Assessing cellular compartmentation of brain lactate using diffusion MR spectroscopy in vivo

Project Information

LactaDiff

Grant agreement ID: 818266

DOI

10.3030/818266

Project closed

EC signature date 19 April 2019

Start date 1 May 2019

End date 31 October 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 868,00

EU contribution

€ 1 999 868,00

Coordinated by

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

Capturing alterations of intracellular–extracellular lactate distribution in the brain using diffusion-weighted MR spectroscopy in vivo

Author(s): Sophie Malaquin, Rodrigo Lerchundi, Eloïse Mougel, Julien Valette
Published in: Proc Natl Acad Sci U S A, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2403635121

Using spectrally-selective radiofrequency pulses to enhance lactate signal for diffusion-weighted MRS measurements in vivo

Author(s): Eloïse Mougel, Sophie Malaquin, Mélissa Vincent, Julien Valette
Published in: Journal of Magnetic Resonance, Issue 334, 2021, ISSN 1090-7807
Publisher: Academic Press
DOI: 10.1016/j.jmr.2021.107113

Assessing potential correlation between T ₂ relaxation and diffusion of lactate in the mouse brain

Author(s): Eloïse Mougel; Sophie Malaquin; Julien Valette
Published in: Magnetic Resonance in Medicine, Issue 1, 2022, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.29395

Characterizing extracellular diffusion properties using diffusion‐weighted MRS of sucrose injected in mouse brain

Author(s): Mélissa Vincent, Mylène Gaudin, Covadonga Lucas‐Torres, Alan Wong, Carole Escartin, Julien Valette
Published in: NMR in Biomedicine, Issue 34/4, 2021, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4478

Investigating exchange, structural disorder, and restriction in gray matter via water and metabolites diffusivity and kurtosis time-dependence

Author(s): Eloïse Mougel, Julien Valette, Marco Palombo
Published in: Imaging Neuroscience, 2024, ISSN 2837-6056
Publisher: MIT Press Direct
DOI: 10.1162/imag_a_00123

Revisiting double diffusion encoding MRS in the mouse brain at 11.7T: Which microstructural features are we sensitive to?

Author(s): Mélissa Vincent, Marco Palombo, Julien Valette
Published in: NeuroImage, Issue 207, 2020, Page(s) 116399, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2019.116399

Conference proceedings (16)

Modeling lactate diffusion in gray matter in the context of the astrocyte-neuron lactate-shuttle

Author(s): Eloïse Mougel, Julien Valette
Published in: Proceedings of the 2025 ISMRM conference, 2025, Page(s) 151
Publisher: International Society for Magnetic Resonance in Medicine

Using selective RF pulses in diffusion-weighted MRS for lactate diffusion measurements with minimal J-modulation

Author(s): Eloïse Mougel, Sophie Malaquin, Melissa Vincent, Julien Valette
Published in: Proceedings of the 2021 ISMRM conference, 2021, Page(s) 286
Publisher: International Society for Magnetic Resonance in Medicine

Robust diffusion-weighted spectroscopic imaging throughout the mouse brain

Author(s): Eloïse Mougel, Julien Valette
Published in: Proceedings of the 2022 ISMRM conference, 2022, Page(s) 308
Publisher: International Society for Magnetic Resonance in Medicine

Probing lactate exchange in Gray Matter via time-dependent DW-MRS

Author(s): Eloïse Mougel, Sophie Malaquin, Marco Palombo, Julien Valette
Published in: Proceedings of the 2023 ISMRM conference, 2023, Page(s) 683
Publisher: International Society for Magnetic Resonance in Medicine

Deciphering the compartmental origin of glucoCEST signal using diffusion-weighted CEST-MRS

Author(s): Yohann Mathieu-Daudé, Mélissa Vincent, Julien Valette, Julien Flament
Published in: Proceedings of the 2022 ISMRM conference, 2022, Page(s) 378
Publisher: International Society for Magnetic Resonance in Medicine

