Programmable nucleic acid toolkits for cell-free diagnostics and genetically encoded biosensing

Project Information

PRO-TOOLKITS

Grant agreement ID: 819160

DOI

10.3030/819160

Project closed

EC signature date 22 March 2019

Start date 1 October 2019

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 375,00

EU contribution

€ 1 999 375,00

Coordinated by

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (21)

Developmental assembly of multi-component polymer systems through interconnected synthetic gene networks in vitro

Author(s): Daniela Sorrentino, Simona Ranallo, Francesco Ricci, Elisa Franco
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-52986-z

MAIGRET: a CRISPR-based immunoassay that employs antibody-induced cell-free transcription of CRISPR guide RNA strands

Author(s): Francesca Miceli, Sara Bracaglia, Daniela Sorrentino, Alessandro Porchetta, Simona Ranallo, Francesco Ricci
Published in: Nucleic Acids Research, 2024, ISSN 1362-4962
Publisher: OSN
DOI: 10.26434/chemrxiv-2024-cdqld

Synthetic DNA-based nanoswimmers driven by enzyme catalysis

Author(s): Tania Patiño; Serena Gentile; Lorena Baranda; Erica Del Grosso; Rafael Mestre; Samuel Sanchez; Francesco Ricci
Published in: Journal of the American Chemical Society, Issue 21, 2024, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.26434/chemrxiv-2023-bxsbh

Bright and pH-sensitive Baby Spinach aptamer with RNA triplex fusion

Author(s): Kinuko Ueno, Kaori Tsukakoshi, Norito Takeuchi, Shintaro Inaba, Andrea Idili, Alessandro Porchetta, Francesco Ricci, Kazunori Ikebukuro
Published in: Nucleic Acids Research, Issue 53, 2025, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaf151

Programmable Cell-Free Transcriptional Switches for Antibody Detection

Author(s): Aitor Patino Diaz; Sara Bracaglia; Simona Ranallo; Tania Patino; Alessandro Porchetta; Francesco Ricci
Published in: Journal of the American Chemical Society, Issue 5, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c11706

Using antibodies to control DNA-templated chemical reactions

Author(s): Lorena Baranda Pellejero, Malihe Mahdifar, Gianfranco Ercolani, Jonathan Watson, Tom Brown, Francesco Ricci
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20024-3

Autonomous and programmable reorganization of DNA-based polymers using redox chemistry

Author(s): Gentile, Serena; Del Grosso, Erica; Prins, Leonard J; Ricci, Francesco
Published in: Chemistry a European Journal, Issue 12, 2022, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.26434/chemrxiv-2022-vjbbz

Spontaneous Reorganization of DNA-Based Polymers in Higher Ordered Structures Fueled by RNA

Author(s): Serena Gentile; Erica Del Grosso; Passa E. Pungchai; Elisa Franco; Leonard J. Prins; Francesco Ricci
Published in: Journal of the American Chemical Society, Issue 2, 2021, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c09503

Reorganization of Self‐Assembled DNA‐Based Polymers using Orthogonally Addressable Building Blocks**

Author(s): Serena Gentile, Erica Del Grosso, Leonard J. Prins, Francesco Ricci
Published in: Angewandte Chemie International Edition, Issue 60/23, 2021, Page(s) 12911-12917, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202101378

Non-natural protein-protein communication mediated by a DNA-based, antibody-responsive device

Author(s): Simona Ranallo; Daniela Sorrentino; Elisabetta Delibato; Gianfranco Ercolani; Kevin W. Plaxco; Francesco Ricci
Published in: Angewandte Chemie International Edition, Issue 4, 2021, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202115680

Orthogonal enzyme-driven timers for DNA strand displacement reactions

Author(s): Bucci, Juliette; Irmisch, Patrick; Del Grosso, Erica; Seidel, Ralf; Ricci, Francesco
Published in: Journal of the American Chemical Society, Issue 8, 2023, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.26434/chemrxiv-2022-2qzzj

Thermo-Programmed Synthetic DNA-Based Receptors

Author(s): Mariottini, Davide; Idili, Andrea; Ercolani, Gianfranco; Ricci, Francesco
Published in: ACS nano, 2023, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.2c07039

Dissipative operation of pH-responsive DNA-based nanodevices.

Author(s): Davide Mariottini; Daniele Del Giudice; Gianfranco Ercolani; Stefano Di Stefano; Francesco Ricci
Published in: Chemical Science, Issue 1, 2021, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc03435a

Timed Pulses in DNA strand displacement reactions

Author(s): Juliette Bucci; Patrick Irmisch; Erica Del Grosso; Ralf Seidel; Francesco Ricci
Published in: Journal of the American Chemical Society, Issue 14, 2023, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.26434/chemrxiv-2023-99815

Programmable, Multiplexed DNA Circuits Supporting Clinically Relevant, Electrochemical Antibody Detection.

Author(s): Sara Bracaglia; Simona Ranallo; Simona Ranallo; Kevin W. Plaxco; Francesco Ricci
Published in: ACS sensors, vol 6, iss 6, Issue 3, 2021, ISSN 2379-3694
Publisher: ACS
DOI: 10.1021/acssensors.1c00790

Protein‐Controlled Actuation of Dynamic Nucleic Acid Networks by Using Synthetic DNA Translators**

Author(s): Alessandro Bertucci, Alessandro Porchetta, Erica Del Grosso, Tania Patiño, Andrea Idili, Francesco Ricci
Published in: Angewandte Chemie, Issue 132/46, 2020, Page(s) 20758-20762, ISSN 0044-8249
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202008553

Covalent Dynamic DNA Networks to Translate Multiple Inputs into Programmable Outputs

Author(s): Simone Brannetti, Serena Gentile, Erica Del Grosso, Sijbren Otto, Francesco Ricci
Published in: Journal of the American Chemical Society, Issue 147, 2025, Page(s) 5755-5763, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.4c13854

Rational Control of the Activity of a Cu 2+ -Dependent DNAzyme by Re-engineering Purely Entropic Intrinsically Disordered Domains

Author(s): Daniela Sorrentino, Simona Ranallo, Francesco Ricci
Published in: ACS Applied Materials & Interfaces, Issue 13/8, 2021, Page(s) 9300-9305, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c09472

Synthetic Genes For Dynamic Regulation Of DNA‐Based Receptors

Author(s): Daniela Sorrentino; Simona Ranallo; Eiji Nakamura; Elisa Franco; Francesco Ricci
Published in: Angewandte Chemie International Edition, Issue 8, 2024, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202319382

Orthogonal regulation of DNA nanostructure self-assembly and disassembly using antibodies

Author(s): Simona Ranallo, Daniela Sorrentino, Francesco Ricci
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13104-6

Synthetic Antigen-Conjugated DNA Systems for Antibody Detection and Characterization

Author(s): Ranallo, Simona; Bracaglia, Sara; Sorrentino, Daniela; Ricci, Francesco
Published in: ACS Sensors, Issue 6, 2022, ISSN 2379-3694
Publisher: ACS
DOI: 10.1021/acssensors.3c00564