Artificial metabolic cells for biomanufacturing of bio-based chiral fine chemicals

Project Information

METACELL

Grant agreement ID: 818089

DOI

10.3030/818089

EC signature date 10 September 2019

Start date 1 January 2020

End date 31 December 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 995 894,00

EU contribution

€ 1 995 894,00

Coordinated by

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

Design of the Enzyme-Carrier Interface to Overcome the O2 and NADH Mass Transfer Limitations of an Immobilized Flavin Oxidase.

Author(s): Ana I. Benítez-Mateos; Ana I. Benítez-Mateos; Christina Huber; Bernd Nidetzky; Juan M. Bolivar; Juan M. Bolivar; Fernando López-Gallego; Fernando López-Gallego
Published in: ACS Applied Materials and Interfaces, Issue 5, 2020, Page(s) 56027-56038, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c17568

Selective Coimmobilization of His-Tagged Enzymes on Yttrium-Stabilized Zirconia-Based Membranes for Continuous Asymmetric Bioreductions

Author(s): Andrés-Sanz, D; Diamanti, E; Di Silvo, D; Gurauskis, J; López-Gallego, F.
Published in: ACS Applied Materials and Interfaces, Issue 14-3, 2022, Page(s) 4285-4296, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.1c20738

A heterogeneous chemoenzymatic route toward the continuous transformation of γ-alkynoic acids into γ-hydroxy acids

Author(s): Javier Santiago-Arcos, Daniel Andrés-Sanz, Nicolás Ríos-Lombardía, Susana Carregal-Romero, Desiré di Silvio, Irantzu Llarena, Joaquín García-Álvarez, Javier González-Sabín, Fernando López-Gallego
Published in: Cell Reports Physical Science, Issue 5, 2024, Page(s) 102015, ISSN 2666-3864
Publisher: Elsevier
DOI: 10.1016/j.xcrp.2024.102015

Self-sufficient asymmetric reduction of β-ketoesters catalysed by a novel and robust thermophilic alcohol dehydrogenase co-immobilised with NADH

Author(s): Alejandro H. Orrego, Daniel Andrés-Sanz, Susana Velasco-Lozano, Mercedes Sanchez-Costa, José Berenguer, José M. Guisan, Javier Rocha-Martin, Fernando López-Gallego
Published in: Catalysis Science & Technology, Issue 11/9, 2021, Page(s) 3217-3230, ISSN 2044-4753
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cy00268f

Intraparticle Kinetics Unveil Crowding and Enzyme Distribution Effects on the Performance of Cofactor-Dependent Heterogeneous Biocatalysts

Author(s): Eleftheria Diamanti; Javier Santiago-Arcos; Daniel A. Grajales-Hernández; Nicolette Czarnievicz; Natalia Comino; Irantzu Llarena; Desiré Di Silvio; Aitziber L. Cortajarena; Fernando López-Gallego
Published in: ACS Catalysis, Issue 2, 2021, Page(s) 15051-15067, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.1c03760

Surpassing Substrate–Enzyme Competition by Compartmentalization

Author(s): Eleftheria Diamanti, Daniel Andrés-Sanz, Alejandro H. Orrego, Susana Carregal-Romero, Fernando López-Gallego
Published in: ACS Catalysis, Issue 13, 2023, Page(s) 11441-11454, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.3c01965

Cell-free biosynthesis of ω-hydroxy acids boosted by a synergistic combination of alcohol dehydrogenases

Author(s): Susana Velasco; Javier Santiago-Arcos; Maria Grazia; Fernando López-Gallego
Published in: ChemSusChem, Issue 1, 2022, ISSN 1864-5631
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.26434/chemrxiv-2021-vgprq

Engineered repeat proteins as scaffolds to assemble multi-enzyme systems for efficient cell-free biosynthesis

Author(s): Alba Ledesma-Fernandez, Susana Velasco-Lozano, Javier Santiago-Arcos, Fernando López-Gallego, Aitziber L. Cortajarena
Published in: Nature Communications, Issue 14, 2023, Page(s) 14 - 1 (2587 ), ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38304-z

Characterization and evaluation of immobilized enzymes for applications in flow reactors

Author(s): Juan M. Bolivar, Fernando López-Gallego
Published in: Current Opinion in Green and Sustainable Chemistry, Issue 25, 2020, Page(s) 100349, ISSN 2452-2236
Publisher: Elsevier
DOI: 10.1016/j.cogsc.2020.04.010

Light-Driven Catalytic Regulation of Enzymes at the Interface with Plasmonic Nanomaterials

Author(s): Heloise Ribeiro de Barros, Fernando López-Gallego, Luis M. Liz-Marzán
Published in: Biochemistry, Issue 60/13, 2021, Page(s) 991-998, ISSN 0006-2960
Publisher: American Chemical Society
DOI: 10.1021/acs.biochem.0c00447

Multienzyme Coimmobilization on Triheterofunctional Supports

Author(s): Javier Santiago-Arcos, Susana Velasco-Lozano, Fernando López-Gallego
Published in: Biomacromolecules, Issue 24, 2023, Page(s) 929-942, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.2c01364

Metal substrate catalysis in the confined space for platinum drug delivery

Author(s): Susana Velasco-Lozano; Silvia Alonso-de Castro; Carlos Sanchez-Cano; Carlos Sanchez-Cano; Ana I. Benítez-Mateos; Fernando López-Gallego; Luca Salassa; Luca Salassa; Luca Salassa
Published in: Chemical Science, Issue 4, 2021, Page(s) 59-67, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc05151b

Region-Directed Enzyme Immobilization through Engineering Protein Surface with Histidine Clusters

Author(s): Nicoll Zeballos, Natalia Comino, Daniel Andrés-Sanz, Javier Santiago-Arcos, Mikel Azkargorta, Felix Elortza, Eleftheria Diamanti, Fernando López-Gallego
Published in: ACS Applied Materials & Interfaces, Issue 16, 2024, Page(s) 833-846, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.3c15993

ATP‐Independent and Cell‐Free Biosynthesis of β‐Hydroxy Acids Using Vinyl Esters as Smart Substrates

Author(s): Alejandro H. Orrego, Maria Grazia Rubanu, Idania L. López, Daniel Andrés‐Sanz, Guillermo García‐Marquina, German E. Pieslinger, Luca Salassa, Fernando López‐Gallego
Published in: Angewandte Chemie International Edition, Issue 62, 2023, Page(s) 62 - 13 (e202218312), ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202218312