Assessing cellular compartmentation of brain lactate using diffusion MR spectroscopy in vivo

Informazioni relative al progetto

LactaDiff

ID dell’accordo di sovvenzione: 818266

DOI

10.3030/818266

Progetto chiuso

Data della firma CE 19 Aprile 2019

Data di avvio 1 Maggio 2019

Data di completamento 31 Ottobre 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 999 868,00

Contributo UE

€ 1 999 868,00

Coordinato da

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (6)

Capturing alterations of intracellular–extracellular lactate distribution in the brain using diffusion-weighted MR spectroscopy in vivo

Autori: Sophie Malaquin, Rodrigo Lerchundi, Eloïse Mougel, Julien Valette
Pubblicato in: Proc Natl Acad Sci U S A, 2024, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2403635121

Using spectrally-selective radiofrequency pulses to enhance lactate signal for diffusion-weighted MRS measurements in vivo

Autori: Eloïse Mougel, Sophie Malaquin, Mélissa Vincent, Julien Valette
Pubblicato in: Journal of Magnetic Resonance, Numero 334, 2021, ISSN 1090-7807
Editore: Academic Press
DOI: 10.1016/j.jmr.2021.107113

Assessing potential correlation between T ₂ relaxation and diffusion of lactate in the mouse brain

Autori: Eloïse Mougel; Sophie Malaquin; Julien Valette
Pubblicato in: Magnetic Resonance in Medicine, Numero 1, 2022, ISSN 0740-3194
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mrm.29395

Characterizing extracellular diffusion properties using diffusion‐weighted MRS of sucrose injected in mouse brain

Autori: Mélissa Vincent, Mylène Gaudin, Covadonga Lucas‐Torres, Alan Wong, Carole Escartin, Julien Valette
Pubblicato in: NMR in Biomedicine, Numero 34/4, 2021, ISSN 0952-3480
Editore: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4478

Investigating exchange, structural disorder, and restriction in gray matter via water and metabolites diffusivity and kurtosis time-dependence

Autori: Eloïse Mougel, Julien Valette, Marco Palombo
Pubblicato in: Imaging Neuroscience, 2024, ISSN 2837-6056
Editore: MIT Press Direct
DOI: 10.1162/imag_a_00123

Revisiting double diffusion encoding MRS in the mouse brain at 11.7T: Which microstructural features are we sensitive to?

Autori: Mélissa Vincent, Marco Palombo, Julien Valette
Pubblicato in: NeuroImage, Numero 207, 2020, Pagina/e 116399, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2019.116399

Conference proceedings (16)

Modeling lactate diffusion in gray matter in the context of the astrocyte-neuron lactate-shuttle

Autori: Eloïse Mougel, Julien Valette
Pubblicato in: Proceedings of the 2025 ISMRM conference, 2025, Pagina/e 151
Editore: International Society for Magnetic Resonance in Medicine

Using selective RF pulses in diffusion-weighted MRS for lactate diffusion measurements with minimal J-modulation

Autori: Eloïse Mougel, Sophie Malaquin, Melissa Vincent, Julien Valette
Pubblicato in: Proceedings of the 2021 ISMRM conference, 2021, Pagina/e 286
Editore: International Society for Magnetic Resonance in Medicine

Robust diffusion-weighted spectroscopic imaging throughout the mouse brain

Autori: Eloïse Mougel, Julien Valette
Pubblicato in: Proceedings of the 2022 ISMRM conference, 2022, Pagina/e 308
Editore: International Society for Magnetic Resonance in Medicine

Probing lactate exchange in Gray Matter via time-dependent DW-MRS

Autori: Eloïse Mougel, Sophie Malaquin, Marco Palombo, Julien Valette
Pubblicato in: Proceedings of the 2023 ISMRM conference, 2023, Pagina/e 683
Editore: International Society for Magnetic Resonance in Medicine

Deciphering the compartmental origin of glucoCEST signal using diffusion-weighted CEST-MRS

