Assessing cellular compartmentation of brain lactate using diffusion MR spectroscopy in vivo

Información del proyecto

LactaDiff

Identificador del acuerdo de subvención: 818266

DOI

10.3030/818266

Proyecto cerrado

Fecha de la firma de la CE 19 Abril 2019

Fecha de inicio 1 Mayo 2019

Fecha de finalización 31 Octubre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 999 868,00

Aportación de la UE

€ 1 999 868,00

Coordinado por

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (6)

Capturing alterations of intracellular–extracellular lactate distribution in the brain using diffusion-weighted MR spectroscopy in vivo

Autores: Sophie Malaquin, Rodrigo Lerchundi, Eloïse Mougel, Julien Valette
Publicado en: Proc Natl Acad Sci U S A, 2024, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2403635121

Using spectrally-selective radiofrequency pulses to enhance lactate signal for diffusion-weighted MRS measurements in vivo

Autores: Eloïse Mougel, Sophie Malaquin, Mélissa Vincent, Julien Valette
Publicado en: Journal of Magnetic Resonance, Edición 334, 2021, ISSN 1090-7807
Editor: Academic Press
DOI: 10.1016/j.jmr.2021.107113

Assessing potential correlation between T ₂ relaxation and diffusion of lactate in the mouse brain

Autores: Eloïse Mougel; Sophie Malaquin; Julien Valette
Publicado en: Magnetic Resonance in Medicine, Edición 1, 2022, ISSN 0740-3194
Editor: John Wiley & Sons Inc.
DOI: 10.1002/mrm.29395

Characterizing extracellular diffusion properties using diffusion‐weighted MRS of sucrose injected in mouse brain

Autores: Mélissa Vincent, Mylène Gaudin, Covadonga Lucas‐Torres, Alan Wong, Carole Escartin, Julien Valette
Publicado en: NMR in Biomedicine, Edición 34/4, 2021, ISSN 0952-3480
Editor: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4478

Investigating exchange, structural disorder, and restriction in gray matter via water and metabolites diffusivity and kurtosis time-dependence

Autores: Eloïse Mougel, Julien Valette, Marco Palombo
Publicado en: Imaging Neuroscience, 2024, ISSN 2837-6056
Editor: MIT Press Direct
DOI: 10.1162/imag_a_00123

Revisiting double diffusion encoding MRS in the mouse brain at 11.7T: Which microstructural features are we sensitive to?

Autores: Mélissa Vincent, Marco Palombo, Julien Valette
Publicado en: NeuroImage, Edición 207, 2020, Página(s) 116399, ISSN 1053-8119
Editor: Academic Press
DOI: 10.1016/j.neuroimage.2019.116399

Conference proceedings (16)

Modeling lactate diffusion in gray matter in the context of the astrocyte-neuron lactate-shuttle

Autores: Eloïse Mougel, Julien Valette
Publicado en: Proceedings of the 2025 ISMRM conference, 2025, Página(s) 151
Editor: International Society for Magnetic Resonance in Medicine

Using selective RF pulses in diffusion-weighted MRS for lactate diffusion measurements with minimal J-modulation

Autores: Eloïse Mougel, Sophie Malaquin, Melissa Vincent, Julien Valette
Publicado en: Proceedings of the 2021 ISMRM conference, 2021, Página(s) 286
Editor: International Society for Magnetic Resonance in Medicine

Robust diffusion-weighted spectroscopic imaging throughout the mouse brain

Autores: Eloïse Mougel, Julien Valette
Publicado en: Proceedings of the 2022 ISMRM conference, 2022, Página(s) 308
Editor: International Society for Magnetic Resonance in Medicine

Probing lactate exchange in Gray Matter via time-dependent DW-MRS

Autores: Eloïse Mougel, Sophie Malaquin, Marco Palombo, Julien Valette
Publicado en: Proceedings of the 2023 ISMRM conference, 2023, Página(s) 683
Editor: International Society for Magnetic Resonance in Medicine

Deciphering the compartmental origin of glucoCEST signal using diffusion-weighted CEST-MRS

Autores: Yohann Mathieu-Daudé, Mélissa Vincent, Julien Valette, Julien Flament
Publicado en: Proceedings of the 2022 ISMRM conference, 2022, Página(s) 378
Editor: International Society for Magnetic Resonance in Medicine

Investigating changes in brain lactate compartmentation using diffusion-weighted MRS in APP/PS1 mice

Autores: Sophie Malaquin, Eloïse Mougel, Rodrigo Lerchundi, Julien Valette
Publicado en: Proceedings of the 2023 ISMRM conference, 2023, Página(s) 4477
Editor: International Society for Magnetic Resonance in Medicine

Evaluation of a spectroscopy sequence using polychromatic refocusing to suppress J-modulation and measure lactate diffusion in the rodent brain

Autores: Sophie Malaquin, Eloïse Mougel, Melissa Vincent, Julien Valette
Publicado en: Proceedings of the 2021 ISMRM conference, 2021, Página(s) 2199
Editor: International Society for Magnetic Resonance in Medicine

Using glutamate-CEST to characterize water diffusion inside neurons: initial results

Autores: Mélissa Vincent, Yohann Mathieu-Daudé, Julien Flament, and Julien Valette
Publicado en: Proceedings of the 2020 ISMRM conference, 2020, Página(s) 729
Editor: International Society for Magnetic Resonance in Medicine

Time-dependent DW-MRS to probe lactate compartmentation in Huntington’s disease mouse model

Autores: Eloïse Mougel, Marco Palombo, Julien Valette
Publicado en: Proceedings of the 2024 ISMRM conference, 2024, Página(s) 5099
Editor: International Society for Magnetic Resonance in Medicine

Characterizing extracellular diffusion properties using diffusion-weighted MRS of sucrose injected in the mouse brain

Autores: Mélissa Vincent, Mylène Gaudin, Covadonga Lucas-Torres, Océane Guillemaud, Carole Escartin, Alan Wong, Julien Valette
Publicado en: Proceedings of the 2020 ISMRM conference, 2020, Página(s) 847
Editor: International Society for Magnetic Resonance in Medicine

Detecting dendritic spine density with double diffusion encoding magnetic resonance spectroscopy

Autores: Maëliss Jallais, Sophie Malaquin, Kadir Simsek, Julien Valette, Marco Palombo
Publicado en: Proceedings of the 2025 ISMRM conference, 2025, Página(s) 3898
Editor: International Society for Magnetic Resonance in Medicine

Assessing potential correlation between T2 relaxation and diffusion of brain lactate

Autores: Eloïse Mougel, Julien Valette
Publicado en: Proceedings of the 2022 ISMRM conference, 2022, Página(s) 312
Editor: International Society for Magnetic Resonance in Medicine

Investigating exchange, structural disorder and restriction in Gray Matter via water and metabolites diffusivity and kurtosis time-dependence

Autores: Eloïse Mougel, Julien Valette, Marco Palombo
Publicado en: Proceedings of the 2022 ISMRM conference, 2022, Página(s) 255
Editor: International Society for Magnetic Resonance in Medicine

Probing compartment-specific diffusion in the brain with 13C diffusion-weighted MRS of hyperpolarized pyruvate and lactate: initial results

Autores: Mélissa Vincent, Xiao Gao, Myriam Chaumeil, Julien Valette
Publicado en: Proceedings of the 2022 ISMRM conference, 2022, Página(s) 2417
Editor: International Society for Magnetic Resonance in Medicine

Probing transient changes in intracellular-extracellular lactate distribution in the mouse brain during i.v. lactate infusion using dMRS

Autores: Sophie Malaquin, Julien Valette, Celine Baligand
Publicado en: Proceedings of the 2025 ISMRM conference, 2025, Página(s) 599
Editor: International Society for Magnetic Resonance in Medicine

How modeling lactate diffusion may inform on its cellular compartmentation? An initial study

Autores: Sophie Malaquin, Julien Valette
Publicado en: Proceedings of the 2022 ISMRM conference, 2022, Página(s) 1508
Editor: International Society for Magnetic Resonance in Medicine