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Navigating the evolutionary routes of influenza viruses

Project description

A unique model system shines light on flu virus evolution

Seasonal influenza is highly infectious. Global pandemics occurred thrice in the twenty-first century alone. Vaccines can effectively prevent respiratory infection but the genes that code for influenza surface proteins (antigens) can change. These 'new' viruses often evade the human immune response and novel vaccines are required for these novel viral strains. Prolonged infection may also contribute to virus evolution. NaviFlu is investigating this hypothesis in a novel culture system mimicking the human airway epithelium. It will provide a unique opportunity to manipulate and study long-term influenza infection, hopefully leading to the amelioration of a significant threat to public health worldwide.

Call for proposal

ERC-2018-COG
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Host institution

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Address
Meibergdreef 15
1105AZ Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 999 331

Beneficiaries (1)

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 1 999 331
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments