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Modular cell factories for the production of 100 compounds from the shikimate pathway

Project description

Producing 100 high added value compounds from the shikimate pathway

Chemical synthesis is often difficult and usually results in undesired by-products. While nature can provide many products, their very low concentrations make extraction costly. Conversely, microbial production is a well-established process for compounds that are host-produced or have fully characterised biosynthetic pathways. However, major screenings are required for the efficient production of target compounds derived from nature in industrial applications. With this in mind, the EU-funded SHIKIFACTORY100 project aims to produce over 100 high added value compounds from the shikimate pathway, a hub in cell metabolism, by developing an optimised shikimate chassis. It will also propose and implement novel biosynthetic routes exploring enzyme promiscuity so as to recommend new pathways for the production of known and newly-designed compounds.

Call for proposal

H2020-NMBP-TR-IND-2018-2020

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Sub call

H2020-NMBP-BIO-2018-two-stage

Coordinator

SILICOLIFE LDA
Net EU contribution
€ 1 228 625,00
Address
Rua Do Canastreiro 15
4715 387 Braga
Portugal

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Region
Continente Norte Cávado
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00

Participants (12)

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Net EU contribution
€ 700 838,75
Address
Batiment Ce 3316 Station 1
1015 Lausanne

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
DANMARKS TEKNISKE UNIVERSITET
Denmark
Net EU contribution
€ 988 000,00
Address
Anker Engelunds Vej 101
2800 Kongens Lyngby

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Region
Danmark Hovedstaden Københavns omegn
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
EUROPEAN MOLECULAR BIOLOGY LABORATORY

Participation ended

Germany
Net EU contribution
€ 316 984,39
Address
Meyerhofstrasse 1
69117 Heidelberg
Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Research Organisations
Other funding
€ 0,00
DSM FOOD SPECIALTIES BV
Netherlands
Net EU contribution
€ 885 000,00
Address
Alexander Fleminglaan 1
2613 AX Delft

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Region
West-Nederland Zuid-Holland Delft en Westland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
THE UNIVERSITY OF MANCHESTER
United Kingdom
Net EU contribution
€ 1 030 016,25
Address
Oxford Road
M13 9PL Manchester

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Region
North West (England) Greater Manchester Manchester
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSIDADE DO MINHO
Portugal
Net EU contribution
€ 351 122,50
Address
Largo Do Paco
4704 553 Braga

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Region
Continente Norte Cávado
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSIDADE NOVA DE LISBOA
Portugal
Net EU contribution
€ 987 450,00
Address
Campus De Campolide
1099 085 Lisboa

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Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
C-LECTA GMBH
Germany
Net EU contribution
€ 400 900,00
Address
Perlickstrasse 5
04103 Leipzig

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Sachsen Leipzig Leipzig
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
GALCHIMIA SA
Spain
Net EU contribution
€ 495 241,25
Address
Parque Empresarial De Touro Parcela 26-27 Fonte Diaz
15822 Touro A Coruna

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Galicia A Coruña
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
THE NATIONAL NON FOOD CROPS CENTRELBG
United Kingdom
Net EU contribution
€ 360 500,00
Address
Innovation Way York Science Park Innovation Centre Heslington
Y010 5DG York

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Yorkshire and the Humber North Yorkshire York
Activity type
Research Organisations
Other funding
€ 0,00
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Net EU contribution
€ 250 665,61
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITAT POLITECNICA DE VALENCIA
Spain
Net EU contribution
€ 0,00
Address
Camino De Vera Sn Edificio 3a
46022 Valencia

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Region
Este Comunitat Valenciana Valencia/València
Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 193,76