Project description
Holistic integrated models will better predict potential undesired effects of nanomaterials
Nanomaterials are revolutionising fields from composites and coatings to energy, biomedicine and optoelectronics. The unique and exotic properties exhibited by many materials at the nanoscale that are not exhibited by the same materials in bulk form have paved the way for unprecedented material and device functions. However, these very small sizes increase the materials' potential to access, settle in and affect living organisms during a product’s life cycle. The EU-funded NanoInformaTIX project is developing a multiscale modelling framework integrating numerous databases and models in one to optimise the assessment of exposure and toxicity associated with engineered nanomaterials.
Objective
NanoInformaTIX aims to create a comprehensive, sustainable, multi-scale modelling framework for exposure and (eco)-toxicity of Engineered Nanomaterials (ENM) to facilitate cost-effective risk assessment, less reliant on animal testing, and to support the design of safer materials and products. Our approach integrates several relevant EU/US databases with validated nanoinformatics models covering: Materials, Exposure, Physiologically-Based Pharmacokinetics (PBPK), Quantitative-Structure-Activity Relations (QSAR) and Systems Biology modelling and in vitro/in vivo extrapolation to support the prediction of biological effects and exposure of ENM at various stages of their life cycle and product development. NanoInformaTIX will address grouping and read-across for risk assessment and safer product design. NanoInformaTIX will use existing curated data from several completed EU/US projects and from peer-reviewed literature to develop, extend the models and will also consider emerging data from ongoing projects for model validation following the OECD validation principles. This will take the NanoInformaTIX models from TLR4 to TLR6. The NanoInformaTIX modelling framework will be a web-based platform with a user-friendly interface tailored to the needs of different stakeholders (industry, regulators, academia and the civil society). To obtain optimal confidence in the use of the NanoInformaTIX modelling and database framework, all models will be described clearly using agreed standards terminology and implemented on harmonized standard operating protocols based on Good Modelling/Software Design practices. Their applicability domain will be clearly documented and referenced for full transparency and detailed user guidance for each will be provided. NanoInformaTIX will achieve considerable impact by providing the much -needed validated accessible data management modelling framework to predict human and environmental risks, to support the design of sustainable ENM and products.
Fields of science
- natural sciencescomputer and information sciencessoftware
- natural sciencescomputer and information sciencesdatabases
- medical and health sciencesbasic medicinepharmacology and pharmacypharmacokinetics
- social sciencespolitical sciencespolitical policiescivil society
- engineering and technologynanotechnologynano-materials
Keywords
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
28006 Madrid
Spain
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Participants (36)
EH14 4AP Edinburgh
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48149 Muenster
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8000 Aarhus C
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10589 Berlin
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30121 VENEZIA
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2440 Geel
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69978 Tel Aviv
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80-309 GDANSK
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4 Dublin
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43003 Tarragona
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1000 Sofia
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
00014 Helsingin Yliopisto
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2311 EZ Leiden
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7052 Trondheim
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00133 Roma
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157 80 ATHINA
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3810-193 Aveiro
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8600 Dubendorf
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50604 Tartu
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
15341 Agia Paraskevi
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10129 Torino
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42015 Correggio Re
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Participation ended
8152 Opfikon
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
00185 Roma
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2100 Kobenhavn
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00250 Helsinki
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SA2 8PP Swansea
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13284 Marseille
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2125 Randburg
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04318 Leipzig
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1799 Sofia
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
100190 BEIJING
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701 Tainan
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75006 Paris
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49005 Angers
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5212 Hausen
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