Synergistic engineering of anti-tumor immunity by synthetic biomaterials

Informazioni relative al progetto

ImmunoBioSynth

ID dell’accordo di sovvenzione: 817938

DOI

10.3030/817938

Progetto chiuso

Data della firma CE 27 Febbraio 2019

Data di avvio 1 Aprile 2019

Data di completamento 30 Settembre 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 000 000,00

Contributo UE

€ 2 000 000,00

Coordinato da

UNIVERSITEIT GENT
Belgium

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (17)

Lipid Nanoparticle Encapsulation Empowers Poly(I:C) to Activate Cytoplasmic RLRs and Thereby Increases Its Adjuvanticity.

Autori: Lamoot, A., Jangra, S., Laghlali, G., Warang, P., Singh, G., Chang, L. A., Park, S.-C., De Swarte, K., Zhong, Z., Louage, B., De Lombaerde, E., Ye, T., Chen, Y., Cuadrado-Castano, S., Lienenklaus, S., Sanders, N. N., Lambrecht, B. N., García-Sastre, A., Schotsaert, M., & De Geest, B. G.
Pubblicato in: Small, 2023, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.

Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles

Autori: Bi Wang, Simon Van Herck, Yong Chen, Xiangyang Bai, Zifu Zhong, Kim Deswarte, Bart N. Lambrecht, Niek N. Sanders, Stefan Lienenklaus, Hans W. Scheeren, Sunil A. David, Fabian Kiessling, Twan Lammers, Bruno G. De Geest, Yang Shi
Pubblicato in: Journal of the American Chemical Society, Numero 142/28, 2020, Pagina/e 12133-12139, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.0c01928

Amplification of Protein Expression by Self-Amplifying mRNA Delivered in Lipid Nanoparticles Containing a β-Aminoester Ionizable Lipid Correlates with Reduced Innate Immune Activation

Autori: Emily De LombaerdeXiaole CuiYong ChenZifu ZhongJulie DeckersGiulia MencarelliLisa OpsomerHaixiu WangJamie De BaereStefan LienenklausBart N. LambrechtNiek N. Sanders*Bruno G. De Geest
Pubblicato in: ACS Nano, 2024, ISSN 1936-0851
Editore: American Chemical Society

Lipid Nature and Alkyl Length Influence Lymph Node Accumulation of Lipid‐Polyethylene Glycol Amphiphiles

Autori: Simon Van Herck; Antonio Pires da Silva Baptista; Haijun Yu; Lutz Nuhn; Bruno G. De Geest; Bart N. Lambrecht; Bart N. Lambrecht; Jana De Vrieze; Kim Deswarte
Pubblicato in: ADVANCED THERAPEUTICS, Numero 4, 2021, Pagina/e 2100079, ISSN 2366-3987
Editore: Wiley
DOI: 10.1002/adtp.202100079

CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Autori: Tingting Ye; Zifu Zhong; Federica Cappellesso; Kim Deswarte; Yong Chen; Heleen Lauwers; Emily De Lombaerde; Mark Gontsarik; Stefan Lienenklaus; Dorien Van Lysebetten; Niek N. Sanders; Bart N. Lambrecht; Stefaan De Koker; Damya Laoui; Bruno G. De Geest
Pubblicato in: Biomaterials, Numero 311, 2024, Pagina/e 122693, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2024.122693

Synthetic Rhamnose Glycopolymer Cell-Surface Receptor for Endogenous Antibody Recruitment

Autori: Ruben De Coen, Lutz Nuhn, Chamani Perera, Maria Arista-Romero, Martijn D. P. Risseeuw, Alec Freyn, Raffael Nachbagauer, Lorenzo Albertazzi, Serge Van Calenbergh, David A. Spiegel, Blake R. Peterson, Bruno G. De Geest
Pubblicato in: Biomacromolecules, 2020, ISSN 1525-7797
Editore: American Chemical Society

Multivalent Antibody-Recruiting Macromolecules: Linking Increased Binding Affinity with Enhanced Innate Immune Killing.

Autori: Uvyn, A., & De Geest, B. G.
Pubblicato in: ChemBioChem, 2020, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.

Lipid-Polyglutamate Nanoparticle Vaccine Platform

Autori: Dorien Van Lysebetten, Alessio Malfanti, Kim Deswarte, Kaloian Koynov, Bianka Golba, Tingting Ye, Zifu Zhong, Sabah Kasmi, Alexander Lamoot, Yong Chen, Simon Van Herck, Bart N. Lambrecht, Niek N. Sanders, Stefan Lienenklaus, Sunil A. David, María J. Vicent, Stefaan De Koker, and Bruno G. De Geest
Pubblicato in: ACS Applied Materials and Interfaces, 2021, ISSN 1944-8244
Editore: American Chemical Society

Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids.

Autori: Lamoot, A., Lammens, J., De Lombaerde, E., Zhong, Z., Gontsarik, M., Chen, Y., De Beer, T. R. M., & De Geest, B. G.
Pubblicato in: Biomaterials Science, 2023, ISSN 2047-4830
Editore: Royal Society of Chemistry

Towards a Rational Design of Antibody-Recruiting Molecules through a Computational Microscopy View of their Interactions with the Target Antibody. Chemistry

Autori: Uvyn, A., Tonneaux, C., Fossépré, M., Ouvrier-Buffet, A., De Geest, B. G., & Surin, M.
Pubblicato in: Chemistry: A European Journal, 2023, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.

Combinatorial Screening of Biscarbamate Ionizable Lipids Identifies a Low Reactogenicity Lipid for Lipid Nanoparticle mRNA Delivery

Autori: Emily De Lombaerde; Yong Chen; Tingting Ye; Julie Deckers; Giulia Mencarelli; Kim De Swarte; Heleen Lauwers; Ruben De Coen; Sabah Kasmi; Sanne Bevers; Anna Kuchmiy; Bram Bogaert; Lies Baekens; Zifu Zhong; Alexander Lamoot; Niek N. Sanders; Bart N. Lambrecht; Antonio P. Baptista; Stefaan De Koker; Bruno G. De Geest
Pubblicato in: Advanced Functional Materials, Numero 34, 2024, Pagina/e 2310623, ISSN 1616-3028
Editore: Wiley
DOI: 10.1002/adfm.202310623

Current Status of COVID‐19 (Pre)Clinical Vaccine Development

Autori: Tingting Ye, Zifu Zhong, Adolfo García‐Sastre, Michael Schotsaert, Bruno G. De Geest
Pubblicato in: Angewandte Chemie International Edition, Numero 59/43, 2020, Pagina/e 18885-18897, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202008319

Covalent Cell Surface Conjugation of Nanoparticles by a Combination of Metabolic Labeling and Click Chemistry

Autori: Alexander Lamoot, Annemiek Uvyn, Dr. Sabah Kasmi, Prof. Dr. Bruno G. De Geest
Pubblicato in: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine

Autori: Dr. Sonia Jangra, Jana De Vrieze, Angela Choi, Raveen Rathnasinghe, Gabriel Laghlali, Annemiek Uvyn, Dr. Simon Van Herck, Dr. Lutz Nuhn, Kim Deswarte, Dr. Zifu Zhong, Prof. Dr. Niek N. Sanders, Dr. Stefan Lienenklaus, Dr. Sunil A. David, Shirin Strohmeier, Fatima Amanat, Prof. Dr. Florian Krammer, Prof. Dr. Hamida Hammad, Prof. Dr. Bart N. Lambrecht, Prof. Dr. Lynda Coughlan, Prof. Dr.
Pubblicato in: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.

Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells

Autori: Annemiek Uvyn, Ruben De Coen, Olivier De Wever, Kim Deswarte, Bart N. Lambrecht and Bruno G. De Geest
Pubblicato in: Chemical Communications, 2021, ISSN 1359-7345
Editore: Royal Society of Chemistry

Lipid Nanoparticle Delivery Alters the Adjuvanticity of the TLR9 Agonist CpG by Innate Immune Activation in Lymphoid Tissue.

Autori: Zhong, Z., Chen, Y., Deswarte, K., Lauwers, H., De Lombaerde, E., Cui, X., Van Herck, S., Ye, T., Gontsarik, M., Lienenklaus, S., Sanders, N. N., Lambrecht, B. N., De Koker, S., & De Geest, B. G.
Pubblicato in: Advanced Healthcare Materials, 2023, ISSN 2192-2659
Editore: World Scientific

Hapten/Myristoyl Functionalized Poly(propyleneimine) Dendrimers as Potent Cell Surface Recruiters of Antibodies for Mediating Innate Immune Killing.

Autori: Uvyn, A., Vleugels, M. E. J., De Waal, B., Hamouda, A. E. I., Dhiman, S., Louage, B., Albertazzi, L., Laoui, D., Meijer, E. W., & De Geest, B. G.
Pubblicato in: Advanced Materials, 2023, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization