Repurposing small RNA from ciliates for genome editing: single-molecule study

Project description

A novel genome-editing tool

Discovery of the genome-editing ability of bacteria through the CRISPR-Cas system has revolutionised genome editing. However, limitations associated with off-target effects hamper the exploitation of CRISPR-Cas for medical applications. The EU-funded MIGHTY_RNA project is investigating the molecular mechanism of Tetrahymena thermophila DNA elimination as an alternative genome-editing approach. Researchers will determine how the eukaryotic RNA system (Twi1) that mediates this DNA elimination in ciliates recognises and cuts its target sequences. The MIGHTY_RNA study has the potential to create a new genome-editing tool that can outperform CRISPR-Cas in various applications.

Fields of science

• medical and health sciences › medical biotechnology › genetic engineering › gene therapy
• natural sciences › biological sciences › genetics › DNA
• natural sciences › biological sciences › genetics › RNA
• natural sciences › chemical sciences › analytical chemistry › mass spectrometry
• natural sciences › biological sciences › genetics › genomes

Programme(s)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Topic(s)

• ERC-2018-COG - ERC Consolidator Grant

Call for proposal

ERC-2018-COG

See other projects for this call

Funding Scheme

ERC-COG - Consolidator Grant

Host institution

TECHNISCHE UNIVERSITEIT DELFT

Net EU contribution

€ 1 792 850,00

Address

Stevinweg 1
2628 CN Delft
Netherlands

Region

West-Nederland › Zuid-Holland › Delft en Westland

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00

Beneficiaries (1)

TECHNISCHE UNIVERSITEIT DELFT

Netherlands

Net EU contribution

€ 1 792 850,00

Address

Stevinweg 1
2628 CN Delft

Region

West-Nederland › Zuid-Holland › Delft en Westland

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00