORY100 project aims to produce over 100 high added value compounds from the shikimate pathway, a hub in cell metabolism, by developing an optimised shikimate chassis. It will also propose and implement novel biosynthetic routes exploring enzyme promiscuity so as to recommend new pathways for the production of known and newly-designed compounds. Show the project objective Hide the project objective Objective Chemical synthesis is often difficult and may be subject to unclear mechanisms, frequently producing undesired by-products, while the complexity of some compounds may rendered them virtually unattainable. Nature can provide a wealth of products, however typically at very low concentrations, which makes their extraction process expensive. Conversely, microbial production is a well-established process for compounds naturally produced by the hosts or for which there are fully characterised biosynthetic pathways. However, relying on nature’s diversity as a provider for industrial applications typically requires major screenings for pathways, genes and optimisation of cell factories for the efficient production of the target compounds.SHIKIFACTORY100 project aims towards the production of a universe of more than 100 high-added value compounds from the shikimate pathway, a hub in cell metabolism, through the development of an optimised shikimate chassis) and the proposal and implementation of novel biosynthetic routes exploring enzyme promiscuity to propose new pathways for the production of known and newly designed compounds. To champion SHIKIFACTORY100 project a consortium with some of the most relevant players in Europe has been assembled, covering research leading institutions in computational design, rapid prototyping and in vivo implementation of pathways and cell factories. As such, six world-leading research partners, four biotechnology SMEs with complementary focus areas and one large industrial company have been integrated. The research partners will be responsible for novel methods for pathway discovery and compound design, collaborating with the SMEs in the implementation and optimisation of the chassis, while SMEs and industrial partners will lead the assessment of the products and the exploitation of the results for different application areas. The industrial partner will be responsible for the validation of the production. Fields of science natural sciencesbiological sciencescell biologycell metabolismnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) H2020-EU.2.1.4. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology Main Programme Topic(s) BIOTEC-03-2018 - Synthetic biology to expand diversity of nature's chemical production (RIA) Call for proposal H2020-NMBP-TR-IND-2018-2020 See other projects for this call Sub call H2020-NMBP-BIO-2018-two-stage Funding Scheme RIA - Research and Innovation action Coordinator SILICOLIFE LDA Net EU contribution € 1 228 625,00 Address Rua do canastreiro 15 4715 387 Braga Portugal See on map Region Continente Norte Cávado Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (12) Sort alphabetically Sort by Net EU contribution Expand all Collapse all ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland Net EU contribution € 700 838,75 Address Batiment ce 3316 station 1 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 DANMARKS TEKNISKE UNIVERSITET Denmark Net EU contribution € 988 000,00 Address Anker engelunds vej 101 2800 Kongens lyngby See on map Region Danmark Hovedstaden Københavns omegn Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EUROPEAN MOLECULAR BIOLOGY LABORATORY Participation ended Germany Net EU contribution € 316 984,39 Address Meyerhofstrasse 1 69117 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 DSM FOOD SPECIALTIES BV Netherlands Net EU contribution € 885 000,00 Address Alexander fleminglaan 1 2613 AX Delft See on map Region West-Nederland Zuid-Holland Delft en Westland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 THE UNIVERSITY OF MANCHESTER United Kingdom Net EU contribution € 1 030 016,25 Address Oxford road M13 9PL Manchester See on map Region North West (England) Greater Manchester Manchester Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSIDADE DO MINHO Portugal Net EU contribution € 351 122,50 Address Largo do paco 4704 553 Braga See on map Region Continente Norte Cávado Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSIDADE NOVA DE LISBOA Portugal Net EU contribution € 987 450,00 Address Campus de campolide 1099 085 Lisboa See on map Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 C-LECTA GMBH Germany Net EU contribution € 400 900,00 Address Perlickstrasse 5 04103 Leipzig See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Sachsen Leipzig Leipzig Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 GALCHIMIA SA Spain Net EU contribution € 495 241,25 Address Parque empresarial de touro parcela 26-27 fonte diaz 15822 Touro a coruna See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Noroeste Galicia A Coruña Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 THE NATIONAL NON FOOD CROPS CENTRELBG United Kingdom Net EU contribution € 360 500,00 Address Innovation way york science park innovation centre heslington Y010 5DG York See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Yorkshire and the Humber North Yorkshire York Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom Net EU contribution € 250 665,61 Address Trinity lane the old schools CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITAT POLITECNICA DE VALENCIA Spain Net EU contribution € 0,00 Address Camino de vera sn edificio 3a 46022 Valencia See on map Region Este Comunitat Valenciana Valencia/València Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 2 193,76