Synergistic engineering of anti-tumor immunity by synthetic biomaterials

Información del proyecto

ImmunoBioSynth

Identificador del acuerdo de subvención: 817938

DOI

10.3030/817938

Proyecto cerrado

Fecha de la firma de la CE 27 Febrero 2019

Fecha de inicio 1 Abril 2019

Fecha de finalización 30 Septiembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 000 000,00

Aportación de la UE

€ 2 000 000,00

Coordinado por

UNIVERSITEIT GENT
Belgium

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (17)

Lipid Nanoparticle Encapsulation Empowers Poly(I:C) to Activate Cytoplasmic RLRs and Thereby Increases Its Adjuvanticity.

Autores: Lamoot, A., Jangra, S., Laghlali, G., Warang, P., Singh, G., Chang, L. A., Park, S.-C., De Swarte, K., Zhong, Z., Louage, B., De Lombaerde, E., Ye, T., Chen, Y., Cuadrado-Castano, S., Lienenklaus, S., Sanders, N. N., Lambrecht, B. N., García-Sastre, A., Schotsaert, M., & De Geest, B. G.
Publicado en: Small, 2023, ISSN 1613-6810
Editor: Wiley - V C H Verlag GmbbH & Co.

Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles

Autores: Bi Wang, Simon Van Herck, Yong Chen, Xiangyang Bai, Zifu Zhong, Kim Deswarte, Bart N. Lambrecht, Niek N. Sanders, Stefan Lienenklaus, Hans W. Scheeren, Sunil A. David, Fabian Kiessling, Twan Lammers, Bruno G. De Geest, Yang Shi
Publicado en: Journal of the American Chemical Society, Edición 142/28, 2020, Página(s) 12133-12139, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.0c01928

Amplification of Protein Expression by Self-Amplifying mRNA Delivered in Lipid Nanoparticles Containing a β-Aminoester Ionizable Lipid Correlates with Reduced Innate Immune Activation

Autores: Emily De LombaerdeXiaole CuiYong ChenZifu ZhongJulie DeckersGiulia MencarelliLisa OpsomerHaixiu WangJamie De BaereStefan LienenklausBart N. LambrechtNiek N. Sanders*Bruno G. De Geest
Publicado en: ACS Nano, 2024, ISSN 1936-0851
Editor: American Chemical Society

Lipid Nature and Alkyl Length Influence Lymph Node Accumulation of Lipid‐Polyethylene Glycol Amphiphiles

Autores: Simon Van Herck; Antonio Pires da Silva Baptista; Haijun Yu; Lutz Nuhn; Bruno G. De Geest; Bart N. Lambrecht; Bart N. Lambrecht; Jana De Vrieze; Kim Deswarte
Publicado en: ADVANCED THERAPEUTICS, Edición 4, 2021, Página(s) 2100079, ISSN 2366-3987
Editor: Wiley
DOI: 10.1002/adtp.202100079

CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Autores: Tingting Ye; Zifu Zhong; Federica Cappellesso; Kim Deswarte; Yong Chen; Heleen Lauwers; Emily De Lombaerde; Mark Gontsarik; Stefan Lienenklaus; Dorien Van Lysebetten; Niek N. Sanders; Bart N. Lambrecht; Stefaan De Koker; Damya Laoui; Bruno G. De Geest
Publicado en: Biomaterials, Edición 311, 2024, Página(s) 122693, ISSN 0142-9612
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2024.122693

Synthetic Rhamnose Glycopolymer Cell-Surface Receptor for Endogenous Antibody Recruitment

Autores: Ruben De Coen, Lutz Nuhn, Chamani Perera, Maria Arista-Romero, Martijn D. P. Risseeuw, Alec Freyn, Raffael Nachbagauer, Lorenzo Albertazzi, Serge Van Calenbergh, David A. Spiegel, Blake R. Peterson, Bruno G. De Geest
Publicado en: Biomacromolecules, 2020, ISSN 1525-7797
Editor: American Chemical Society

Multivalent Antibody-Recruiting Macromolecules: Linking Increased Binding Affinity with Enhanced Innate Immune Killing.

Autores: Uvyn, A., & De Geest, B. G.
Publicado en: ChemBioChem, 2020, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.

Lipid-Polyglutamate Nanoparticle Vaccine Platform

Autores: Dorien Van Lysebetten, Alessio Malfanti, Kim Deswarte, Kaloian Koynov, Bianka Golba, Tingting Ye, Zifu Zhong, Sabah Kasmi, Alexander Lamoot, Yong Chen, Simon Van Herck, Bart N. Lambrecht, Niek N. Sanders, Stefan Lienenklaus, Sunil A. David, María J. Vicent, Stefaan De Koker, and Bruno G. De Geest
Publicado en: ACS Applied Materials and Interfaces, 2021, ISSN 1944-8244
Editor: American Chemical Society

Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids.

Autores: Lamoot, A., Lammens, J., De Lombaerde, E., Zhong, Z., Gontsarik, M., Chen, Y., De Beer, T. R. M., & De Geest, B. G.
Publicado en: Biomaterials Science, 2023, ISSN 2047-4830
Editor: Royal Society of Chemistry

Towards a Rational Design of Antibody-Recruiting Molecules through a Computational Microscopy View of their Interactions with the Target Antibody. Chemistry

Autores: Uvyn, A., Tonneaux, C., Fossépré, M., Ouvrier-Buffet, A., De Geest, B. G., & Surin, M.
Publicado en: Chemistry: A European Journal, 2023, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.

Combinatorial Screening of Biscarbamate Ionizable Lipids Identifies a Low Reactogenicity Lipid for Lipid Nanoparticle mRNA Delivery

Autores: Emily De Lombaerde; Yong Chen; Tingting Ye; Julie Deckers; Giulia Mencarelli; Kim De Swarte; Heleen Lauwers; Ruben De Coen; Sabah Kasmi; Sanne Bevers; Anna Kuchmiy; Bram Bogaert; Lies Baekens; Zifu Zhong; Alexander Lamoot; Niek N. Sanders; Bart N. Lambrecht; Antonio P. Baptista; Stefaan De Koker; Bruno G. De Geest
Publicado en: Advanced Functional Materials, Edición 34, 2024, Página(s) 2310623, ISSN 1616-3028
Editor: Wiley
DOI: 10.1002/adfm.202310623

Current Status of COVID‐19 (Pre)Clinical Vaccine Development

Autores: Tingting Ye, Zifu Zhong, Adolfo García‐Sastre, Michael Schotsaert, Bruno G. De Geest
Publicado en: Angewandte Chemie International Edition, Edición 59/43, 2020, Página(s) 18885-18897, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202008319

Covalent Cell Surface Conjugation of Nanoparticles by a Combination of Metabolic Labeling and Click Chemistry

Autores: Alexander Lamoot, Annemiek Uvyn, Dr. Sabah Kasmi, Prof. Dr. Bruno G. De Geest
Publicado en: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine

Autores: Dr. Sonia Jangra, Jana De Vrieze, Angela Choi, Raveen Rathnasinghe, Gabriel Laghlali, Annemiek Uvyn, Dr. Simon Van Herck, Dr. Lutz Nuhn, Kim Deswarte, Dr. Zifu Zhong, Prof. Dr. Niek N. Sanders, Dr. Stefan Lienenklaus, Dr. Sunil A. David, Shirin Strohmeier, Fatima Amanat, Prof. Dr. Florian Krammer, Prof. Dr. Hamida Hammad, Prof. Dr. Bart N. Lambrecht, Prof. Dr. Lynda Coughlan, Prof. Dr.
Publicado en: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.

Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells

Autores: Annemiek Uvyn, Ruben De Coen, Olivier De Wever, Kim Deswarte, Bart N. Lambrecht and Bruno G. De Geest
Publicado en: Chemical Communications, 2021, ISSN 1359-7345
Editor: Royal Society of Chemistry

Lipid Nanoparticle Delivery Alters the Adjuvanticity of the TLR9 Agonist CpG by Innate Immune Activation in Lymphoid Tissue.

Autores: Zhong, Z., Chen, Y., Deswarte, K., Lauwers, H., De Lombaerde, E., Cui, X., Van Herck, S., Ye, T., Gontsarik, M., Lienenklaus, S., Sanders, N. N., Lambrecht, B. N., De Koker, S., & De Geest, B. G.
Publicado en: Advanced Healthcare Materials, 2023, ISSN 2192-2659
Editor: World Scientific

Hapten/Myristoyl Functionalized Poly(propyleneimine) Dendrimers as Potent Cell Surface Recruiters of Antibodies for Mediating Innate Immune Killing.

Autores: Uvyn, A., Vleugels, M. E. J., De Waal, B., Hamouda, A. E. I., Dhiman, S., Louage, B., Albertazzi, L., Laoui, D., Meijer, E. W., & De Geest, B. G.
Publicado en: Advanced Materials, 2023, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization