Spatial fractionation of the dose in proton therapy: a novel therapeutic approach

Informazioni relative al progetto

PROTONMBRT

ID dell’accordo di sovvenzione: 817908

DOI

10.3030/817908

Progetto chiuso

Data della firma CE 25 Febbraio 2019

Data di avvio 1 Ottobre 2019

Data di completamento 28 Febbraio 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 997 870,00

Contributo UE

€ 1 997 870,00

Coordinato da

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (44)

Dosimetric feasibility study (“proof of concept”) of refractory ventricular tachycardia radioablation using proton minibeams

Autori: P. Loap, M. Giorgi, J. Vu-Bezin, K. Kirov, J.M. Sampai, Y. Prezado, Y. Kirova
Pubblicato in: Cancer/Radiothérapie, Numero 28, 2024, Pagina/e 195-201, ISSN 1278-3218
Editore: Elsevier Masson
DOI: 10.1016/j.canrad.2024.02.002

Combining FLASH and spatially fractionated radiation therapy: The best of both worlds

Autori: Tim Schneider, Cristian Fernandez Palomo, Annaig Bertho, Jennifer Fazzari, Lorea Iturri, Olga A. Martin, Verdiana Trappeti, Valentin Djonov, Yolanda Prezado
Pubblicato in: Radiotherapy and Oncology, Numero 01678140, 2022, ISSN 0167-8140
Editore: Elsevier BV
DOI: 10.1016/j.radonc.2022.08.004

Monte Carlo Comparison of Proton and Helium-ion Minibeam Generation Techniques

Autori: Tim Schneider, Ludovic De Marzi, Annalisa Patriarca, Yolanda Prezado
Pubblicato in: Frontiers in Physics, Numero 9, 2021, ISSN 2296-424X
Editore: Frontiers
DOI: 10.3389/fphy.2021.595721

Towards improved prescription metrics in novel radiotherapy techniques: a machine learning study

Autori: Alfredo Fernandez-Rodriguez, Yolanda Prezado
Pubblicato in: Physics in Medicine & Biology, Numero 70, 2025, Pagina/e 085011, ISSN 0031-9155
Editore: Institute of Physics Publishing
DOI: 10.1088/1361-6560/adc96c

Thoracic Proton Minibeam Radiation Therapy: Tissue Preservation and Survival Advantage Over Conventional Proton Therapy

Autori: Annaïg Bertho, Ramon Ortiz, Mathieu Maurin, Marjorie Juchaux, Cristèle Gilbert, Julie Espenon, Gabriel Ramasamy, Annalisa Patriarca, Ludovic De Marzi, Frédéric Pouzoulet, Yolanda Prezado
Pubblicato in: International Journal of Radiation Oncology*Biology*Physics, Numero 120, 2025, Pagina/e 579-592, ISSN 0360-3016
Editore: Elsevier BV
DOI: 10.1016/j.ijrobp.2024.04.011

Oxygen supplementation in anesthesia can block FLASH effect and anti-tumor immunity in conventional proton therapy

Autori: Lorea Iturri, Annaïg Bertho, Charlotte Lamirault, Elise Brisebard, Marjorie Juchaux, Cristèle Gilbert, Julie Espenon, Catherine Sébrié, Laurène Jourdain, Ludovic de Marzi, Frédéric Pouzoulet, Jane Muret, Pierre Verrelle, Yolanda Prezado
Pubblicato in: Communications Medicine, Numero 12, 2023, ISSN 2730-664X
Editore: Nature
DOI: 10.1038/s43856-023-00411-9

The significance of dose heterogeneity on the anti-tumor response of minibeam radiation therapy

Autori: Sarah Potiron, Lorea Iturri, Marjorie Juchaux, Julie Espenon, Cristèle Gilbert, Josie McGarrigle, Ramon Ortiz Catalan, Alfredo Fernandez-Rodriguez, Catherine Sebrié, Laurène Jourdain, Ludovic De Marzi, Gilles Créhange, Yolanda Prezado
Pubblicato in: Radiotherapy and Oncology, Numero 201, 2024, Pagina/e 110577, ISSN 0167-8140
Editore: Elsevier BV
DOI: 10.1016/j.radonc.2024.110577