Investigating changes in brain lactate compartmentation using diffusion-weighted MRS in APP/PS1 mice

Author(s): Sophie Malaquin, Eloïse Mougel, Rodrigo Lerchundi, Julien Valette
Published in: Proceedings of the 2023 ISMRM conference, 2023, Page(s) 4477
Publisher: International Society for Magnetic Resonance in Medicine

Evaluation of a spectroscopy sequence using polychromatic refocusing to suppress J-modulation and measure lactate diffusion in the rodent brain

Author(s): Sophie Malaquin, Eloïse Mougel, Melissa Vincent, Julien Valette
Published in: Proceedings of the 2021 ISMRM conference, 2021, Page(s) 2199
Publisher: International Society for Magnetic Resonance in Medicine

Using glutamate-CEST to characterize water diffusion inside neurons: initial results

Author(s): Mélissa Vincent, Yohann Mathieu-Daudé, Julien Flament, and Julien Valette
Published in: Proceedings of the 2020 ISMRM conference, 2020, Page(s) 729
Publisher: International Society for Magnetic Resonance in Medicine

Time-dependent DW-MRS to probe lactate compartmentation in Huntington’s disease mouse model

Author(s): Eloïse Mougel, Marco Palombo, Julien Valette
Published in: Proceedings of the 2024 ISMRM conference, 2024, Page(s) 5099
Publisher: International Society for Magnetic Resonance in Medicine

Characterizing extracellular diffusion properties using diffusion-weighted MRS of sucrose injected in the mouse brain

Author(s): Mélissa Vincent, Mylène Gaudin, Covadonga Lucas-Torres, Océane Guillemaud, Carole Escartin, Alan Wong, Julien Valette
Published in: Proceedings of the 2020 ISMRM conference, 2020, Page(s) 847
Publisher: International Society for Magnetic Resonance in Medicine

Detecting dendritic spine density with double diffusion encoding magnetic resonance spectroscopy

Author(s): Maëliss Jallais, Sophie Malaquin, Kadir Simsek, Julien Valette, Marco Palombo
Published in: Proceedings of the 2025 ISMRM conference, 2025, Page(s) 3898
Publisher: International Society for Magnetic Resonance in Medicine

Assessing potential correlation between T2 relaxation and diffusion of brain lactate

Author(s): Eloïse Mougel, Julien Valette
Published in: Proceedings of the 2022 ISMRM conference, 2022, Page(s) 312
Publisher: International Society for Magnetic Resonance in Medicine

Investigating exchange, structural disorder and restriction in Gray Matter via water and metabolites diffusivity and kurtosis time-dependence

Author(s): Eloïse Mougel, Julien Valette, Marco Palombo
Published in: Proceedings of the 2022 ISMRM conference, 2022, Page(s) 255
Publisher: International Society for Magnetic Resonance in Medicine

Probing compartment-specific diffusion in the brain with 13C diffusion-weighted MRS of hyperpolarized pyruvate and lactate: initial results

Author(s): Mélissa Vincent, Xiao Gao, Myriam Chaumeil, Julien Valette
Published in: Proceedings of the 2022 ISMRM conference, 2022, Page(s) 2417
Publisher: International Society for Magnetic Resonance in Medicine

Probing transient changes in intracellular-extracellular lactate distribution in the mouse brain during i.v. lactate infusion using dMRS

Author(s): Sophie Malaquin, Julien Valette, Celine Baligand
Published in: Proceedings of the 2025 ISMRM conference, 2025, Page(s) 599
Publisher: International Society for Magnetic Resonance in Medicine

How modeling lactate diffusion may inform on its cellular compartmentation? An initial study

Author(s): Sophie Malaquin, Julien Valette
Published in: Proceedings of the 2022 ISMRM conference, 2022, Page(s) 1508
Publisher: International Society for Magnetic Resonance in Medicine