Autori: Yohann Mathieu-Daudé, Mélissa Vincent, Julien Valette, Julien Flament
Pubblicato in: Proceedings of the 2022 ISMRM conference, 2022, Pagina/e 378
Editore: International Society for Magnetic Resonance in Medicine

Investigating changes in brain lactate compartmentation using diffusion-weighted MRS in APP/PS1 mice

Autori: Sophie Malaquin, Eloïse Mougel, Rodrigo Lerchundi, Julien Valette
Pubblicato in: Proceedings of the 2023 ISMRM conference, 2023, Pagina/e 4477
Editore: International Society for Magnetic Resonance in Medicine

Evaluation of a spectroscopy sequence using polychromatic refocusing to suppress J-modulation and measure lactate diffusion in the rodent brain

Autori: Sophie Malaquin, Eloïse Mougel, Melissa Vincent, Julien Valette
Pubblicato in: Proceedings of the 2021 ISMRM conference, 2021, Pagina/e 2199
Editore: International Society for Magnetic Resonance in Medicine

Using glutamate-CEST to characterize water diffusion inside neurons: initial results

Autori: Mélissa Vincent, Yohann Mathieu-Daudé, Julien Flament, and Julien Valette
Pubblicato in: Proceedings of the 2020 ISMRM conference, 2020, Pagina/e 729
Editore: International Society for Magnetic Resonance in Medicine

Time-dependent DW-MRS to probe lactate compartmentation in Huntington’s disease mouse model

Autori: Eloïse Mougel, Marco Palombo, Julien Valette
Pubblicato in: Proceedings of the 2024 ISMRM conference, 2024, Pagina/e 5099
Editore: International Society for Magnetic Resonance in Medicine

Characterizing extracellular diffusion properties using diffusion-weighted MRS of sucrose injected in the mouse brain

Autori: Mélissa Vincent, Mylène Gaudin, Covadonga Lucas-Torres, Océane Guillemaud, Carole Escartin, Alan Wong, Julien Valette
Pubblicato in: Proceedings of the 2020 ISMRM conference, 2020, Pagina/e 847
Editore: International Society for Magnetic Resonance in Medicine

Detecting dendritic spine density with double diffusion encoding magnetic resonance spectroscopy

Autori: Maëliss Jallais, Sophie Malaquin, Kadir Simsek, Julien Valette, Marco Palombo
Pubblicato in: Proceedings of the 2025 ISMRM conference, 2025, Pagina/e 3898
Editore: International Society for Magnetic Resonance in Medicine

Assessing potential correlation between T2 relaxation and diffusion of brain lactate

Autori: Eloïse Mougel, Julien Valette
Pubblicato in: Proceedings of the 2022 ISMRM conference, 2022, Pagina/e 312
Editore: International Society for Magnetic Resonance in Medicine

Investigating exchange, structural disorder and restriction in Gray Matter via water and metabolites diffusivity and kurtosis time-dependence

Autori: Eloïse Mougel, Julien Valette, Marco Palombo
Pubblicato in: Proceedings of the 2022 ISMRM conference, 2022, Pagina/e 255
Editore: International Society for Magnetic Resonance in Medicine

Probing compartment-specific diffusion in the brain with 13C diffusion-weighted MRS of hyperpolarized pyruvate and lactate: initial results

Autori: Mélissa Vincent, Xiao Gao, Myriam Chaumeil, Julien Valette
Pubblicato in: Proceedings of the 2022 ISMRM conference, 2022, Pagina/e 2417
Editore: International Society for Magnetic Resonance in Medicine

Probing transient changes in intracellular-extracellular lactate distribution in the mouse brain during i.v. lactate infusion using dMRS

Autori: Sophie Malaquin, Julien Valette, Celine Baligand
Pubblicato in: Proceedings of the 2025 ISMRM conference, 2025, Pagina/e 599
Editore: International Society for Magnetic Resonance in Medicine

How modeling lactate diffusion may inform on its cellular compartmentation? An initial study

Autori: Sophie Malaquin, Julien Valette
Pubblicato in: Proceedings of the 2022 ISMRM conference, 2022, Pagina/e 1508
Editore: International Society for Magnetic Resonance in Medicine