Secondary neutron dose contribution from pencil beam scanning, scattered and spatially fractionated proton therapy

Autori: AM Leite, M G Ronga, M Giorgi, Y Ristic, Y Perrot, F Trompier, Y Prezado, G Créhange, L De Marzi
Pubblicato in: Physics in Medicine and Biology, Numero 12, 2021, ISSN 0031-9155
Editore: Institute of Physics Publishing
DOI: 10.1088/1361-6560/ac3209

Proton minibeam radiation therapy: a promising therapeutic approach for radioresistant tumors

Autori: Yolanda Prezado
Pubblicato in: Comptes Rendus Biologies, Numero 4, 2021, Pagina/e 409-420, ISSN 1631-0691
Editore: Elsevier Masson
DOI: 10.5802/crbiol.71

Divide and conquer: spatially fractionated radiation therapy

Autori: Yolanda Prezado
Pubblicato in: Expert Reviews in Molecular Medicine, 2022, ISSN 1462-3994
Editore: Cambridge University Press
DOI: 10.1017/erm.2021.34

Investigating the biochemical response of proton minibeam radiation therapy by means of synchrotron-based infrared microspectroscopy

Autori: Roberto González-Vegas, Ibraheem Yousef, Olivier Seksek, Ramon Ortiz, Annaïg Bertho, Marjorie Juchaux, Catherine Nauraye, Ludovic De Marzi, Annalisa Patriarca, Yolanda Prezado, Immaculada Martínez-Rovira
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-024-62373-9

Challenges for the Implementation of Primary Standard Dosimetry in Proton Minibeam Radiation Therapy

Autori: John Cotterill, Samuel Flynn, Russell Thomas, Anna Subiel, Nigel Lee, Michael Homer, Hugo Palmans, Ludovic De Marzi, Yolanda Prezado, David Shipley, Ana Lourenço
Pubblicato in: Cancers, Numero 16, 2025, Pagina/e 4013, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers16234013

Carbon minibeam radiation therapy results in tumor growth delay in an osteosarcoma murine model

Autori: Annaïg Bertho, Christian Graeff, Ramon Ortiz, Maria Giorgi, Christoph Schuy, Marjorie Juchaux, Cristèle Gilbert, Julie Espenon, Julius Oppermann, Olga Sokol, Walter Tinganelli, Yolanda Prezado
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-025-91872-6

On the significance of the different geometrical and dosimetric parameters in microbeam and minibeam radiation therapy a retrospective evaluation

Autori: Josie May McGarrigle, Kenneth Richard Long, Yolanda Prezado
Pubblicato in: Frontiers in Oncology, Numero 14, 2024, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2024.1449293

On the significance of peak dose in normal tissue toxicity in spatially fractionated radiotherapy: The case of proton minibeam radiation therapy

Autori: Yolanda Prezado, Charlotte Lamirault, Thibaut Larcher, Cristele Gilbert, Julie Espenon, A. Patriarca, L. de Marzi, Angela Corvino, Ramon Ortiz, Marjorie Juchaux
Pubblicato in: Radiotherapy and Oncology, Numero 205, 2025, Pagina/e 110769, ISSN 0167-8140
Editore: Elsevier BV
DOI: 10.1016/j.radonc.2025.110769

Short and long-term evaluation of the impact of proton minibeam radiation therapy on motor, emotional and cognitive functions

Autori: Charlotte Lamirault, Valérie Doyère, Marjorie Juchaux, Frederic Pouzoulet, Dalila Labiod, Remi Dendale, Annalisa Patriarca, Catherine Nauraye, Marine Le Dudal, Grégory Jouvion, David Hardy, Nicole El Massioui, Yolanda Prezado
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-70371-w

Converging Proton Minibeams with Magnetic Fields for Optimized Radiation Therapy: A Proof of Concept

Autori: Marco Cavallone, Yolanda Prezado, Ludovic De Marzi
Pubblicato in: Cancers, Numero 14, 2025, Pagina/e 26, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14010026

Synchrotron-based infrared microspectroscopy study on the biomolecular impact of carbon minibeam radiation therapy on a mouse osteosarcoma cell line

Autori: R. González-Vegas, M. Cots-Costa, C. Gilbert, A. Bertho, O. Seksek, C. Graeff, O. Sokol, W. Tinganelli, Y. Prezado, I. Yousef, I. Martínez-Rovira
Pubblicato in: Infrared Physics & Technology, Numero 152, 2026, Pagina/e 106247, ISSN 1350-4495
Editore: Elsevier BV
DOI: 10.1016/j.infrared.2025.106247

First Evaluation of Temporal and Spatial Fractionation in Proton Minibeam Radiation Therapy of Glioma-Bearing Rats

Autori: Annaïg Bertho,Ramon Ortiz,Marjorie Juchaux,Cristèle Gilbert,Charlotte Lamirault,Frederic Pouzoulet,Laura Polledo,Alethea Liens,Nils Warfving,Catherine Sebrie ,Laurène Jourdain,Annalisa Patriarca,Ludovic de Marzi, Yolanda Prezado
Pubblicato in: Cancers, Numero 13, 2021, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13194865

Synchrotron-based infrared microspectroscopy unveils the biomolecular response of healthy and tumour cell lines to neon minibeam radiation therapy

Autori: R. González-Vegas, O. Seksek, A. Bertho, J. Bergs, R. Hirayama, T. Inaniwa, N. Matsufuji, T. Shimokawa, Y. Prezado, I. Yousef, I. Martínez-Rovira
Pubblicato in: The Analyst, Numero 150, 2025, Pagina/e 342-352, ISSN 0003-2654
Editore: Royal Society of Chemistry
DOI: 10.1039/d4an01038h

Spatially fractionated radiation therapy: a critical review on current status of clinical and preclinical studies and knowledge gaps

Autori: Yolanda Prezado, Michael Grams, Emmanuel Jouglar, Immaculada Martínez-Rovira, Ramon Ortiz, Joao Seco, Sha Chang
Pubblicato in: Physics in Medicine & Biology, Numero 69, 2024, Pagina/e 10TR02, ISSN 0031-9155
Editore: Institute of Physics Publishing
DOI: 10.1088/1361-6560/ad4192

Photon mini‐GRID therapy for preoperative breast cancer tumor treatment: A treatment plan study

Autori: Angela Corvino, Tim Schneider, Jeremi Vu‐Bezin, Pierre Loap, Youlia Kirova, Yolanda Prezado
Pubblicato in: Medical Physics, Numero 52, 2025, Pagina/e 2493-2506, ISSN 0094-2405
Editore: American Association of Physicists in Medicine
DOI: 10.1002/mp.17634

Proton Minibeam Radiation Therapy and Arc Therapy: Proof ofConcept of a Winning Alliance

Autori: Ramon Ortiz, Ludovic De Marzi, and Yolanda Prezado
Pubblicato in: Cancers, Numero 12, 2022, Pagina/e 13, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14010116

β-delayed multiple-particle emitters minibeam radiation therapy: first dosimetric evaluation with Monte Carlo simulations

Autori: Angela Corvino, Tim Schneider, Yolanda Prezado
Pubblicato in: Frontiers in Physics, Numero 12, 2024, ISSN 2296-424X
Editore: Frontiers Media SA
DOI: 10.3389/fphy.2024.1390439

Monte Carlo study of the free radical yields in minibeam radiation therapy

Autori: Thongchai Masilela, Yolanda Prezado
Pubblicato in: Medical Physics, Numero 12, 2023, ISSN 0094-2405
Editore: American Association of Physicists in Medicine
DOI: 10.1002/mp.16475

Preclinical dosimetry in proton minibeam radiation therapy: Robustness analysis and guidelines

Autori: Ramon Ortiz, Ludovic de Marzi, Yolanda Prezado
Pubblicato in: Medical Physics, Numero 24734209, 2022, ISSN 2473-4209
Editore: Wiley
DOI: 10.1002/mp.15780

Advancing proton minibeam radiation therapy: magnetically focussed proton minibeams at a clinical centre

Autori: Tim Schneider, Ludovic De Marzi, Annalisa Patriarca, Yolanda Prezado
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-58052-0

First proton minibeam radiation therapy treatment plan evaluation

Autori: P. Lansonneur, H. Mammar, C. Nauraye, A. Patriarca, E. Hierso, R. Dendale, Y. Prezado, L. De Marzi
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-63975-9

Should Peak Dose Be Used to Prescribe Spatially Fractionated Radiation Therapy?—A Review of Preclinical Studies

Autori: Cristian Fernandez-Palomo, Sha Chang, Yolanda Prezado
Pubblicato in: Cancers, Numero 12, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14153625

A first evaluation of the efficacy of minibeam radiation therapy combined with an immune check point inhibitor in a model of glioma-bearing rats

Autori: Lorea Iturri, Emmanuel Jouglar, Cristèle Gilbert, Julie Espenon, Marjorie Juchaux, Yolanda Prezado
Pubblicato in: Clinical and Translational Radiation Oncology, Numero 51, 2025, Pagina/e 100911, ISSN 2405-6308
Editore: Elsevier
DOI: 10.1016/j.ctro.2025.100911

The FLASH effect—an evaluation of preclinical studies of ultra-high dose rate radiotherapy

Autori: Josie May McGarrigle, Kenneth Richard Long, Yolanda Prezado
Pubblicato in: Frontiers in Oncology, Numero 14, 2024, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2024.1340190

A scanning dynamic collimator for spot-scanning proton minibeam production

Autori: Marios Sotiropoulos, Yolanda Prezado
Pubblicato in: Scientific Reports, Numero 11/1, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-97941-w

Evaluation of the role of the immune system response following minibeam radiation therapy

Autori: Annaig Bertho, Lorea Iturri, Elise Brisebard, Marjorie Juchaux, Cristele Gilbert, Ramon Ortiz, Catherine Sebrie, Laurene Jourdain, Gabriel Ramsay, Charlotte Lamirault, Frederic Pouzoulet, Yolanda Prezado
Pubblicato in: International Journal Radiation Oncology Biology Physics, Numero 03603016, 2022, ISSN 0360-3016
Editore: Elsevier BV
DOI: 10.1016/j.ijrobp.2022.08.011

Converging Proton Minibeams with Magnetic Fields forOptimized Radiation Therapy: A Proof of Concept

Autori: Marco Cavallone, Ludovic de Marzi, Yolanda Prezado
Pubblicato in: Cancers, Numero 13, 2022, Pagina/e 26-40, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14010026

Proton Minibeam Radiation Therapy and Arc Therapy: Proof of Concept of a Winning Alliance

Autori: Ramon Ortiz, Ludovic De Marzi, Yolanda Prezado
Pubblicato in: Cancers, Numero 14, 2025, Pagina/e 116, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14010116

Investigating Slit-Collimator-Produced Carbon Ion Minibeams with High-Resolution CMOS Sensors

Autori: Lennart Volz; Claire-Anne Reidel; Marco Durante; Yolanda Prezado; Christoph Schuy; Uli Weber; Christian Graeff
Pubblicato in: Instruments; Volume 7; Numero 2; Pages: 18, Numero 5, 2023, ISSN 2410-390X
Editore: MDPI
DOI: 10.3390/instruments7020018

Radiation quality correction factors for improved dosimetry in preclinical minibeam radiotherapy

Autori: Marios Sotiropoulos, Yolanda Prezado
Pubblicato in: Medical Physics, Numero 24734209, 2022, ISSN 2473-4209
Editore: Wiley
DOI: 10.1002/mp.15838

A Potential Renewed Use of Very Heavy Ions for Therapy: Neon Minibeam Radiation Therapy

Autori: Yolanda Prezado, Ryochi Hirayama ,Naruhiro Matsufuji ,Taku Inaniwa,Immaculada Martínez-Rovira ,Olivier Seksek, Annaïg Bertho,Sachiko Koike,Dalila Labiod ,Frederic Pouzoulet ,Laura Polledo ,Nils Warfving ,Aléthéa Liens,Judith Bergs andTakashi Shimokawa
Pubblicato in: Cancers, Numero 13, 2021, Pagina/e 20726694, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13061356

Spatially Modulated Proton Minibeams Results in the Same Increase of Lifespan as a Uniform Target Dose Coverage in F98-Glioma-Bearing Rats

Autori: Charlotte Lamirault, Elise Brisebard, Annalisa Patriarca, Marjorie Juchaux, Delphine Crepin, Dalila Labiod, Frederic Pouzoulet, Catherine Sebrie, Laurene Jourdain, Marine Le Dudal, David Hardy, Ludovic De Marzi, Remi Dendale, Gregory Jouvion, Yolanda Prezado
Pubblicato in: Radiation Research, Numero 12, 2020, ISSN 1938-5404
Editore: AllenPress
DOI: 10.1667/rade-19-00013.1

Proton FLASH Radiation Therapy and Immune Infiltration: Evaluation in an Orthotopic Glioma Rat Model

Autori: Lorea Iturri, Annaïg Bertho, Charlotte Lamirault, Marjorie Juchaux, Cristèle Gilbert, Julie Espenon, Catherine Sebrie, Laurène Jourdain, Frédéric Pouzoulet, Pierre Verrelle, Ludovic De Marzi, Yolanda Prezado
Pubblicato in: International Journal Radiation Oncology, Biology, Physics, Numero 12, 2023, ISSN 0360-3016
Editore: Elsevier BV
DOI: 10.1016/j.ijrobp.2022.12.018

Conceptual Design of a Novel Nozzle Combined with a Clinical Proton Linac for Magnetically Focussed Minibeams

Autori: Tim Schneider, Annalisa Patriarca, Alberto Degiovanni, Manuel Gallas, Yolanda Prezado
Pubblicato in: Cancers, Numero 13/18, 2021, Pagina/e 4657, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13184657

Proton minibeam radiation therapy for treating metastases: A treatment plan study

Autori: Ramon Ortiz, Rezart Belshi, Ludovic De Marzi, Yolanda Prezado
Pubblicato in: Medical Physics, Numero 12, 2023, ISSN 2473-4209
Editore: Wiley
DOI: 10.1002/mp.16203

Orthovoltage X-ray Minibeam Radiation Therapy for the Treatment of Ocular Tumours—An In Silico Evaluation

Autori: Tim Schneider; Denis Malaise; Frédéric Pouzoulet; Yolanda Prezado
Pubblicato in: Cancers, Numero 12, 2023, ISSN 2410-390X
Editore: MDPI
DOI: 10.3390/cancers15030679

Evaluation of three radiochromic film types in x-ray minibeam radiation therapy pre-clinical dosimetry

Autori: Marios Sotiropoulos, Alfredo Fernandez-Rodriguez, Yolanda Prezado
Pubblicato in: Physica Medica, Numero 139, 2025, Pagina/e 105195, ISSN 1120-1797
Editore: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2025.105195

Book chapters (1)

Radiation-induced immune response in novel radiotherapy approaches FLASH and spatially fractionated radiotherapies

Autori: Annaig Bertho, Lorea Iturri, Yolanda Prezado
Pubblicato in: International Review of Cell and Molecular Biology, Ionizing Radiation and the Immune Response - Part A, 2025, Pagina/e 37-68
Editore: Elsevier
DOI: 10.1016/bs.ircmb.2022.11.005

Diritti di proprietà intellettuale

Patent (1)

DEVICE, APPARATUS AND METHOD FOR MINIBEAM RADIATION THERAPY

Numero candidatura/pubblicazione: 20 20082766
Data: 2020-11-19
Candidato/i: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS