Synergistic engineering of anti-tumor immunity by synthetic biomaterials

Project Information

ImmunoBioSynth

Grant agreement ID: 817938

DOI

10.3030/817938

Project closed

EC signature date 27 February 2019

Start date 1 April 2019

End date 30 September 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

UNIVERSITEIT GENT
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Lipid Nanoparticle Encapsulation Empowers Poly(I:C) to Activate Cytoplasmic RLRs and Thereby Increases Its Adjuvanticity.

Author(s): Lamoot, A., Jangra, S., Laghlali, G., Warang, P., Singh, G., Chang, L. A., Park, S.-C., De Swarte, K., Zhong, Z., Louage, B., De Lombaerde, E., Ye, T., Chen, Y., Cuadrado-Castano, S., Lienenklaus, S., Sanders, N. N., Lambrecht, B. N., García-Sastre, A., Schotsaert, M., & De Geest, B. G.
Published in: Small, 2023, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.

Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles

Author(s): Bi Wang, Simon Van Herck, Yong Chen, Xiangyang Bai, Zifu Zhong, Kim Deswarte, Bart N. Lambrecht, Niek N. Sanders, Stefan Lienenklaus, Hans W. Scheeren, Sunil A. David, Fabian Kiessling, Twan Lammers, Bruno G. De Geest, Yang Shi
Published in: Journal of the American Chemical Society, Issue 142/28, 2020, Page(s) 12133-12139, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c01928

Amplification of Protein Expression by Self-Amplifying mRNA Delivered in Lipid Nanoparticles Containing a β-Aminoester Ionizable Lipid Correlates with Reduced Innate Immune Activation

Author(s): Emily De LombaerdeXiaole CuiYong ChenZifu ZhongJulie DeckersGiulia MencarelliLisa OpsomerHaixiu WangJamie De BaereStefan LienenklausBart N. LambrechtNiek N. Sanders*Bruno G. De Geest
Published in: ACS Nano, 2024, ISSN 1936-0851
Publisher: American Chemical Society

Lipid Nature and Alkyl Length Influence Lymph Node Accumulation of Lipid‐Polyethylene Glycol Amphiphiles

Author(s): Simon Van Herck; Antonio Pires da Silva Baptista; Haijun Yu; Lutz Nuhn; Bruno G. De Geest; Bart N. Lambrecht; Bart N. Lambrecht; Jana De Vrieze; Kim Deswarte
Published in: ADVANCED THERAPEUTICS, Issue 4, 2021, Page(s) 2100079, ISSN 2366-3987
Publisher: Wiley
DOI: 10.1002/adtp.202100079

CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Author(s): Tingting Ye; Zifu Zhong; Federica Cappellesso; Kim Deswarte; Yong Chen; Heleen Lauwers; Emily De Lombaerde; Mark Gontsarik; Stefan Lienenklaus; Dorien Van Lysebetten; Niek N. Sanders; Bart N. Lambrecht; Stefaan De Koker; Damya Laoui; Bruno G. De Geest
Published in: Biomaterials, Issue 311, 2024, Page(s) 122693, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2024.122693

Synthetic Rhamnose Glycopolymer Cell-Surface Receptor for Endogenous Antibody Recruitment

Author(s): Ruben De Coen, Lutz Nuhn, Chamani Perera, Maria Arista-Romero, Martijn D. P. Risseeuw, Alec Freyn, Raffael Nachbagauer, Lorenzo Albertazzi, Serge Van Calenbergh, David A. Spiegel, Blake R. Peterson, Bruno G. De Geest
Published in: Biomacromolecules, 2020, ISSN 1525-7797
Publisher: American Chemical Society

Multivalent Antibody-Recruiting Macromolecules: Linking Increased Binding Affinity with Enhanced Innate Immune Killing.

Author(s): Uvyn, A., & De Geest, B. G.
Published in: ChemBioChem, 2020, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.

Lipid-Polyglutamate Nanoparticle Vaccine Platform

Author(s): Dorien Van Lysebetten, Alessio Malfanti, Kim Deswarte, Kaloian Koynov, Bianka Golba, Tingting Ye, Zifu Zhong, Sabah Kasmi, Alexander Lamoot, Yong Chen, Simon Van Herck, Bart N. Lambrecht, Niek N. Sanders, Stefan Lienenklaus, Sunil A. David, María J. Vicent, Stefaan De Koker, and Bruno G. De Geest
Published in: ACS Applied Materials and Interfaces, 2021, ISSN 1944-8244
Publisher: American Chemical Society

Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids.

Author(s): Lamoot, A., Lammens, J., De Lombaerde, E., Zhong, Z., Gontsarik, M., Chen, Y., De Beer, T. R. M., & De Geest, B. G.
Published in: Biomaterials Science, 2023, ISSN 2047-4830
Publisher: Royal Society of Chemistry

Towards a Rational Design of Antibody-Recruiting Molecules through a Computational Microscopy View of their Interactions with the Target Antibody. Chemistry

Author(s): Uvyn, A., Tonneaux, C., Fossépré, M., Ouvrier-Buffet, A., De Geest, B. G., & Surin, M.
Published in: Chemistry: A European Journal, 2023, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.

Combinatorial Screening of Biscarbamate Ionizable Lipids Identifies a Low Reactogenicity Lipid for Lipid Nanoparticle mRNA Delivery

Author(s): Emily De Lombaerde; Yong Chen; Tingting Ye; Julie Deckers; Giulia Mencarelli; Kim De Swarte; Heleen Lauwers; Ruben De Coen; Sabah Kasmi; Sanne Bevers; Anna Kuchmiy; Bram Bogaert; Lies Baekens; Zifu Zhong; Alexander Lamoot; Niek N. Sanders; Bart N. Lambrecht; Antonio P. Baptista; Stefaan De Koker; Bruno G. De Geest
Published in: Advanced Functional Materials, Issue 34, 2024, Page(s) 2310623, ISSN 1616-3028
Publisher: Wiley
DOI: 10.1002/adfm.202310623

Current Status of COVID‐19 (Pre)Clinical Vaccine Development

Author(s): Tingting Ye, Zifu Zhong, Adolfo García‐Sastre, Michael Schotsaert, Bruno G. De Geest
Published in: Angewandte Chemie International Edition, Issue 59/43, 2020, Page(s) 18885-18897, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202008319

Covalent Cell Surface Conjugation of Nanoparticles by a Combination of Metabolic Labeling and Click Chemistry

Author(s): Alexander Lamoot, Annemiek Uvyn, Dr. Sabah Kasmi, Prof. Dr. Bruno G. De Geest
Published in: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine

Author(s): Dr. Sonia Jangra, Jana De Vrieze, Angela Choi, Raveen Rathnasinghe, Gabriel Laghlali, Annemiek Uvyn, Dr. Simon Van Herck, Dr. Lutz Nuhn, Kim Deswarte, Dr. Zifu Zhong, Prof. Dr. Niek N. Sanders, Dr. Stefan Lienenklaus, Dr. Sunil A. David, Shirin Strohmeier, Fatima Amanat, Prof. Dr. Florian Krammer, Prof. Dr. Hamida Hammad, Prof. Dr. Bart N. Lambrecht, Prof. Dr. Lynda Coughlan, Prof. Dr.
Published in: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.

Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells

Author(s): Annemiek Uvyn, Ruben De Coen, Olivier De Wever, Kim Deswarte, Bart N. Lambrecht and Bruno G. De Geest
Published in: Chemical Communications, 2021, ISSN 1359-7345
Publisher: Royal Society of Chemistry

Lipid Nanoparticle Delivery Alters the Adjuvanticity of the TLR9 Agonist CpG by Innate Immune Activation in Lymphoid Tissue.

Author(s): Zhong, Z., Chen, Y., Deswarte, K., Lauwers, H., De Lombaerde, E., Cui, X., Van Herck, S., Ye, T., Gontsarik, M., Lienenklaus, S., Sanders, N. N., Lambrecht, B. N., De Koker, S., & De Geest, B. G.
Published in: Advanced Healthcare Materials, 2023, ISSN 2192-2659
Publisher: World Scientific

Hapten/Myristoyl Functionalized Poly(propyleneimine) Dendrimers as Potent Cell Surface Recruiters of Antibodies for Mediating Innate Immune Killing.

Author(s): Uvyn, A., Vleugels, M. E. J., De Waal, B., Hamouda, A. E. I., Dhiman, S., Louage, B., Albertazzi, L., Laoui, D., Meijer, E. W., & De Geest, B. G.
Published in: Advanced Materials, 2023, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization