spontaneous Evolution and Clonal heterOgeneity in MoNoclonal Gammopathies: from mechanisms of progression to clinical management

Informations projet

bECOMiNG

N° de convention de subvention: 817997

DOI

10.3030/817997

Projet clôturé

Date de signature de la CE 25 Février 2019

Date de début 1 Mars 2019

Date de fin 28 Février 2025

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total

€ 1 998 781,00

Contribution de l’UE

€ 1 998 781,00

Coordonné par

UNIVERSITA DEGLI STUDI DI MILANO
Italy

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Publications

Peer reviewed articles (30)

Activation of long non-coding RNA NEAT1 leads to survival advantage of multiple myeloma cells by supporting a positive regulatory loop with DNA repair proteins

Auteurs: Elisa Taiana, Cecilia Bandini, Vanessa Katia Favasuli, Domenica Ronchetti, Ilaria Silvestris, Noemi Puccio, Katia Todoerti, Silvia Erratico, Domenica Giannandrea, Niccolò Bolli, Nicola Amodio, Alessia Ciarrocchi, Raffaella Chiaramonte, Yvan Torrente, Roberto Piva, Antonino Neri
Publié dans: Haematologica, Numéro 108, 2023, Page(s) 219-233, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2022.281167

Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities

Auteurs: Bénedith Oben, Guy Froyen, Kylee H. Maclachlan, Daniel Leongamornlert, Federico Abascal, Binbin Zheng-Lin, Venkata Yellapantula, Andriy Derkach, Ellen Geerdens, Benjamin T. Diamond, Ingrid Arijs, Brigitte Maes, Kimberly Vanhees, Malin Hultcrantz, Elisabet E. Manasanch, Dickran Kazandjian, Alexander Lesokhin, Ahmet Dogan, Yanming Zhang, Aneta Mikulasova, Brian Walker, Gareth Morgan, Peter J. Campb
Publié dans: Nature Communications, Numéro 12/1, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-22140-0

Application of Next-Generation Sequencing for the Genomic Characterization of Patients with Smoldering Myeloma

Auteurs: Martina Manzoni, Valentina Marchica, Paola Storti, Bachisio Ziccheddu, Gabriella Sammarelli, Giannalisa Todaro, Francesca Pelizzoni, Simone Salerio, Laura Notarfranchi, Alessandra Pompa, Luca Baldini, Niccolò Bolli, Antonino Neri, Nicola Giuliani, Marta Lionetti
Publié dans: Cancers, Numéro 12/5, 2020, Page(s) 1332, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12051332

Next-Generation Sequencing for Clinical Management of Multiple Myeloma: Ready for Prime Time?

Auteurs: Niccolo Bolli, Elisa Genuardi, Bachisio Ziccheddu, Marina Martello, Stefania Oliva, Carolina Terragna
Publié dans: Frontiers in Oncology, Numéro 10, 2020, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.00189

Limits and Applications of Genomic Analysis of Circulating Tumor DNA as a Liquid Biopsy in Asymptomatic Forms of Multiple Myeloma

Auteurs: Martina Manzoni, Alessandra Pompa, Sonia Fabris, Francesca Pelizzoni, Gabriella Ciceri, Manuela Seia, Bachisio Ziccheddu, Niccolò Bolli, Paolo Corradini, Luca Baldini, Antonino Neri, Marta Lionetti
Publié dans: HemaSphere, Numéro 4/4, 2020, Page(s) e402, ISSN 2572-9241
Éditeur: Wolters Kluwer Health, Inc. on behalf of the European Hematology Association
DOI: 10.1097/hs9.0000000000000402

Transcriptomic Analysis in Multiple Myeloma and Primary Plasma Cell Leukemia with t(11;14) Reveals Different Expression Patterns with Biological Implications in Venetoclax Sensitivity

Auteurs: Katia Todoerti, Elisa Taiana, Noemi Puccio, Vanessa Favasuli, Marta Lionetti, Ilaria Silvestris, Massimo Gentile, Pellegrino Musto, Fortunato Morabito, Umberto Gianelli, Niccolò Bolli, Luca Baldini, Antonino Neri, Domenica Ronchetti
Publié dans: Cancers, Numéro 13/19, 2021, Page(s) 4898, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13194898

Moving From Cancer Burden to Cancer Genomics for Smoldering Myeloma

Auteurs: Francesco Maura, Niccolò Bolli, Even H. Rustad, Malin Hultcrantz, Nikhil Munshi, Ola Landgren
Publié dans: JAMA Oncology, Numéro 6, 2020, Page(s) 425, ISSN 2374-2437
Éditeur: American Medical Association
DOI: 10.1001/jamaoncol.2019.4659

Pathogenetic and Prognostic Implications of Increased Mitochondrial Content in Multiple Myeloma

Auteurs: Yanira Ruiz-Heredia, Alejandra Ortiz-Ruiz, Mehmet K. Samur, Vanesa Garrido, Laura Rufian, Ricardo Sanchez, Pedro Aguilar-Garrido, Santiago Barrio, Miguel A. Martín, Niccolò Bolli, Yu-Tzu Tai, Raphaël Szalat, Mariateresa Fulciniti, Nikhil Munshi, Joaquín Martínez-López, María Linares, Miguel Gallardo
Publié dans: Cancers, Numéro 13/13, 2021, Page(s) 3189, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13133189

Timing the initiation of multiple myeloma

Auteurs: Even H. Rustad, Venkata Yellapantula, Daniel Leongamornlert, Niccolò Bolli, Guy Ledergor, Ferran Nadeu, Nicos Angelopoulos, Kevin J. Dawson, Thomas J. Mitchell, Robert J. Osborne, Bachisio Ziccheddu, Cristiana Carniti, Vittorio Montefusco, Paolo Corradini, Kenneth C. Anderson, Philippe Moreau, Elli Papaemmanuil, Ludmil B. Alexandrov, Xose S. Puente, Elias Campo, Reiner Siebert, Herve Avet-Loiseau
Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-15740-9

Genomic and immune determinants of resistance to daratumumab-based therapy in relapsed refractory multiple myeloma

Auteurs: Bachisio Ziccheddu, Claudia Giannotta, Mattia D’Agostino, Giuseppe Bertuglia, Elona Saraci, Stefania Oliva, Elisa Genuardi, Marios Papadimitriou, Benjamin Diamond, Paolo Corradini, David Coffey, Ola Landgren, Niccolò Bolli, Benedetto Bruno, Mario Boccadoro, Massimo Massaia, Francesco Maura, Alessandra Larocca
Publié dans: Blood Cancer Journal, Numéro 14, 2024, ISSN 2044-5385
Éditeur: Nature Publishing Group
DOI: 10.1038/s41408-024-01096-6

DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome

Auteurs: Katia Todoerti, Domenica Ronchetti, Vanessa Favasuli, Francesco Maura, Fortunato Morabito, Niccolò Bolli, Elisa Taiana, Antonino Neri
Publié dans: Haematologica, 2020, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2021.278342

TENT5C/FAM46C modulation <i>in vivo</i> reveals a trade-off between antibody secretion and tumor growth in multiple myeloma

Auteurs: Massimo Resnati, Sara Pennacchio, Lisa Viviani, Tommaso Perini, Maria Materozzi, Ugo Orfanelli, Jessica Bordini, Raffaella Molteni, Mario Nuvolone, Matteo Da Vià, Francesca Lazzaroni, Niccolò Bolli, Simone Cenci, Enrico Milan
Publié dans: Haematologica, 2024, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2023.284299

Genomics of Smoldering Multiple Myeloma: Time for Clinical Translation of Findings?

Auteurs: Marta Lionetti, Matteo C. Da Vià, Francesco Albano, Antonino Neri, Niccolò Bolli, Pellegrino Musto
Publié dans: Cancers, Numéro 13/13, 2021, Page(s) 3319, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13133319

Integrative analysis of the genomic and transcriptomic landscape of double-refractory multiple myeloma

Auteurs: Bachisio Ziccheddu, Giulia Biancon, Filippo Bagnoli, Chiara De Philippis, Francesco Maura, Even H. Rustad, Matteo Dugo, Andrea Devecchi, Loris De Cecco, Marialuisa Sensi, Carolina Terragna, Marina Martello, Tina Bagratuni, Efstathios Kastritis, Meletios A. Dimopoulos, Michele Cavo, Cristiana Carniti, Vittorio Montefusco, Paolo Corradini, Niccolo Bolli
Publié dans: Blood Advances, Numéro 4/5, 2020, Page(s) 830-844, ISSN 2473-9529
Éditeur: American Society of Hematology
DOI: 10.1182/bloodadvances.2019000779

Expression levels of NONO, a nuclear protein primarily involved in paraspeckles function, are associated with several deregulated molecular pathways and poor clinical outcome in multiple myeloma

Auteurs: Domenica Ronchetti, Vanessa Katia Favasuli, Ilaria Silvestris, Katia Todoerti, Federica Torricelli, Niccolò Bolli, Alessia Ciarrocchi, Elisa Taiana, Antonino Neri
Publié dans: Discover Oncology, Numéro 13, 2022, ISSN 2730-6011
Éditeur: Springer Nature
DOI: 10.1007/s12672-022-00582-2

Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma

Auteurs: Kylee H. Maclachlan, Even H. Rustad, Andriy Derkach, Binbin Zheng-Lin, Venkata Yellapantula, Benjamin Diamond, Malin Hultcrantz, Bachisio Ziccheddu, Eileen M. Boyle, Patrick Blaney, Niccolò Bolli, Yanming Zhang, Ahmet Dogan, Alexander M. Lesokhin, Gareth J. Morgan, Ola Landgren, Francesco Maura
Publié dans: Nature Communications, Numéro 12/1, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-25469-8

mmsig: a fitting approach to accurately identify somatic mutational signatures in hematological malignancies

Auteurs: Even H. Rustad, Ferran Nadeu, Nicos Angelopoulos, Bachisio Ziccheddu, Niccolò Bolli, Xose S. Puente, Elias Campo, Ola Landgren, Francesco Maura
Publié dans: Communications Biology, Numéro 4/1, 2021, ISSN 2399-3642
Éditeur: Nature Publishing Group
DOI: 10.1038/s42003-021-01938-0

Impact of clonal hematopoiesis of indeterminate potential on hepatocellular carcinoma in individuals with steatotic liver disease

Auteurs: Alfredo Marchetti, Serena Pelusi, Alessio Marella, Francesco Malvestiti, Antony Ricchiuti, Luisa Ronzoni, Marta Lionetti, Vittoria Moretti, Elisabetta Bugianesi, Luca Miele, Umberto Vespasiani-Gentilucci, Paola Dongiovanni, Alessandro Federico, Giorgio Soardo, Roberta D’Ambrosio, Misti V. McCain, Helen L. Reeves, Vincenzo La Mura, Daniele Prati, Niccolò Bolli, Luca Valenti, null null
Publié dans: Hepatology, Numéro 80, 2025, Page(s) 816-827, ISSN 0270-9139
Éditeur: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000839

What Is New in the Treatment of Smoldering Multiple Myeloma?

Auteurs: Niccolo’ Bolli, Nicola Sgherza, Paola Curci, Rita Rizzi, Vanda Strafella, Mario Delia, Vito Pier Gagliardi, Antonino Neri, Luca Baldini, Francesco Albano, Pellegrino Musto
Publié dans: Journal of Clinical Medicine, Numéro 10/3, 2021, Page(s) 421, ISSN 2077-0383
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10030421

A practical guide for mutational signature analysis in hematological malignancies

Auteurs: Francesco Maura, Andrea Degasperi, Ferran Nadeu, Daniel Leongamornlert, Helen Davies, Luiza Moore, Romina Royo, Bachisio Ziccheddu, Xose S. Puente, Herve Avet-Loiseau, Peter J. Campbell, Serena Nik-Zainal, Elias Campo, Nikhil Munshi, Niccolò Bolli
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-11037-8

Genomic landscape and chronological reconstruction of driver events in multiple myeloma

Auteurs: Francesco Maura, Niccoló Bolli, Nicos Angelopoulos, Kevin J. Dawson, Daniel Leongamornlert, Inigo Martincorena, Thomas J. Mitchell, Anthony Fullam, Santiago Gonzalez, Raphael Szalat, Federico Abascal, Bernardo Rodriguez-Martin, Mehmet Kemal Samur, Dominik Glodzik, Marco Roncador, Mariateresa Fulciniti, Yu Tzu Tai, Stephane Minvielle, Florence Magrangeas, Philippe Moreau, Paolo Corradini, Kenneth
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-11680-1

Functional Impact of Genomic Complexity on the Transcriptome of Multiple Myeloma

Auteurs: Bachisio Ziccheddu, Matteo C. Da Vià, Marta Lionetti, Akihiro Maeda, Silvia Morlupi, Matteo Dugo, Katia Todoerti, Stefania Oliva, Mattia D'Agostino, Paolo Corradini, Ola Landgren, Francesco Iorio, Loredana Pettine, Alessandra Pompa, Martina Manzoni, Luca Baldini, Antonino Neri, Francesco Maura, Niccolò Bolli
Publié dans: Clinical Cancer Research, 2021, ISSN 1078-0432
Éditeur: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-20-4366

The pleiotropic nature of NONO, a master regulator of essential biological pathways in cancers

Auteurs: Domenica Ronchetti, Valentina Traini, Ilaria Silvestris, Giuseppina Fabbiano, Francesco Passamonti, Niccolò Bolli, Elisa Taiana
Publié dans: Cancer Gene Therapy, Numéro 31, 2024, Page(s) 984-994, ISSN 0929-1903
Éditeur: Nature Publishing Group
DOI: 10.1038/s41417-024-00763-x

The Dynamics of Nucleotide Variants in the Progression from Low–Intermediate Myeloma Precursor Conditions to Multiple Myeloma: Studying Serial Samples with a Targeted Sequencing Approach

Auteurs: Bénedith Oben, Charlotte Cosemans, Ellen Geerdens, Loes Linsen, Kimberly Vanhees, Brigitte Maes, Koen Theunissen, Bert Cruys, Marta Lionetti, Ingrid Arijs, Niccolò Bolli, Guy Froyen, Jean-Luc Rummens
Publié dans: Cancers, Numéro 14, 2025, Page(s) 1035, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14041035

