Protein Dynamics in Antiviral Processes

Publicaciones

Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread

Autores: Shubhankar Ambike; Cho-Chin Cheng; Martin Feuerherd; Stoyan Velkov; Domizia Baldassi; Suliman Qadir Afridi; Diana Porras-Gonzalez; Xin Wei; Philipp Hagen; Nikolaus Kneidinger; Mircea Gabriel Stoleriu; Vincent Grass; Gerald Burgstaller; Andreas Pichlmair; Olivia M Merkel; Chunkyu Ko; Thomas Michler
Publicado en: Nucleic Acids Research, Edición 2, 2021, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkab1248

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

Autores: Alexey Stukalov; Virginie Girault; Vincent Grass; Ozge Karayel; Valter Bergant; Christian Urban; Darya A. Haas; Yiqi Huang; Lila Oubraham; Anqi Wang; M. Sabri Hamad; Antonio Piras; Fynn M. Hansen; Maria C. Tanzer; Igor Paron; Luca Zinzula; Thomas Enghleitner; Maria Reinecke; Maria Reinecke; Teresa M. Lavacca; Rosina Ehmann; Roman Wölfel; Jörg Jores; Bernhard Kuster; Bernhard Kuster; Ulrike Protz
Publicado en: Nature/Vol 594, Edición 2, 2021, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-021-03493-4

ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly

Autores: Christopher J. Neufeldt, Mirko Cortese, Pietro Scaturro, Berati Cerikan, Jeremy G. Wideman, Keisuke Tabata, Thaís Moraes, Olga Oleksiuk, Andreas Pichlmair & Ralf Bartenschlager
Publicado en: Nature Microbiology, 2019, ISSN 2058-5276
Editor: Nature publishing group
DOI: 10.1038/s41564-019-0586-3

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

Autores: Alexey Stukalov, Virginie Girault, Vincent Grass, Ozge Karayel, Valter Bergant, Christian Urban, Darya A. Haas, Yiqi Huang, Lila Oubraham, Anqi Wang, M. Sabri Hamad, Antonio Piras, Fynn M. Hansen, Maria C. Tanzer, Igor Paron, Luca Zinzula, Thomas Engleitner, Maria Reinecke, Teresa M. Lavacca, Rosina Ehmann, Roman Wölfel, Jörg Jores, Bernhard Kuster, Ulrike Protzer, Roland Rad, John Ziebuhr, Volk
Publicado en: Nature, Edición 594/7862, 2021, Página(s) 246-252, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-021-03493-4

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape

Autores: Philipp Hubel, Christian Urban, Valter Bergant, William M. Schneider, Barbara Knauer, Alexey Stukalov, Pietro Scaturro, Angelika Mann, Linda Brunotte, Heinrich H. Hoffmann, John W. Schoggins, Martin Schwemmle, Matthias Mann, Charles M. Rice, Andreas Pichlmair
Publicado en: Nature Immunology, Edición 20/4, 2019, Página(s) 493-502, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-019-0323-3

Chasing Intracellular Zika Virus Using Proteomics

Autores: Pietro Scaturro, Anna Lena Kastner, Andreas Pichlmair
Publicado en: Viruses, Edición 11/9, 2019, Página(s) 878, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11090878

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

Autores: Sepideh Sadegh, Julian Matschinske, David B. Blumenthal, Gihanna Galindez, Tim Kacprowski, Markus List, Reza Nasirigerdeh, Mhaned Oubounyt, Andreas Pichlmair, Tim Daniel Rose, Marisol Salgado-Albarrán, Julian Späth, Alexey Stukalov, Nina K. Wenke, Kevin Yuan, Josch K. Pauling and Jan Baumbach
Publicado en: Nature Communications, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-17189-2

Persistent Innate Immune Stimulation Results in IRF3-Mediated but Caspase-Independent Cytostasis

Autores: Christian Urban, Hendrik Welsch, Katharina Heine, Sandra Wüst, Darya A. Haas, Christopher Dächert, Aparna Pandey, Andreas Pichlmair and Marco Binder
Publicado en: Viruses, 2020, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12060635

Human cytomegalovirus-induced host protein citrullination is crucial for viral replication

Autores: Gloria Griffante, Francesca Gugliesi, Selina Pasquero, Valentina Dell’Oste, Matteo Biolatti, Ari J. Salinger, Santanu Mondal, Paul R. Thompson, Eranthie Weerapana, Robert J. Lebbink, Jasper A. Soppe, Thomas Stamminger, Virginie Girault, Andreas Pichlmair, Gábor Oroszlán, Donald M. Coen, Marco De Andrea, Santo Landolfo
Publicado en: Nature Communications, Edición 12/1, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-24178-6

Two cGAS-like receptors induce antiviral immunity in Drosophila

Autores: Andreas Holleufer, Kasper Grønbjerg Winther, Hans Henrik Gad, Xianlong Ai, Yuqiang Chen, Lihua Li, Ziming Wei, Huimin Deng, Jiyong Liu, Ninna Ahlmann Frederiksen, Bine Simonsen, Line Lykke Andersen, Karin Kleigrewe, Louise Dalskov, Andreas Pichlmair, Hua Cai, Jean-Luc Imler, Rune Hartmann
Publicado en: Nature, Edición 597/7874, 2021, Página(s) 114-118, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-021-03800-z

A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle

Autores: Anna Płaszczyca, Pietro Scaturro, Christopher John Neufeldt, Mirko Cortese, Berati Cerikan, Salvatore Ferla, Andrea Brancale, Andreas Pichlmair, Ralf Bartenschlager
Publicado en: PLOS Pathogens, Edición 15/5, 2019, Página(s) e1007736, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1007736

eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition

Autores: Jennifer Deborah Wuerth, Matthias Habjan, Markus Kainulainen, Besim Berisha, Damien Bertheloot, Giulio Superti-Furga, Andreas Pichlmair, Friedemann Weber
Publicado en: mBio, 2020, ISSN 2150-7511
Editor: American Society for Microbiology
DOI: 10.1128/mbio.00976-20

Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway

Autores: Maria Krivega, Clara M. Stiefel, Sahar Karbassi, Line L. Andersen, Narendra K. Chunduri, Neysan Donnelly, Andreas Pichlmair, Zuzana Storchová
Publicado en: Communications Biology, Edición 4/1, 2021, ISSN 2399-3642
Editor: Springer Nature
DOI: 10.1038/s42003-021-02278-9

Human NLRP1 is a sensor for double-stranded RNA

Autores: Stefan Bauernfried, Matthias J. Scherr, Andreas Pichlmair, Karl E. Duderstadt, Veit Hornung
Publicado en: Science, Edición 371/6528, 2021, Página(s) eabd0811, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abd0811

The UFM1 Pathway Impacts HCMV US2-Mediated Degradation of HLA Class I.

Autores: Anouk B. C. Schuren; Ingrid G. J. Boer; Esther M. C. Bouma; M. L. van de Weijer; Ana I. Costa; P. Hubel; Andreas Pichlmair; Robert Jan Lebbink; Emmanuel J. H. J. Wiertz
Publicado en: MDPI/Volume 26, Edición 1, 2021, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26020287

Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription

Autores: Jingjing Pei, Nina R. Beri, Angela J. Zou, Philipp Hubel, Hannah K. Dorando, Valter Bergant, Rebecca D. Andrews, Jiehong Pan, Jared M. Andrews, Kathleen C.F. Sheehan, Andreas Pichlmair, Gaya K. Amarasinghe, Steven L. Brody, Jacqueline E. Payton, Daisy W. Leung
Publicado en: Cell Reports, Edición 37/2, 2021, Página(s) 109803, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.109803

Data, Reagents, Assays and Merits of Proteomics for SARS-CoV-2 Research and Testing

Autores: Jana Zecha, Chien-Yun Lee, Florian P. Bayer, Chen Meng, Vincent Grass, Johannes Zerweck, Karsten Schnatbaum, Thomas Michler, Andreas Pichlmair, Christina Ludwig, Bernhard Kuster
Publicado en: Molecular & Cellular Proteomics, Edición 19/9, 2020, Página(s) 1503-1522, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra120.002164

The alternative cap-binding complex is required for antiviral defense in vivo

Autores: Anna Gebhardt,Valter Bergant,Daniel Schnepf,Markus Moser,Arno Meiler,Dieudonnée Togbe,Claire Mackowiak,Line S. Reinert,Søren R. Paludan,Bernhard Ryffel,Alexey Stukalov,Peter Staeheli,Andreas Pichlmair
Publicado en: PLOS Pathogens, 2019, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1008155

The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription

Autores: Markus Fabits, Vladimir Gonçalves Magalhães, Baca Chan ,Virginie Girault, Endrit Elbasani, Elisa Rossetti, Eirikur Saeland, Martin Messerle,Andreas Pichlmair, Vanda Juranić Lisnić and Melanie M. Brinkmann
Publicado en: Microorganisms, 2020, ISSN 2076-2607
Editor: MDPI
DOI: 10.3390/microorganisms8060790

A Nanoscaffolded Spike-RBD Vaccine Provides Protection against SARS-CoV-2 with Minimal Anti-Scaffold Response

Autores: Duško Lainšček, Tina Fink, Vida Forstnerič, Iva Hafner-Bratkovič, Sara Orehek, Žiga Strmšek, Mateja Manček-Keber, Peter Pečan, Hana Esih, Špela Malenšek, Jana Aupič, Petra Dekleva, Tjaša Plaper, Sara Vidmar, Lucija Kadunc, Mojca Benčina, Neža Omersa, Gregor Anderluh, Florence Pojer, Kelvin Lau, David Hacker, Bruno E. Correia, David Peterhoff, Ralf Wagner, Valter Bergant, Alexander H
Publicado en: Vaccines, Edición 9/5, 2021, Página(s) 431, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9050431

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