Project description
A sustainable approach to producing the antifungal medicine terbinafine
Terbinafine is an antifungal medicine used to treat fungal skin infections including candidiasis, athlete’s foot, ringworm and onychomycosis. The medicine is produced in China and India using a complex and expensive synthesis reaction. However, stricter environmental regulations are severely restricting its production. The EU-funded TERES project is developing a safer, more eco-friendly and more cost-effective method of manufacturing terbinafine that is expected to relocate its production from Asia to Europe. The key innovation is the use of a clever catalyst that greatly accelerates the chemical reaction. TERES aims to optimise and scale up the production capacity and ultimately make sure that the method fully complies with the REACH Regulation.
Objective
Synthetics Int. AG is a Swiss company strongly R&D driven which holds a variety of IP/commercial processes in the chemical business focused on the custom manufacturing and multi-customer products for the fine chemical market and the supply of polyfunctional cross linkers, tailor made manufacturing equipment, and natural products for treatment of wood. With a consolidated 20 years of history, Synthetics is a reference in the fine chemistry market. Within this project, in order to improve the synthesis of one of the most efficient dermatologic antifungals in the market, Terbinafine Hydrochloride, Synthetics has developed TERES, an innovative manufacturing process for this API, achieving a cycle time reduction from 6 steps to 2 steps by using a clever catalyst in order to accelerate the reaction. This implies a lower operation time and, at the same time, raw materials savings and environmental costs reduction (water/air, energy, solvents and toxic products). In addition, a better impurity profile is achieved, what means less risk of side effects in the drug product and purifying costs reduction. Consequently, Synthetics can ease the move Terbinafine manufacturing back from India (currently 80% of production) to a manufacturing plant in Denmark with an extreme competitive pricing.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology mechanical engineering manufacturing engineering
- medical and health sciences health sciences public health
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- engineering and technology materials engineering amorphous solids
- agricultural sciences agriculture, forestry, and fisheries forestry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.2.3. - INDUSTRIAL LEADERSHIP - Innovation In SMEs
MAIN PROGRAMME
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H2020-EU.3. - PRIORITY 'Societal challenges
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H2020-EU.2.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
SME-1 - SME instrument phase 1
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-EIC-SMEInst-2018-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
4052 BASEL
Switzerland
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.