MGUS and clonal hematopoiesis show unrelated clinical and biological trajectories in an older population cohort

Auteurs: Matteo Claudio Da Vià, Marta Lionetti, Alessio Marella, Antonio Matera, Erica Travaglino, Elena Signaroldi, Alessia Antonella Galbussera, Ugo Lucca, Sara Mandelli, Emma Riva, Mauro Tettamanti, Loredana Pettine, Alessandra Pompa, Luca Baldini, Antonino Neri, Matteo Giovanni Della Porta, Niccolò Bolli
Publié dans: Blood Advances, Numéro 6, 2023, Page(s) 5702-5706, ISSN 2473-9529
Éditeur: American Society of Hematology
DOI: 10.1182/bloodadvances.2021006498

A Journey Through Myeloma Evolution: From the Normal Plasma Cell to Disease Complexity

Auteurs: Matteo C. Da Vià, Bachisio Ziccheddu, Akihiro Maeda, Filippo Bagnoli, Giulia Perrone, Niccolò Bolli
Publié dans: HemaSphere, Numéro 4/6, 2020, Page(s) e502, ISSN 2572-9241
Éditeur: Wolters Kluwer Health, Inc. on behalf of the European Hematology Association
DOI: 10.1097/hs9.0000000000000502

Single-Cell RNA Sequencing for the Detection of Clonotypic V(D)J Rearrangements in Multiple Myeloma

Auteurs: Antonio Matera, Alessio Marella, Akihiro Maeda, Matteo C. Da Vià, Francesca Lazzaroni, Sonia Fabris, Stefania Pioggia, Laura Porretti, Federico Colombo, Federica Torricelli, Antonino Neri, Elisa Taiana, Giuseppina Fabbiano, Valentina Traini, Elisa Genuardi, Daniela Drandi, Niccolò Bolli, Marta Lionetti
Publié dans: International Journal of Molecular Sciences, Numéro 23, 2025, Page(s) 15691, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232415691

Clonal hematopoiesis of indeterminate potential in patients with immunoglobulin light-chain AL amyloidosis

Auteurs: Paolo Lopedote, Benjamin Evans, Alfredo Marchetti, Tianzeng Chen, Maria Moscvin, Samuel Boullt, Niccolò Bolli, Giada Bianchi
Publié dans: Blood Advances, Numéro 8, 2024, Page(s) 3427-3436, ISSN 2473-9529
Éditeur: American Society of Hematology
DOI: 10.1182/bloodadvances.2024012840

mmsig: a fitting approach to accurately identify somatic mutational signatures in hematological malignancies.

Auteurs: Even H Rustad; Even H Rustad; Ferran Nadeu; Nicos Angelopoulos; Bachisio Ziccheddu; Bachisio Ziccheddu; Niccolo Bolli; Niccolo Bolli; Xose S. Puente; Elias Campo; Ola Landgren; Ola Landgren; Francesco Maura; Francesco Maura
Publié dans: 12, Numéro 1, 2021, ISSN 2399-3642
Éditeur: Nature Publishing Group
DOI: 10.1038/s42003-021-01938-0

Inference of genomic lesions from single-cell RNA-seq in myeloma improves functional intraclonal and interclonal analysis

Auteurs: Francesca Lazzaroni, Antonio Matera, Alessio Marella, Akihiro Maeda, Giancarlo Castellano, Alfredo Marchetti, Sonia Fabris, Stefania Pioggia, Ilaria Silvestris, Domenica Ronchetti, Silvia Lonati, Giuseppina Fabbiano, Valentina Traini, Elisa Taiana, Laura Porretti, Federico Colombo, Claudio De Magistris, Margherita Scopetti, Marzia Barbieri, Loredana Pettine, Federica Torricelli, Antonino Neri, Fra
Publié dans: Blood Advances, Numéro 8, 2024, Page(s) 3972-3984, ISSN 2473-9529
Éditeur: American Society of Hematology
DOI: 10.1182/bloodadvances.2023012409

Other (1)

Copy number signatures predict chromothripsis and associate with poor clinical outcomes in patients with newly diagnosed multiple myeloma

Auteurs: Kylee H Maclachlan, Even H Rustad, Andriy Derkach, Binbin Zheng-Lin, Venkata Yellapantula, Benjamin Diamond, Malin Hultcrantz, Bachisio Ziccheddu, Eileen Boyle, Patrick Blaney, Niccolò Bolli, Yanming Zhang, Ahmet Dogan, Alexander Lesokhin, Gareth Morgan, Ola Landgren, Francesco Maura
Publié dans: Biorxiv, 2024
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.11.24.395939