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Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology (NanoSolveIT)

Project description

Effectively assessing the risks of nanomaterials

The health, safety and environmental management of nanomaterials (NMs) is increasingly important. Currently, there is no complete understanding of NMs' impacts, and emerging NMs require new risk management approaches. The EU-funded NanoSolveIT project will introduce a ground-breaking in silico Integrated Approach to Testing and Assessment (IATA) for NMs, implemented as a decision support system presented via stand-alone open software and a cloud platform. The project will develop a knowledge-based infrastructure for data hosting, sharing and exploitation via predictive modelling, to support NM grouping and risk assessment using nanodescriptors that are predictively linked to NM functionality, exposure and hazard. Project outcomes will benefit stakeholders at each stage of the NM value chain.

Objective

NanoSolveIT will introduce a ground-breaking in silico Integrated Approach to Testing and Assessment (IATA) for the environmental health and safety of Nanomaterials (NM), implemented as a decision support system packaged as a standalone open software and a Cloud platform. NanoSolveIT will develop and deliver: (i) a reliable user friendly knowledge-based infrastructure for data hosting, sharing and exploitation, (ii) NM fingerprints, sets of nanodescriptors and properties that can be predictively linked to NM functionality, exposure and hazard, thereby supporting NM grouping, safe-by-design (SbD) and regulatory risk assessment (RA), (iii) innovative methodologies for NMs predictive (eco)toxicology underpinned by artificial intelligence and state-of-the-art in silico techniques, and, (iv) integration with multi-scale modelling, RA and governance frameworks developed in EU H2020 funded and in the forthcoming NMBP-13 project(s). NanoSolveIT will deliver a validated, sustainable, multi-scale nanoinformatics IATA, tested and demonstrated at TLR6 via OECD style IATA case studies, serving the needs of diverse stakeholders at each stage of the NMs value chain, for assessment of potential adverse effects of NM on human health and the environment. NanoSolveIT is fully aligned to the objectives of the EU-US Nanoinformactics Roadmap, addressing all 13 of its short, medium and long term milestones, and supports the recommendations of the EMMC on standards for developing material modelling software and OECD best practice. The NanoSolveIT consortium (EU and international partners) is the only grouping capable of delivering the ambitious goals of the NMBP-14-2018 call, since they have collectively driven most of the current progress in nanoinformatics: 81% of the nanoinormatics papers cited in the EU-US nanoinformatics roadmap had NanoSolveIT authors. NanoSolveIT will integrate across the consortium-wide modelling approaches to provide the IATA platform for in silico NMs RA.

Call for proposal

H2020-NMBP-TO-IND-2018-2020

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Sub call

H2020-NMBP-TO-IND-2018

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Coordinator

NOVAMECHANICS LIMITED
Net EU contribution
€ 946 100,00
Address
Digeni akrita 51
1070 Nicosia
Cyprus

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Κύπρος Κύπρος Κύπρος
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Other funding
€ 0,00

Participants (27)