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Protein Dynamics in Antiviral Processes

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Publications

Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread

Author(s): Shubhankar Ambike; Cho-Chin Cheng; Martin Feuerherd; Stoyan Velkov; Domizia Baldassi; Suliman Qadir Afridi; Diana Porras-Gonzalez; Xin Wei; Philipp Hagen; Nikolaus Kneidinger; Mircea Gabriel Stoleriu; Vincent Grass; Gerald Burgstaller; Andreas Pichlmair; Olivia M Merkel; Chunkyu Ko; Thomas Michler
Published in: Nucleic Acids Research, 2, 2021, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkab1248

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

Author(s): Alexey Stukalov; Virginie Girault; Vincent Grass; Ozge Karayel; Valter Bergant; Christian Urban; Darya A. Haas; Yiqi Huang; Lila Oubraham; Anqi Wang; M. Sabri Hamad; Antonio Piras; Fynn M. Hansen; Maria C. Tanzer; Igor Paron; Luca Zinzula; Thomas Enghleitner; Maria Reinecke; Maria Reinecke; Teresa M. Lavacca; Rosina Ehmann; Roman Wölfel; Jörg Jores; Bernhard Kuster; Bernhard Kuster; Ulrike Protz
Published in: Nature/Vol 594, 2, 2021, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03493-4

ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly

Author(s): Christopher J. Neufeldt, Mirko Cortese, Pietro Scaturro, Berati Cerikan, Jeremy G. Wideman, Keisuke Tabata, Thaís Moraes, Olga Oleksiuk, Andreas Pichlmair & Ralf Bartenschlager
Published in: Nature Microbiology, 2019, ISSN 2058-5276
Publisher: Nature publishing group
DOI: 10.1038/s41564-019-0586-3

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

Author(s): Alexey Stukalov, Virginie Girault, Vincent Grass, Ozge Karayel, Valter Bergant, Christian Urban, Darya A. Haas, Yiqi Huang, Lila Oubraham, Anqi Wang, M. Sabri Hamad, Antonio Piras, Fynn M. Hansen, Maria C. Tanzer, Igor Paron, Luca Zinzula, Thomas Engleitner, Maria Reinecke, Teresa M. Lavacca, Rosina Ehmann, Roman Wölfel, Jörg Jores, Bernhard Kuster, Ulrike Protzer, Roland Rad, John Ziebuhr, Volk
Published in: Nature, 594/7862, 2021, Page(s) 246-252, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03493-4

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape

Author(s): Philipp Hubel, Christian Urban, Valter Bergant, William M. Schneider, Barbara Knauer, Alexey Stukalov, Pietro Scaturro, Angelika Mann, Linda Brunotte, Heinrich H. Hoffmann, John W. Schoggins, Martin Schwemmle, Matthias Mann, Charles M. Rice, Andreas Pichlmair
Published in: Nature Immunology, 20/4, 2019, Page(s) 493-502, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-019-0323-3

Chasing Intracellular Zika Virus Using Proteomics

Author(s): Pietro Scaturro, Anna Lena Kastner, Andreas Pichlmair
Published in: Viruses, 11/9, 2019, Page(s) 878, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11090878

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

Author(s): Sepideh Sadegh, Julian Matschinske, David B. Blumenthal, Gihanna Galindez, Tim Kacprowski, Markus List, Reza Nasirigerdeh, Mhaned Oubounyt, Andreas Pichlmair, Tim Daniel Rose, Marisol Salgado-Albarrán, Julian Späth, Alexey Stukalov, Nina K. Wenke, Kevin Yuan, Josch K. Pauling and Jan Baumbach
Published in: Nature Communications, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17189-2

Persistent Innate Immune Stimulation Results in IRF3-Mediated but Caspase-Independent Cytostasis

Author(s): Christian Urban, Hendrik Welsch, Katharina Heine, Sandra Wüst, Darya A. Haas, Christopher Dächert, Aparna Pandey, Andreas Pichlmair and Marco Binder
Published in: Viruses, 2020, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12060635

Human cytomegalovirus-induced host protein citrullination is crucial for viral replication

Author(s): Gloria Griffante, Francesca Gugliesi, Selina Pasquero, Valentina Dell’Oste, Matteo Biolatti, Ari J. Salinger, Santanu Mondal, Paul R. Thompson, Eranthie Weerapana, Robert J. Lebbink, Jasper A. Soppe, Thomas Stamminger, Virginie Girault, Andreas Pichlmair, Gábor Oroszlán, Donald M. Coen, Marco De Andrea, Santo Landolfo
Published in: Nature Communications, 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24178-6

