Protein Dynamics in Antiviral Processes

Pubblicazioni

Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread

Autori: Shubhankar Ambike; Cho-Chin Cheng; Martin Feuerherd; Stoyan Velkov; Domizia Baldassi; Suliman Qadir Afridi; Diana Porras-Gonzalez; Xin Wei; Philipp Hagen; Nikolaus Kneidinger; Mircea Gabriel Stoleriu; Vincent Grass; Gerald Burgstaller; Andreas Pichlmair; Olivia M Merkel; Chunkyu Ko; Thomas Michler
Pubblicato in: Nucleic Acids Research, Numero 2, 2021, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkab1248

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

Autori: Alexey Stukalov; Virginie Girault; Vincent Grass; Ozge Karayel; Valter Bergant; Christian Urban; Darya A. Haas; Yiqi Huang; Lila Oubraham; Anqi Wang; M. Sabri Hamad; Antonio Piras; Fynn M. Hansen; Maria C. Tanzer; Igor Paron; Luca Zinzula; Thomas Enghleitner; Maria Reinecke; Maria Reinecke; Teresa M. Lavacca; Rosina Ehmann; Roman Wölfel; Jörg Jores; Bernhard Kuster; Bernhard Kuster; Ulrike Protz
Pubblicato in: Nature/Vol 594, Numero 2, 2021, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03493-4

ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly

Autori: Christopher J. Neufeldt, Mirko Cortese, Pietro Scaturro, Berati Cerikan, Jeremy G. Wideman, Keisuke Tabata, Thaís Moraes, Olga Oleksiuk, Andreas Pichlmair & Ralf Bartenschlager
Pubblicato in: Nature Microbiology, 2019, ISSN 2058-5276
Editore: Nature publishing group
DOI: 10.1038/s41564-019-0586-3

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

Autori: Alexey Stukalov, Virginie Girault, Vincent Grass, Ozge Karayel, Valter Bergant, Christian Urban, Darya A. Haas, Yiqi Huang, Lila Oubraham, Anqi Wang, M. Sabri Hamad, Antonio Piras, Fynn M. Hansen, Maria C. Tanzer, Igor Paron, Luca Zinzula, Thomas Engleitner, Maria Reinecke, Teresa M. Lavacca, Rosina Ehmann, Roman Wölfel, Jörg Jores, Bernhard Kuster, Ulrike Protzer, Roland Rad, John Ziebuhr, Volk
Pubblicato in: Nature, Numero 594/7862, 2021, Pagina/e 246-252, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03493-4

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape

Autori: Philipp Hubel, Christian Urban, Valter Bergant, William M. Schneider, Barbara Knauer, Alexey Stukalov, Pietro Scaturro, Angelika Mann, Linda Brunotte, Heinrich H. Hoffmann, John W. Schoggins, Martin Schwemmle, Matthias Mann, Charles M. Rice, Andreas Pichlmair
Pubblicato in: Nature Immunology, Numero 20/4, 2019, Pagina/e 493-502, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-019-0323-3

Chasing Intracellular Zika Virus Using Proteomics

Autori: Pietro Scaturro, Anna Lena Kastner, Andreas Pichlmair
Pubblicato in: Viruses, Numero 11/9, 2019, Pagina/e 878, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11090878

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

Autori: Sepideh Sadegh, Julian Matschinske, David B. Blumenthal, Gihanna Galindez, Tim Kacprowski, Markus List, Reza Nasirigerdeh, Mhaned Oubounyt, Andreas Pichlmair, Tim Daniel Rose, Marisol Salgado-Albarrán, Julian Späth, Alexey Stukalov, Nina K. Wenke, Kevin Yuan, Josch K. Pauling and Jan Baumbach
Pubblicato in: Nature Communications, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-17189-2

Persistent Innate Immune Stimulation Results in IRF3-Mediated but Caspase-Independent Cytostasis

Autori: Christian Urban, Hendrik Welsch, Katharina Heine, Sandra Wüst, Darya A. Haas, Christopher Dächert, Aparna Pandey, Andreas Pichlmair and Marco Binder
Pubblicato in: Viruses, 2020, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12060635

Human cytomegalovirus-induced host protein citrullination is crucial for viral replication

Autori: Gloria Griffante, Francesca Gugliesi, Selina Pasquero, Valentina Dell’Oste, Matteo Biolatti, Ari J. Salinger, Santanu Mondal, Paul R. Thompson, Eranthie Weerapana, Robert J. Lebbink, Jasper A. Soppe, Thomas Stamminger, Virginie Girault, Andreas Pichlmair, Gábor Oroszlán, Donald M. Coen, Marco De Andrea, Santo Landolfo
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-24178-6

Two cGAS-like receptors induce antiviral immunity in Drosophila

Autori: Andreas Holleufer, Kasper Grønbjerg Winther, Hans Henrik Gad, Xianlong Ai, Yuqiang Chen, Lihua Li, Ziming Wei, Huimin Deng, Jiyong Liu, Ninna Ahlmann Frederiksen, Bine Simonsen, Line Lykke Andersen, Karin Kleigrewe, Louise Dalskov, Andreas Pichlmair, Hua Cai, Jean-Luc Imler, Rune Hartmann
Pubblicato in: Nature, Numero 597/7874, 2021, Pagina/e 114-118, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03800-z

A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle

Autori: Anna Płaszczyca, Pietro Scaturro, Christopher John Neufeldt, Mirko Cortese, Berati Cerikan, Salvatore Ferla, Andrea Brancale, Andreas Pichlmair, Ralf Bartenschlager
Pubblicato in: PLOS Pathogens, Numero 15/5, 2019, Pagina/e e1007736, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1007736

eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition

Autori: Jennifer Deborah Wuerth, Matthias Habjan, Markus Kainulainen, Besim Berisha, Damien Bertheloot, Giulio Superti-Furga, Andreas Pichlmair, Friedemann Weber
Pubblicato in: mBio, 2020, ISSN 2150-7511
Editore: American Society for Microbiology
DOI: 10.1128/mbio.00976-20

Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway

Autori: Maria Krivega, Clara M. Stiefel, Sahar Karbassi, Line L. Andersen, Narendra K. Chunduri, Neysan Donnelly, Andreas Pichlmair, Zuzana Storchová
Pubblicato in: Communications Biology, Numero 4/1, 2021, ISSN 2399-3642
Editore: Springer Nature
DOI: 10.1038/s42003-021-02278-9

Human NLRP1 is a sensor for double-stranded RNA

Autori: Stefan Bauernfried, Matthias J. Scherr, Andreas Pichlmair, Karl E. Duderstadt, Veit Hornung
Pubblicato in: Science, Numero 371/6528, 2021, Pagina/e eabd0811, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abd0811

The UFM1 Pathway Impacts HCMV US2-Mediated Degradation of HLA Class I.

Autori: Anouk B. C. Schuren; Ingrid G. J. Boer; Esther M. C. Bouma; M. L. van de Weijer; Ana I. Costa; P. Hubel; Andreas Pichlmair; Robert Jan Lebbink; Emmanuel J. H. J. Wiertz
Pubblicato in: MDPI/Volume 26, Numero 1, 2021, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26020287

Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription

Autori: Jingjing Pei, Nina R. Beri, Angela J. Zou, Philipp Hubel, Hannah K. Dorando, Valter Bergant, Rebecca D. Andrews, Jiehong Pan, Jared M. Andrews, Kathleen C.F. Sheehan, Andreas Pichlmair, Gaya K. Amarasinghe, Steven L. Brody, Jacqueline E. Payton, Daisy W. Leung
Pubblicato in: Cell Reports, Numero 37/2, 2021, Pagina/e 109803, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.109803

Data, Reagents, Assays and Merits of Proteomics for SARS-CoV-2 Research and Testing

Autori: Jana Zecha, Chien-Yun Lee, Florian P. Bayer, Chen Meng, Vincent Grass, Johannes Zerweck, Karsten Schnatbaum, Thomas Michler, Andreas Pichlmair, Christina Ludwig, Bernhard Kuster
Pubblicato in: Molecular & Cellular Proteomics, Numero 19/9, 2020, Pagina/e 1503-1522, ISSN 1535-9476
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra120.002164

The alternative cap-binding complex is required for antiviral defense in vivo

Autori: Anna Gebhardt,Valter Bergant,Daniel Schnepf,Markus Moser,Arno Meiler,Dieudonnée Togbe,Claire Mackowiak,Line S. Reinert,Søren R. Paludan,Bernhard Ryffel,Alexey Stukalov,Peter Staeheli,Andreas Pichlmair
Pubblicato in: PLOS Pathogens, 2019, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1008155

The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription

Autori: Markus Fabits, Vladimir Gonçalves Magalhães, Baca Chan ,Virginie Girault, Endrit Elbasani, Elisa Rossetti, Eirikur Saeland, Martin Messerle,Andreas Pichlmair, Vanda Juranić Lisnić and Melanie M. Brinkmann
Pubblicato in: Microorganisms, 2020, ISSN 2076-2607
Editore: MDPI
DOI: 10.3390/microorganisms8060790

A Nanoscaffolded Spike-RBD Vaccine Provides Protection against SARS-CoV-2 with Minimal Anti-Scaffold Response

Autori: Duško Lainšček, Tina Fink, Vida Forstnerič, Iva Hafner-Bratkovič, Sara Orehek, Žiga Strmšek, Mateja Manček-Keber, Peter Pečan, Hana Esih, Špela Malenšek, Jana Aupič, Petra Dekleva, Tjaša Plaper, Sara Vidmar, Lucija Kadunc, Mojca Benčina, Neža Omersa, Gregor Anderluh, Florence Pojer, Kelvin Lau, David Hacker, Bruno E. Correia, David Peterhoff, Ralf Wagner, Valter Bergant, Alexander H
Pubblicato in: Vaccines, Numero 9/5, 2021, Pagina/e 431, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9050431

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