Programmable nucleic acid toolkits for cell-free diagnostics and genetically encoded biosensing

Project Information

PRO-TOOLKITS

Grant agreement ID: 819160

DOI 10.3030/819160

EC signature date 22 March 2019

Start date 1 October 2019

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 375,00

EU contribution € 1 999 375,00

Coordinated by

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy

Publications

Peer reviewed articles (16)

Synthetic DNA-based nanoswimmers driven by enzyme catalysis

Author(s): Tania Patiño; Serena Gentile; Lorena Baranda; Erica Del Grosso; Rafael Mestre; Samuel Sanchez; Francesco Ricci
Published in: Journal of the American Chemical Society, Issue 21, 2024, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.26434/chemrxiv-2023-bxsbh

Programmable Cell-Free Transcriptional Switches for Antibody Detection

Author(s): Aitor Patino Diaz; Sara Bracaglia; Simona Ranallo; Tania Patino; Alessandro Porchetta; Francesco Ricci
Published in: Journal of the American Chemical Society, Issue 5, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c11706

Using antibodies to control DNA-templated chemical reactions

Author(s): Lorena Baranda Pellejero, Malihe Mahdifar, Gianfranco Ercolani, Jonathan Watson, Tom Brown, Francesco Ricci
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20024-3

Autonomous and programmable reorganization of DNA-based polymers using redox chemistry

Author(s): Gentile, Serena; Del Grosso, Erica; Prins, Leonard J; Ricci, Francesco
Published in: Chemistry a European Journal, Issue 12, 2022, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.26434/chemrxiv-2022-vjbbz

Spontaneous Reorganization of DNA-Based Polymers in Higher Ordered Structures Fueled by RNA

Author(s): Serena Gentile; Erica Del Grosso; Passa E. Pungchai; Elisa Franco; Leonard J. Prins; Francesco Ricci
Published in: Journal of the American Chemical Society, Issue 2, 2021, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c09503

Reorganization of Self‐Assembled DNA‐Based Polymers using Orthogonally Addressable Building Blocks**

Author(s): Serena Gentile, Erica Del Grosso, Leonard J. Prins, Francesco Ricci
Published in: Angewandte Chemie International Edition, Issue 60/23, 2021, Page(s) 12911-12917, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202101378

Non-natural protein-protein communication mediated by a DNA-based, antibody-responsive device

Author(s): Simona Ranallo; Daniela Sorrentino; Elisabetta Delibato; Gianfranco Ercolani; Kevin W. Plaxco; Francesco Ricci
Published in: Angewandte Chemie International Edition, Issue 4, 2021, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202115680

Orthogonal enzyme-driven timers for DNA strand displacement reactions

Author(s): Bucci, Juliette; Irmisch, Patrick; Del Grosso, Erica; Seidel, Ralf; Ricci, Francesco
Published in: Journal of the American Chemical Society, Issue 8, 2023, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.26434/chemrxiv-2022-2qzzj

Dissipative operation of pH-responsive DNA-based nanodevices.

Author(s): Davide Mariottini; Daniele Del Giudice; Gianfranco Ercolani; Stefano Di Stefano; Francesco Ricci
Published in: Chemical Science, Issue 1, 2021, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc03435a

Timed Pulses in DNA strand displacement reactions

Author(s): Juliette Bucci; Patrick Irmisch; Erica Del Grosso; Ralf Seidel; Francesco Ricci
Published in: Journal of the American Chemical Society, Issue 14, 2023, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.26434/chemrxiv-2023-99815

Programmable, Multiplexed DNA Circuits Supporting Clinically Relevant, Electrochemical Antibody Detection.

Author(s): Sara Bracaglia; Simona Ranallo; Simona Ranallo; Kevin W. Plaxco; Francesco Ricci
Published in: ACS sensors, vol 6, iss 6, Issue 3, 2021, ISSN 2379-3694
Publisher: ACS
DOI: 10.1021/acssensors.1c00790

Protein‐Controlled Actuation of Dynamic Nucleic Acid Networks by Using Synthetic DNA Translators**

Author(s): Alessandro Bertucci, Alessandro Porchetta, Erica Del Grosso, Tania Patiño, Andrea Idili, Francesco Ricci
Published in: Angewandte Chemie, Issue 132/46, 2020, Page(s) 20758-20762, ISSN 0044-8249
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202008553

Rational Control of the Activity of a Cu 2+ -Dependent DNAzyme by Re-engineering Purely Entropic Intrinsically Disordered Domains

Author(s): Daniela Sorrentino, Simona Ranallo, Francesco Ricci
Published in: ACS Applied Materials & Interfaces, Issue 13/8, 2021, Page(s) 9300-9305, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c09472

Synthetic Genes For Dynamic Regulation Of DNA‐Based Receptors

Author(s): Daniela Sorrentino; Simona Ranallo; Eiji Nakamura; Elisa Franco; Francesco Ricci
Published in: Angewandte Chemie International Edition, Issue 8, 2024, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202319382

Orthogonal regulation of DNA nanostructure self-assembly and disassembly using antibodies

Author(s): Simona Ranallo, Daniela Sorrentino, Francesco Ricci
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13104-6

Synthetic Antigen-Conjugated DNA Systems for Antibody Detection and Characterization

Author(s): Ranallo, Simona; Bracaglia, Sara; Sorrentino, Daniela; Ricci, Francesco
Published in: ACS Sensors, Issue 6, 2022, ISSN 2379-3694
Publisher: ACS
DOI: 10.1021/acssensors.3c00564