Two cGAS-like receptors induce antiviral immunity in Drosophila

Author(s): Andreas Holleufer, Kasper Grønbjerg Winther, Hans Henrik Gad, Xianlong Ai, Yuqiang Chen, Lihua Li, Ziming Wei, Huimin Deng, Jiyong Liu, Ninna Ahlmann Frederiksen, Bine Simonsen, Line Lykke Andersen, Karin Kleigrewe, Louise Dalskov, Andreas Pichlmair, Hua Cai, Jean-Luc Imler, Rune Hartmann
Published in: Nature, 597/7874, 2021, Page(s) 114-118, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03800-z

A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle

Author(s): Anna Płaszczyca, Pietro Scaturro, Christopher John Neufeldt, Mirko Cortese, Berati Cerikan, Salvatore Ferla, Andrea Brancale, Andreas Pichlmair, Ralf Bartenschlager
Published in: PLOS Pathogens, 15/5, 2019, Page(s) e1007736, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1007736

eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition

Author(s): Jennifer Deborah Wuerth, Matthias Habjan, Markus Kainulainen, Besim Berisha, Damien Bertheloot, Giulio Superti-Furga, Andreas Pichlmair, Friedemann Weber
Published in: mBio, 2020, ISSN 2150-7511
Publisher: American Society for Microbiology
DOI: 10.1128/mbio.00976-20

Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway

Author(s): Maria Krivega, Clara M. Stiefel, Sahar Karbassi, Line L. Andersen, Narendra K. Chunduri, Neysan Donnelly, Andreas Pichlmair, Zuzana Storchová
Published in: Communications Biology, 4/1, 2021, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-021-02278-9

Human NLRP1 is a sensor for double-stranded RNA

Author(s): Stefan Bauernfried, Matthias J. Scherr, Andreas Pichlmair, Karl E. Duderstadt, Veit Hornung
Published in: Science, 371/6528, 2021, Page(s) eabd0811, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abd0811

The UFM1 Pathway Impacts HCMV US2-Mediated Degradation of HLA Class I.

Author(s): Anouk B. C. Schuren; Ingrid G. J. Boer; Esther M. C. Bouma; M. L. van de Weijer; Ana I. Costa; P. Hubel; Andreas Pichlmair; Robert Jan Lebbink; Emmanuel J. H. J. Wiertz
Published in: MDPI/Volume 26, 1, 2021, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26020287

Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription

Author(s): Jingjing Pei, Nina R. Beri, Angela J. Zou, Philipp Hubel, Hannah K. Dorando, Valter Bergant, Rebecca D. Andrews, Jiehong Pan, Jared M. Andrews, Kathleen C.F. Sheehan, Andreas Pichlmair, Gaya K. Amarasinghe, Steven L. Brody, Jacqueline E. Payton, Daisy W. Leung
Published in: Cell Reports, 37/2, 2021, Page(s) 109803, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109803

Data, Reagents, Assays and Merits of Proteomics for SARS-CoV-2 Research and Testing

Author(s): Jana Zecha, Chien-Yun Lee, Florian P. Bayer, Chen Meng, Vincent Grass, Johannes Zerweck, Karsten Schnatbaum, Thomas Michler, Andreas Pichlmair, Christina Ludwig, Bernhard Kuster
Published in: Molecular & Cellular Proteomics, 19/9, 2020, Page(s) 1503-1522, ISSN 1535-9476
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra120.002164

The alternative cap-binding complex is required for antiviral defense in vivo

Author(s): Anna Gebhardt,Valter Bergant,Daniel Schnepf,Markus Moser,Arno Meiler,Dieudonnée Togbe,Claire Mackowiak,Line S. Reinert,Søren R. Paludan,Bernhard Ryffel,Alexey Stukalov,Peter Staeheli,Andreas Pichlmair
Published in: PLOS Pathogens, 2019, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1008155

The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription

Author(s): Markus Fabits, Vladimir Gonçalves Magalhães, Baca Chan ,Virginie Girault, Endrit Elbasani, Elisa Rossetti, Eirikur Saeland, Martin Messerle,Andreas Pichlmair, Vanda Juranić Lisnić and Melanie M. Brinkmann
Published in: Microorganisms, 2020, ISSN 2076-2607
Publisher: MDPI
DOI: 10.3390/microorganisms8060790

A Nanoscaffolded Spike-RBD Vaccine Provides Protection against SARS-CoV-2 with Minimal Anti-Scaffold Response

Author(s): Duško Lainšček, Tina Fink, Vida Forstnerič, Iva Hafner-Bratkovič, Sara Orehek, Žiga Strmšek, Mateja Manček-Keber, Peter Pečan, Hana Esih, Špela Malenšek, Jana Aupič, Petra Dekleva, Tjaša Plaper, Sara Vidmar, Lucija Kadunc, Mojca Benčina, Neža Omersa, Gregor Anderluh, Florence Pojer, Kelvin Lau, David Hacker, Bruno E. Correia, David Peterhoff, Ralf Wagner, Valter Bergant, Alexander H
Published in: Vaccines, 9/5, 2021, Page(s) 431, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9050431